Stage at diagnosis of colorectal cancer through diagnostic route:Who should be screened?

BACKGROUND Colorectal cancer(CRC)is a global health concern,with advanced-stage diagnoses contributing to poor prognoses.The efficacy of CRC screening has been well-established;nevertheless,a significant proportion of patients remain unscreened,with>70%of cases diagnosed outside screening.Although identifying specific subgroups for whom CRC screening should be particularly recommended is crucial owing to limited resources,the association between the diagnostic routes and identification of these subgroups has been less appreciated.In the Japanese cancer registry,the diagnostic routes for groups discovered outside of screening are primarily categorized into those with comorbidities found during hospital visits and those with CRC-related symptoms.AIM To clarify the stage at CRC diagnosis based on diagnostic routes.METHODS We conducted a retrospective observational study using a cancer registry of patients with CRC between January 2016 and December 2019 at two hospitals.The diagnostic routes were primarily classified into three groups:Cancer screening,follow-up,and symptomatic.The early-stage was defined as Stages 0 or I.Multivariate and univariate logistic regressions were exploited to determine the odds of early-stage diagnosis in the symptomatic and cancer screening groups,referencing the follow-up group.The adjusted covariates were age,sex,and tumor location.RESULTS Of the 2083 patients,715(34.4%),1064(51.1%),and 304(14.6%)belonged to the follow-up,symptomatic,and cancer screening groups,respectively.Among the 2083 patients,CRCs diagnosed at an early stage were 57.3%(410 of 715),23.9%(254 of 1064),and 59.5%(181 of 304)in the follow-up,symptomatic,and cancer screening groups,respectively.The symptomatic group exhibited a lower likelihood of early-stage diagnosis than the follow-up group[P<0.001,adjusted odds ratio(aOR),0.23;95%confidence interval(95%CI):0.19-0.29].The likelihood of diagnosis at an early stage was similar between the follow-up and cancer screening groups(P=0.493,aOR for early-stage diagnosis in the cancer screening group vs follow-up group=1.11;95%CI=0.82-1.49).CONCLUSION CRCs detected during hospital visits for comorbidities were diagnosed earlier,similar to cancer screening.CRC screening should be recommended,particularly for patients without periodical hospital visits for comorbidities.

An Ant Colony Algorithm Based on Cross-Layer Design for Routing and Wavelength Assignment in Optical Satellite Networks

This paper introduces an ant colony routing and wavelength assignment algorithm based on cross-layer design(CL-ACRWA),which can overcome the adverse effects of Doppler wavelength shift on data transmission in optical satellite networks. Firstly, a cross-layer optimization model is built, which considers the Doppler wavelength shift, the transmission delay as well as wavelength-continuity constraint. Then an ant colony algorithm is utilized to solve the cross-layer optimization model, resulting in finding an optimal light path satisfying the above constraints for every connection request. The performance of CL-ACRWA is measured by the communication success probability, the convergence property and the transmission delay. Simulation results show that CL-ACRWA performs well in communication success probability and has good global search ability as well as fast convergence speed. Meanwhile, the transmission delay can meet the basic requirement of real-time transmission of business.

Cross-Layer Design of Energy-Saving AODV Routing Protocol

Since most ad hoc mobile devices today operate on batteries,the power consumption becomes an important issue.This paper proposes a cross-layer design of energy-aware ad hoc on-demand distance vector(CEAODV) routing protocol which adopts cross-layer mechanism and energy-aware metric to improve AODV routing protocol to reduce the energy consumption and then prolong the life of the whole network.In CEAODV,the link layer and the routing layer work together to choose the optimized transmission power for nodes and the route for packets.The link layer provides the energy consumption information for the routing layer and the routing layer chooses route accordingly and conversely controls the link layer to adjust the transmission power.The simulation result shows that CEAODV can outperform AODV to save more energy.It can reduce the consumed energy by about 8%over traditional energy-aware algorithm.And the performance is better when the traffic load is higher in the network.

