期刊文献+
共找到19篇文章
< 1 >
每页显示 20 50 100
Multi-dimensional database design and implementation of dam safety monitoring system 被引量:1
1
作者 Zhao Erfeng Wang Yachao +2 位作者 Jiang Yufeng Zhang Lei Yu Hong 《Water Science and Engineering》 EI CAS 2008年第3期112-120,共9页
To improve the effectiveness of dam safety monitoring database systems, the development process of a multi-dimensional conceptual data model was analyzed and a logic design wasachieved in multi-dimensional database mo... To improve the effectiveness of dam safety monitoring database systems, the development process of a multi-dimensional conceptual data model was analyzed and a logic design wasachieved in multi-dimensional database mode. The optimal data model was confirmed by identifying data objects, defining relations and reviewing entities. The conversion of relations among entities to external keys and entities and physical attributes to tables and fields was interpreted completely. On this basis, a multi-dimensional database that reflects the management and analysis of a dam safety monitoring system on monitoring data information has been established, for which factual tables and dimensional tables have been designed. Finally, based on service design and user interface design, the dam safety monitoring system has been developed with Delphi as the development tool. This development project shows that the multi-dimensional database can simplify the development process and minimize hidden dangers in the database structure design. It is superior to other dam safety monitoring system development models and can provide a new research direction for system developers. 展开更多
关键词 dam safety multi-dimensional database conceptual data model database mode monitoring system
下载PDF
Goodness-of-fit tests for multi-dimensional copulas:Expanding application to historical drought data 被引量:2
2
作者 Ming-wei MA Li-liang REN +2 位作者 Song-bai SONG Jia-li SONG Shan-hu JIANG 《Water Science and Engineering》 EI CAS CSCD 2013年第1期18-30,共13页
The question of how to choose a copula model that best fits a given dataset is a predominant limitation of the copula approach, and the present study aims to investigate the techniques of goodness-of-fit tests for mul... The question of how to choose a copula model that best fits a given dataset is a predominant limitation of the copula approach, and the present study aims to investigate the techniques of goodness-of-fit tests for multi-dimensional copulas. A goodness-of-fit test based on Rosenblatt's transformation was mathematically expanded from two dimensions to three dimensions and procedures of a bootstrap version of the test were provided. Through stochastic copula simulation, an empirical application of historical drought data at the Lintong Gauge Station shows that the goodness-of-fit tests perform well, revealing that both trivariate Gaussian and Student t copulas are acceptable for modeling the dependence structures of the observed drought duration, severity, and peak. The goodness-of-fit tests for multi-dimensional copulas can provide further support and help a lot in the potential applications of a wider range of copulas to describe the associations of correlated hydrological variables. However, for the application of copulas with the number of dimensions larger than three, more complicated computational efforts as well as exploration and parameterization of corresponding copulas are required. 展开更多
关键词 goodness-of-fit test multi-dimensional copulas stochastic simulation Rosenblatt'stransformation bootstrap approach drought data
下载PDF
Data inversion of multi-dimensional magnetic resonance in porous media
3
作者 Fangrong Zong Huabing Liu +1 位作者 Ruiliang Bai Petrik Galvosas 《Magnetic Resonance Letters》 2023年第2期127-139,I0004,共14页
Since its inception in the 1970s,multi-dimensional magnetic resonance(MR)has emerged as a powerful tool for non-invasive investigations of structures and molecular interactions.MR spectroscopy beyond one dimension all... Since its inception in the 1970s,multi-dimensional magnetic resonance(MR)has emerged as a powerful tool for non-invasive investigations of structures and molecular interactions.MR spectroscopy beyond one dimension allows the study of the correlation,exchange processes,and separation of overlapping spectral information.The multi-dimensional concept has been re-implemented over the last two decades to explore molecular motion and spin dynamics in porous media.Apart from Fourier transform,methods have been developed for processing the multi-dimensional time-domain data,identifying the fluid components,and estimating pore surface permeability via joint relaxation and diffusion spectra.Through the resolution of spectroscopic signals with spatial encoding gradients,multi-dimensional MR imaging has been widely used to investigate the microscopic environment of living tissues and distinguish diseases.Signals in each voxel are usually expressed as multi-exponential decay,representing microstructures or environments along multiple pore scales.The separation of contributions from different environments is a common ill-posed problem,which can be resolved numerically.Moreover,the inversion methods and experimental parameters determine the resolution of multi-dimensional spectra.This paper reviews the algorithms that have been proposed to process multidimensional MR datasets in different scenarios.Detailed information at the microscopic level,such as tissue components,fluid types and food structures in multi-disciplinary sciences,could be revealed through multi-dimensional MR. 展开更多
