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LOCAL TOPOLOGICAL STRUCTURE OF THE PLANE CUBIC SYSTEM IN THE UNDETERMINED SIGN CASE
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作者 李学敏 杨殿武 《Acta Mathematica Scientia》 SCIE CSCD 1995年第1期113-120,共8页
In this paper we discuss the topological structure near the singular point O (0,0) of the plane cubic system in the undetermined sign case, and give their coefficient conditions.
关键词 TOPOLOGICAL STRUCTURE cubic system UNDETERMINED SIGN CASE
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ANovel Non-Isolated Cubic DC-DC Converter with High Voltage Gain for Renewable Energy Power Generation System
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作者 Qin Yao Yida Zeng Qingui Jia 《Energy Engineering》 EI 2024年第1期221-241,共21页
In recent years,switched inductor(SL)technology,switched capacitor(SC)technology,and switched inductor-capacitor(SL-SC)technology have been widely applied to optimize and improve DC-DC boost converters,which can effec... In recent years,switched inductor(SL)technology,switched capacitor(SC)technology,and switched inductor-capacitor(SL-SC)technology have been widely applied to optimize and improve DC-DC boost converters,which can effectively enhance voltage gain and reduce device stress.To address the issue of low output voltage in current renewable energy power generation systems,this study proposes a novel non-isolated cubic high-gain DC-DC converter based on the traditional quadratic DC-DC boost converter by incorporating a SC and a SL-SC unit.Firstly,the proposed converter’s details are elaborated,including its topology structure,operating mode,voltage gain,device stress,and power loss.Subsequently,a comparative analysis is conducted on the voltage gain and device stress between the proposed converter and other high-gain converters.Then,a closed-loop simulation system is constructed to obtain simulation waveforms of various devices and explore the dynamic performance.Finally,an experimental prototype is built,experimental waveforms are obtained,and the experimental dynamic performance and conversion efficiency are analyzed.The theoretical analysis’s correctness is verified through simulation and experimental results.The proposed converter has advantages such as high voltage gain,low device stress,high conversion efficiency,simple control,and wide input voltage range,achieving a good balance between voltage gain,device stress,and power loss.The proposed converter is well-suited for renewable energy systems and holds theoretical significance and practical value in renewable energy applications.It provides an effective solution to the issue of low output voltage in renewable energy power generation systems. 展开更多
关键词 cubic DC-DC converter high voltage gain low device stress high efficiency renewable energy
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1∶2 INTERNAL RESONANCE OF COUPLED DYNAMIC SYSTEM WITH QUADRATIC AND CUBIC NONLINEARITIES 被引量:3
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作者 陈予恕 杨彩霞 +1 位作者 吴志强 陈芳启 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI 2001年第8期917-924,共8页
The 1:2 internal resonance of coupled dynamic system with quadratic and cubic nonlinearities is studied. The normal forms of this system in 1 :2 internal resonance were derived by using the direct method of normal for... The 1:2 internal resonance of coupled dynamic system with quadratic and cubic nonlinearities is studied. The normal forms of this system in 1 :2 internal resonance were derived by using the direct method of normal form. In the normal,forms, quadratic and cubic nonlinearities were remained. Based on a new convenient transformation technique, the 4-dimension bifurcation equations were reduced to 3-dimension. A bifurcation equation with one-dimension was obtained. Then the bifurcation behaviors of a universal unfolding were studied by using the singularity theory. The method of this paper can be applied to analyze the bifurcation behavior in strong internal resonance on 4-dimension center manifolds. 展开更多
关键词 quadratic and cubic nonlinearities Normal Form 1 : 2 internal resonance
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Existence of Limit Cycles for a Cubic Kolmogorov System with a Hyperbolic Solution 被引量:4
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作者 沈伯骞 刘德明 《Northeastern Mathematical Journal》 CSCD 2000年第1期91-95,共5页
This paper is concerned with a cubic Kolmogorov system with a solution of central quadratic curve which neither contacts with the coordinate axes, nor passes through the origin. The conclusion is that such a system ma... This paper is concerned with a cubic Kolmogorov system with a solution of central quadratic curve which neither contacts with the coordinate axes, nor passes through the origin. The conclusion is that such a system may possess limit cycles. 展开更多
关键词 cubic kolmogorov system central quadratic curve limit cycle