Cross-Layer Design and Ant-Colony Optimization Based Routing Algorithm for Low Earth Orbit Satellite Networks

To improve the robustness of the Low Earth Orbit(LEO) satellites networks and realise load balancing, a Cross-layer design and Ant-colony optimization based Load-balancing routing algorithm for LEO Satellite Networks(CAL-LSN) is proposed in this paper. In CALLSN, mobile agents are used to gather routing information actively. CAL-LSN can utilise the information of the physical layer to make routing decision during the route construction phase. In order to achieve load balancing, CALLSN makes use of a multi-objective optimization model. Meanwhile, how to take the value of some key parameters is discussed while designing the algorithm so as to improve the reliability. The performance is measured by the packet delivery rate, the end-to-end delay, the link utilization and delay jitter. Simulation results show that CAL-LSN performs well in balancing traffic load and increasing the packet delivery rate. Meanwhile, the end-to-end delay and delay jitter performance can meet the requirement of video transmission.

Efficient Route Planning for Real-Time Demand-Responsive Transit

Demand Responsive Transit (DRT) responds to the dynamic users’ requests without any fixed routes and timetablesand determines the stop and the start according to the demands. This study explores the optimization of dynamicvehicle scheduling and real-time route planning in urban public transportation systems, with a focus on busservices. It addresses the limitations of current shared mobility routing algorithms, which are primarily designedfor simpler, single origin/destination scenarios, and do not meet the complex demands of bus transit systems. Theresearch introduces an route planning algorithm designed to dynamically accommodate passenger travel needsand enable real-time route modifications. Unlike traditional methods, this algorithm leverages a queue-based,multi-objective heuristic A∗ approach, offering a solution to the inflexibility and limited coverage of suburbanbus routes. Also, this study conducts a comparative analysis of the proposed algorithm with solutions based onGenetic Algorithm (GA) and Ant Colony Optimization Algorithm (ACO), focusing on calculation time, routelength, passenger waiting time, boarding time, and detour rate. The findings demonstrate that the proposedalgorithmsignificantly enhances route planning speed, achieving an 80–100-fold increase in efficiency over existingmodels, thereby supporting the real-time demands of Demand-Responsive Transportation (DRT) systems. Thestudy concludes that this algorithm not only optimizes route planning in bus transit but also presents a scalablesolution for improving urban mobility.

Joint channel assignment and cross-layer routing protocol for multi-radio multi-channel Ad Hoc networks

To study multi-radio multi-channel （MR-MC） Ad Hoc networks based on 802.11, an efficient cross-layer routing protocol with the function of joint channel assignment, called joint channel assignment and cross-layer routing （JCACR）, is presented. Firstly, this paper introduces a new concept called channel utilization percentage （CUP）, which is for measuring the contention level of different channels in a node’s neighborhood, and deduces its optimal value for determining whether a channel is overloaded or not. Then, a metric parameter named channel selection metric （CSM） is designed, which actually reffects not only the channel status but also corresponding node’s capacity to seize it. JCACR evaluates channel assignment by CSM, performs a local optimization by assigning each node a channel with the smaller CSM value, and changes the working channel dynamically when the channel is overloaded. Therefore, the network load balancing can be achieved. In addition, simulation shows that, when compared with the protocol of weighted cumulative expected transfer time （WCETT）, the new protocol can improve the network throughput and reduce the end-to-end average delay with fewer overheads.

CAW-YOLO:Cross-Layer Fusion and Weighted Receptive Field-Based YOLO for Small Object Detection in Remote Sensing

In recent years,there has been extensive research on object detection methods applied to optical remote sensing images utilizing convolutional neural networks.Despite these efforts,the detection of small objects in remote sensing remains a formidable challenge.The deep network structure will bring about the loss of object features,resulting in the loss of object features and the near elimination of some subtle features associated with small objects in deep layers.Additionally,the features of small objects are susceptible to interference from background features contained within the image,leading to a decline in detection accuracy.Moreover,the sensitivity of small objects to the bounding box perturbation further increases the detection difficulty.In this paper,we introduce a novel approach,Cross-Layer Fusion and Weighted Receptive Field-based YOLO(CAW-YOLO),specifically designed for small object detection in remote sensing.To address feature loss in deep layers,we have devised a cross-layer attention fusion module.Background noise is effectively filtered through the incorporation of Bi-Level Routing Attention(BRA).To enhance the model’s capacity to perceive multi-scale objects,particularly small-scale objects,we introduce a weightedmulti-receptive field atrous spatial pyramid poolingmodule.Furthermore,wemitigate the sensitivity arising from bounding box perturbation by incorporating the joint Normalized Wasserstein Distance(NWD)and Efficient Intersection over Union(EIoU)losses.The efficacy of the proposedmodel in detecting small objects in remote sensing has been validated through experiments conducted on three publicly available datasets.The experimental results unequivocally demonstrate the model’s pronounced advantages in small object detection for remote sensing,surpassing the performance of current mainstream models.

