期刊文献+
共找到7篇文章
< 1 >
每页显示 20 50 100
Nickel-Catalyzed Cross-Electrophile Coupling of Triazine Esters with Aryl Bromides
1
作者 Xiang Liu Cai-Yu He +6 位作者 Hao-Nan Yin Chengping Miao Xue-Qiang Chu Weidong Rao Hao Xu Xiaocong Zhou Zhi-Liang Shen 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2023年第24期3539-3546,共8页
Cross-electrophile coupling of triazine esters with aryl bromides could be facilely accomplished by employing nickel as catalyst,magnesium as metal mediator,and lithium chloride as additive.The reactions proceeded eff... Cross-electrophile coupling of triazine esters with aryl bromides could be facilely accomplished by employing nickel as catalyst,magnesium as metal mediator,and lithium chloride as additive.The reactions proceeded efficiently in THF at room temperature through C—O bond activation to afford an array of structurally different diaryl ketones in moderate to good yields with wide functional group tolerance.Control experiments showed that nickel,magnesium,lithium chloride,and THF are all indispensable for the good performance of the coupling reaction.Preliminary mechanistic exploration indicated that in situ formed arylmagnesium reagent by the insertion of magnesium into aryl bromide might serve as the key intermediate of the cross-coupling.The method which avoids the utilization of moisture-labile and relatively difficult-to-obtain organometallics is step-economical,cost-efficient,and operationally simple,potentially serving as an attractive alternative to documented methods. 展开更多
关键词 Cross-coupling Triazine esters Diaryl ketones Nickel Magnesium Lithium chloride cross-electrophile coupling
原文传递
Iron-Catalyzed Cross-Electrophile Coupling of Inert C-O Bonds with Alkyl Bromides
2
作者 Shuo Chen Zijian Wang +5 位作者 Shasha Geng Hongdan Zhu Zhengli Liu Yun He Qian Peng Zhang Feng 《CCS Chemistry》 CSCD 2023年第7期1674-1685,共12页
An example of iron-catalyzed cross-electrophile couplingof inert C-O bonds with alkyl bromides via aniron/B_(2)pin_(2) catalytic system has been developed.Aryl and heteroaryl carbamates can smoothly undergothis transf... An example of iron-catalyzed cross-electrophile couplingof inert C-O bonds with alkyl bromides via aniron/B_(2)pin_(2) catalytic system has been developed.Aryl and heteroaryl carbamates can smoothly undergothis transformation under mild conditions, deliveringthe alkylated products with good efficiency.This protocol exhibits good functional group compatibilityand enables the late-stage functionalizationof biorelevant compounds, thus providingexcellent opportunities for applications in medicinalchemistry. Control experiments and computationalstudies reveal that a high spin Fe(I/II/III) catalyticmechanism might be involved in this reactionthrough single electron transfer to activate alkylbromides, oxidative addition of aryl carbamates, andreductive elimination to form Csp^(2)-Csp^(3) bonds. 展开更多
关键词 iron catalysis cross-electrophile coupling inert C-O bonds single-electron transfer pathway
原文传递
Selective Ni-catalyzed cross-electrophile coupling of alkynes,fluoroalkyl halides,and vinyl halides
3
作者 Yubei Dai Fang Wang +1 位作者 Shengqing Zhu Lingling Chu 《Chinese Chemical Letters》 SCIE CAS CSCD 2022年第8期4074-4078,共5页
We report a Ni-catalyzed three-component cross-electrophile coupling of alkynes with alkenyl halides and fluoroalkyl halides to generate fluoroalkyl-incorporated 1,3-dienes.This mild and operationally simple protocol ... We report a Ni-catalyzed three-component cross-electrophile coupling of alkynes with alkenyl halides and fluoroalkyl halides to generate fluoroalkyl-incorporated 1,3-dienes.This mild and operationally simple protocol is distinguished by its broad substrate scope and excellent chemo-,regio-,and stereo-selectivity,offering a new and organometallic agent-free platform for the construction of fluoroalkyl-incorporated diene motifs.Preliminary mechanistic studies have been conducted to probe the potential reaction pathway. 展开更多
关键词 FLUOROALKYLATION cross-electrophile coupling Nickel catalysis Difunctionalization ALKYNES
原文传递
Nickel-Catalyzed Cross-Electrophile Coupling of Aryl Bromides with Pyrimidin-2-yl Tosylates
4
作者 Chunyu Gong Congde Huo +1 位作者 Xicun Wang Zhengjun Quan 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2017年第9期1366-1370,共5页