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Linear, Cubic and Quintic Coordinate-Dependent Forces and Kinematic Characteristics of a Spring-Mass System 被引量:3
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作者 Haiduke Sarafian 《World Journal of Mechanics》 2013年第6期265-269,共5页
By combining a pair of linear springs we devise a nonlinear vibrator. For a one dimensional scenario the nonlinear force is composed of a polynomial of odd powers of position-dependent variable greater than or equal t... By combining a pair of linear springs we devise a nonlinear vibrator. For a one dimensional scenario the nonlinear force is composed of a polynomial of odd powers of position-dependent variable greater than or equal three. For a chosen initial condition without compromising the generality of the problem we analyze the problem considering only the leading cubic term. We solve the equation of motion analytically leading to The Jacobi Elliptic Function. To avoid the complexity of the latter, we propose a practical, intuitive-based and easy to use alternative semi-analytic method producing the same result. We demonstrate that our method is intuitive and practical vs. the plug-in Jacobi function. According to the proposed procedure, higher order terms such as quintic and beyond easily may be included in the analysis. We also extend the application of our method considering a system of a three-linear spring. Mathematica [1] is being used throughout the investigation and proven to be an indispensable computational tool. 展开更多
关键词 LINEAR cubic and Quintic Nonlinear OSCILLATIONS Semi-Analytic Solution to Equation of Motion MATHEMATICA
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Limit Cycle Containing Nine Critical Points in its Interior for a Class of Cubic Systems
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作者 Liu Yi-rong Xiao Ping 《Journal of Central South University》 SCIE EI CAS 2000年第2期111-112,共2页
Discuss a class of real planar cubic systems with a critical point O (0,0) of nine orders and obtain the conditions for its limit cycle surrounding the origin, and prove that when small pertubations of coefficients ar... Discuss a class of real planar cubic systems with a critical point O (0,0) of nine orders and obtain the conditions for its limit cycle surrounding the origin, and prove that when small pertubations of coefficients are made, the critical point O (0,0) of nine orders is split into nine real simple critical points and the limit cycle surrounding the origin becomes the limit cycle containing nine critical points in its interior. 展开更多
关键词 cubic systemS critical point of NINE ORDERS limit cycle
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An apodized cubic phase mask used in a wavefront coding system to extend the depth of field
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作者 Lina Zhu Fei Li +1 位作者 Zeyu Huang Tingyu Zhao 《Chinese Physics B》 SCIE EI CAS CSCD 2022年第5期422-428,共7页
The point spread function(PSF)caused by a wavefront coding system with a cubic phase mask has big side-lobes which leads to bad image restoration.This paper proposes a novel apodized cubic phase mask to suppress the s... The point spread function(PSF)caused by a wavefront coding system with a cubic phase mask has big side-lobes which leads to bad image restoration.This paper proposes a novel apodized cubic phase mask to suppress the side-lobes of the PSF.Simulated annealing algorithm is used to optimize the cubic and the truncation parameter of the phase mask.The system with the novel phase mask has better performance in the modulation transfer function(MTF)especially in low-and-medium spatial frequency region.The simulation results show that the restored images with the novel phase mask are superior to the one with the classic cubic phase mask in contrast and ringing effect.The experimental results show that the side-lobes of the PSF are suppressed by using the apodized cubic phase mask. 展开更多
关键词 apodized cubic phase mask wavefront coding depth of field image restoration
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Synthesizing active and durable cubic ceria catalysts(<6 nm)for fast dehydrogenation of bio-polyols to carboxylic acids coproducing green H_(2)
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作者 Mengyuan Liu Puhua Sun +3 位作者 Guangyu Zhang Xin Jin Chaohe Yang Honghong Shan 《Green Energy & Environment》 SCIE EI CAS CSCD 2024年第3期529-543,共15页
