Successful Treatment of PFAPA (Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Adenitis) Syndrome with Shinbuto

Periodic fever with aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome is an autoimmune disorder and the most common disorder characterized by periodic fever in children. A male patient has been followed up from 11 months to 10 years of age because of repeated high fever. We prescribed antifebriles and antibiotics for each febrile episode without a beneficial effect to him each time. He required several days of rest at home to recover from each episode. During his most recent febrile episode at 10 years of age, we prescribed 5.0 g of shinbuto (TJ-30;Tsumura Co., Tokyo, Japan). His fever resolved the next day and he was able to attend school. His growth and development are normal. Shinbuto had a therapeutic effect in this patient with PFAPA syndrome and may be useful in this condition.

Infectivity of Severe Acute Respiratory Syndrome during Its Incubation Period

Objective To evaluate the infectivity of severe acute respiratory syndrome （SARS） during its incubation period by investigating chains of transmission and individuals isolated for medical observation with a view to providing scientific evidence for updating protocols of medical isolation. Methods Individuals related with the two SARS chains of transmission in Beijing in 2003 and a group of individuals isolated for medical observation in Haidian district of Beijing during the SARS outbreak were selected as subjects of study. Contactors with SARS patients and those with symptom development following the contacts were investigated via questionnaire. Serum samples were collected from super transmitters and tested for SARS-CoV antibody by neutralization test and enzyme linked immunosorbent assay （ELISA）. Results A total of 1 112 contactors were investigated in three surveys. Of them, 669 had a history of close contact with symptomatic SARS patients, 101 developed symptoms with a rate of 15.1%, 363 had a history of close contact with patients in their incubation period, none of whom developed symptoms （0%）. Serum samples were collected fi＇om 32 highly-exposed individuals, of whom 13 developing SARS symptoms atter contact had serum samples positive for SARS-CoV antibody. Samples collected from the asymptomatic contactors were all negative for SARS-CoV antibody. Conclusion SARS cases are infectious only during their symptomatic period and are non-infectious during the incubation period. Isolation for medical observation should be placed for individuals who are in close contact with symptomatic SARS patients. The results of our study are of decisive significance for the Ministry of Health to the definition of SARS close contactor.

Peutz-Jeghers syndrome:Diagnostic and therapeutic approach

Peutz-Jeghers syndrome （P3S） is an inherited, autosomal dominant disorder distinguished by hamartomatous polyps in the gastrointestinal tract and pigmented mucocutaneous lesions. Prevalence of PJS is estimated from 1 in 8300 to 1 in 280000 individuals. PJS predisposes sufferers to various malignancies （gastrointestinal, pancreatic, lung, breast, uterine, ovarian and testicular tumors）. Bleeding, obstruction and intussusception are common complications in patients with P3S. Double balloon enteroscopy （DBE） allows examination and treatment of the small bowel. Polypectomy using DBE may obviate the need for repeated urgent operations and small bowel resection that leads to short bowel syndrome. Prophylaxis and polypectomy of the entire small bowel is the gold standard in PJS patients. Intraoperative enteroscopy （IOE） was the only possibility for endoscopic treatment of patients with PJS before the DBE era. Both DBE and IOE facilitate exploration and treatment of the small intestine. DBE is less invasive and more convenient for the patient. Both procedures are generally safe and useful. An overall recommendation for PJS patients includes not only gastrointestinal multiple polyp resolution, but also regular lifelong cancer screening （colonoscopy, upper endoscopy, computed tomography, magnetic resonance imaging or ultrasound of the pancreas, chest X-ray, mammography and pelvic examination with ultrasound in women, and testicular examination in men）. Although the incidence of PJS is low, it is important for clinicians to recognize these disorders to prevent morbidity and mortality in these patients, and to perform presymptomatic testing in the first-degree relatives of PJS patients.

