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Characterizations of semihoops based on derivations
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作者 WANG Mei ZHANG Xiao-hong 《Applied Mathematics(A Journal of Chinese Universities)》 SCIE CSCD 2024年第2期291-310,共20页
In this paper,we discuss the related properties of some particular derivations in semihoops and give some characterizations of them.Then,we prove that every Heyting algebra is isomorphic to the algebra of all multipli... In this paper,we discuss the related properties of some particular derivations in semihoops and give some characterizations of them.Then,we prove that every Heyting algebra is isomorphic to the algebra of all multiplicative derivations and show that every Boolean algebra is isomorphic to the algebra of all implicative derivations.Finally,we show that the sets of multiplicative and implicative derivations on bounded regular idempotent semihoops are in oneto-one correspondence. 展开更多
关键词 (prelinear)semihoop derivation Heyting algebra Galois connection
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Some results on derivations of MV-algebras 被引量:1
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作者 WANG Jun-tao HE Peng-fei SHE Yan-hong 《Applied Mathematics(A Journal of Chinese Universities)》 SCIE CSCD 2023年第1期126-143,共18页
In this paper, we review some of their related properties of derivations on MValgebras and give some characterizations of additive derivations. Then we prove that the fixed point set of Boolean additive derivations an... In this paper, we review some of their related properties of derivations on MValgebras and give some characterizations of additive derivations. Then we prove that the fixed point set of Boolean additive derivations and that of their adjoint derivations are isomorphic.In particular, we prove that every MV-algebra is isomorphic to the direct product of the fixed point set of Boolean additive derivations and that of their adjoint derivations. Finally we show that every Boolean algebra is isomorphic to the algebra of all Boolean additive(implicative)derivations. These results also give the negative answers to two open problems, which were proposed in [Fuzzy Sets and Systems, 303(2016), 97-113] and [Information Sciences, 178(2008),307-316]. 展开更多
关键词 MV-ALGEBRA derivation fixed point set IDEAL Boolean algebra
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(ρ, τ, σ)-Derivations of Dendriform Algebras
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作者 Yousuf A. Alkhezi 《Applied Mathematics》 2023年第12期839-846,共8页
We introduce and investigate the properties of a generalization of the derivation of dendriform algebras. We specify all possible parameter values for the generalized derivations, which depend on parameters. We provid... We introduce and investigate the properties of a generalization of the derivation of dendriform algebras. We specify all possible parameter values for the generalized derivations, which depend on parameters. We provide all generalized derivations for complex low-dimensional dendriform algebras. 展开更多
关键词 Dendriform Algebras derivationS Generalized derivations
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A Blockchain-Based Efficient Cross-Domain Authentication Scheme for Internet of Vehicles
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作者 Feng Zhao Hongtao Ding +3 位作者 Chunhai Li Zhaoyu Su Guoling Liang Changsong Yang 《Computers, Materials & Continua》 SCIE EI 2024年第7期567-585,共19页
The Internet of Vehicles(IoV)is extensively deployed in outdoor and open environments to effectively address traffic efficiency and safety issues by connecting vehicles to the network.However,due to the open and varia... The Internet of Vehicles(IoV)is extensively deployed in outdoor and open environments to effectively address traffic efficiency and safety issues by connecting vehicles to the network.However,due to the open and variable nature of its network topology,vehicles frequently engage in cross-domain interactions.During such processes,directly uploading sensitive information to roadside units for interaction may expose it to malicious tampering or interception by attackers,thus compromising the security of the cross-domain authentication process.Additionally,IoV imposes high real-time requirements,and existing cross-domain authentication schemes for IoV often encounter efficiency