Dehydrogenation is considered as one of the most important industrial applications for renewable energy.Cubic ceria-based catalysts are known to display promising dehydrogenation performances in this area.Large partic... Dehydrogenation is considered as one of the most important industrial applications for renewable energy.Cubic ceria-based catalysts are known to display promising dehydrogenation performances in this area.Large particle size(>20 nm)and less surface defects,however,hinder further application of ceria materials.Herein,an alternative strategy involving lactic acid(LA)assisted hydrothermal method was developed to synthesize active,selective and durable cubic ceria of<6 nm for dehydrogenation reactions.Detailed studies of growth mechanism revealed that,the carboxyl and hydroxyl groups in LA molecule synergistically manipulate the morphological evolution of ceria precursors.Carboxyl groups determine the cubic shape and particle size,while hydroxyl groups promote compositional transformation of ceria precursors into CeO_(2) phases.Moreover,enhanced oxygen vacancies(Vo)on the surface of CeO_(2) were obtained owing to continuous removal of O species under reductive atmosphere.Cubic CeO_(2) catalysts synthesized by the LA-assisted method,immobilized with bimetallic PtCo clusters,exhibit a record high activity(TOF:29,241 h^(-1))and Vo-dependent synergism for dehydrogenation of bio-derived polyols at 200℃.We also found that quenching Vo defects at air atmosphere causes activity loss of PtCo/CeO_(2) catalysts.To regenerate Vo defects,a simple strategy was developed by irradiating deactivated catalysts using hernia lamp.The outcome of this work will provide new insights into manufacturing durable catalyst materials for aqueous phase dehydrogenation applications. 展开更多
关键词 cubic ceria Oxygen vacancy DEHYDROGENATION C-H bond activation
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Metastable face-centered cubic ruthenium-based binary alloy for efficient alkaline hydrogen oxidation electrocatalysis
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作者 Yunbo Li Jianchao Yue +3 位作者 Chaoyi Yang Hongnan Jia Hengjiang Cong Wei Luo 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2024年第5期207-215,共9页
Metastable nanostructured electrocatalyst with a completely different surface environment compared to conventional phase-based electrocatalyst often shows distinctive catalytic property.Although Ru-based electrocataly... Metastable nanostructured electrocatalyst with a completely different surface environment compared to conventional phase-based electrocatalyst often shows distinctive catalytic property.Although Ru-based electrocatalysts have been widely investigated toward hydrogen oxidation reaction(HOR)under alkaline electrolytes,these studies are mostly limited to conventional hexagonal-close-packed(hcp)phase,mainly arising from the lack of sufficient synthesis strategies.In this study,we report the precise synthesis of metastable binary RuW alloy with face-centered-cubic(fcc)phase.We find that the introduction of W can serve as fcc phase seeds and reduce the formation energy of metastable fcc-RuW alloy.Impressively,fcc-RuW exhibits remarkable alkaline HOR performance and stability with the activity of 0.67 mA cm_(Ru)^(-2)which is almost five and three times higher than that of hcp-Ru and commercial Pt/C,respectively,which is attributed to the optimized binding strength of adsorbed hydroxide intermediate derived from tailored electronic structure through W doping and phase engineering.Moreover,this strategy can also be applied to synthesize other metastable fcc-RuCr and fcc-RuMo alloys with enhanced HOR performances. 展开更多
关键词 Hydrogen oxidation reaction Metastable phase Face-centered cubic(fcc) Ru Phase engineering
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A novel rapid cooling assembly design in a high-pressure cubic press apparatus
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作者 Peiyan Wu Yongjiang Xu Yanhao Lin 《Matter and Radiation at Extremes》 SCIE EI CSCD 2024年第2期98-104,共7页
In traditional high-pressure–temperature assembly design, priority has been given to temperature insulation and retention at high pressures.This limits the efficiency of cooling of samples at the end of experiments, ... In traditional high-pressure–temperature assembly design, priority has been given to temperature insulation and retention at high pressures.This limits the efficiency of cooling of samples at the end of experiments, with a negative impact on many studies in high-pressure Earth andplanetary science. Inefficient cooling of experiments containing molten phases at high temperature leads to the formation of quench textures,which makes it impossible to quantify key compositional parameters of the original molten phase, such as their volatile contents. Here,we present a new low-cost experimental assembly for rapid cooling in a six-anvil cubic press. This assembly not only retains high heatingefficiency and thermal insulation, but also enables a very high cooling rate (∼600 ℃/s from 1900 ℃ to the glass transition temperature).Without using expensive materials or external modification of the press, the cooling rate in an assembly (∼600 ℃/s) with cube lengths of38.5 mm is about ten times faster than that in the traditional assembly (∼60 ℃/s). Experiments yielding inhomogeneous quenched melttextures when the traditional assembly is used are shown to yield homogeneous silicate glass without quench textures when the rapid coolingassembly is used. 展开更多