Metabolic Syndrome and Perioperative Complications during Scheduled Surgeries with Spinal Anesthesia

Background: Metabolic syndrome (MS) is a constellation of factors associated with increased risk of developing cardiovascular diseases and Diabetes Mellitus. Despite of the many studies related to MS, little is known about its impact on scenarios such as surgical anesthesia. Objective: To examine the correlation between demographic and metabolic variables with the occurrence of perioperative complications in patients with MS undergoing scheduled surgeries using a spinal anesthesia technique in the surgery department at the University Clinic San Juan de Dios in Cartagena de Indias, Colombia. Methods: Observational, analytical, cross-sectional, single-center study of 150 subjects with MS and 150 control subjects. Perioperative complications, socio-demographic, hemodynamic and respiratory variables were registered. Groups were compared using t test, Fisher’s exact test or Chi-square, as appropriate. We applied a logistic multiple regression model, adjusted by backward stepwise at 0.25 and forward at 0.05, to find possible incompatible associations. p value < 0.05 was considered significant. Results: There were significant differences between groups in age, American Society of Anesthesiologists physical status classification, frequency of diseases associated to MS and perioperative complications. There were no cases of mortality among patients. There was statistically significant difference between the two groups for intraoperative hypotension and hypertension with p values of <0.0001 and 0.034. Among postoperative complications there was statistically significant difference in pain (13.3% vs 5.3% in patients without MS) and nausea and/or postoperative vomiting (8% vs 2% in patients without MS) with a p value of 0.027 and 0.015 (by Fisher) respectively. Conclusions: Metabolic abnormalities in MS are a risk factor for developing complications in the perioperative period of patients scheduled for surgeries using the subarachnoid anesthesia technique. Accordingly, it is appropriate to implement health intervention strategies by the surgical team, aiming at their prevention and management.

Post-cardiac arrest syndrome:Mechanisms and evaluation of adrenal insufficiency

Cardiac arrest is one of the leading causes of death and represents maximal stress in humans. After restoration of spontaneous circulation, post-cardiac arrest syndrome is the predominant disorder in survivors. Besides the post-arrest brain injury, the post-resuscitation myocardial stunning, and the systemic ischemia/reperfusion response, this syndrome is characterized by adrenal insufficiency, a disorder that often remains undiagnosed. The pathophysiology of adrenal insufficiency has not been elucidated. We performed a comprehensive search of three medical databases in order to describe the major pathophysiological disturbances which are responsible for the occurrence of the disorder. Based on the available evidence, this article will help physicians to better evaluate and understand the hidden yet deadly post-cardiac arrest adrenal insufficiency.

Neither hereditary periodic fever nor periodic fever, aphthae, pharingitis, adenitis: Undifferentiated periodic fever in a tertiary pediatric center

AIM To describe the frequency and clinical characteristics of patients with undifferentiated periodic fever(UPF) and to investigate whether a clinical classification of UPF based on the PRINTO-Eurofever score can help predicting the response to treatment and the outcome at follow-up.METHODS Clinical and therapeutic information of patients with recurrent fever who presented at a single pediatric rheumatology center from January 2006 through April 2016 were retrospectively collected. Patients with a clinical suspicion of hereditary periodic fever(HPF) syndrome and patients with clinical picture of periodic fever, aphthae, pharingitis, adenitis(PFAPA) who were refractory to tonsillectomy underwent molecular analysis of five HPF-related genes: MEFV(NM_000243.2), MVK(NM_000431.3), TNFRSF1 A(NM_001065.3), NLRP3(NM_001079821.2), NLRP12(NM_001277126.1). All patients who had a negative genetic result were defined as UPF and further investigated. PRINTO-Eurofever score for clinical diagnosis of HPF was calculated in all cases. RESULTS Of the 221 patients evaluated for periodic fever, twelve subjects with a clinical picture of PFAPA who were refractory to tonsillectomy and 22 subjects with a clinical suspicion of HPF underwent genetic analysis. Twenty-three patients(10.4%) resulted negative and were classified as UPF. The median age at presentation of patients with UPF was 9.5 mo(IQR 4-24). Patients with UPF had a higher frequency of aphthae(52.2% vs 0%, P = 0.0026) and musculoskeletal pain(65.2% vs 18.2%, P = 0.0255) than patients with genetic confirmed HPF. Also, patients with UPF had a higher frequency of aphthous stomatitis(52.2% vs 10.7%, P < 0.0001), musculoskeletal pain(65.2% vs 8,0%, P < 0.0001), and abdominal pain(52.2% vs 4.8%, P < 0.0001) and a lower frequency of pharyngitis(56.6% vs 81.3%, P = 0.0127) compared with typical PFAPA in the same cohort. Twenty-one of 23 patients with UPF(91.3%) received steroids, being effective in 16; 13(56.2%) were given colchicine, which was effective in 6. Symptoms resolution occurred in 2 patients with UPF at last follow-up. Classification according to the PRINTOEurofever score did not correlate with treatment response and prognosis. CONCLUSION UPF is not a rare diagnosis among patients with periodic fever. Clinical presentation place UPF half way on a clinical spectrum between PFAPA and HPF. The PRINTOEurofever score is not useful to predict clinical outcome and treatment response in these patients.