issues.To mitigate these challenges,we propose CAIoV,a blockchain-based efficient cross-domain authentication scheme for IoV.This scheme comprehensively integrates technologies such as zero-knowledge proofs,smart contracts,and Merkle hash tree structures.It divides the cross-domain process into anonymous cross-domain authentication and safe cross-domain authentication phases to ensure efficiency while maintaining a balance between efficiency and security.Finally,we evaluate the performance of CAIoV.Experimental results demonstrate that our proposed scheme reduces computational overhead by approximately 20%,communication overhead by around 10%,and storage overhead by nearly 30%. 展开更多
关键词 Blockchain cross-domain authentication internet of vehicle zero-knowledge proof
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A Post-Quantum Cross-Domain Authentication Scheme Based on Multi-Chain Architecture
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作者 Yi-Bo Cao Xiu-Bo Chen +6 位作者 Yun-Feng He Lu-Xi Liu Yin-Mei Che Xiao Wang Ke Xiao Gang Xu Si-Yi Chen 《Computers, Materials & Continua》 SCIE EI 2024年第2期2813-2827,共15页
Due to the rapid advancements in network technology,blockchain is being employed for distributed data storage.In the Internet of Things(IoT)scenario,different participants manage multiple blockchains located in differ... Due to the rapid advancements in network technology,blockchain is being employed for distributed data storage.In the Internet of Things(IoT)scenario,different participants manage multiple blockchains located in different trust domains,which has resulted in the extensive development of cross-domain authentication techniques.However,the emergence of many attackers equipped with quantum computers has the potential to launch quantum computing attacks against cross-domain authentication schemes based on traditional cryptography,posing a significant security threat.In response to the aforementioned challenges,our paper demonstrates a post-quantum cross-domain identity authentication scheme to negotiate the session key used in the cross-chain asset exchange process.Firstly,our paper designs the hiding and recovery process of user identity index based on lattice cryptography and introduces the identity-based signature from lattice to construct a post-quantum cross-domain authentication scheme.Secondly,our paper utilizes the hashed time-locked contract to achieves the cross-chain asset exchange of blockchain nodes in different trust domains.Furthermore,the security analysis reduces the security of the identity index and signature to Learning With Errors(LWE)and Short Integer Solution(SIS)assumption,respectively,indicating that our scheme has post-quantum security.Last but not least,through comparison analysis,we display that our scheme is efficient compared with the cross-domain authentication scheme based on traditional cryptography. 展开更多
关键词 cross-domain identity authentication lattice-based cryptography blockchain hashed time-locked contract
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On Boolean elements and derivations in 2-dimension linguistic lattice implication algebras
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作者 ZHU Hua ZHAO Jian-bin 《Applied Mathematics(A Journal of Chinese Universities)》 SCIE CSCD 2023年第2期274-292,共19页
A 2-dimension linguistic lattice implication algebra(2DL-LIA)can build a bridge between logical algebra and 2-dimension fuzzy linguistic information.In this paper,the notion of a Boolean element is proposed in a 2DL-L... A 2-dimension linguistic lattice implication algebra(2DL-LIA)can build a bridge between logical algebra and 2-dimension fuzzy linguistic information.In this paper,the notion of a Boolean element is proposed in a 2DL-LIA and some properties of Boolean elements are discussed.Then derivations on 2DL-LIAs are introduced and the related properties of derivations are investigated.Moreover,it proves that the derivations on 2DL-LIAs can be constructed by Boolean elements. 展开更多
关键词 derivation Boolean element Lattice implication algebra(LIA) 2-dimension linguistic lattice implication algebra(2DL-LIA) 2-dimension fuzzy linguistic information
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Organic solar cells with D18 or derivatives offer efficiency over 19%