关键词 multi-dimensional MR data inversion Porous media Inverse Laplace transform FOURIERTRANSFORM
下载PDF
Finding Main Causes of Elevator Accidents via Multi-Dimensional Association Rule in Edge Computing Environment 被引量:2
4
作者 Hongman Wang Mengqi Zeng +1 位作者 Zijie Xiong Fangchun Yang 《China Communications》 SCIE CSCD 2017年第11期39-47,共9页
In order to discover the main causes of elevator group accidents in edge computing environment, a multi-dimensional data model of elevator accident data is established by using data cube technology, proposing and impl... In order to discover the main causes of elevator group accidents in edge computing environment, a multi-dimensional data model of elevator accident data is established by using data cube technology, proposing and implementing a method by combining classical Apriori algorithm with the model, digging out frequent items of elevator accident data to explore the main reasons for the occurrence of elevator accidents. In addition, a collaborative edge model of elevator accidents is set to achieve data sharing, making it possible to check the detail of each cause to confirm the causes of elevator accidents. Lastly the association rules are applied to find the law of elevator Accidents. 展开更多
关键词 elevator group accidents APRIORI multi-dimensional association rules data cube edge computing
下载PDF
Design of similarity measure for discrete data and application to multi-dimension 被引量:1
5
作者 LEE Myeong-ho 魏荷 +2 位作者 LEE Sang-hyuk LEE Sang-min SHIN Seung-soo 《Journal of Central South University》 SCIE EI CAS 2013年第4期982-987,共6页
Similarity measure design for discrete data group was proposed. Similarity measure design for continuous membership function was also carried out. Proposed similarity measures were designed based on fuzzy number and d... Similarity measure design for discrete data group was proposed. Similarity measure design for continuous membership function was also carried out. Proposed similarity measures were designed based on fuzzy number and distance measure, and were proved. To calculate the degree of similarity of discrete data, relative degree between data and total distribution was obtained. Discrete data similarity measure was completed with combination of mentioned relative degrees. Power interconnected system with multi characteristics was considered to apply discrete similarity measure. Naturally, similarity measure was extended to multi-dimensional similarity measure case, and applied to bus clustering problem. 展开更多
关键词 similarity measure multi-dimension discrete data relative degree power interconnected system
下载PDF
Outlier detection based on multi-dimensional clustering and local density
6
作者 SHOU Zhao-yu LI Meng-ya LI Si-min 《Journal of Central South University》 SCIE EI CAS CSCD 2017年第6期1299-1306,共8页
Outlier detection is an important task in data mining. In fact, it is difficult to find the clustering centers in some sophisticated multidimensional datasets and to measure the deviation degree of each potential outl... Outlier detection is an important task in data mining. In fact, it is difficult to find the clustering centers in some sophisticated multidimensional datasets and to measure the deviation degree of each potential outlier. In this work, an effective outlier detection method based on multi-dimensional clustering and local density(ODBMCLD) is proposed. ODBMCLD firstly identifies the center objects by the local density peak of data objects, and clusters the whole dataset based on the center objects. Then, outlier objects belonging to different clusters will be marked as candidates of abnormal data. Finally, the top N points among these abnormal candidates are chosen as final anomaly objects with high outlier factors. The feasibility and effectiveness of the method are verified by experiments. 展开更多
关键词 data MINING OUTLIER DETECTION OUTLIER DETECTION method based on multi-dimensional CLUSTERING and local density (ODBMCLD) algorithm deviation DEGREE
下载PDF
Multi-dimension and multi-modal rolling mill vibration prediction model based on multi-level network fusion
7
作者 CHEN Shu-zong LIU Yun-xiao +3 位作者 WANG Yun-long QIAN Cheng HUA Chang-chun SUN Jie 《Journal of Central South University》 SCIE EI CAS CSCD 2024年第9期3329-3348,共20页
