双馈异步电机在实际工程运行情况下是一种高度非线性动态系统,并且由于其参数随环境的强变化性,常规方法难以实时得到其高精度参数。结合粒子群算法的高效多模态收敛性能以及免疫机理全局优化能力强等特点,研究了分层型免疫协同进化粒...双馈异步电机在实际工程运行情况下是一种高度非线性动态系统,并且由于其参数随环境的强变化性,常规方法难以实时得到其高精度参数。结合粒子群算法的高效多模态收敛性能以及免疫机理全局优化能力强等特点,研究了分层型免疫协同进化粒子群算法(co-evolutionary particle swarm optimization algorithm based on hierarchical-particle immune,HICPSO)智能计算模型参数。将该方法应用于双馈电机参数辨识与建模,提出了分层型免疫协同进化粒子群算法的双馈电机在线参数辨识。仿真结果表明该算法只需要采集控制过程中的数据,不需要数据手册的电机设计值等其他参数,且能在双馈电机运行实时跟随电机参数变化。展开更多
The issue of selection of bandwidth in kernel smoothing method is considered within the context of partially linear models, hi this paper, we study the asymptotic behavior of the bandwidth choice based on generalized ...The issue of selection of bandwidth in kernel smoothing method is considered within the context of partially linear models, hi this paper, we study the asymptotic behavior of the bandwidth choice based on generalized cross-validation （CCV） approach and prove that this bandwidth choice is asymptotically optimal. Numerical simulation are also conducted to investigate the empirical performance of generalized cross-valldation.展开更多
Visual cognition,as one of the fundamental aspects of cognitive neuroscience,is generally associated with high-order brain functions in animals and human.Drosophila,as a model organism,shares certain features of visua...Visual cognition,as one of the fundamental aspects of cognitive neuroscience,is generally associated with high-order brain functions in animals and human.Drosophila,as a model organism,shares certain features of visual cognition in common with mammals at the genetic,molecular,cellular,and even higher behavioral levels.From learning and memory to decision making,Drosophila covers a broad spectrum of higher cognitive behaviors beyond what we had expected.Armed with powerful tools of genetic manipulation in Drosophila,an increasing number of studies have been conducted in order to elucidate the neural circuit mechanisms underlying these cognitive behaviors from a genes-brain-behavior perspective.The goal of this review is to integrate the most important studies on visual cognition in Drosophila carried out in China's Mainland during the last decade into a body of knowledge encompassing both the basic neural operations and circuitry of higher brain function in Drosophila.Here,we consider a series of the higher cognitive behaviors beyond learning and memory,such as visual pattern recognition,feature and context generalization,different feature memory traces,salience-based decision,attention-like behavior,and cross-modal leaning and memory.We discuss the possible general gain-gating mechanism implementing by dopamine-mushroom body circuit in fly's visual cognition.We hope that our brief review on this aspect will inspire further study on visual cognition in flies,or even beyond.展开更多
In 1979, the mechanism of chemical carcinogenesis, a challenging anddifficult scientific problem pending for a number of years, was explained by Dai Qianhuan. Themechanism named di-region theory predicted that a carci...In 1979, the mechanism of chemical carcinogenesis, a challenging anddifficult scientific problem pending for a number of years, was explained by Dai Qianhuan. Themechanism named di-region theory predicted that a carcinogen always metabolizes to form a specialbi-functional alky-lating agent. This agent induces cross-linkages between the complementary basepairs in DMA and switches on initial mutageneses in genomes including point and frameshiftmutations. This, in turn, induces further deep mutageneses including the production of variouschimeric chromosomes, deletions and other aberrations found in genomes. In the end this initiatescarcinogenesis of the whole cell through the reverse transcription mechanism after a lengthyincubation period. Recently, this laboratory has verified that physical carcinogenesis, includingthe oncogenesis induced by radiation and asbestos as well as the carcinogenesis induced byendogenous factors such as estrogen or diethyl-stilbestrol switch on carcinogenesis by inducing theformation of cross-linkages between the complementary base pairs in DNA. Di-region theory has nowbeen supported by many experimental observations such as mutational spectra of various carcinogens.The potential for carcinogenesis, teratogenesis, sterility and mutagenesis lumped together asgenetic toxicity appears to originate almost uniformly from the cross-linking between complementarybases, i.e. malignant cross-linking, which is in accordance with di-region theory. Other forms ofcross-linking between non-complementary bases, benign cross-linkings, show bi-functional alkylationanticancer activity but lack genetic toxicity. The predictable design and synthesis of a highselectivity anticancer agent with high efficacy and low genetic toxicity, a goal long pursued incancer chemotherapy, have been realized for the first time in this laboratory by inhibitingmalignant and heightening benign cross-linking using the principles of di-region theory. A series ofpatented new anticancer platinum complexes called di-regioplatins, based on the above predetermineddesign, have been reported. In these cancer cell kill rates, tumor-inhibition rates and theultimate life-span for two mouse carcinoma models using several compounds ofcis-di-substituted-benzylaminodihaloplatinum (II) are notably higher than those of cisplatin, buttheir toxicities all are much lower than cisplatin. Based on a predictive design using di-regiontheory and group theory, a new anticancer complex,cis-diammine-cyclopentane-1,1-dicarboxylato-platinum (II) called minoplatin, has been synthesized inthis laboratory by making the minimal structural revision of adding an CH_2 unit on the four-memberring of carboplatin.展开更多
文摘双馈异步电机在实际工程运行情况下是一种高度非线性动态系统,并且由于其参数随环境的强变化性,常规方法难以实时得到其高精度参数。结合粒子群算法的高效多模态收敛性能以及免疫机理全局优化能力强等特点,研究了分层型免疫协同进化粒子群算法(co-evolutionary particle swarm optimization algorithm based on hierarchical-particle immune,HICPSO)智能计算模型参数。将该方法应用于双馈电机参数辨识与建模,提出了分层型免疫协同进化粒子群算法的双馈电机在线参数辨识。仿真结果表明该算法只需要采集控制过程中的数据,不需要数据手册的电机设计值等其他参数,且能在双馈电机运行实时跟随电机参数变化。
文摘The issue of selection of bandwidth in kernel smoothing method is considered within the context of partially linear models, hi this paper, we study the asymptotic behavior of the bandwidth choice based on generalized cross-validation （CCV） approach and prove that this bandwidth choice is asymptotically optimal. Numerical simulation are also conducted to investigate the empirical performance of generalized cross-valldation.