More Benefits of Oral Administration of Arsenic-containing Qinghuang Powder Compared with Decitabine for High/Very-high Risk Myelodysplastic Syndrome

OBJECTIVE: To evaluated the benefits of oral administration of arsenic-containing Qinghuang Powder(QHP)compared with decitabine for patients with high/very-high(H/VH) risk myelodysplastic syndrome(MDS) according to the Revised International Prognostic Score System. METHODS: The OS(mOS) rate, annual OS rate and progression to acute myeloid leukemia(AML) in patients with H/VH MDS treated with QHP(QHP group, n = 27) and decitabine(decitabine group, n = 20) were retrospectively analyzed. The effects of prognostic factors of age, proportion of bone marrow blast,peripheral blood cell count, karyotype and Charlson Comorbidity Index(CCI) on OS were further analyzed. RESULTS: The m OS rate of QHP group(29 months) was signi?cantly longer than that of the decitabine group(18 months)(P = 0.043). The OS rates of 1, 2, and 3 years were signi?cantly higher in the QHP group(88.9%, 59.3%, 29.6%) than that in the decitabine group(70%, 25%, and 5%)(P = 0.01). There was no signi?cant difference of 5-year OS rate between the 2 groups(P = 0.133).The effects of prognostic factors on mOS were further analyzed, and it was found that there was no signi?cant difference of m OS rate between the QHP group(29 months) and the decitabine group(21 months) in the patients with age 65 years old(P = 0.673). The mOS rate was signi?cantly longer in QHP group(28.5 months) than that in decitabine group(18 months) in the patients with age of < 65 years old(P = 0.04). The proportions of bone marrow blast cells with 10% or < 10% had no signi?cant effects on the mOS rate of patients in the 2 groups(P = 0.429, P = 0.183). In patients with HGB 80 g/L, mOS rate was signi?cantly longer in the QHP group(57 months) than that in the decitabine group(21 months)(P = 0.047), while in patients with HGB < 80 g/L, there was no signi?cant difference of mOS rate between the 2 groups(P = 0.265). In the patients with PLT < 50×10~9/L, the mOS rate was signi?cantly longer in the QHP group(33 months) than that in the decitabine group(16 months)(P = 0.028). In the patients with PLT 50×10~9/L, there was no signi?cant difference of the mOS rate between the 2 groups(P = 0.338). In the patients with ANC < 0.8×10~9/L, the mOS rate was signi?cantly longer in the QHP group(20 months) than that in the decitabine group(7 months)(P = 0.014). In the patients with normal karyotype, the mOS was signi?cantly longer in the QHP group(32 months) than that in the decitabine group(15 months)(P = 0.009). In the patients with abnormal karyotypes, there was no significant difference of the mOS rate between the 2 groups(P = 0.882). In the patients with good karyotypes, the mOS rate was signi?cantly longer in the QHP group(37 months) than that in the decitabine group(20 months)(P = 0.019). In the patients with moderate/poor/very poor karyotype, there was no signi?cant difference of the mOS rate between the 2 groups(P = 0.685). In the patients with CCI 3, the mOS rate was signi?cantly longer in the QHP group(34 months) than that in the decitabine group(10.5 months)(P = 0.017). In patients with CCI < 3, there was no signi?cant difference of the mOS rate between the 2 groups(P = 0.581). The proportion of progression to AML in the QHP group(18.8%) was signi?cantly lower than that in the decitabine group(25%)(P = 0.03). CONCLUSION: Compared with decitabine, oral administration of arsenic-containing Qinghuang Powder could help patients to survive longer and decrease incidence of progression to acute myeloid leukemia in the treatment of patients with high/very high MDS.