Mill vibration is a common problem in rolling production,which directly affects the thickness accuracy of the strip and may even lead to strip fracture accidents in serious cases.The existing vibration prediction mode... Mill vibration is a common problem in rolling production,which directly affects the thickness accuracy of the strip and may even lead to strip fracture accidents in serious cases.The existing vibration prediction models do not consider the features contained in the data,resulting in limited improvement of model accuracy.To address these challenges,this paper proposes a multi-dimensional multi-modal cold rolling vibration time series prediction model(MDMMVPM)based on the deep fusion of multi-level networks.In the model,the long-term and short-term modal features of multi-dimensional data are considered,and the appropriate prediction algorithms are selected for different data features.Based on the established prediction model,the effects of tension and rolling force on mill vibration are analyzed.Taking the 5th stand of a cold mill in a steel mill as the research object,the innovative model is applied to predict the mill vibration for the first time.The experimental results show that the correlation coefficient(R^(2))of the model proposed in this paper is 92.5%,and the root-mean-square error(RMSE)is 0.0011,which significantly improves the modeling accuracy compared with the existing models.The proposed model is also suitable for the hot rolling process,which provides a new method for the prediction of strip rolling vibration. 展开更多
关键词 rolling mill vibration multi-dimension data multi-modal data convolutional neural network time series prediction
下载PDF
Visual exploration of multi-dimensional data via rule-based sample embedding
8
作者 Tong Zhang Jie Li Chao Xu 《Visual Informatics》 EI 2024年第3期53-56,共4页
We propose an approach to learning sample embedding for analyzing multi-dimensional datasets.The basic idea is to extract rules from the given dataset and learn the embedding for each sample based on the rules it sati... We propose an approach to learning sample embedding for analyzing multi-dimensional datasets.The basic idea is to extract rules from the given dataset and learn the embedding for each sample based on the rules it satisfies.The approach can filter out pattern-irrelevant attributes,leading to significant visual structures of samples satisfying the same rules in the projection.In addition,analysts can understand a visual structure based on the rules that the involved samples satisfy,which improves the projection’s pattern interpretability.Our research involves two methods for achieving and applying the approach.First,we give a method to learn rule-based embedding for each sample.Second,we integrate the method into a system to achieve an analytical workflow.Cases on real-world dataset and quantitative experiment results show the usability and effectiveness of our approach. 展开更多
关键词 Tabular data multi-dimensional exploration Embedding projection RULE Visual analytics
原文传递
Painting image browser applying an associate-rule-aware multidimensional data visualization technique 被引量:1
9
作者 Ayaka Kaneko Akiko Komatsu +1 位作者 Takayuki Itoh Florence Ying Wang 《Visual Computing for Industry,Biomedicine,and Art》 2020年第1期18-30,共13页
Exploration of artworks is enjoyable but often time consuming.For example,it is not always easy to discover the favorite types of unknown painting works.It is not also always easy to explore unpopular painting works w... Exploration of artworks is enjoyable but often time consuming.For example,it is not always easy to discover the favorite types of unknown painting works.It is not also always easy to explore unpopular painting works which looks similar to painting works created by famous artists.This paper presents a painting image browser which assists the explorative discovery of user-interested painting works.The presented browser applies a new multidimensional data visualization technique that highlights particular ranges of particular numeric values based on association rules to suggest cues to find favorite painting images.This study assumes a large number of painting images are provided where categorical information(e.g.,names of artists,created year)is assigned to the images.The presented system firstly calculates the feature values of the images as a preprocessing step.Then the browser visualizes the multidimensional feature values as a heatmap and highlights association rules discovered from the relationships between the feature values and categorical information.This mechanism enables users to explore favorite painting images or painting images that look similar to famous painting works.Our case study and user evaluation demonstrates the effectiveness of the presented image browser. 展开更多
关键词 Painting image multi-dimensional data visualization Association rule
下载PDF
Multidimensional Data Querying on Tree-Structured Overlay
10
作者 XU Lizhen WANG Shiyuan 《Wuhan University Journal of Natural Sciences》 CAS 2006年第5期1367-1372,共6页
Multidimensional data query has been gaining much interest in database research communities in recent years, yet many of the existing studies focus mainly on ten tralized systems. A solution to querying in Peer-to-Pee... Multidimensional data query has been gaining much interest in database research communities in recent years, yet many of the existing studies focus mainly on ten tralized systems. A solution to querying in Peer-to-Peer(P2P) environment was proposed to achieve both low processing cost in terms of the number of peers accessed and search messages and balanced query loads among peers. The system is based on a balanced tree structured P2P network. By partitioning the query space intelligently, the amount of query forwarding is effectively controlled, and the number of peers involved and search messages are also limited. Dynamic load balancing can be achieved during space partitioning and query resolving. Extensive experiments confirm the effectiveness and scalability of our algorithms on P2P networks. 展开更多
