The mixed ligand coordination compound of copper with norfloxacin (NFLX) and 1, 10-phen has been synthesized and characterized by means of X-ray single crystal diffraction. The structure features of the coordination ...The mixed ligand coordination compound of copper with norfloxacin (NFLX) and 1, 10-phen has been synthesized and characterized by means of X-ray single crystal diffraction. The structure features of the coordination compound are described. Antibacterial activities of the coordination compound have been tested against different microorganisms. The antitumor activities of the coordination compound on leukemia HL-60 cell line and liver cancer BEL-7402 cell line have been measured, respectively. The results indicated that the coordination compound has strong inhibitory effect on HL-60 and BEL-7402 cell lines.展开更多
The title compound 4-(5-(2,6-difluorophenyl)-1,3,4-oxadiazol-2-ylthio)-2-(trifluoromethyl)thieno[2,3-d]pyrimidine(C15H5F5N4OS2, Mr = 416.35) was designed and synthesized as antitumor agent, and its structure was deter...The title compound 4-(5-(2,6-difluorophenyl)-1,3,4-oxadiazol-2-ylthio)-2-(trifluoromethyl)thieno[2,3-d]pyrimidine(C15H5F5N4OS2, Mr = 416.35) was designed and synthesized as antitumor agent, and its structure was determined by 1H NMR, 13C NMR, MS, elemental analysis and single-crystal X-ray diffraction. The crystal belongs to monoclinic system, space group P21/c with a = 9.904(2), b = 10.057(2), c = 16.595(3) ?, β = 100.000(3)°, V = 1627.9(6) ?3, Z = 4, F(000) = 832, Dc = 1.699 g/cm3, μ = 0.395 mm-1, R = 0.0468 and wR = 0.1255 for 4726 independent reflections(Rint = 0.0336) and 2847 observed ones(I > 2σ(I)). The in vitro antitumor activity of the title compound was preliminarily evaluated by the standard MTT assay.展开更多
The title compound has been synthesized in good yield in H2O/ethersystem by using 2--chloroselenobenzoyl chloride as the key intermediate. its structurewas characterized by elemental analysisi IR, IH NMR and X--ray di...The title compound has been synthesized in good yield in H2O/ethersystem by using 2--chloroselenobenzoyl chloride as the key intermediate. its structurewas characterized by elemental analysisi IR, IH NMR and X--ray diffraction analyses.Crystal data: C15H19NO3Se, M.r= 340. 28, hexagonal, P61, a= 8. 903(2), c= 34. 352(1)A, V=2358. I A3, Z=6, Dx=1. 438 g/cm3, λ(CuKa)=l. 5418 A, μ=33. 56cm--1, F (000) = 1044, final R = 0. 034 for 1396 observed reflections. Molecules incrystal form helieal chains with intermolecular Se...O distance of 2. 812(5) A as wellas intramolecular Se ...O distance of 3. 089 (5) A. Biological studies show that thiscompound is very active against human tumor cells, including HCT--8, Bel--7402,A432, HL--60 and K562.展开更多
Di-n-butyltin oxide reacted with p-[N,N-bis（2-chloroethyl）amino]benzoic acid to yield the compounds {{4-[（ClCH2CH2）2N]C6H4COOSnBu2}2O}2 （1） and {4-[（ClCH2CH2）2N]C6H4COO}2SnBu2 （2）, which have been characteri...Di-n-butyltin oxide reacted with p-[N,N-bis（2-chloroethyl）amino]benzoic acid to yield the compounds {{4-[（ClCH2CH2）2N]C6H4COOSnBu2}2O}2 （1） and {4-[（ClCH2CH2）2N]C6H4COO}2SnBu2 （2）, which have been characterized by IR and ^1H NMR spectra. The X-ray diffractional studies of 1 reveal the structure of the molecule to be a dimer, in which the two Bu2Sn groups were linked via two bridging oxygen atoms to form a central Bu4Sn2O2 unit. And the tin atom adopts two carbons from two n-butyl groups and three oxygen atoms from the acid and the bridging oxygen. In vitro test showed compound 1 to exhibit high cytotoxicity against P388 and HL-60 cell lines.展开更多