Advances in the Pathogenesis of Perimenopausal Syndrome

Perimenopause syndrome refers to the syndrome of the disorders of multiple systems of women around menopause caused by the reduction in secreted estrogen and is also known as menopause syndrome.Its pathogenesis involves increasing age,the abatement of ovarian function,and psychological change caused by the increasing life pressure.The above factors lead to physical and mental changes in postmenopausal women.This paper summarizes the pathogenesis of perimenopause from the perspective of gene studies and existing experimental studies and provide some ideas for clinical treatment and research.

A case of Noonan syndrome and Whipple's disease in the same patient

We report the first known case of both Noonan syndrome and Whipple's disease occurring in the same patient.A 36-year-old female with history of Noonan syndrome developed fatigue,anorexia,arthritis of the knees and hands with a diffuse hyperpigmented rash,night sweats,and an unintentional fifteen pound weight loss over 4 mo.Small bowel enteroscopy demonstrated mild edematous yellowish mucosa without friability.Random small bowel biopsies revealed extensive periodic acid-Schiff positive material within the foamy macrophages.She was treated with a 12 mo course of trimethoprim-sulfamethoxazole DS with clinical improvement to baseline status.

Correlation between circulating endothelial cell level and acute respiratory distress syndrome in postoperative patients

BACKGROUND Acute respiratory distress syndrome(ARDS)is injury of alveolar epithelial cells and capillary endothelial cells caused by various factors,including endogenous and exogenous lung factors,leading to diffuse pulmonary interstitial and alveolar edema,and acute respiratory failure.ARDS involves alveolar epithelial cells and pulmonary interstitial capillary endothelial cells.Circulating endothelial cells(CECs)are the only marker that directly reflects vascular endothelial injury in vivo.There have been few studies on the correlation between peripheral blood CECs and ARDS at home and abroad.The lungs are the organs with the highest capillary density and the most endothelial cells,thus,it is speculated that when ARDS occurs,CECs are stimulated and damaged,and released into the circulatory system.AIM To explore the correlation between CEC level and severity of ARDS in patients postoperatively.METHODS Blood samples were collected from all patients on day 2(d2)and day 5(d5)after surgery.The control group comprised 32 healthy volunteers.Number of CECs was measured by flow cytometry,and operation time was recorded.Changes in various indexes of patients were monitored,and diagnosis of ARDS was determined based on ARDS Berlin definition.We comprised d2 CECs in different groups,correlation between operation time and d2 CECs,ARDS of different severity by d2 CECs,and predictive value of d2 CECs for ARDS in postoperative patients.RESULTS The number of d2 CECs in the ARDS group was significantly higher than that in the healthy control group(P<0.001).The number of d2 CECs in the ARDS group was significantly higher than that in the non-ARDS group(P<0.001).The number of d2 CECs in the non-ARDS group was significantly higher than that in the healthy control group(P<0.001).Operation time was positively correlated with number of CECs on d2(rs=0.302,P=0.001).The number of d2 CECs in the deceased group was significantly higher than that in the improved group(P<0.001).There was no significant difference in number of d2 CECs between patients with mild and moderate ARDS.The number of d2 CECs in patients with severe ARDS was significantly higher than that in patients with mild and moderate ARDS(P=0.041,P=0.037).There was no significant difference in number of d5 and d2 CECs in the non-ARDS group after admission to intensive care.The number of d5 CECs was higher than the number of d2 CECs in the ARDS improved group(P<0.001).The number of d5 CECs was higher than the number of d2 CECs in the ARDS deceased group(P=0.002).If the number of CECs was>1351/mL,sensitivity and specificity of predicting ARDS were 80.8%and 78.1%,respectively.CONCLUSION Changes in number of CECs might predict occurrence and adverse outcome of ARDS after surgery,and higher numbers of CECs indicate worse prognosis of ARDS.