关键词 range query skyline query P2P indexing multi-dimensional data partition
下载PDF
FAAD:an unsupervised fast and accurate anomaly detection method for a multi-dimensional sequence over data stream 被引量:1
11
作者 Bin LI Yi-jie WANG +2 位作者 Dong-sheng YANG Yong-mou LI Xing-kong MA 《Frontiers of Information Technology & Electronic Engineering》 SCIE EI CSCD 2019年第3期388-404,共17页
Recently, sequence anomaly detection has been widely used in many fields. Sequence data in these fields are usually multi-dimensional over the data stream. It is a challenge to design an anomaly detection method for a... Recently, sequence anomaly detection has been widely used in many fields. Sequence data in these fields are usually multi-dimensional over the data stream. It is a challenge to design an anomaly detection method for a multi-dimensional sequence over the data stream to satisfy the requirements of accuracy and high speed. It is because:(1) Redundant dimensions in sequence data and large state space lead to a poor ability for sequence modeling;(2) Anomaly detection cannot adapt to the high-speed nature of the data stream, especially when concept drift occurs, and it will reduce the detection rate. On one hand, most existing methods of sequence anomaly detection focus on the single-dimension sequence. On the other hand, some studies concerning multi-dimensional sequence concentrate mainly on the static database rather than the data stream. To improve the performance of anomaly detection for a multi-dimensional sequence over the data stream, we propose a novel unsupervised fast and accurate anomaly detection(FAAD) method which includes three algorithms. First, a method called "information calculation and minimum spanning tree cluster" is adopted to reduce redundant dimensions. Second, to speed up model construction and ensure the detection rate for the sequence over the data stream, we propose a method called"random sampling and subsequence partitioning based on the index probabilistic suffix tree." Last, the method called "anomaly buffer based on model dynamic adjustment" dramatically reduces the effects of concept drift in the data stream. FAAD is implemented on the streaming platform Storm to detect multi-dimensional log audit data.Compared with the existing anomaly detection methods, FAAD has a good performance in detection rate and speed without being affected by concept drift. 展开更多
关键词 data STREAM multi-dimensional SEQUENCE ANOMALY detection Concept DRIFT Feature selection
原文传递
EPMDA:an efficient privacy-preserving multi-dimensional data aggregation scheme for edge computing-based IoT system 被引量:1
12
作者 Tao Yunting Kong Fanyu Yu Jia 《The Journal of China Universities of Posts and Telecommunications》 EI CSCD 2021年第6期26-35,共10页
In order to perform multi-dimensional data aggregation operations efficiently in edge computing-based Internet of things(IoT) systems, a new efficient privacy-preserving multi-dimensional data aggregation(EPMDA) schem... In order to perform multi-dimensional data aggregation operations efficiently in edge computing-based Internet of things(IoT) systems, a new efficient privacy-preserving multi-dimensional data aggregation(EPMDA) scheme is proposed in this paper. EPMDA scheme is characterized by employing the homomorphic Paillier encryption and SM9 signature algorithm. To improve the computation efficiency of the Paillier encryption operation, EPMDA scheme generates a pre-computed modular exponentiation table of each dimensional data, and the Paillier encryption operation can be implemented by using only several modular multiplications. For the multi-dimensional data, the scheme concatenates zeros between two adjacent dimensional data to avoid data overflow in the sum operation of ciphertexts. To enhance security, EPMDA scheme sets random number at the high address of the exponent. Moreover, the scheme utilizes SM9 signature scheme to guarantee device authentication and data integrity. The performance evaluation and comparison show that EPMDA scheme is more efficient than the existing multi-dimensional data aggregation schemes. 展开更多
关键词 multi-dimensional data aggregation Paillier cryptosystem Internet of things(IoT) edge computing-based
原文传递
Similarity measure on intuitionistic fuzzy sets 被引量:5
13
作者 PARK Jean-Ho HWANG Jai-Hyuk +2 位作者 PARK Wook-Je 魏荷 LEE Sang-Hyuk 《Journal of Central South University》 SCIE EI CAS 2013年第8期2233-2238,共6页
