Dysfunctional attitudes,social support,negative life events,and depressive symptoms in Chinese adolescents:A moderated mediation model

BACKGROUND Depression is a prevalent psychological issue in adolescents that is significantly related to negative life events(NLEs)and dysfunctional attitudes.High levels of social support can significantly buffer NLEs’effect on depression.Currently,there is limited research on how social support moderates the relationship between NLEs,dysfunctional attitudes,and depression in adolescents in China.It is imperative to investigate this moderating effect to mitigate dysfunctional attitudes in adolescent undergoing depressive mood,ultimately enhancing their overall mental health.AIM To investigate the relationship and underlying mechanisms between specific dysfunctional attitudes,social support,and depression among Chinese adolescents.METHODS This is a cross-sectional study which selected five middle schools in Shandong Province for investigation in March 2022.Participants included 795 adolescents(49.87%male,mage=15.15,SD=1.84,age range=11-18 years old).All participants completed the Dysfunctional Attitude Scale,Adolescent Life Event Scale,Beck Depression Inventory,and Social Support Rating Scale.A moderated mediation model was conducted to examine the relationship between specific dysfunctional attitudes,social support,and depression.RESULTS Results indicated that NLEs affected depression through the mediating role of specific dysfunctional attitudes(autonomy attitudesβ=0.21;perfectionismβ=0.25).Moreover,social support was found to moderate the mediating effect between NLEs,specific dysfunctional attitudes,and depressive symptoms(autonomy attitudes b2=-0.08;perfectionism b2=-0.09).CONCLUSION Dysfunctional attitudes mediated and social support moderated the relationship between NLEs and depression.Social support can buffer depression symptoms among adolescents with autonomy attitudes and perfectionism.

Parental Psychological Control and Internet Gaming Disorder Tendency:A Moderated Mediation Model of Core Self-Evaluation and Intentional Self-Regulation

Internet gaming disorder(IGD)among junior high school students is an increasingly prominent mental health concern.It is important to look for influences behind internet gaming disorder tendency(IGDT)in the junior high school student population.The present study aimed to reveal the explanatory mechanisms underlying the association between parental psychological control(PPC)and internet gaming disorder tendency among junior high school students by testing the mediating role of core self-evaluation(CSE)and the moderating role of intentional self-regulation(ISR).Participants in present study were 735 Chinese junior high school students who completed offline self-report questionnaires on parental psychological control,core self-evaluation,intentional self-regulation,and Internet gaming disorder tendency.Analyses were conducted via mediation and moderated mediation.The results showed that:(1)Parental psychological control was positively related to junior high school students’Internet gaming disorder tendency.Core self-evaluation,and intentional self-regulation were negatively related to junior high school students’Internet gaming disorder tendency,respectively.(2)Core self-evaluation partially mediated the relationship between parental psychological control and junior high school students’Internet gaming disorder tendency.(3)Intentional self-regulation moderated the association between parental psychological control and Internet gaming disorder tendency,as well as the relationships between parental psychological control and core self-evaluation and core self-evaluation and Internet gaming disorder tendency in the mediated model.Based on these findings,we believe that there is a need to weaken parental psychological control,strengthen junior high school students’core self-evaluation and intentional self-regulation,and to recognize the important role of parents as well as their children’s personal positive traits in the healthy development of junior high school students.

Mediation effects of social support on relationships of perceived environment and self-efficacy with school-based physical activity: A structural equation model tailored for Japanese adolescent girls