Multifactor dimensionality reduction analysis of syndrome characteristics of chronic persistent asthma

Objective:To analyze the syndrome characteristics in patients with chronic persistent asthma.Methods:365 patients(121 males,244 females,60.829.1 years old)with chronic persistent asthma were enrolled in this cross-sectional study.The information of syndrome,symptoms,signs,tongue coating and pulse were collected from all patients.The syndrome characteristics of chronic persistent asthma were examined through the multifactor dimensionality reduction(MDR)analysis and the results were verified by the Chi-square test.Results:The results of the MDR analysis and the Chi-square test showed the following positive correlation of the interaction among:the deficiency syndrome of the lung and spleen and deep pulse,disinclination to talk due to lack of qi,fatigue,lassitude and thick tongue coating;the deficiency syndrome of the lung and kidney and dizziness and disinclination to talk due to lack of qi,fatigue,lassitude and pallid complexion;the syndrome of phlegm-heat obstructing the lung and rapid pulse,abdominal distension,disinclination to talk due to lack of qi,frequent urination and lassitude;the syndrome of phlegm-dampness obstructing the lung and disinclination to talk due to lack of qi,greasy coating,fatigue and lassitude.(P<.05 for all).Conclusion:The syndrome of chronic persistent asthma is characterized by fatigue and lassitude due to dysfunction of the lung,spleen and kidney.

Perioperative nursing of a newborn with Beckwith-Wiedemann syndrome

Objective:To explore the perioperative nursing of a newborn with Beckwith-Wiedemann syndrome.Methods:We observed the blood glucose of the child and prevent infection of omphalocele before transpor tation and before the operation;after the operation,we performed airway nursing,blood glucose monitoring,urination observation,and tumor marker monitoring;finally,at the time of discharge from the hospital,we provided health education.Results:After a series of perioperative nursing measures,the child was discharged smoothly from hospital 34 d after operation.Conclusions:Beckwith-Wiedemann syndrome is a rare congenital malformation.Timely and accurate observation and evaluation of the child during perioperative period and targeted nursing measures can effectively reduce or avoid the occurrence of postoperative complications.

代谢综合征对肾透明细胞癌分级分期及围手术期相关指标的影响

目的探讨代谢综合征(metabolic syndrome,MS)对肾透明细胞癌(clear cell renal cell carcinoma,ccRCC)的病理分级、分期及围手术期相关指标的影响。方法选取2020年1月至2022年12月在苏州大学附属第一医院接受手术治疗的226例ccRCC患者的临床资料进行回顾性分析,根据是否合并MS分为MS组(n=67)与非MS组(n=159)。比较两组患者的病理分级、分期以及围手术期相关指标,主要包括美国麻醉医师协会分级(American society of anesthesiologists,ASA)评分、术前准备时间、手术时间、肾动脉阻断时间、术中出血量、术中输血率,术后肠道功能恢复、拔出导尿管时间、拔出腹膜后引流管时间、术后发热情况、术后住院时间等。结果高血压、糖尿病、高血脂与ccRCC病理分级、分期相关,差异均有统计学意义(P<0.05)。多因素logistic回归分析结果显示,高血压、糖尿病、高血脂是ccRCC分级的独立危险因素(P<0.05),高血脂是ccRCC分期的独立危险因素(P<0.05)。在腹腔镜下肾部分切除术(laparoscopic partial nephrectomy,LPN)与腹腔镜下肾根治切除术(laparoscopic radial nephrectomy,LRN)围手术期,MS组术前准备、手术、拔出腹膜后引流管、术后住院时间均长于非MS组,ASA分级≥Ⅲ级比例与术后发热比例高于非MS组,术中出血量大于非MS组,差异均有统计学意义(P<0.05)。结论MS与ccRCC病理分级、分期及围手术期相关指标均有相关性。因此,在ccRCC诊疗过程中,应重视MS,加强围手术期管理,帮助患者取得良好预后。

补肺息喘方结合常规西药治疗COPD稳定期(肺脾气虚证)患者的效果

目的探讨补肺息喘方结合常规西药治疗慢性阻塞性肺疾病(COPD)稳定期(肺脾气虚证)患者的效果及对肺功能和免疫功能的影响。方法本研究纳入2021年8月至2023年1月在河南大学第一附属医院就诊的100例COPD稳定期(肺脾气虚证)患者,以随机数字表法分成观察组和对照组。对照组接受乌美溴铵维兰特罗吸入粉雾剂治疗,观察组在此基础上联合补肺息喘方治疗,均治疗2个月。观察两组临床疗效、中医肺脾气虚证证候积分、COPD患者自我评估测试量表(CAT)评分、6 min步行测试(6MWT)、改良英国医学研究学会呼吸困难指数量表(mMRC)评分、肺功能指标[第1秒用力呼气容积(FEV_(1))、用力肺活量(FVC)、FEV_(1)/FVC]、免疫功能指标[CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)]水平和不良反应。结果治疗2个月后,观察组总有效率、6MWT、FEV_(1)、FVC、FEV_(1)/FVC、CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)高于对照组(P<0.05),肺脾气虚证证候积分、CAT评分、mMRC评分、CD8^(+)低于对照组(P<0.05),两组均未发生与治疗药物相关的不良反应事件。结论补肺息喘方结合常规西药治疗COPD稳定期(肺脾气虚证)的效果显著,能够有效缓解临床症状,减轻呼吸困难程度,提高活动耐力,改善机体免疫功能,安全有效。