A 1：1 reaction of triphenyltin chloride with potassium N-[（3,5-dibromo-2-hydroxylphenyl）methylene]valinate in benzene led to the formation of a novel mixed organotin dinuclear complex, （HL）SnPh3oPh2SnL [L=2-O-3,5...A 1：1 reaction of triphenyltin chloride with potassium N-[（3,5-dibromo-2-hydroxylphenyl）methylene]valinate in benzene led to the formation of a novel mixed organotin dinuclear complex, （HL）SnPh3oPh2SnL [L=2-O-3,5-Br2C6H3CH=NCH（i-Pr）COO], by means of a facile phenyl-tin bond cleavage process. In the complex, there are two distinct types of carboxylate moieties and a trans-O2SnC2N and a trans-O2SnC3 in distorted trigonal bipyramidal geometries were bridged by a carboxylate group. In vitro antitumor activity of the complex against three human tumour cell lines （HeLa, CoLo205 and MCF-7） was found to be much higher than cis-platin used in clinic.展开更多
Four chiral diorganotin complexes of N-[4-(diethylamino)salicylidene]-(L)-tryptophane,R2Sn[4-(Et2N)-2-OC6H3CH=NCH(CH2Ind)COO](Ind=3-indolyl;R=Me(1);Et,(2);n-Bu(3);Cy(cyclohexyl)(4)),have been synthesized and character...Four chiral diorganotin complexes of N-[4-(diethylamino)salicylidene]-(L)-tryptophane,R2Sn[4-(Et2N)-2-OC6H3CH=NCH(CH2Ind)COO](Ind=3-indolyl;R=Me(1);Et,(2);n-Bu(3);Cy(cyclohexyl)(4)),have been synthesized and characterized by elemental analysis,IR,and 1H and 13C NMR spectra.The crystal structures of 1-CH3OH-CHCl3,2,3-CH3OH and 4-CH3CH2OH have been determined by single-crystal X-ray diffraction.The complexes crystallize in orthorhombic system with P212121 space group,and the tin atoms are in distorted trigonal bipyramidal geometry and form five-and six-membered chelate rings with the chiral ONO tridentate ligand N-[4-(diethylamino)salicylidene]-(L)-tryptophane.In the complexes,the molecules are connected into one-dimensional supramolecular chain by intermolecular N–H…O–H…O=C or N–H…O–C hydrogen bonds.The fluorescence spectrum indicates that the complexes may be explored for potential blue luminescent materials.Bioassay results show that 3 and 4 belong to the efficient cytostatic agents against A549 human tumor cell.展开更多
Diorganotin(Ⅳ) compound [(p-CNC6H4CH2)2Sn(C9H7N3O3)(H2O)]2 was synthesized by the reaction of tri-p-cyanobenzyltin chloride with Schiff base ligand pyruvic acid isonicotinyl hydrazone. The compound was characterized ...Diorganotin(Ⅳ) compound [(p-CNC6H4CH2)2Sn(C9H7N3O3)(H2O)]2 was synthesized by the reaction of tri-p-cyanobenzyltin chloride with Schiff base ligand pyruvic acid isonicotinyl hydrazone. The compound was characterized by elemental analysis, IR, 1H NMR. The crystal structure was determined by X-ray single crystal diffraction. The crystal belongs to monoclinic space group C2/c, with a=3.143 1(3) nm, b=0.989 99(10) nm, c=1.785 68(18) nm, β=114.908 0(13)°, V=5.039 6(9) nm3, Z=4, μ=1.054 mm-1, Dc=1.513 Mg·m-3, F(000)=2 304, R=0.042 8, wR=0.090 3, GOF=0.997. In this compound, the Sn atom exists in a distorted octahedral coordination environment in which one water molecule, one tridentate pyruvic acid isonicotinyl hydrazone ligand, and two trans p-cyanobenzyl groups coordinate to each Sn center, the angle of the axial C10-Sn1-C18 is 166.1(2)°. Two molecules form a weak-bridged dimmer with weak interactions of Sn...O bonding and hydrogen bonds. CCDC: 270796.展开更多
A new Cadmium!-Ciprofloxacin ionic compound, (HCPFX)2CdCl4·3H2O, is synthesized and its crys- tal structure is determined. The crystallography data are as follows, monoclinic, space group P21/c, a=1.01039(6) nm, ...A new Cadmium!