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作者 Erming Feng Chujun Zhang +3 位作者 Jianhui Chang Hengyue Li Liming Ding Junliang Yang 《Journal of Semiconductors》 EI CAS CSCD 2024年第5期1-4,共4页
In recent years,organic solar cells(OSCs)have garnered significant attention due to their distinctive attributes,such as flexibility,lightweight,and solution processing,which position them as alternatives for next-gen... In recent years,organic solar cells(OSCs)have garnered significant attention due to their distinctive attributes,such as flexibility,lightweight,and solution processing,which position them as alternatives for next-generation solar technologies[1−5].Thanks to breakthroughs in materials development,the power conversion efficiency(PCE)for single-junction OSCs has already surpassed 19%[6−13].The development of photoactive materials is pivotal in enhancing the PCEs,and several reviews have provided insights into materials design[14−18].Herein,we highlight single-junction OSCs based on D18 and its derivatives[19,20]. 展开更多
关键词 BREAKTHROUGH INSIGHT derivATIVES
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Fullerenes and derivatives as electrocatalysts: Promises and challenges
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作者 Kun Guo Ning Li +1 位作者 Lipiao Bao Xing Lu 《Green Energy & Environment》 SCIE EI CAS CSCD 2024年第1期7-27,共21页
Carbon-based metal-free nanomaterials are promising alternatives to precious metals as electrocatalysts of key energy storage and conversion technologies.Of paramount significance are the establishment of design princi... Carbon-based metal-free nanomaterials are promising alternatives to precious metals as electrocatalysts of key energy storage and conversion technologies.Of paramount significance are the establishment of design principles by understanding the catalytic mechanisms and identifying the active sites.Distinct from sp2-conjugated graphene and carbon nanotube,fullerene possesses unique characteristics that are growingly being discovered and exploited by the electrocatalysis community.For instance,the well-defined atomic and molecular structures,the good electron affinity to tune the electronic structures of other substances,the intermolecular self-assembly into superlattices,and the on-demand chemical modification have endowed fullerene with incomparable advantages as electrocatalysts that are otherwise not applicable to other carbon ma-terials.As increasing studies are being reported on this intriguing topic,it is necessary to provide a state-of-the-art overview of the recent progress.This review takes such an initiative by summarizing the promises and challenges in the electrocatalytic applications of fullerene and its derivatives.The content is structured according to the composition and structure of fullerene,including intact fullerene(e.g.,fullerene composite and superlattices)and fullerene derivatives(e.g.,doped,endohedral,and disintegrated fullerene).The synthesis,characterization,catalytic mechanisms,and deficiencies of these fullerene-based materials are explicitly elaborated.We conclude it by sharing our perspectives on the key aspects that future efforts shall consider. 展开更多
关键词 FULLERENE Fullerene derivative Metal-free catalyst Structural defect ELECTROCATALYST
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Discovery and structure-activity relationship studies of novel tetrahydro-β-carboline derivatives as apoptosis initiators for treating bacterial infections
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作者 Shanshan Su Hongwu Liu +7 位作者 Junrong Zhang Puying Qi Yue Ding Ling Zhang Linli Yang Liwei Liu Xiang Zhou Song Yang 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2024年第4期1259-1273,共15页
Developing and excavating new agrochemicals with highly active and safe is an important tactic for protecting crop health and food safety.In this paper,to discover the new bactericide candidates,we designed,prepared a... Developing and excavating new agrochemicals with highly active and safe is an important tactic for protecting crop health and food safety.In this paper,to discover the new bactericide candidates,we designed,prepared a new type of1,2,3,4-tetrahydro-β-carboline(THC)derivatives and evaluated the in vitro and in vivo bioactivities against the Xanthomonas oryzae pv.oryzae(Xoo),Xanthomonas axonopodis pv.citri(Xac),and Pseudomonas syringae pv.actinidiae(Psa).The in vitro bioassay results exhibited that most title molecules possessed good activity