Background: Identifying correlates of physical activity that can be targeted as potential mediators is important for developing interventions to promote physical activity in adolescent girls. However, the mediated effects of multilevel correlates of physical activity remain poorly understood. Therefore, the present study aimed to examine direct and mediated effects of personal, social and perceived school physical environmental factors on school-based physical activity of Japanese adolescent girls. Methods: In this cross-sectional survey of the Japanese adolescent lifestyles, 344 junior high school girls were invited to complete self-report measures of age, grade, weight, height, self-efficacy, social support (family, friends and teachers), perceived school physical environment (equipment, facilities and safety) and physical activity at school (min per week during lunch time and after- school hours). Structural equation modeling analysis controlling for age was performed to examine the effects of body mass index (BMI), self-efficacy, social support and school physical environmental variables on lunchtime and after-hours physical activity. Results: The final structural model demonstrated an acceptable fit for each context-specific physical activity. During lunch recess, perceived equipment and friend support exhibited direct effects on physical activity;perceived facilities, safety, and self-efficacy were indirectly associated with physical activity through friend support. During after-school hours, both family and friend support directly affected physical activity at school;perceived safety, facilities and self-efficacy exhibited indirect effects on physical activity through family or friend support. However, there were no significant associations between equipment and after-school-hours physical activity. Regardless of contexts, BMI had neither direct nor indirect effects on physical activity. Conclusion: Social support from family and friends was identified as factors mediating the effects of perceived environment and self-efficacy on school-based physical activity among Japanese adolescent girls. This finding encourages the future development of effective interventions to promote physical activity through family and friend support in the future.

Angiogenesis in a 3D model containing adipose tissue stem cells and endothelial cells is mediated by canonical Wnt signaling

Adipose-derived stromal cells （ASCs） have gained great attention in regenerative medicine. Progress in our understanding of adult neovascularization further suggests the potential of ASCs in promoting vascular regeneration, although the specific cues that stimulate their angiogenic behavior remain controversial In this study, we established a three-dimensional （3D） angiogenesis model by co-culturing ASCs and endothelial cells （ECs） in collagen gel and found that ASC-EC-instructed angiogenesis was regulated by the canonical Wnt pathway. Furthermore, the angiogenesis that occurred in implants collected after injections of our collagen gel- based 3D angiogenesis model into nude mice was confirmed to be functional and also regulated by the canonical Wnt pathway. Wnt regulation of angiogenesis involving changes in vessel length, vessel density, vessel sprout, and connection numbers occurred in our system. Wnt signaling was then shown to regulate ASC- mediated paracrine signaling during angiogenesis through the nuclear translocation of β-catenin after its cytoplasmic accumulation in both ASCs and ECs. This translocation enhanced the expression of nuclear cofactor Lef-1 and cyclin D1 and activated the angiogenic transcription of vascular endothelial growth factor A （VEGFA）, basic fibroblast growth factor （bFGF）, and insulin-like growth factor 1 （IGF-1）. The angiogenesis process in the 3D collagen model appeared to follow canonical Wnt signaling, and this model can help us understand the importance of the canonical Wnt pathway in the use of ASCs in vascular regeneration.

Modeling and Estimation of the Kinetics of Seeded Solvent-mediated Phase Transformation in a Batch Crystallizer

Modeling the kinetics of the preparing process is necessary to produce a product with the appropriate particle properties and minimum production cost.Owing to the lackness of crystal size distributor （CSD） information,however,solvent-mediated phase transformation encounters difficulty in modeling the kinetics as compared to solution crystallization.Consequently,a model was established by making the product CSD to move along by horizontal translation to obtain the CSDs of the stable phase in the process of transformation.Then the moment method was used to solve the popular balance equation,and the least square nonlinear regression method was applied to estimate the kinetics parameters.The model has been successfully used to simulate the transformation of CaSO4？2H2O to α-CaSO4？1/2H2O in an isothermal seeded batch crystallizer with different stirring speeds,and it is beneficial to producing high performance α-CaSO4？1/2H2O crystals which have the right particle characteristics.