A new protocol for the NiC12-catalyzed cross-electrophile coupling of aryl bromides with pyrimidin-2-yl tosyl- ates to give the corresponding C2-arylation pyrimidine derivatives has been developed. This study provides... A new protocol for the NiC12-catalyzed cross-electrophile coupling of aryl bromides with pyrimidin-2-yl tosyl- ates to give the corresponding C2-arylation pyrimidine derivatives has been developed. This study provides an improvement over previous methods by using pyrimidin-2-yl tosylates instead of halides as coupling partners that are stable and easily available. 展开更多
关键词 pyrimidin-2-yltosylates functional pyrimidines cross-electrophile coupling aryl bromides Nickel-catalyst
原文传递
Cobalt-catalyzed reductive alkynylation to construct C(sp)-C(sp^(3))and C(sp)-C(sp^(2))bonds 被引量:1
5
作者 Lei Wan Yizhou Tong +1 位作者 Xi Lu Yao Fu 《Chinese Chemical Letters》 SCIE CAS CSCD 2024年第7期253-258,共6页
Transition-metal-catalyzed cross-electrophile coupling has emerged as a reliable method for constructing carbon–carbon bonds.Herein,we report a general method,cobalt-catalyzed reductive alkynylation,to construct C(sp... Transition-metal-catalyzed cross-electrophile coupling has emerged as a reliable method for constructing carbon–carbon bonds.Herein,we report a general method,cobalt-catalyzed reductive alkynylation,to construct C(sp)-C(sp^(3))and C(sp)-C(sp^(2))bonds.This presented reaction has a broad substrate scope,enabling the efficient cross-electrophile coupling between alkynyl bromides with alkyl halides and aryl or alkenyl(pseudo)halides.This presented reaction is conducted under mild conditions,tolerating many functional groups,thus suitable for the modification and synthesis of biologically active molecules. 展开更多
关键词 Cobalt-catalysis cross-electrophile coupling Carbon-carbon bond formation Reductive alkynylation Alkyne synthesis
原文传递
The synergism of sequential paired electrosynthesis with halogen bonding activation for the cyclization of organochlorides with olefins 被引量:1
6
作者 Fei Lian Kun Xu Chengchu Zeng 《Science China Chemistry》 SCIE EI CAS CSCD 2023年第2期540-547,共8页
Reported herein is the design of a new catalytic paradigm by synergistically combining sequential paired electrosynthesis with halogen-bonding(XB)activation for the cyclization of organochlorides with olefins.This dua... Reported herein is the design of a new catalytic paradigm by synergistically combining sequential paired electrosynthesis with halogen-bonding(XB)activation for the cyclization of organochlorides with olefins.This dual activation strategy enables rapid access to densely functionalized 2-alkylidene-tetrahydrofurans with exclusive Z-selectivities,which are challenging to be synthesized by other methods.4,4′-Di-tert-butyl-2,2′-bipyridine(dtbbpy)showed an unprecedented reactivity as a XB acceptor to activate C-Cl bond by shifting its reduction potential positively by 220 m V.Distinctly different from previous electroreductions of C-Cl bonds relying upon high electrode potentials or matched redox properties between mediators and organochlorides,the XB activator employed herein has no limit on the abovementioned redox property matching but can lower the applied electrode potentials.The decreased operating potential allows broad functional group tolerance,which was highlighted by the late-stage functionalization of 11 examples of drugs and natural products-derived alkenes. 展开更多
关键词 ELECTROCHEMISTRY cross-electrophile coupling ELECTROCATALYSIS paired electrolysis
原文传递
Nickel-Catalyzed Reductive Electrophilic Ring-Opening of Benzofurans with Alkyl Halides
7
作者 Decai Ding Haiyan Dong Chuan Wang 《CCS Chemistry》 CAS 2022年第2期548-556,共9页
In this paper,we developed an electrophilic ring-opening reaction,which is beyond the strained small ring system.Under reductive nickel catalysis,ring-opening of diverse benzofurans via endocyclic inert carbon–oxygen... In this paper,we developed an electrophilic ring-opening reaction,which is beyond the strained small ring system.Under reductive nickel catalysis,ring-opening of diverse benzofurans via endocyclic inert carbon–oxygen bond cleavage can be achieved with an array of inactivated secondary and tertiary alkyl halides as coupling partners,allowing for the preparation of a series of(E)-o-alkenylphenols with excellent E/Z-selectivity and high functional tolerance.The utility of this method was further demonstrated through derivatizations of the ring-opening products using the o-hydroxyl group as a functional handle,providing various organic compounds in good to high efficiency. 展开更多
关键词 BENZOFURAN RING-OPENING DEAROMATIZATION cross-electrophile coupling nickel
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部