6-O-(Hydroxypropyltrimethylammonia)-β-cyclodextrin with Low Degree of Substitution: Convenient Preparation and its Application as a Chiral Selector in Capillary Electrophoresis

A cationic cyclodextrin derivative 6-O-（hydroxypropyltrimethylammonia）-β-cyclodextrin （GTA-β-CD） with low degree of substitution was prepared through a convenient method in solid phase. The product could be used as a valuable chiral selector in the capillary electrophoresis （CE） separation of some acidic drug enantiomers such as naproxen, ofloxacin, ibuprofen and warfarin.

Synergistic Effect in Mixed Capillary Gas Chromatographic Stationap Phases Containing Heptakis(2,3,6-tri-o-pentyl)-β-cyclodextrin and Dibenzo-18-crown-6

used－silical capillary columns containing heptakis（2、3、6－tri－o－pentyl）-β-cyclodextrinand dibenzo-18-crown-6 were prepared．By studying the selectivity of mixed stationary phases forsome solute pairs.as well as comparing with the heptakis（2．3、6-tri-O-pentyl）-β-cyclodextrin and thedibenzo-18-crown-6 used as individual stationary phase、the synergistic effects were observed.These effects were affected by the column temperature．mixed ratio and linear velocity of carrier gas．

Capillary Column Coated with Heptakis(2,3, 6-tri-O-octyl)-β-cyclodextrin Using Sol-gel Technology

Heptakis(2, 3, 6-tri-O-octyl)-β-cyclodextrin was coated onto the fused silica capillary by sol-gel technology. Column efficiency and column selectivity were studied. The results indicated that high ability of separation was acquired . Positional isomers of aromatic compounds were well separated.

An Excellent Gas Chromatographic Stationary Phase for Separation of Phenol and Cresol Isomers--Heptakis(2,6-di-O-pentyl-3-O-allyl)-β-Cyclodextrin

Heptakis(2.6-di-O-pentyl-3-O-ally)-β-cyclodextrin as an excellent gas chromatographic stationary phase separating phenol and cresol isomers is described.

Synthesis of Folate-Appended <i>β</i>-Cyclodextrin Using Phenanthroline as Linker for Cancer Targeting Drug Delivery

Here we have synthesized cancer targeting drug delivery system that contains β-cyclodextrin as a drug carrier and folic acid as a targeting ligand. Folic acid was selected as a cancer targeting ligand because folic acid receptors are highly expressed in a variety of tumor types. β-cyclodextrin and folic acid were connected through a linker [1,10-phenanthroline or 5-(hydroxymethyl) furfural]. β-cyclodextrin and folic acid were attached to the linker by formation of Schiffbase and ester, respectively. Our targeted synthetic products were confirmed by NMR, Mass and IR spectroscopy. We anticipate that our synthetic products can confer cancer cell-specific drug delivery as well as desired properties such as nanoparticle formation.

乙二胺-β—环糊精对胆固醇的增溶研究

研究了乙二胺-β—CD(β—CDen)对胆固醇的增溶效果,结果表明,增溶倍数(St/So)可达到最大值(约15.0)。在达到最大增溶之前,β—CDen和胆固醇可形成稳定的1∶1包合物。

Syntheses and properties of photostable near-infrared cyanines and their cyclodextrin conjugates

Three fluorescent indocyanines containing p-carboxybenzyl groups on N atoms in the heterocyclic tings were synthesized under supersonic. The maxima wavelength of the absorption and emission of the dyes were 550-800 nm in water. Compared with those in aqueous solutions, the fluorescence intensity of the dyes in the α/β-cyclodextrin, Al^3＋, Zn^2＋, Sn^2＋ or the α/β-cyclodextrin in the aqueous solutions of the cations became stronger. The crystal Shapes of the dyes and their cyclodextrin inclusions were mostly acicular or polygon. The NHS-carboxyl squarylium indocyanine was prepared and used to conjugate with taurine or benzylamine, the results indicated that the dyes could couple covalently to biomass containing free NH2 group. Structure and some thermal parameters of the molecule of the trimethine cyanine were obtained by DFT method of Gaussian O3.

Electrochemical Sensor for Sensitive Determination of Ga（III） Ion Based on β-Cyclodextrin Incorporated Multi-walled Carbon Nanotubes and Imprinted Sol-gel Composite Film

A novel sensor for detection of trace gallium ion [Ga（III）] was created by stepwise modification of a gold electrode with fl-cyclodextrin （β-CD）/multi-walled carbon nanotubes （MWCNTs） and an ion imprinted polymer （IIP）. The sensor surface morphology was characterized by scanning electron microscopy. The electrochemical performance of the imprinted sensor was investigated by cyclic voltammetry, differential pulse voltammetry and chronoamperometry. The sensor displayed excellent selectivity towards the target Ga（III） ion. Meanwhile, the introduced MWCNTs displayed noticeable catalytic activity, and fl：CD demonstrated significant enrichment capacity. A linear calibration curve was obtained covering the concentration range from 5.0 × 10 8 to 1.0 × 10-4 moloL-1, with a detection limit of 7.6× 10 9 mol·L-1. The proposed sensor was successfully applied to detect Ga（III） in real urine samples.