Mechanisms Influencing Learning Gains Under Information Security: Structural Equation Modeling with Mediating Effect

With the expanding enrollments in higher education,the quality of col-lege education and the learning gains of students have attracted much attention.It is important to study the influencing factors and mechanisms of individual stu-dents’acquisition of learning gains to improve the quality of talent cultivation in colleges.However,in the context of information security,the original data of learning situation surveys in various universities involve the security of educa-tional evaluation data and daily privacy of teachers and students.To protect the original data,data feature mining and correlation analyses were performed at the model level.This study selected 12,181 pieces of data from X University,which participated in the Chinese College Student Survey(CCSS)from 2018 to 2021.A confirmatory factor analysis was conducted and a structural equation modeling was conducted using AMOS 24.0.Through hypothesis testing,this study explored the mechanisms that influence learning gains from the per-spectives of student involvement,teacher involvement,and school support.The results indicated that the quality of student involvement has an important mediat-ing effect on learning gains and that a supportive campus environment has the greatest influence on learning gains.Establishing positive emotional communica-tions between teachers and students is a more direct and effective method than improving the teaching level to improve the quality of student involvement.This study discusses the implications of these results on the research and practice of connotative development in higher education.

Anatomical distributional defects in mutant genes associated with dominant intermediate Charcot-Marie-Tooth disease type C in an adenovirus-mediated mouse model

Dominant intermediate Charcot-Marie-Tooth disease type C（DI-CMTC） is a dominantly inherited neuropathy that has been classified primarily based on motor conduction velocity tests but is now known to involve axonal and demyelination features.DI-CMTC is linked to tyrosyl-t RNA synthetase（YARS）-associated neuropathies,which are caused by E196 K and G41 R missense mutations and a single de novo deletion（153-156 del VKQV）.It is well-established that these YARS mutations induce neuronal dysfunction,morphological symptoms involving axonal degeneration,and impaired motor performance.The present study is the first to describe a novel mouse model of YARS-mutation-induced neuropathy involving a neuron-specific promoter with a deleted mitochondrial targeting sequence that inhibits the expression of YARS protein in the mitochondria.An adenovirus vector system and in vivo techniques were utilized to express YARS fusion proteins with a Flag-tag in the spinal cord,peripheral axons,and dorsal root ganglia.Following transfection of YARS-expressing viruses,the distributions of wild-type（WT） YARS and E196 K mutant proteins were compared in all expressed regions; G41 R was not expressed.The proportion of Flag/green fluorescent protein（GFP） double-positive signaling in the E196 K mutant-type mice did not significantly differ from that of WT mice in dorsal root ganglion neurons.All adenovirus genes,and even the empty vector without the YARS gene,exhibited GFP-positive signaling in the ventral horn of the spinal cord because GFP in an adenovirus vector is driven by a cytomegalovirus promoter.The present study demonstrated that anatomical differences in tissue can lead to dissimilar expressions of YARS genes.Thus,use of this novel animal model will provide data regarding distributional defects between mutant and WT genes in neurons,the DICMTC phenotype,and potential treatment approaches for this disease.

Relation between Interparental Conflict and Non-Suicidal Self-Injury in Adolescents:Mediating Role of Alexithymia and Moderating Role of Resilience

Background:Adolescents frequently engage in Non-Suicidal Self-Injury(NSSI),with recent trends indicating an increase in this behavior.At the same time,Chinese adolescents have a higher incidence of NSSI than Western adolescents.Therefore,it is necessary to explore the relationship between interparental conflict and NSSI among adolescents within the context of Chinese families.Methods:The research sample comprised 755 senior high school students(46.62%male;age M=16.82,SD=0.94 years)who completed the Interparental Conflict Child Perception Scale(CPIC),Adolescent Self-Injury Behavior Questionnaire(ASHS),Toronto Alexithymia Scale-20(TAS-20),and Scale of Adolescent Resilience(RSCA).Results:Findings suggest that interparental conflict is a significant positive predictor of NSSI(r=0.22,p<0.01).Alexithymia mediates the relation between interparental conflict and NSSI(effect size=0.09,95%CI[0.05,0.13]).Additionally,resilience moderates both the direct relation(β=−0.08,p<0.05)and the latter half of the mediating pathway(β=−0.08,p<0.05)in the moderated mediation model.Conclusion:This study indicates that interparental conflict have an impact on adolescents’NSSI in Chinese families,and alexithymia and resilience play important roles in the relationship.These findings offer valuable guidance for the prevention and intervention efforts targeting NSSI among adolescents in China and in similar family contexts.