-Ciprofloxacin ionic compound, (HCPFX)2CdCl4·3H2O, is synthesized and its crys- tal structure is determined. The crystallography data are as follows, monoclinic, space group P21/c, a=1.01039(6) nm, b=1.39989(9) nm, c=2.82245(18) nm, β=95.765 0(10)°, V=3.972 0(4) nm3, Z=4, Dc=1.627 g·cm-3, F(000)= 1984. R1=0.0540, wR2=0.1503 (I>2σ(I)). In the title compound, four chloride ions are coordinated to the cadmi- um ion forming a slightly distorted tetrahedron. Both Ciprofloxacin and the compound were assayed against gram- positive and gram-negative bacteria by doubling dilutions method, the compound shows the same minimal in- hibitory concentration (MIC) as the Ciprofloxacin against S. Aureus, M. Lutens, E. Coli and P. Aeruginosa bacte- ria. The inhibitory effect of the two compounds on leukemia HL-60 cell line has been measured by using MTT (Methyl-Thiazol-Tetrozolium) assay method. The results indicate that the complex has very strong inhibitory effect on HL-60 cell line. CCDC: 259367.展开更多
基金funded by the National Natural Science Foundation of China(No.50073019)
文摘The mixed ligand coordination compound of copper with norfloxacin (NFLX) and 1, 10-phen has been synthesized and characterized by means of X-ray single crystal diffraction. The structure features of the coordination compound are described. Antibacterial activities of the coordination compound have been tested against different microorganisms. The antitumor activities of the coordination compound on leukemia HL-60 cell line and liver cancer BEL-7402 cell line have been measured, respectively. The results indicated that the coordination compound has strong inhibitory effect on HL-60 and BEL-7402 cell lines.
基金supported by the National Natural Science Foundation of China(No.21262012)
文摘The title compound 4-(5-(2,6-difluorophenyl)-1,3,4-oxadiazol-2-ylthio)-2-(trifluoromethyl)thieno[2,3-d]pyrimidine(C15H5F5N4OS2, Mr = 416.35) was designed and synthesized as antitumor agent, and its structure was determined by 1H NMR, 13C NMR, MS, elemental analysis and single-crystal X-ray diffraction. The crystal belongs to monoclinic system, space group P21/c with a = 9.904(2), b = 10.057(2), c = 16.595(3) ?, β = 100.000(3)°, V = 1627.9(6) ?3, Z = 4, F(000) = 832, Dc = 1.699 g/cm3, μ = 0.395 mm-1, R = 0.0468 and wR = 0.1255 for 4726 independent reflections(Rint = 0.0336) and 2847 observed ones(I > 2σ(I)). The in vitro antitumor activity of the title compound was preliminarily evaluated by the standard MTT assay.
文摘The title compound has been synthesized in good yield in H2O/ethersystem by using 2--chloroselenobenzoyl chloride as the key intermediate. its structurewas characterized by elemental analysisi IR, IH NMR and X--ray diffraction analyses.Crystal data: C15H19NO3Se, M.r= 340. 28, hexagonal, P61, a= 8. 903(2), c= 34. 352(1)A, V=2358. I A3, Z=6, Dx=1. 438 g/cm3, λ(CuKa)=l. 5418 A, μ=33. 56cm--1, F (000) = 1044, final R = 0. 034 for 1396 observed reflections. Molecules incrystal form helieal chains with intermolecular Se...O distance of 2. 812(5) A as wellas intramolecular Se ...O distance of 3. 089 (5) A. Biological studies show that thiscompound is very active against human tumor cells, including HCT--8, Bel--7402,A432, HL--60 and K562.
基金Project supported by the National Natural Science Foundation of China （No. 20271025）, the Natural Science Foundation of Shandong Province （No. L2003B01） and the State Key Laboratory of Crystal Materials, Shandong University.
文摘Di-n-butyltin oxide reacted with p-[N,N-bis（2-chloroethyl）amino]benzoic acid to yield the compounds {{4-[（ClCH2CH2）2N]C6H4COOSnBu2}2O}2 （1） and {4-[（ClCH2CH2）2N]C6H4COO}2SnBu2 （2）, which have been characterized by IR and ^1H NMR spectra. The X-ray diffractional studies of 1 reveal the structure of the molecule to be a dimer, in which the two Bu2Sn groups were linked via two bridging oxygen atoms to form a central Bu4Sn2O2 unit. And the tin atom adopts two carbons from two n-butyl groups and three oxygen atoms from the acid and the bridging oxygen. In vitro test showed compound 1 to exhibit high cytotoxicity against P388 and HL-60 cell lines.