CoopAI-Route: DRL Empowered Multi-Agent Cooperative System for Efficient QoS-Aware Routing for Network Slicing in Multi-Domain SDN

The emergence of beyond 5G networks has the potential for seamless and intelligent connectivity on a global scale.Network slicing is crucial in delivering services for different,demanding vertical applications in this context.Next-generation applications have time-sensitive requirements and depend on the most efficient routing path to ensure packets reach their intended destinations.However,the existing IP(Internet Protocol)over a multi-domain network faces challenges in enforcing network slicing due to minimal collaboration and information sharing among network operators.Conventional inter-domain routing methods,like Border Gateway Protocol(BGP),cannot make routing decisions based on performance,which frequently results in traffic flowing across congested paths that are never optimal.To address these issues,we propose CoopAI-Route,a multi-agent cooperative deep reinforcement learning(DRL)system utilizing hierarchical software-defined networks(SDN).This framework enforces network slicing in multi-domain networks and cooperative communication with various administrators to find performance-based routes in intra-and inter-domain.CoopAI-Route employs the Distributed Global Topology(DGT)algorithm to define inter-domain Quality of Service(QoS)paths.CoopAI-Route uses a DRL agent with a message-passing multi-agent Twin-Delayed Deep Deterministic Policy Gradient method to ensure optimal end-to-end routes adapted to the specific requirements of network slicing applications.Our evaluation demonstrates CoopAI-Route’s commendable performance in scalability,link failure handling,and adaptability to evolving topologies compared to state-of-the-art methods.

Frequency-tunable single-photon router based on a microresonator containing a driven three-level emitter

We propose a frequency-tunable router of single photons with high routing efficiency, which is constructed by two waveguides mediately linked by a single-mode whispering gallery resonator with a driven three-level emitter. Quantum routing probability in the output port is obtained via the real-space Hamiltonian. By adjusting the resonator–emitter coupling and the drive, the desired continuous central frequencies for the resonance peaks of routing photons can be manipulated nearly linearly, with the assistance of Rabi splitting effect and optical Stark shift. The proposed routing system may provide potential applications in designing other frequency-modulation quantum optical devices, such as multiplexers,filters, and so on.

The Impact of Sea Level Rise on Roadway Design and Evacuation Routes in Delaware

As the global temperature continues to increase, the sea level continues to rise at a rapid rate that has never been seen before. This becomes an issue for many facets of life but one of the most impacted is the transportation infrastructure. Many people living in low elevation coastal areas can become trapped by flooding with no way in or out. With Delaware being a coastal state, this would affect a large portion of the population and will have detrimental effects over time if nothing is done to combat sea level rise. The issue with sea level rise in transportation is that once the roads become flooded, they become virtually unusable and detour routes would be needed. If all the roads in a coastal area were to be affected by sea level rise, the options for detours would become limited. This article looks at direct solutions to combat sea level rise and indirect solutions that would specifically help transportation infrastructure and evacuation routes in Delaware. There is not one solution that can fix every problem, so many solutions are laid out to see what is applicable to each affected area. Some solutions include defense structures that would be put close to the coast, raising the elevation of vulnerable roads throughout the state and including pumping stations to drain the water on the surface of the road. With an understanding of all these solutions around the world, the ultimate conclusion came in the form of a six-step plan that Delaware should take in order to best design against sea level rise in these coastal areas.

Red Study Greenway Route Selection at County Scale: A Case Study of Ji’an County, Jiangxi Province, China

Using multi-source data like remote sensing images,resource point coordinates,road networks and land type,a suitability assessment system for red study greenway route selection is constructed with red study resource layer,traffic condition layer,ecological condition layer,and service radius layer as the selection elements.Analytic Hierarchy Process(AHP)and Delphi method aree used to determine the selection factors and weight allocation of each element,and the single factor evaluation and multi factor overlaying analysis are used to accurately identify suitable selection corridors.The potential position is determined based on the lowest cost path.Finally,the final red study greenway is obtained through manual optimization based on the current situation of the road network.The analysis results show that the areas with the highest suitability were those with the richest distribution of first,second,and third level red study resources.An effective connection of red resource points and various elements helps to enhance the competitiveness of red study tours in Ji’an County,providing a realistic path for selecting study greenways for cities rich in red resources.