Assistive technologies and habit development:a Semiotic Model of Technological Mediation

In the field of philosophy of technology,the concept of mediation is central to understanding how technology shapes human experience and behavior.Our aim in this paper is to contribute to the understanding of technological mediation,in particular how and why it is possible.Technological mediation occurs within a mediation space between the technological realm and the user realm.In the technological realm,technology regularizes events and actions,while in the user realm,the user interprets the significative potential of the technology.This interpretation process is identical with use and involves the formation of user habits,which are constrained by technological,cognitive,and sociocultural factors.To provide a theoretical framework for our analysis,we propose the Semiotic Model of Technological Mediation(SMTM),which draws on Charles Peirceʼs semiotics.To illustrate our argument,we focus on assistive technology and provide a recurring example of the Medimi®Smart,a digital,comprehensive system for medication handling.

Preparation method of an ideal model of multiple organ injury of rat with severe acute pancreatitis

AIM： To establish an ideal model of multiple organ injury of rats with severe acute pancreatitis （SAP）.METHODS： SAP models were induced by retrograde injection of 0.1 mL/100 g 3.5% sodium taurocholate into the biliopancreatic duct of Sprague-Dawley rats. The plasma and samples of multiple organ tissues of rats were collected at 3, 6 and 12 h after modeling. The ascites volume, ascites/body weight ratio, and contents of amylase, endotoxin, endothelin-1 （ET-1）, nitrogen monoxidum （NO）, phospholipase A2 （PLA2）, tumor necrosis factor-α （TNF-α）, interleukin-6 （IL-6） in plasma were determined. The histological changes of multiple organs were observed under light microscope.RESULTS： The ascites volume, ascites/body weight ratio, and contents of various inflammatory mediators in blood were higher in the model group than in the sham operation group at all time points [2.38 （1.10）, 2.58 （0.70）, 2.54 （0.71） vs 0.20 （0.04）, 0.30 （0.30）, 0.22 （0.10） at 3, 6 and 12 h in ascites/body weight ratio; 1582 （284）, 1769 （362）, 1618 （302） （U/L） vs 5303 （1373）, 6276 （1029）, 7538 （2934） （U/L） at 3, 6 and 12 h in Amylase; 0.016 （0.005）, 0.016 （0.010）, 0.014 （0.015） （EU/mL） vs 0,053 （0.029）, 0.059 （0.037）, 0.060 （0.022） （EU/mL） at 3, 6 and 12 h in Endotoxin; 3.900 （3.200）, 4.000 （1.700）, 5.300 （3.000） （ng/L） vs 41.438 （37.721）, 92.151 （23.119）, 65.016 （26.806） （ng/L） at 3, 6 and 12 h in TNF-α, all P 〈 0.01]. Visible congestion, edema and lamellar necrosis and massive leukocytic infiltration were found in the pancreas of rats of model group. There were also pathological changes of lung, liver, kidney, ileum, lymphonode, thymus, myocardium and brain.CONCLUSION： This rat model features reliability, convenience and a high achievement ratio. Complicated with multiple organ injury, it is an ideal animal model of SAR

Mediator模型的SystemC代码自动生成

Mediator是一种基于组件的建模语言,该语言主要通过自动机和系统对模型进行描述。将Mediator语言描述的模型自动生成为可执行代码,可以避免编码过程中由于人为疏忽而造成的错误,从而提高编码的可靠性,同时缩短模型开发周期。介绍一种从Mediator模型到SystemC代码的自动生成工具,该工具旨在将基于特定平台的模型转换为能直接仿真运行的代码。首先对Mediator语言的语法语义进行分析,选择合适的SystemC代码组织形式,然后针对Mediator模型的每一个组成部分设计生成规则,其中重点对类型生成、状态转移语句生成、同步语句的生成进行分析。最后,通过一个机器掉电检测系统说明该工具运行结果的正确性。