toward the three plant pathogenic bacteria,the compound A17 showed the most active against Xoo and Xac with EC50 values of 7.27 and 4.89 mg mL^(-1)respectively,and compound A8 exhibited the best inhibitory activity against Psa with EC50value of 4.87 mg mL^(-1).Pot experiments showed that compound A17 exhibited excellent in vivo antibacterial activities to manage rice bacterial leaf blight and citrus bacterial canker,with protective efficiencies of 52.67 and 79.79%at 200 mgmL^(-1),respectively.Meanwhile,compound A8 showed good control efficiency(84.31%)against kiwifruit bacterial canker at 200 mg mL^(-1).Antibacterial mechanism suggested that these compounds could interfere with the balance of the redox system,damage the cell membrane,and induce the apoptosis of Xoo cells.Taken together,our study revealed that tetrahydro-β-carboline derivatives could be a promising candidate model for novel broadspectrum bactericides. 展开更多
关键词 tetrahydro-β-carboline derivatives antibacterial activity ROS cell apoptosis
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Development and identification of two novel wheat-rye 6R derivative lines with adult-plant resistance to powdery mildew and high-yielding potential
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作者 Guohao Han Jing Wang +10 位作者 Hanwen Yan Tiantian Gu Lijun Cao Shiyu Liu Xiuquan Li Yilin Zhou Jieru Fan Zhipeng Shi Hong Liu Lihui Li Diaoguo An 《The Crop Journal》 SCIE CSCD 2024年第1期308-313,共6页
Powdery mildew,caused by Blumeria graminis f.sp.tritici(Bgt),is a devastating disease that seriously threatens wheat yield and quality.To control this disease,host resistance is the most effective measure.Compared wit... Powdery mildew,caused by Blumeria graminis f.sp.tritici(Bgt),is a devastating disease that seriously threatens wheat yield and quality.To control this disease,host resistance is the most effective measure.Compared with the resistance genes from common wheat,alien resistance genes can better withstand infection of this highly variable pathogen.Development of elite alien germplasm resources with powdery mildew resistance and other key breeding traits is an attractive strategy in wheat breeding.In this study,three wheat-rye germplasm lines YT4-1,YT4-2,and YT4-3 were developed through hybridization between octoploid triticale and common wheat,out of which the lines YT4-1 and YT4-2 conferred adult-plant resistance(APR)to powdery mildew while the line YT4-3 was susceptible to powdery mildew during all of its growth stages.Using genomic in situ hybridization,multi-color fluorescence in situ hybridization,multi-color GISH,and molecular marker analysis,YT4-1,YT4-2,and YT4-3 were shown to be cytogenetically stable wheat-rye 6R addition and T1RS.1BL translocation line,6RL ditelosomic addition and T1RS.1BL translocation line,and T1RS.1BL translocation line,respectively.Compared with previously reported wheat-rye derivative lines carrying chromosome 6R,YT4-1 and YT4-2 showed stable APR without undesirable pleiotropic effects on agronomic traits.Therefore,these novel wheat-rye 6R derivative lines are expected to be promising bridge resources in wheat disease breeding. 展开更多
关键词 Powdery mildew Secale cereale Triticum aestivum Wheat-rye 6R derivatives Agronomic performance
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High-Value-Added Utilization of Turpentine:Screening of Anti-Influenza Virus Agents fromβ-Pinene Derivatives
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作者 Yiwen Li Hongyan Si +7 位作者 Peng Wang Hai Luo Minggui Shen Xiaoping Rao Zhanqian Song Shibin Shang Zongde Wang Shengliang Liao 《Journal of Renewable Materials》 EI CAS 2024年第1期45-56,共12页
Turpentine is a renewable and resourceful forest product.The deep processing and utilization of turpentine,particularly its primary componentβ-pinene,has garnered widespread attention.This study aimed to synthesize 4... Turpentine is a renewable and resourceful forest product.The deep processing and utilization of turpentine,particularly its primary componentβ-pinene,has garnered widespread attention.This study aimed to synthesize 40 derivatives ofβ-pinene,including nopinone,3-cyanopyridines of nopinone,myrtanyl acid,myrtanyl acylthioureas,and myrtanyl amides.We assessed the antiviral activities of theseβ-pinene derivatives against influenza virus A/Puerto Rico/8/34(H1N1)using the 3-(4,5-dimetylthiazol-2-yl)-2,5-diphenyltetrazolium