The design and implementation of fast algorithms related to Elliptic Curve Cryptography (ECC) over the field GF(p), such as modular addition, modular subtraction, point addition, point production, choice of embedding ...The design and implementation of fast algorithms related to Elliptic Curve Cryptography (ECC) over the field GF(p), such as modular addition, modular subtraction, point addition, point production, choice of embedding plaintext to a point, etc. are given. A practical software library has been produced which supports variable length implementation of the ECCbased ElGamal cryptosystem. More importantly, this scalable architecture of the design enables the ECC being used in restricted platforms as well as high-end servers based on Intel Pentium CPU. Applications such as electronic commerce security, data encryption communication, etc.are thus made possible for real time and effective ECC.展开更多
This research paper analyzes the urgent topic of quantum cybersecurity and the current federal quantum-cyber landscape. Quantum-safe implementations within existing and future Internet of Things infrastructure are dis...This research paper analyzes the urgent topic of quantum cybersecurity and the current federal quantum-cyber landscape. Quantum-safe implementations within existing and future Internet of Things infrastructure are discussed, along with quantum vulnerabilities in public key infrastructure and symmetric cryptographic algorithms. Other relevant non-encryption-specific areas within cybersecurity are similarly raised. The evolution and expansion of cyberwarfare as well as new developments in cyber defense beyond post-quantum cryptography and quantum key distribution are subsequently explored, with an emphasis on public and private sector awareness and vigilance in maintaining strong security posture.展开更多
Despite the recent advances in the therapeutic modalities,colorectal cancer(CRC)remains to be one of the most common causes of cancer-related death.CRC arises through accumulation of multiple genetic and epigenetic al...Despite the recent advances in the therapeutic modalities,colorectal cancer(CRC)remains to be one of the most common causes of cancer-related death.CRC arises through accumulation of multiple genetic and epigenetic alterations that transform normal colonic epithelium into adenocarcinomas.Among crucial roles of epigenetic alterations,gene silencing by aberrant DNA methylation of promoter regions is one of the most important epigenetic mechanisms.Recent comprehensive methylation analyses on genome-wide scale revealed that sporadic CRC can be classified into distinct epigenotypes.Each epigenotype cooperates with specific genetic alterations,suggesting that they represent different molecular carcinogenic pathways.Precursor lesions of CRC,such as conventional and serrated adenomas,already show similar methylation accumulation to CRC,and can therefore be classified into those epigenotypes of CRC.In addition,specific DNA methylation already occurs in the normal colonic mucosa,which might be utilized for prediction of the personal CRC risk.DNA methylation is suggested to occur at an earlier stage than carcinoma formation,and may predict the molecular basis for future development of CRC.Here,we review DNA methylation and CRC classification,and discuss the possible clinical usefulness of DNA methylation as biomarkers for the diagnosis,prediction of the prognosis and the response to therapy of CRC.展开更多
基金the National Natural Science Foundation of China(No.60271025)
文摘The design and implementation of fast algorithms related to Elliptic Curve Cryptography (ECC) over the field GF(p), such as modular addition, modular subtraction, point addition, point production, choice of embedding plaintext to a point, etc. are given. A practical software library has been produced which supports variable length implementation of the ECCbased ElGamal cryptosystem. More importantly, this scalable architecture of the design enables the ECC being used in restricted platforms as well as high-end servers based on Intel Pentium CPU. Applications such as electronic commerce security, data encryption communication, etc.are thus made possible for real time and effective ECC.
文摘This research paper analyzes the urgent topic of quantum cybersecurity and the current federal quantum-cyber landscape. Quantum-safe implementations within existing and future Internet of Things infrastructure are discussed, along with quantum vulnerabilities in public key infrastructure and symmetric cryptographic algorithms. Other relevant non-encryption-specific areas within cybersecurity are similarly raised. The evolution and expansion of cyberwarfare as well as new developments in cyber defense beyond post-quantum cryptography and quantum key distribution are subsequently explored, with an emphasis on public and private sector awareness and vigilance in maintaining strong security posture.
文摘Despite the recent advances in the therapeutic modalities,colorectal cancer(CRC)remains to be one of the most common causes of cancer-related death.CRC arises through accumulation of multiple genetic and epigenetic alterations that transform normal colonic epithelium into adenocarcinomas.Among crucial roles of epigenetic alterations,gene silencing by aberrant DNA methylation of promoter regions is one of the most important epigenetic mechanisms.Recent comprehensive methylation analyses on genome-wide scale revealed that sporadic CRC can be classified into distinct epigenotypes.Each epigenotype cooperates with specific genetic alterations,suggesting that they represent different molecular carcinogenic pathways.Precursor lesions of CRC,such as conventional and serrated adenomas,already show similar methylation accumulation to CRC,and can therefore be classified into those epigenotypes of CRC.In addition,specific DNA methylation already occurs in the normal colonic mucosa,which might be utilized for prediction of the personal CRC risk.DNA methylation is suggested to occur at an earlier stage than carcinoma formation,and may predict the molecular basis for future development of CRC.Here,we review DNA methylation and CRC classification,and discuss the possible clinical usefulness of DNA methylation as biomarkers for the diagnosis,prediction of the prognosis and the response to therapy of CRC.