基金supported by the Natural Science Foundation of Shandong Province(No.Z2002F01)and Qufu Normal Universiy
文摘A 1：1 reaction of triphenyltin chloride with potassium N-[（3,5-dibromo-2-hydroxylphenyl）methylene]valinate in benzene led to the formation of a novel mixed organotin dinuclear complex, （HL）SnPh3oPh2SnL [L=2-O-3,5-Br2C6H3CH=NCH（i-Pr）COO], by means of a facile phenyl-tin bond cleavage process. In the complex, there are two distinct types of carboxylate moieties and a trans-O2SnC2N and a trans-O2SnC3 in distorted trigonal bipyramidal geometries were bridged by a carboxylate group. In vitro antitumor activity of the complex against three human tumour cell lines （HeLa, CoLo205 and MCF-7） was found to be much higher than cis-platin used in clinic.
基金Financially supported by the Natural Science Foundation of Shandong Province(ZR2013BM007)the National Natural Science Foundation of China(21702119)
文摘Four chiral diorganotin complexes of N-[4-(diethylamino)salicylidene]-(L)-tryptophane,R2Sn[4-(Et2N)-2-OC6H3CH=NCH(CH2Ind)COO](Ind=3-indolyl;R=Me(1);Et,(2);n-Bu(3);Cy(cyclohexyl)(4)),have been synthesized and characterized by elemental analysis,IR,and 1H and 13C NMR spectra.The crystal structures of 1-CH3OH-CHCl3,2,3-CH3OH and 4-CH3CH2OH have been determined by single-crystal X-ray diffraction.The complexes crystallize in orthorhombic system with P212121 space group,and the tin atoms are in distorted trigonal bipyramidal geometry and form five-and six-membered chelate rings with the chiral ONO tridentate ligand N-[4-(diethylamino)salicylidene]-(L)-tryptophane.In the complexes,the molecules are connected into one-dimensional supramolecular chain by intermolecular N–H…O–H…O=C or N–H…O–C hydrogen bonds.The fluorescence spectrum indicates that the complexes may be explored for potential blue luminescent materials.Bioassay results show that 3 and 4 belong to the efficient cytostatic agents against A549 human tumor cell.
文摘Diorganotin(Ⅳ) compound [(p-CNC6H4CH2)2Sn(C9H7N3O3)(H2O)]2 was synthesized by the reaction of tri-p-cyanobenzyltin chloride with Schiff base ligand pyruvic acid isonicotinyl hydrazone. The compound was characterized by elemental analysis, IR, 1H NMR. The crystal structure was determined by X-ray single crystal diffraction. The crystal belongs to monoclinic space group C2/c, with a=3.143 1(3) nm, b=0.989 99(10) nm, c=1.785 68(18) nm, β=114.908 0(13)°, V=5.039 6(9) nm3, Z=4, μ=1.054 mm-1, Dc=1.513 Mg·m-3, F(000)=2 304, R=0.042 8, wR=0.090 3, GOF=0.997. In this compound, the Sn atom exists in a distorted octahedral coordination environment in which one water molecule, one tridentate pyruvic acid isonicotinyl hydrazone ligand, and two trans p-cyanobenzyl groups coordinate to each Sn center, the angle of the axial C10-Sn1-C18 is 166.1(2)°. Two molecules form a weak-bridged dimmer with weak interactions of Sn...O bonding and hydrogen bonds. CCDC: 270796.
文摘A new Cadmium!-Ciprofloxacin ionic compound, (HCPFX)2CdCl4·3H2O, is synthesized and its crys- tal structure is determined. The crystallography data are as follows, monoclinic, space group P21/c, a=1.01039(6) nm, b=1.39989(9) nm, c=2.82245(18) nm, β=95.765 0(10)°, V=3.972 0(4) nm3, Z=4, Dc=1.627 g·cm-3, F(000)= 1984. R1=0.0540, wR2=0.1503 (I>2σ(I)). In the title compound, four chloride ions are coordinated to the cadmi- um ion forming a slightly distorted tetrahedron. Both Ciprofloxacin and the compound were assayed against gram- positive and gram-negative bacteria by doubling dilutions method, the compound shows the same minimal in- hibitory concentration (MIC) as the Ciprofloxacin against S. Aureus, M. Lutens, E. Coli and P. Aeruginosa bacte- ria. The inhibitory effect of the two compounds on leukemia HL-60 cell line has been measured by using MTT (Methyl-Thiazol-Tetrozolium) assay method. The results indicate that the complex has very strong inhibitory effect on HL-60 cell line. CCDC: 259367.