Study of fuzzy entropy and similarity measure on intuitionistic fuzzy sets (IFSs) was proposed and analyzed. Unlike fuzzy set, IFSs contain uncertainty named hesitance, which is contained in fuzzy membership function ... Study of fuzzy entropy and similarity measure on intuitionistic fuzzy sets (IFSs) was proposed and analyzed. Unlike fuzzy set, IFSs contain uncertainty named hesitance, which is contained in fuzzy membership function itself. Hence, designing fuzzy entropy is not easy because of many entropy definitions. By considering different fuzzy entropy definitions, fuzzy entropy on IFSs is designed and discussed. Similarity measure was also presented and its usefulness was verified to evaluate degree of similarity. 展开更多
关键词 similarity measure multi-dimension discrete data relative degree power interconnected system
下载PDF
Least squares fitting of coordinate parameters model
14
作者 YU Sheng-wen~(1), DONG Jun~(2), WANG Ai-min~(3) (1. Shandong University of Science and Technology, Tai’an 271019, China 2. Bao’an Coal Mine of Huaning Group, Hua’ning, Tai’an 271000, China 3. The Plan Bureau of Laiwu, Laiwu 272000, China) 《中国有色金属学会会刊:英文版》 CSCD 2005年第S1期197-199,共3页
This paper starts with untime-diversification of the time-diversification deformation model and gives displacement distribution model of untime-diversification and simplifies further the study of deformation model. Th... This paper starts with untime-diversification of the time-diversification deformation model and gives displacement distribution model of untime-diversification and simplifies further the study of deformation model. The paper discusses the problem of least squares fitting of coordinate parameters model—parameters of deformation model. During discussion, the basic means of cubic B splines and two steps of multidimensional disorder datum fitting are adopted which can make fitting function calculated mostly approximate coordinate parameters model and it can make calculation easier. 展开更多
关键词 COORDINATE parameter MODEL least SQUARES FITTING two STEPS of multi-dimensional disorder data curve FITTING
下载PDF
New indexes and methods in earthquake prediction research
15
作者 冯德益 大内 《Acta Seismologica Sinica(English Edition)》 CSCD 1994年第2期331-332,334-342,共11页
This paper gives a brief introduction to a few new indexes and methods published in recent issues of seismological literature which have been explored especially by the authors and many of their collaborators for appl... This paper gives a brief introduction to a few new indexes and methods published in recent issues of seismological literature which have been explored especially by the authors and many of their collaborators for applying in earthquake prediction research. The new indexes include the statistical indexes of seismicity (Morishita index Iδ, the parameters C and b-value spectrum derived from the magnitude-frequency relation, etc. )and indexes describing the dynamical characteristics of seismic waves obtained from digitized seismologicrecords (wave form linearities, spectral characteristics, etc. ). The new methods fall into two categories:namely the methods of non-linear sciences (fractal analysis, self-similarity and self-organization structure,neural network) and graphical analysis methods of multi-dimensional data (face analysis, projection pursuit,chronogeometric analysis ). 展开更多
关键词 SEISMICITY seismic wave non-linear sciences multi-dimensional data earthquake prediction
下载PDF
Mapping frequent spatio-temporal wind profile patterns using multi-dimensional sequential pattern mining
16
作者 Norhakim Yusof Raul Zurita-Milla 《International Journal of Digital Earth》 SCIE EI 2017年第3期238-256,共19页
Holistic understanding of wind behaviour over space,time and height is essential for harvesting wind energy application.This study presents a novel approach for mapping frequent wind profile patterns using multidimen... Holistic understanding of wind behaviour over space,time and height is essential for harvesting wind energy application.This study presents a novel approach for mapping frequent wind profile patterns using multidimensional sequential pattern mining(MDSPM).This study is illustrated with a time series of 24 years of European Centre for Medium-Range Weather Forecasts European Reanalysis-Interim gridded(0.125°×0.125°)wind data for the Netherlands every 6 h and at six height levels.The wind data were first transformed into two spatio-temporal sequence databases(for speed and direction,respectively).Then,the Linear time Closed Itemset Miner Sequence algorithm was used to extract the multidimensional sequential patterns,which were then visualized using a 3D wind rose,a circular histogram and a geographical map.These patterns were further analysed to determine their wind shear coefficients and turbulence intensities as well as their spatial overlap with current areas with wind turbines.Our analysis identified four frequent wind profile patterns.One of them highly suitable to harvest wind energy at a height of 128 m and 68.97%of the geographical area covered by this pattern already contains wind turbines.This study shows that the proposed approach is capable of efficiently extracting meaningful patterns from complex spatio-temporal datasets. 展开更多
关键词 Spatio-temporal data mining multi-dimensional sequential pattern mining wind shear coefficient turbulence intensity wind energy
原文传递