关键词 cubic INSULATION apparatus
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A Mathematical Modeling of 3D Cubical Geometry Hypothetical Reservoir under the Effect of Nanoparticles Flow Rate,Porosity,and Relative Permeability
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作者 Mudasar Zafar Hamzah Sakidin +6 位作者 Abida Hussain Loshini Thiruchelvam Mikhail Sheremet Iskandar Dzulkarnain Roslinda Nazar Abdullah Al-Yaari Rizwan Safdar 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第11期1193-1211,共19页
This study aims to formulate a steady-state mathematical model for a three-dimensional permeable enclosure(cavity)to determine the oil extraction rate using three distinct nanoparticles,SiO_(2),Al_(2)O_(3),and Fe_(2)O... This study aims to formulate a steady-state mathematical model for a three-dimensional permeable enclosure(cavity)to determine the oil extraction rate using three distinct nanoparticles,SiO_(2),Al_(2)O_(3),and Fe_(2)O_(3),in unconventional oil reservoirs.The simulation is conducted for different parameters of volume fractions,porosities,and mass flow rates to determine the optimal oil recovery.The impact of nanoparticles on relative permeability(kr)and water is also investigated.The simulation process utilizes the finite volume ANSYS Fluent.The study results showed that when the mass flow rate at the inlet is low,oil recovery goes up.In addition,they indicated that silicon nanoparticles are better at getting oil out of the ground(i.e.,oil reservoir)than Al_(2)O_(3)and Fe_(2)O_(3).Most oil can be extracted from SiO_(2),Al_(2)O_(3),and Fe_(2)O_(3)at a rate of 97.8%,96.5%,and 88%,respectively. 展开更多
关键词 Unconventional reservoir cubical cavity oil recovery rate reservoir engineering mathematical modeling
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Invariant measure for cubic Fibonacci-like polynomials
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作者 Wenxiu Ma 《中国科学技术大学学报》 CAS CSCD 北大核心 2024年第8期7-12,6,I0002,共8页
A special class of cubic polynomials possessing decay of geometry property is studied.This class of cubic bimodal maps has generalized Fibonacci combinatorics.For maps with bounded combinatorics,we show that they have... A special class of cubic polynomials possessing decay of geometry property is studied.This class of cubic bimodal maps has generalized Fibonacci combinatorics.For maps with bounded combinatorics,we show that they have an absolutely continuous invariant probability measure. 展开更多
关键词 Fibonacci combinatorics cubic polynomial decay of geometry invariant measure
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High-Quality and Wafer-Scale Cubic Silicon Carbide Single Crystals
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作者 Guobin Wang Da Sheng +6 位作者 Yunfan Yang Hui Li Congcong Chai Zhenkai Xie Wenjun Wang Jiangang Guo Xiaolong Chen 《Energy & Environmental Materials》 SCIE EI CAS CSCD 2024年第4期442-449,共8页
Cubic silicon carbide(3C-SiC)has superior mobility and thermal conduction over that of widely applied hexagonal 4H-SiC.Moreover,much lower concentration of interfacial traps between insulating oxide gate and 3C-SiC he... Cubic silicon carbide(3C-SiC)has superior mobility and thermal conduction over that of widely applied hexagonal 4H-SiC.Moreover,much lower concentration of interfacial traps between insulating oxide gate and 3C-SiC helps fabricate reliable and long-life devices like metal-oxidesemiconductor field effect transistors.However,the growth of high-quality and wafer-scale 3C-SiC crystals has remained a big challenge up to now despite decades-long efforts by researchers because of its easy transformation into other polytypes during growth,limiting the development of 3C-SiC-based devices.Herein,we report that 3C-SiC can be made thermodynamically favored from nucleation to growth on a 4H-SiC substrate by top-seeded solution growth technique,beyond what is expected by classical nucleation theory.This enables the steady growth of high-quality and large-size 3C-SiC crystals(2-4-inch in diameter and 4.0-10.0 mm in thickness)sustainable.The as-grown 3C-SiC crystals are free of other polytypes and have high-crystalline quality.Our findings broaden the mechanism of hetero-seed crystal growth and provide a feasible route to mass production of 3C-SiC crystals,offering new opportunities to develop power electronic devices potentially with better performances than those based on 4H-SiC. 展开更多
关键词 cubic SiC high-temperature solution growth high-temperature surface tension solid-liquid interfacial energy wide band gap semiconductor
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Accounting for Quadratic and Cubic Invariants in Continuum Mechanics–An Overview
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作者 Artur V.Dmitrenko Vladislav M.Ovsyannikov 《Fluid Dynamics & Materials Processing》 EI 2024年第9期1925-1939,共15页