肉桂精油纳米乳液的抑菌性和稳定性研究

为改善精油的稳定性及抑菌性能,利用羟丙基-β-环糊精(HPCD)与酪蛋白酸钠(SC)共同乳化肉桂精油(CEO)制备纳米乳液,探究乳液的粒径、抑菌性的变化及乳液在不同温度下的储存稳定性。结果表明,相比单独使用酪蛋白酸钠稳定的乳液,HPCD的添加可以显著降低酪蛋白酸钠-精油乳液的粒径及PDI值。1%酪蛋白酸钠和3%HPCD共同稳定的肉桂精油纳米乳液对大肠杆菌和金黄色葡萄球菌的生长有良好的抑制作用,当精油添加量为10%时,大肠杆菌浓度降低了2.62 lg(CFU/mL),金黄色葡萄球菌浓度降低了0.85 lg(CFU/mL);乳液在4、25、40℃下储存过程中的粒径、乳化指数的变化表明,1%酪蛋白酸钠和3%HPCD共同乳化的肉桂精油纳米乳液具备良好的稳定性。当精油体积分数为10%时,乳液的粒径、乳化指数随着储藏时间的延长有所增加,但荧光显微镜显示乳液中油滴仍然分布相对均匀。

Layer-by-layer Assembled Multilayers of Graphene/Mono-(6-amino-6-deoxy)-β-cyclodextrin for Detection of Dopamine

Graphene/mono-(6-amino-6-deoxy)-β-cyclodextrin multilayer films composed of graphene sheet(GS)and mono-(6-amino-6-deoxy)-β-cyclodextrin(NH_(2)-β-CD)were fabricated easily by two steps.First,negatively charged graphene oxide(GO)and positively charged mono-(6-amino-6-deoxy)-β-cyclodextrin(NH_(2)-β-CD)were layer-by-layer(LBL)self-assembled on glassy carbon electrode(GCE)modified with a layer of poly(diallyldimethylammo-nium chloride)(PDDA).Then graphene/mono-(6-amino-6-deoxy)-β-cyclodextrin(GS/NH_(2)-β-CD)multilayer films were built up by electrochemical reduction of graphene oxide/mono-(6-amino-6-deoxy)-β-cyclodextrin(GO/NH_(2)-β-CD).Combining the high surface area of GS and the active recognition sites onβ-cyclodextrin(β-CD),the GS/NH_(2)-β-CD multilayer films show excellent electrochemical sensing performance for the detection of DA with an extraordinary broad linear range from 2.53 to 980.05μmol•L^(−1).This study offers a simple route to the controlla-ble formation of graphene-based electrochemical sensor for the detection of DA.

Interfacial assembly and host-guest interaction of anthracene-conjugated L-glutamate dendron with cyclodextrin at the air/water interface

The interracial assembly of photo-induced dimerization of atypical anthracene-containing amphiphilic dendron and host-guest interaction with γ-cyclodextrin has been investigated. It has been proved that even without long alkyl chain the amphiphilic dendron could still form stable Langmuir monolayer at the air/water interface. Through the host-guest interaction,γ-cyclodextrin can be used to encapsulate two headgroups of amphiphilic dendron in the antiparallel direction. However, the formed host-guest complex was sensitive to the surface pressure. Slight compression of surface pressure led amphiphilic dendron to reassemble into nanofibers through the strong π-π stacking between headgroups. On the other hand, under in situ irradiation, the amphiphilic dendron was stabilized in the cavity of γ- cyclodextrin through headgroup dimerization and the host-guest complex further irregularly aggregated to nanoparticles. Meanwhile, γ-cyclodextrin, as a silencer, blocked the supramolecular chirality transfer. Our conclusion was demonstrated through UV/vis, FT-IR, CD spectrum and AFM images, respectively.

Surface molecularly imprinted polymers for solid-phase extraction of （-）-epigallocatechin gallate from toothpaste

Surface molecularly imprinted polymers （SMIPs） have been synthesized to selectively determine （-）-epigallocatechin gallate in aqueous media. SMIPs were prepared using a surface grafting copolymerization method on a functionalized silica gel modified with β-cyclodextrin and vinyl groups. The morphology and composition of the SMIPs were investigated by scanning electron microscopy, Fourier transform-infrared spectroscopy and thermogravimetric analysis. In addition, the molecular binding capacity, recognition properties and selectivity of the SMIPs were evaluated. The imprinted polymers were found to have a highly specific recognition and binding capacity for aqueous media which is （-）-epigallocatechin gallate in the result of the hydrophobic properties of the β-cyclodextrin and the hydrogen-bonding interactions of methacrylic acid. The SMIPs were successfully employed as solid-phase extraction adsor- bents prior to the HPLC determination of （-）-epigallocatechin gallate in toothpaste. The HPLC analysis had a linear dynamic range of 0.5-50.0 μg·mL^-1 with a correlation coefficient of 0.9998 and the recoveries ranged from 89.4% to 97.0% with relative standard deviations less than 4.8%. The limit of detection and limit of quantification were 0.17 and 0.33 μg·mL^-1, respectively. The method provides a promising approach for the preparation of selective materials for the purification and determination of complex samples.