A hierarchical indexing strategy for optimizing Apache Spark with HDFS to efficiently query big geospatial raster data 被引量:5
17
作者 Fei Hu Chaowei Yang +5 位作者 Yongyao Jiang Yun Li Weiwei Song Daniel Q.Duffy John L.Schnase Tsengdar Lee 《International Journal of Digital Earth》 SCIE 2020年第3期410-428,共19页
Earth observations and model simulations are generating big multidimensional array-based raster data.However,it is difficult to efficiently query these big raster data due to the inconsistency among the geospatial ras... Earth observations and model simulations are generating big multidimensional array-based raster data.However,it is difficult to efficiently query these big raster data due to the inconsistency among the geospatial raster data model,distributed physical data storage model,and the data pipeline in distributed computing frameworks.To efficiently process big geospatial data,this paper proposes a three-layer hierarchical indexing strategy to optimize Apache Spark with Hadoop Distributed File System(HDFS)from the following aspects:(1)improve I/O efficiency by adopting the chunking data structure;(2)keep the workload balance and high data locality by building the global index(k-d tree);(3)enable Spark and HDFS to natively support geospatial raster data formats(e.g.,HDF4,NetCDF4,GeoTiff)by building the local index(hash table);(4)index the in-memory data to further improve geospatial data queries;(5)develop a data repartition strategy to tune the query parallelism while keeping high data locality.The above strategies are implemented by developing the customized RDDs,and evaluated by comparing the performance with that of Spark SQL and SciSpark.The proposed indexing strategy can be applied to other distributed frameworks or cloud-based computing systems to natively support big geospatial data query with high efficiency. 展开更多
关键词 Big data hierarchical indexing multi-dimensional Apache Spark HDFS distributed computing GIS
原文传递
General multidimensional cloud model and its application on spatial clustering in Zhanjiang, Guangdong 被引量:3
18
作者 DENG Yu LIU Shenghe +2 位作者 ZHANG Wenting WANG Li WANG Jianghao 《Journal of Geographical Sciences》 SCIE CSCD 2010年第5期787-798,共12页
Traditional spatial clustering methods have the disadvantage of "hardware division", and can not describe the physical characteristics of spatial entity effectively. In view of the above, this paper sets forth a gen... Traditional spatial clustering methods have the disadvantage of "hardware division", and can not describe the physical characteristics of spatial entity effectively. In view of the above, this paper sets forth a general multi-dimensional cloud model, which describes the characteristics of spatial objects more reasonably according to the idea of non-homogeneous and non-symmetry. Based on infrastructures' classification and demarcation in Zhanjiang, a detailed interpretation of clustering results is made from the spatial distribution of membership degree of clustering, the comparative study of Fuzzy C-means and a coupled analysis of residential land prices. General multi-dimensional cloud model reflects the integrated char- acteristics of spatial objects better, reveals the spatial distribution of potential information, and realizes spatial division more accurately in complex circumstances. However, due to the complexity of spatial interactions between geographical entities, the generation of cloud model is a specific and challenging task. 展开更多
关键词 multi-dimensional cloud spatial clustering data mining membership degree Zhanjiang
原文传递
Synthetic Lethal Interactions Prediction Based on Multiple Similarity Measures Fusion
19
作者 Lian-Lian Wu Yu-Qi Wen +3 位作者 Xiao-Xi Yang Bo-Wei Yan Song He Xiao-Chen Bo 《Journal of Computer Science & Technology》 SCIE EI CSCD 2021年第2期261-275,共15页
The synthetic lethality(SL)relationship arises when a combination of deficiencies in two genes leads to cell death,whereas a deficiency in either one of the two genes does not.The survival of the mutant tumor cells de... The synthetic lethality(SL)relationship arises when a combination of deficiencies in two genes leads to cell death,whereas a deficiency in either one of the two genes does not.The survival of the mutant tumor cells depends on the SL partners of the mutant gene,thereby the cancer cells could be selectively killed by inhibiting the SL partners of the oncogenic genes but normal cells could not.Therefore,there is an urgent need to develop more efficient computational methods of SL pairs identification for cancer targeted therapy.In this paper,we propose a new approach based on similarity fusion to predict SL pairs.Multiple types of gene similarity measures are integrated and/c-nearest neighbors algorithm(k-NN)is applied to achieve the similarity-based classification task between gene pairs.As a similarity-based method,our method demonstrated excellent performance in multiple experiments.Besides the effectiveness of our method,the ease of use and expansibility can also make our method more widely used in practice. 展开更多
关键词 synthetic lethality similarity measures fusion k-nearest neighbor multi-dimensional data
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部