文摘Visual cognition,as one of the fundamental aspects of cognitive neuroscience,is generally associated with high-order brain functions in animals and human.Drosophila,as a model organism,shares certain features of visual cognition in common with mammals at the genetic,molecular,cellular,and even higher behavioral levels.From learning and memory to decision making,Drosophila covers a broad spectrum of higher cognitive behaviors beyond what we had expected.Armed with powerful tools of genetic manipulation in Drosophila,an increasing number of studies have been conducted in order to elucidate the neural circuit mechanisms underlying these cognitive behaviors from a genes-brain-behavior perspective.The goal of this review is to integrate the most important studies on visual cognition in Drosophila carried out in China's Mainland during the last decade into a body of knowledge encompassing both the basic neural operations and circuitry of higher brain function in Drosophila.Here,we consider a series of the higher cognitive behaviors beyond learning and memory,such as visual pattern recognition,feature and context generalization,different feature memory traces,salience-based decision,attention-like behavior,and cross-modal leaning and memory.We discuss the possible general gain-gating mechanism implementing by dopamine-mushroom body circuit in fly's visual cognition.We hope that our brief review on this aspect will inspire further study on visual cognition in flies,or even beyond.
文摘In 1979, the mechanism of chemical carcinogenesis, a challenging anddifficult scientific problem pending for a number of years, was explained by Dai Qianhuan. Themechanism named di-region theory predicted that a carcinogen always metabolizes to form a specialbi-functional alky-lating agent. This agent induces cross-linkages between the complementary basepairs in DMA and switches on initial mutageneses in genomes including point and frameshiftmutations. This, in turn, induces further deep mutageneses including the production of variouschimeric chromosomes, deletions and other aberrations found in genomes. In the end this initiatescarcinogenesis of the whole cell through the reverse transcription mechanism after a lengthyincubation period. Recently, this laboratory has verified that physical carcinogenesis, includingthe oncogenesis induced by radiation and asbestos as well as the carcinogenesis induced byendogenous factors such as estrogen or diethyl-stilbestrol switch on carcinogenesis by inducing theformation of cross-linkages between the complementary base pairs in DNA. Di-region theory has nowbeen supported by many experimental observations such as mutational spectra of various carcinogens.The potential for carcinogenesis, teratogenesis, sterility and mutagenesis lumped together asgenetic toxicity appears to originate almost uniformly from the cross-linking between complementarybases, i.e. malignant cross-linking, which is in accordance with di-region theory. Other forms ofcross-linking between non-complementary bases, benign cross-linkings, show bi-functional alkylationanticancer activity but lack genetic toxicity. The predictable design and synthesis of a highselectivity anticancer agent with high efficacy and low genetic toxicity, a goal long pursued incancer chemotherapy, have been realized for the first time in this laboratory by inhibitingmalignant and heightening benign cross-linking using the principles of di-region theory. A series ofpatented new anticancer platinum complexes called di-regioplatins, based on the above predetermineddesign, have been reported. In these cancer cell kill rates, tumor-inhibition rates and theultimate life-span for two mouse carcinoma models using several compounds ofcis-di-substituted-benzylaminodihaloplatinum (II) are notably higher than those of cisplatin, buttheir toxicities all are much lower than cisplatin. Based on a predictive design using di-regiontheory and group theory, a new anticancer complex,cis-diammine-cyclopentane-1,1-dicarboxylato-platinum (II) called minoplatin, has been synthesized inthis laboratory by making the minimal structural revision of adding an CH_2 unit on the four-memberring of carboplatin.