The Influence of Price Discrimination from Airports on the Route Development Behavior of Airlines

Given the prominence and magnitude of airport incentive schemes,it is surprising that literature hitherto remains silent as to their effectiveness.In this paper,the relationship between airport incentive schemes and the route development behavior of airlines is analyzed.Because of rare and often controversial findings in the extant literature regarding relevant influencing variables for attracting airlines at an airport,expert interviews are used as a complement to formulate testable hypotheses in this regard.A fixed effects regression model is used to test the hypotheses with a dataset that covers all seat capacity offered at the 22 largest German commercial airports in the week 46 from 2004 to 2011.It is found that incentives from primary choice,as well as secondary choice airports,have a significant influence on Low Cost Carriers.Furthermore,Low Cost Carriers,in general,do not leave any of both types of airports when the incentives cease.In the case of Network Carriers,no case is found where one joins a primary choice airport and receives an incentive.Insufficient data between Network Carriers and secondary choice airports in the time when incentives have ceased means that no statement can be given.

Cross-Layer Design Based Optimized Link State Routing Protocol for Wireless Mesh Networks

A proactive routing protocol CL-OLSR （cross-layer based optimized link state routing） by using a brand-new routing metric CLM （cross-layer metric） is proposed. CL-OLSR takes into account four link quality impact factors in route calculation through the cross-layer operation mechanism： the node available bandwidth, the node load, the link delivery rate, and the link interference, and thus the effect of route selection is optimized greatly. The simulation results show that the proposed CL-OLSR protocol can not only improve the network throughput to a large extent, but also reduce the end-to-end delay, while achieving load balance route results.

Cross-layer Enhancement to Multi-hop Routing in Sensor Networks: an Empirical Study

Lossy link is one of the unique characteristics in random-deployed sensor networks. We envision that robustness and reliability of routing cannot be ensured purely in network layer. Our idea is to enhance the performance of routing protocol by cross-layer interaction. We modified mint protocol, a routing protocol in TinyOS and proposed an enhanced version of mint called PA-mint. A transmission power control interface is added to network layer in PA-mint. When routing performance of the current network is not satisfied, PA-mint monotonically increases the transmission power via the interface we added. PA-mint is able to connect orphan nodes and robust to node mobility or key nodes failure. In the case that automatic request retransmission is employed, the number of retransmissions can be reduced by PA-mint. Results from experiments show that PA-mint increases the reliability and robustness of routing protocol by cross-layer interaction.

Manual Order Picking Route Optimization in Distribution Warehouse of Chain Furniture Retail Enterprise

Due to the effects of the COVID-19 pandemic and the rise of online shopping, the offline sales of IKEA Fuzhou have been declining since 2020. Because the cost of distribution warehouse is a major expense for offline chain furniture retailers, and the picking process is a key activity in distribution warehouse operations. To reduce the cost of distribution warehouse and alleviate the survival pressure of the offline chain furniture retailers, this paper focuses on optimizing the picking route of the IKEA Fuzhou distribution warehouse. It starts by creating a two-dimensional coordinate system for the storage location of the distribution warehouse using the traditional S-type picking strategy to calculate the distance and time of the sorting route. Then, the problem of optimizing the picking route is then transformed into the travelling salesman problem (TSP), and picking route optimization model is developed using a genetic algorithm to analyze the sorting efficiency and picking route optimization. Results show that the order-picking route using the genetic algorithm strategy is significantly better than the traditional S-type picking strategy, which can improve overall sorting efficiency and operations, reduce costs, and increase efficiency. Thus, this establishes an implementation process for the order-picking path based on genetic algorithm optimization to improve overall sorting efficiency and operations, reduce costs, increase efficiency, and alleviate the survival pressure of pandemic-affected enterprises.

Performance Study of a Cross-Layer Based Multipath Routing Protocol for IEEE 802.11e Mobile Ad Hoc Networks

Communication over wireless links identifies significant challenges for routing protocols operating. This paper proposes a Cross-layer design based Multipath Routing Protocol (CMRP) for mobile ad hoc networks, by means of the node energy signal from the physical layer. The purpose is to optimize routing decision and path quality. The nodes’ mobility behavior is predicted using a notion of “Signal Fading Degree, SFD”. Especially, in combination of the IEEE 802.11e standard at the MAC layer, we determine that the IEEE 802.11e makes a significant contribution to performance improvement of CMRP. Performance evaluation of AODV in legacy 802.11 and CMRP in IEEE 802.11e shows that, as a function of speed of node mobility, a tremendous reduction achieved, in metrics such as the average end-to-end delay, route overhead, route discovery frequency, normalized routing load - almost more than 80%, 40%, 40%, and 40%. In the case of varying number of sessions, the reduction for route discovery frequency and normalized routing load are up to 70% and 80%.