Opening Moves Involved in Text-based Computer-Mediated-Communication (CMC) by Chinese Adults

The development of science and technology has made it not only possible but very convenient for people living in different parts of the world to communicate with each other, thus bringing forth a new form of communication: computer-mediated communication (CMC). Text-based CMC is one of the most popular forms of CMC in which people send instant messages to others in different settings. Since this mode of interaction combines features of both the written and spoken language (Greenfield & Subrahmanyam, 2003), it's of great interest whether it follows the same sequential rule as the telephone conversation. However, compared to telephone conversations, computer-mediated communication has received much less attention, let alone text-based CMC. The existing body of literature mostly focuses on content analysis and linguistic features but neglects the sequential organization of such interaction (Paolillo, 1999; Greenfield and Subrahmanyam, 2003; Herring, 1999). In light of this, this paper examines the opening moves of instant message exchanges among Chinese adults in an attempt to find out the unique features characterizing the way they open an online chat. The framework that was chosen for data analysis was the sequential model proposed by Schegloff for American telephone openings.

Construction of Mediators for Heterogeneous Data Source Integration Systems

To construct mediators for data integration systems that integrate structured and semi-structured data, and to facilitate the reformulation and decomposition of the query, the presented system uses the XML processing language (XPL) for the mediator. With XPL, it is easy to construct mediators for data integration based on XML, and it can accelerate the work in the mediator.

Mediator的概率扩展

Mediator是一种基于组件的形式化建模语言,它提供了分层的模块化结构,从而可以方便地对复杂系统进行建模。它以自动机为其底层单位,自动机连接成的系统作为高级结构,能在对模型进行形式化描述的同时让其本身简单易用。为了使Mediator具有更强的表达能力,可对具有概率行为的系统进行形式化建模,对Mediator做了概率方面的扩展,并对扩展后的语言给出了基于马尔可夫决策过程的语义。同时还介绍了由Mediator模型自动生成PRISM代码的方法,能够使用PRISM工具对Mediator模型的相关性质进行验证。

The Relationship Between Exposure to Televised Violence and Malaysian Adolescents＇ Aggressive Behaviours＂ A Structural Equation Modelling Analysis

Previous studies on the relationship between exPosure to televised violence and viewers＇ aggressive behaviours have produced mixed results. Some studies have found significant effect sizes while others have found low and non-significant effect sizes. Television effects scholars have postulated that these mixed results are caused by the inconsistencies of research methodology employed and the inability to control major mediating variables in the studies. The present study is designed with the objectives to overcome these shortcomings. The respondents for this study were 514 students aged between 13 and 18 from 10 schools in the State of Perak, Malaysia. Exploratory data analyses provided evidence that the employed instruments achieved sound psychometric properties. Hypotheses testing suggested that exposure to the Contents of Television Violence （TVCN） did not have a direct relationship with adolescents＇ aggressive behaviours; instead, Contextual Features of Television Violence （TVCX） totally mediated this relationship. Some other mediating variables then mediated totally and some mediated partially the relationship between TVCX and adolescents＇ aggressive behaviours. To conclude, this study provides valuable information for parents, the television industry, and the policy makers in recognizing pro-violent and anti-violent features of television violence programmes for Malaysian school-going adolescents. It also provides a new perspective for future studies of television violence in Malaysia.