bromide method.Theβ-pinene derivatives were used before and after cellular infection with the influenza virus to evaluate their preventive and therapeutic effects against the H1N1 virus.The results showed that only compound 10o exhibited a preventive effect against the H1N1 virus with a half-maximal inhibitory concentration(IC50)value of 47.6μmol/L.Among the compounds,4e,4i,and 4l demonstrated therapeutic effects against cellular infection,with compound 4e displaying the most potent therapeutic effect(IC50=17.5μmol/L),comparable to the positive control ribavirin.These findings indicated that certainβ-pinene derivatives exhibited in vitro antiviral activity against the H1N1 influenza A virus,warranting further investigation as potential anti-influenza agents. 展开更多
关键词 Antiviral activity Β-PINENE derivATIVE 3-CYANOPYRIDINE influenza virus
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Identification of key genes regulating the synthesis of quercetin derivatives in Rosa roxburghii through integrated transcriptomics and metabolomics
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作者 Liyao Su Min Wu +2 位作者 Tian Zhang Yan Zhong Zongming(Max) Cheng 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2024年第3期876-887,共12页
Rosa roxburghii fruit is rich in flavonoids, but little is known about their biosynthetic pathways. In this study, we employed transcriptomics and metabolomics to study changes related to the flavonoids at five differ... Rosa roxburghii fruit is rich in flavonoids, but little is known about their biosynthetic pathways. In this study, we employed transcriptomics and metabolomics to study changes related to the flavonoids at five different stages of R. roxburghii fruit development. Flavonoids and the genes related to their biosynthesis were found to undergo significant changes in abundance across different developmental stages, and numerous quercetin derivatives were identified. We found three gene expression modules that were significantly associated with the abundances of the different flavonoids in R. roxburghii and identified three structural UDP-glycosyltransferase genes directly involved in the synthesis of quercetin derivatives within these modules. In addition, we found that RrBEH4, RrLBD1 and RrPIF8could significantly increase the expression of downstream quercetin derivative biosynthesis genes. Taken together,these results provide new insights into the metabolism of flavonoids and the accumulation of quercetin derivatives in R. roxburghii. 展开更多
关键词 Rosa roxburghii quercetin derivatives weighted gene co-expression network analysis transcription factor transcriptome METABOLOME
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Tailored multifunctional hydrazine derivatives for efficient printable hole-conductive-free mesoscopic perovskite solar cells via enhancing defect passivation
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作者 Minghao Xia Ziwei Zheng +6 位作者 Yanjie Cheng Chaoyang Wang Zhaozhen Cui Guodong Zhang Jinwei Gonga Anyi Mei Hongwei Han 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2024年第8期357-363,I0008,共8页
The low-cost and easy large-scale fabrication advantages of printable mesoscopic perovskite solar cells(p-MPSCs)are overshadowed by their limited photovoltaic conversion efficiency(PCE).Here,we introduce the hydrazide... The low-cost and easy large-scale fabrication advantages of printable mesoscopic perovskite solar cells(p-MPSCs)are overshadowed by their limited photovoltaic conversion efficiency(PCE).Here,we introduce the hydrazide derivative of 4-Hydroxybenzoylhydrazine(4-HBH)to improve the PCE of p-MPSCs by inducing enhanced defect passivation.Both carbonyl and hydrazine groups in hydrazide groups present strong interaction with perovskite.The hydroxyl group,as an electron donor group,increases the electron cloud density of the hydrazide group in 4-HBH under the conjugation of the benzene ring,and thus enhances its interaction with perovskite.Additionally,the hydroxy group itself interacts with perovskite and passivates defects synergistically.The hydrazine agents can also reduce I2and suppress the loss of iodine in perovskite films,which inhibits the formation of iodine-related defects.Consequently,p-MPSCs with 4-HBH achieve a high PCE of 19.21%,and present well improved stability. 展开更多