围手术期中医证候虚实变化研究进展

证候是中医理论体系的基石,是中医临床研究的基础,证候的变化与转归又是中医临床疗效的重要评价指标,中医临床诊治基于整体观念,实施个体化辨证论治,注重改善患者的各类临床症状和体征,而手术为西方医学的治疗手段,中医药联合手术为患者提供综合性治疗,观察疾病围手术期证候变化,不仅为中西医结合治疗提供理论指导,同时作为临床疗效评价指标,能够切实评价临床干预手段的有效性以及判断疾病预后。现以心血管疾病、肿瘤疾病、骨伤疾病、脑血管疾病以及其他疾病五个方向,分别论述疾病围手术期证候的虚实变化情况,对手术干预方式与证候变化的相关性研究提供启发,为中西医结合证候研究提供切入点。

成人支气管哮喘发作期患者中医证型特点及与miR-155-5p、Treg/Th17细胞平衡的关系

目的:探讨成人支气管哮喘发作期患者中医证型特点及与miR-155-5p、Treg/Th17细胞平衡的关系。方法:选择2022年3月~2024年2月在我院及我院上级医联体医院就诊的成人支气管哮喘发作期患者116例作为研究对象。收集患者一般资料、miR-155-5p mRNA、Treg/Th17及相关细胞因子[白细胞介素(IL)-17、IL-23]指标,同时对患者进行中医辨证分型,比较不同中医证型患者一般资料、miR-155-5p、Treg/Th17、IL-17、IL-23水平。结果:116例成人支气管哮喘发作期患者中医辨证为热哮、风哮、冷哮、虚哮,占比分别为34.48%(40/116),31.90%(37/116),22.41%(26/116),11.21%(13/116)。其中虚哮者年龄均高于风哮、热哮、冷哮者(P<0.05),其余证型年龄无差异(P>0.05)。不同中医证型患者病程、肺功能指标无差异(P>0.05)。不同中医证型患者miR-155-5p mRNA、Treg/Th17、IL-17、IL-23水平比较有差异(P<0.05),且风哮>冷哮>热哮>虚哮(P<0.05)。结论:成人支气管哮喘发作期以热哮、风哮为主,风哮患者miR-155-5p水平升高,Treg/Th17失衡,两者可能作为成人支气管哮喘发作期证型客观化的指标之一。

中药周期疗法联合促排卵方案治疗多囊卵巢综合征不孕症Meta分析

目的:系统评价中药周期疗法联合促排卵方案治疗多囊卵巢综合征(PCOS)不孕症的临床疗效及安全性。方法:计算机检索PubMed、EMbase、Web of Science、the Cochrane Library、中国生物医学文献数据库(CBM)、中国知网(CNKI)、万方数据库、维普数据库,检索时限为建库至2024年2月,纳入中药周期疗法治疗PCOS不孕症的随机对照试验。由2位研究人员独立按照纳入、排除标准进行文献筛选和数据收集。采用RevMan5.4软件进行Meta分析。结果:最终纳入15项研究,涉及患者1171例,其中治疗组594例,对照组577例。Meta分析结果显示,与对照组比较,治疗组妊娠率[RR=1.80,95%CI(1.58,2.04),P<0.00001]、排卵率[RR=1.10,95%CI(1.06,1.14),P<0.00001]和总有效率[RR=1.25,95%CI=(1.15,1.37),P<0.00001]升高,子宫内膜厚度增厚[MD=1.12,95%CI(0.94,1.29),P<0.00001],雄激素[MD=-0.39,95%CI(-0.52,-0.26),P<0.00001]、促黄体生成激素[MD=-1.49,95%CI(-1.93,-1.05),P<0.00001]水平及卵巢过度刺激征发生率[RR=0.25,95%CI(0.08,0.79),P=0.02]与不良反应发生率[RR=0.36,95%CI(0.19,0.67),P=0.001]降低。结论:中药周期疗法联合促排卵方案治疗PCOS不孕症疗效优于单纯促排卵方案治疗,能够促进生育,调节性激素水平,安全性较高。