数字经济对体育产业高质量发展的影响——基于中介模型和门槛模型的检验

对我国19个省级行政区2012—2021年的面板数据进行实证分析,通过建立中介模型和门槛模型探究数字经济与我国体育产业高质量发展的关系。结果显示:①在固定效应模型的基础上进行实证分析发现,数字经济对体育产业高质量发展产生推动作用;②在数字经济促进体育产业高质量发展过程中,产业结构作为中介变量、科技创新作为调节变量在其中起到相应的促进作用;③数字经济与体育产业高质量发展之间显著存在产业结构一阶门槛和科技创新二阶门槛效应。提出:应从提升数字经济发展水平、优化产业结构以及提升科技创新水平等方面促进体育产业高质量发展,推进社会主义现代化体育强国建设。

Theoretical studies on s RNA-mediated regulation in bacteria

Small RNA（sRNA）-mediated post-transcriptional regulation differs from protein-mediated regulation. Through basepairing, sRNA can regulate the target m RNA in a catalytic or stoichiometric manner. Some theoretical models were built for comparison of the protein-mediated and sRNA-mediated modes in the steady-state behaviors and noise properties. Many experiments demonstrated that a single sRNA can regulate several m RNAs, which causes crosstalk between the targets.Here, we focus on some models in which two target mRNAs are silenced by the same sRNA to discuss their crosstalk features. Additionally, the sequence-function relationship of sRNA and its role in the kinetic process of base-pairing have been highlighted in model building.

主客体互倚中介模型的不孕不育夫妇生育压力、心理弹性与生活质量的相关性

目的:通过主客体互倚中介模型分析生育压力对不孕不育夫妇双方生活质量的影响与心理弹性的中介作用。方法:采用便利抽样法选取于苏州某三甲医院就诊的532对不孕不育夫妇作为研究对象。采用一般资料调查表、生育困难压力量表、心理弹性量表、生育生活质量量表进行横断面调查。通过主客体互倚中介模型分析不孕不育夫妇生育压力、心理弹性与生活质量之间的路径关系。结果:个体的生育压力负向预测夫妇双方的生活质量(β=-0.261,P<0.001;β=-0.061,P<0.05);个体的心理弹性正向预测双方的生活质量(β=0.557,P<0.001;β=0.152,P<0.01)。但个体的生育压力只能负向预测配偶的心理弹性(β=-0.028,P<0.05)。结论:高水平的心理弹性不仅有利于个人的生活质量,而且作为中介因素帮助配偶缓冲生育压力对生活质量的不利影响。

信息技术与企业绩效:知识管理能力与商业模式创新的链式中介作用

信息化时代背景下,企业可以通过先进的信息技术提高管理能力与组织绩效。基于资源基础观和动态能力理论,依循“资源—能力—绩效”的逻辑,以知识管理能力和商业模式创新为中介,探讨信息技术对企业绩效的影响机理。以创新型企业为研究对象,采用问卷调查法收集297份样本数据,并运用偏最小二乘结构方程模型和模糊集定性比较分析方法进行实证检验。结果表明,信息技术对知识管理能力和企业绩效的正向直接效应均显著,知识管理能力对商业模式创新、商业模式创新对企业绩效的正向直接效应均显著,且商业模式创新与知识管理能力在信息技术对企业绩效的正向影响中发挥链式中介作用;企业实现高水平绩效存在3种组态,也间接证实知识管理能力与商业模式创新在信息技术与企业绩效之间存在链式中介效应。研究有助于增进对信息技术与企业绩效间作用关系的理解,丰富资源基础观与动态能力理论,进而为创新型企业可持续成长提供路径指引。

绿色金融发展对中国253个地级市碳排放的影响——基于空间计量模型检验

基于2010—2019年中国253个地级市的面板数据构建空间杜宾模型,分析绿色金融发展对二氧化碳排放量的影响及其空间溢出效应,并结合中介效应模型检验其作用渠道。结果表明,绿色金融发展可以显著降低地级市及邻近地级市的二氧化碳排放,存在正向的空间溢出效应;绿色技术进步和产业结构优化是绿色金融发挥碳减排作用的两个重要渠道;绿色金融发展对我国不同地区的碳减排作用存在明显差异;环境规制在绿色金融实现碳减排过程中存在正向调节作用。研究结果试图探究绿色金融发展能否真正降低地级市碳排放及其发挥碳减排效应的作用机制,为如何通过完善绿色金融的发展,最大程度地降低二氧化碳排放,以促进我国中长期碳减排目标的实现积累理论经验。