关键词 Printable mesoscopic perovskite solar cells Multifunctional hydrazine derivatives Cooperative coordination Conjugation redox activity
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Numerical Treatments for Crossover Cancer Model of Hybrid Variable-Order Fractional Derivatives
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作者 Nasser Sweilam Seham Al-Mekhlafi +2 位作者 Aya Ahmed Ahoud Alsheri Emad Abo-Eldahab 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第8期1619-1645,共27页
In this paper,two crossover hybrid variable-order derivatives of the cancer model are developed.Grünwald-Letnikov approximation is used to approximate the hybrid fractional and variable-order fractional operators... In this paper,two crossover hybrid variable-order derivatives of the cancer model are developed.Grünwald-Letnikov approximation is used to approximate the hybrid fractional and variable-order fractional operators.The existence,uniqueness,and stability of the proposed model are discussed.Adams Bashfourth’s fifth-step method with a hybrid variable-order fractional operator is developed to study the proposed models.Comparative studies with generalized fifth-order Runge-Kutta method are given.Numerical examples and comparative studies to verify the applicability of the used methods and to demonstrate the simplicity of these approximations are presented.We have showcased the efficiency of the proposed method and garnered robust empirical support for our theoretical findings. 展开更多
关键词 Cancer diseases hybrid variable-order fractional derivatives adams bashfourth fifth step generalized fifth order Runge-Kutta method
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Laboratory Implementation of Direct Torque Controller based Speed Loop Pseudo Derivative Feedforward Controller for PMSM Drive
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作者 Prabhakaran Koothu Kesavan Umashankar Subramaniam Dhafer J.Almakhles 《CES Transactions on Electrical Machines and Systems》 EI CSCD 2024年第1期12-21,共10页
This paper,evaluate the effectiveness of a proposed speed loop pseudo derivative feedforward(PDFF)controller-based direct torque controller(DTC)for a PMSM drive against the performance of existing PI speed controller-... This paper,evaluate the effectiveness of a proposed speed loop pseudo derivative feedforward(PDFF)controller-based direct torque controller(DTC)for a PMSM drive against the performance of existing PI speed controller-based DTC and hysteresis current controller(HCC).The proposed PDFF-based speed regulator effectively reduces oscillation and overshoot associated with rotor angular speed,electromagnetic torque,and stator current.Two case studies,one using forward-to-reverse motoring operation and the other involving reverse-to-forward braking operation,has been validated to show the effectiveness of the proposed control strategy.The proposed controller's superior performance is demonstrated through experimental verification utilizing an FPGA controller for a 1.5 kW PMSM drive laboratory prototype. 展开更多
关键词 Direct torque control Pseudo derivative feedforward controller Permanent magnet synchronous motor(PMSM)
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Sepsis Prediction Using CNNBDLSTM and Temporal Derivatives Feature Extraction in the IoT Medical Environment
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作者 Sapiah Sakri Shakila Basheer +4 位作者 Zuhaira Muhammad Zain Nurul Halimatul Asmak Ismail Dua’Abdellatef Nassar Manal Abdullah Alohali Mais Ayman Alharaki 《Computers, Materials & Continua》 SCIE EI 2024年第4期1157-1185,共29页
Background:Sepsis,a potentially fatal inflammatory disease triggered by infection,carries significant healthimplications worldwide.Timely detection is crucial as sepsis can rapidly escalate if left undetected.Recentad... Background:Sepsis,a potentially fatal inflammatory disease triggered by infection,carries significant healthimplications worldwide.Timely detection is crucial as sepsis can rapidly escalate if left undetected.Recentadvancements in deep learning(DL)offer powerful tools to address this challenge.Aim:Thus,this study proposeda hybrid CNNBDLSTM,a combination of a convolutional neural network(CNN)with a bi-directional long shorttermmemory(BDLSTM)model to predict sepsis onset.Implementing the proposed model provides a robustframework that capitalizes on the complementary strengths of both architectures,resulting in more accurate andtimelier predictions.Method:The