围绝经期及绝经后女性中医证型与焦虑、抑郁情绪的相关性

目的探讨围绝经期及绝经后女性中医证型与焦虑、抑郁情绪的相关性。方法借助自主研发的更年期应用程序收集围绝经期及绝经后女性的资料,同时采用广泛焦虑障碍量表(GAD-7)、抑郁筛查量表(PHQ-9)进行焦虑、抑郁情绪评估,分析围绝经期及绝经后女性焦虑、抑郁情绪发生情况以及中医证型与焦虑、抑郁情绪的相关性。结果①共收集有效病例2379例,其中伴有焦虑情绪者737例、伴有抑郁情绪者826例,同时伴有焦虑、抑郁情绪者537例。月经情况、流产史、生育史对焦虑情绪的发生有影响(P<0.05),而年龄、月经情况、流产史、生育史对抑郁情绪的发生有影响(P<0.05)。②不同程度(轻度、中度、中重度/重度)焦虑、抑郁情绪的人数分布比较,差异无统计学意义(P>0.05)。③不同中医证型在焦虑、抑郁情绪中的分布,差异具有统计学意义(P<0.05)。④肾虚肝郁证与轻度、中度、重度焦虑情绪有较强关联性,尤其与轻度焦虑情绪关联性最强;肾阴阳两虚证、肝肾阴虚证、心肾不交证与无焦虑情绪关联性较强。肾虚肝郁证与轻度、中度、中重度/重度抑郁情绪有较强关联性,尤其与轻度、中度抑郁情绪关联性最强;肝肾阴虚证、心肾不交证、肾阴阳两虚证与无抑郁情绪有较强关联性。结论围绝经期及绝经后女性焦虑、抑郁情绪的发生与肾虚肝郁证的关联性最强,因此在临床工作中更应关注肾虚肝郁证围绝经期及绝经后女性的情绪状态,在早期采用补肾疏肝法进行治疗,改善患者的症状,提高围绝经期及绝经后女性的生活质量。

1例严重多发伤合并急性呼吸窘迫综合征患者围手术期ECMO治疗的护理

创伤是全球面临的突出问题,目前,在我国已成为青壮年第1位死亡原因[1]。约50%的创伤患者合并有严重的胸部外伤[2],10%~20%严重创伤患者(损伤严重度评分(injury severity score,ISS)≥16分)可进展为呼吸功能衰竭甚至急性呼吸窘迫综合征(acute respiratory distress syndrome,ARDS),病死率高达50%~80%[3-4]。

基于数据挖掘探讨国医大师张琪治疗儿童肾病综合征激素撤减期用药规律

目的采用数据挖掘方法对国医大师张琪教授治疗儿童肾病综合征激素撤减期的用药规律进行分析,传承其学术思想。方法收集2008年1月-2018年12月黑龙江省中医医院张琪教授门诊的儿童肾病综合征激素撤减期患者病案,利用Excel2019建立数据档案,基于中医传承计算平台3.5,运用频次统计、关联规则、聚类分析等数据挖掘方法,探讨张琪教授用药规律。结果共筛选纳入中药处方271首,涉及中药194味,药物总频次为4610。高频药物包括甘草、黄芪、莲子、麦冬、地骨皮、茯苓、太子参、柴胡、金银花等。药性以寒、平居多,药味以甘、苦、辛为主,归经以肺经、脾经、肾经居多。药物功效统计中补虚类、清热类、利水渗湿类使用频次较高。关联规则分析得出高频药物组合模式184组;支持度为60%时,包含核心药物组合为黄芪、太子参、莲子、麦冬、地骨皮、茯苓、甘草;聚类分析得到6类新方组合。结论儿童肾病综合征激素撤减期以肺、脾、肾三脏虚弱为本,多见气阴两虚证,张琪教授治疗本病以调理肺脾肾之气为要,清补兼施,随证治以清利湿热、理气和胃、利水渗湿之品,以调整阴阳平衡为期。