Dynamic routing and wavelength assignment algorithm of optical satellite networks based on cross-layer design

In order to overcome the adverse effects of Doppler wavelength shift on data transmission in the optical satellite networks,a dynamic routing and wavelength assignment algorithm based on crosslayer design( CL-DRWA) is introduced which can improve robustness of the network. Above all,a cross-layer optimization model is designed,which considers transmission delay and wavelength-continuity constraint,as well as Doppler wavelength shift. Then CL-DRWA is applied to solve this model,resulting in finding an optimal light path satisfying the above constraints for every connection request. In CL-DRWA,Bellman-Ford method is used to find an optimal route and a distributed relative capacity loss method is implemented to get an optimal wavelength assignment result on the optimal route. Moreover,compared with the dynamic routing and wavelength assignment algorithm based on minimum delay strategy( MD-DRWA),CL-DRWA can make an improvement of 5. 3% on the communication success probability. Meanwhile,CL-DRWA can meet the requirement of transmission delay for real-time services.

Track Bed Total Route Evaluation for Track Renewals&Asset Management“A Network Rail Perspective”

Over the last 10 years there have been significant developments and improvements in the understanding of railway track bed in the UK and its relationship and impact on track quality,ballast life and maintenance following track renewals.This paper aims to describe the process adopted by Network Rail for track bed investigation and design which offers Network Rail optimum design solutions and value for money from an investigation and construction perspective,balancing design with possession availability to maximise construction output.It also describes innovative investigation and construction techniques that have been developed over the last 5 years maximising the use of rail mounted asset condition data collection systems which run at line speed,allowing targeted investigations and in some case removing the requirements for physical site investigation.It also allows Network Rail to predict sections of track bed which may be affected by line speed increases which would cause the track bed to fail prematurely or,retain its ability to maintain good track geometry post line speed increase.These problems can manifest themselves as stiffness related problems such as critical velocity issues(surface wave velocity,Rayleigh Wave velocity)or,sub-grade erosion resulting in high rates of deterioration in the vertical track geometry.The paper also describes the development and installation process for Enhanced Axial Micropiles to address stiffness related track bed problems whilst leaving the track in-situ a technique which is new to the UK railways.

Cross-layer routing protocol design for high mobility multi-hop cognitive radio networks

In multi-hop cognitive radio networks （ CRNs）, the heterogeneous environment increases the complexity of common control channel （CCC） formation and routing protocol design. In this paper, we consider the on-demand routing protocol transmits over CCC. However, since CR transceivers （secondary users） have different available channel sets and it must vacate the licensed channel when a primary user arrives, forming a CCC becomes a main challenge in routing protocol design for CRNs. Our proposed CCC formation algorithm is based on a spectrum-tree structure, which consists of all cluster heads in CRNs. The cluster heads are with smaller moving range and lower mobility, and also act as a router in the whole network which maintains information of its cluster. Hence, a route is constituted in part by a set of cluster-head identity （ID） numbers, which represent the spe- cific cluster heads the path traverses, and in part by a set of member nodes ID numbers, which are included in the clusters containing the source and destination nodes. Due to high mobility and dynamic available spectrum, we define the stability parameters of path as two parts. One stability parameter is mobility factor, which represents the probability that a pairwise node can keep in communication range for the next flow transmission. The another stability parameter is spectrum opportunistic （SOP） factor, which represents the probability that a pairwise links can obtain the assigned spectrum band for the next flow transmission. Simulation results show that CCC formation algorithm produces a high probability of CCC formation, and the proposed routing protocol performs better than typical routing protocols.

A Fast and Efficient Global Router for Congestion Optimization

An efficient parallel global router using random optimization that is independent of net ordering is proposed.Parallel approaches are described and strategies guaranteeing the routing quality are discussed.The wire length model is implemented on multiprocessor,which enables the algorithm to approach feasibility of large scale problems.Timing driven model on multiprocessor and wire length model on distributed processors are also presented.The parallel algorithm greatly reduces the run time of routing.The experimental results show good speedups with no degradation of the routing quality.