sepsis prediction method proposed here utilizes temporal feature extraction todelineate six distinct time frames before the onset of sepsis.These time frames adhere to the sepsis-3 standardrequirement,which incorporates 12-h observation windows preceding sepsis onset.All models were trained usingthe Medical Information Mart for Intensive Care III(MIMIC-III)dataset,which sourced 61,522 patients with 40clinical variables obtained from the IoT medical environment.The confusion matrix,the area under the receiveroperating characteristic curve(AUCROC)curve,the accuracy,the precision,the F1-score,and the recall weredeployed to evaluate themodels.Result:The CNNBDLSTMmodel demonstrated superior performance comparedto the benchmark and other models,achieving an AUCROC of 99.74%and an accuracy of 99.15%one hour beforesepsis onset.These results indicate that the CNNBDLSTM model is highly effective in predicting sepsis onset,particularly within a close proximity of one hour.Implication:The results could assist practitioners in increasingthe potential survival of the patient one hour before sepsis onset. 展开更多
关键词 Temporal derivatives hybrid deep learning predicting sepsis onset MIMIC III machine learning(ML) deep learning
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Hypoxia-preconditioned bone marrow-derived mesenchymal stem cells protect neurons from cardiac arrest-induced pyroptosis
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作者 Xiahong Tang Nan Zheng +8 位作者 Qingming Lin Yan You Zheng Gong Yangping Zhuang Jiali Wu Yu Wang Hanlin Huang Jun Ke Feng Chen 《Neural Regeneration Research》 SCIE CAS 2025年第4期1103-1123,共21页
Cardiac arrest can lead to severe neurological impairment as a result of inflammation,mitochondrial dysfunction,and post-cardiopulmonary resuscitation neurological damage.Hypoxic preconditioning has been shown to impr... Cardiac arrest can lead to severe neurological impairment as a result of inflammation,mitochondrial dysfunction,and post-cardiopulmonary resuscitation neurological damage.Hypoxic preconditioning has been shown to improve migration and survival of bone marrow–derived mesenchymal stem cells and reduce pyroptosis after cardiac arrest,but the specific mechanisms by which hypoxia-preconditioned bone marrow–derived mesenchymal stem cells protect against brain injury after cardiac arrest are unknown.To this end,we established an in vitro co-culture model of bone marrow–derived mesenchymal stem cells and oxygen–glucose deprived primary neurons and found that hypoxic preconditioning enhanced the protective effect of bone marrow stromal stem cells against neuronal pyroptosis,possibly through inhibition of the MAPK and nuclear factor κB pathways.Subsequently,we transplanted hypoxia-preconditioned bone marrow–derived mesenchymal stem cells into the lateral ventricle after the return of spontaneous circulation in an 8-minute cardiac arrest rat model induced by asphyxia.The results showed that hypoxia-preconditioned bone marrow–derived mesenchymal stem cells significantly reduced cardiac arrest–induced neuronal pyroptosis,oxidative stress,and mitochondrial damage,whereas knockdown of the liver isoform of phosphofructokinase in bone marrow–derived mesenchymal stem cells inhibited these effects.To conclude,hypoxia-preconditioned bone marrow–derived mesenchymal stem cells offer a promising therapeutic approach for neuronal injury following cardiac arrest,and their beneficial effects are potentially associated with increased expression of the liver isoform of phosphofructokinase following hypoxic preconditioning. 展开更多
关键词 bone marrow–derived mesenchymal stem cells cardiac arrest cardiac resuscitation hypoxic preconditioning liver isoform of phosphofructokinase mitochondria NEUROINFLAMMATION oxidative stress PYROPTOSIS reactive oxygen species
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Transplantation of human placental chorionic plate-derived mesenchymal stem cells for repair of neurological damage in neonatal hypoxic-ischemic encephalopathy
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作者 Lulu Xue Ruolan Du +8 位作者 Ning Bi Qiuxia Xiao Yifei Sun Ruize Niu Yaxin Tan Li Chen Jia Liu Tinghua Wang Liulin Xiong 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第9期2027-2035,共9页
Neonatal hypoxic-ischemic encephalopathy is often associated with permanent cerebral palsy,neurosensory impairments,and cognitive deficits,and there is no effective treatment for complications related to hypoxic-ische... Neonatal hypoxic-ischemic encephalopathy is often associated with permanent cerebral palsy,neurosensory impairments,and cognitive deficits,and there is no effective treatment for complications related to hypoxic-ischemic encephalopathy.The therapeutic potential of human placental chorionic plate-derived mesenchymal stem cells for various diseases has been explored.However,the potential use of human placental chorionic plate-derived mesenchymal stem cells for the treatment of neonatal hypoxic-ischemic encephalopathy has not yet been investigated.In this study,we injected human placental chorionic plate-derived mesenchymal stem cells into the lateral ventricle of a neonatal hypoxic-ischemic encephalopathy rat model and observed significant improvements in both cognitive and motor function.Protein chip analysis showed that interleukin-3 expression was significantly elevated in neonatal hypoxic-ischemic encephalopathy model rats.Following transplantation of human placental chorionic plate-derived mesenchymal stem cells,interleukin-3 expression was downregulated.To further investigate the role of interleukin-3 in neonatal hypoxic-ischemic encephalopathy,we established an in vitro SH-SY5Y cell model of hypoxic-ischemic injury through oxygen-glucose deprivation and silenced interleukin-3 expression using small interfering RNA.We found that the activity and proliferation of SH-SY5Y cells subjected to oxygen-glucose deprivation were further suppressed by interleukin-3 knockdown.Furthermore,interleukin-3 knockout exacerbated neuronal damage and cognitive and motor function impairment in rat models of hypoxic-ischemic encephalopathy.The findings suggest that transplantation of hpcMSCs ameliorated behavioral impairments in a rat model of hypoxic-ischemic encephalopathy,and this effect was mediated by interleukin-3-dependent neurological function. 展开更多
关键词 behavioral evaluations gene knockout human neuroblastoma cells(SH-SY5Y) human placental chorionic derived mesenchymal stem cells INTERLEUKIN-3 neonatal hypoxic-ischemic encephalopathy nerve injury oxygen-glucose deprivation protein chip small interfering RNA
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Determination of Ten Kinds of Alpha-2 Agonists Residues in Animal Derived Food by UHPLC-Triple Quadrupole/Composite Linear Ion Trap Mass Spectrometry
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作者 Fang LI Xuemei LI +3 位作者 Xiangang LI Sining LIU Sha LIU Ying WANG 《Plant Diseases and Pests》 2024年第1期28-32,共5页
[Objectives]The paper was to establish an ultra high performance liquid chromatography-quadrupole/linear ion trap complex mass spectrometry for the determination of 10 kinds ofα2-receptor agonists in animal derived f... [Objectives]The paper was to establish an ultra high performance liquid chromatography-quadrupole/linear ion trap complex mass spectrometry for the determination of 10 kinds ofα2-receptor agonists in animal derived food.[Methods]The samples were extracted with sodium carbonate buffer solution and ethyl acetate,and analyzed by mass spectrometry after solid phase extraction and high performance liquid chromatography separation.[Results]Ten kinds ofα2-receptor agonists showed a good linear relationship in the range of 1-100μg/mL,with the average recovery of over 69%and the relative standard deviation less than 8.32%.The detection limit of 10 kinds of α_(2)-receptor agonists was up to 1μg/kg.[Conclusions]The method has good selectivity and strong anti-interference ability,and can meet the requirements of 10 kinds ofα2-receptor agonists residues in animal derived food. 展开更多
关键词 Animal derived food α_(2)-receptor agonist Solid-phase extraction Ultra-high performance liquid phase-triple quadrupole/linear ion trap composite mass spectrometry
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DERIVATION ALGEBRAS OF THE MODULAR LIE SUPERALGEBRAS W AND S OF CARTAN-TYPE 被引量:32
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作者 张庆成 张永正 《Acta Mathematica Scientia》 SCIE CSCD 2000年第1期137-144,共8页
Let F be a field and char F = p > 3. In this paper the derivation algebras of Lie superalgebras W and S of Cartan-type over F are determined by the calculating method.
关键词 Lie superalgebra exterior algebra derivation algebra
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