The differential equations of continuum mechanics are the basis of an uncountable variety of phenomena and technological processes in fluid-dynamics and related fields.These equations contain derivatives of the first ... The differential equations of continuum mechanics are the basis of an uncountable variety of phenomena and technological processes in fluid-dynamics and related fields.These equations contain derivatives of the first order with respect to time.The derivation of the equations of continuum mechanics uses the limit transitions of the tendency of the volume increment and the time increment to zero.Derivatives are used to derive the wave equation.The differential wave equation is second order in time.Therefore,increments of volume and increments of time in continuum mechanics should be considered as small but finite quantities for problems of wave formation.This is important for calculating the generation of sound waves and water hammer waves.Therefore,the Euler continuity equation with finite time increments is of interest.The finiteness of the time increment makes it possible to take into account the quadratic and cubic invariants of the strain rate tensor.This is a new branch in hydrodynamics.Quadratic and cubic invariants will be used in differential wave equations of the second and third order in time. 展开更多
关键词 Quadratic invariant cubic invariant continuity equation generation of periodic waves N.E.Zhukovsky’s hydraulic shock TURBULENCE
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Effect of Size and Initial Water Content on the Effective Diffusion Coefficient during Convective Drying of Sweet Potato Cut into Cubic and Cylindrical Shapes
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作者 Ibrango Abdoul Salam Ouoba Kondia Honoré +3 位作者 Bama Désiré Traoré Yssa Zongo Karim Ouedraogo Salifou 《Journal of Materials Science and Chemical Engineering》 2024年第6期71-82,共12页
In this article, we investigated the influence of size and initial water content on the effective diffusion coefficient of sweet potatoes samples cut into cubic and cylindrical shapes. The sizes of the cubic samples a... In this article, we investigated the influence of size and initial water content on the effective diffusion coefficient of sweet potatoes samples cut into cubic and cylindrical shapes. The sizes of the cubic samples are 0.5, 1, 1.5, 1.75, 2, 2.5 and 3 cm edge with a respective initial water content of 2.7, 3.76, 3.48, 2.68, 3.28, 2.17 and 2.29 kg/kgms. For cylindrical samples, the radius is set at 0.5 cm and sample heights are 1, 1.5, 2, 2.5, 3, 3.5 and 4 cm with respective water contents of 2.2, 3.19, 2.85, 2.1, 2.17, 2.39 and 2.03 kg/kgms. The effective diffusion coefficients of cubic samples are of the order of 10−10 and 10−9 m2∙s−1 grew with sample edge. As for the cylindrical samples, the effective diffusion coefficients were of the order of 10−9 m2∙s−1 and there was no linear correlation between cylinder height and their effective diffusion coefficient. As for the examination of the initial water content on the effective diffusion coefficient, it turned out that the initial water content had no influence on the effective diffusion coefficient of the sweet potato samples. 展开更多
关键词 Effective Diffusion Coefficient Initial Water Content Sweet Potato cubic CYLINDRICAL
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Anti-Plane Elasticity Problem and Mode Ⅲ Crack Problem of Cubic Quasicrystal 被引量:3
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作者 周旺民 范天佑 +1 位作者 尹姝媛 王念鹏 《Journal of Beijing Institute of Technology》 EI CAS 2001年第3期250-254,共5页
The fracture theory of cubic quasicrystal was developed. The exact analytic solution of a Mode Ⅲ Griffith crack in the material was obtained by using the Fourier transform and dual integral equations theory, and so t... The fracture theory of cubic quasicrystal was developed. The exact analytic solution of a Mode Ⅲ Griffith crack in the material was obtained by using the Fourier transform and dual integral equations theory, and so the displacement and stress fields, the stress intensity factor and strain energy release rate were determined. The results show that the stress intensity factor is independent of material constants, and the strain energy release rate is dependent on all material constants. These provide important information for studying the deformation and fracture of the new solid material. 展开更多
关键词 anti plane elasticity problem Mode crack cubic quasicrystal stress intensity factor strain energy release rate
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双正交Hermite Cubics的对称预滤波设计 被引量:3
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作者 程蓉 李万社 《信号处理》 CSCD 北大核心 2005年第z1期12-15,共4页
将多小波预滤波器设计的"超函数"法推广到了双正交系统,得到使联合滤波器具有m阶平衡的条件,并针对双正交Hermite Cubics,分别设计了使系统具有2阶平衡与4阶平衡的对称预滤波器.
关键词 预滤波 对称性 超函数 HERMITE cubics
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Application of face centred cubic TiB powder as conductive filler for electrically conductive adhesives 被引量:1
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作者 赵健闯 胡建东 +1 位作者 焦东宁 S.TOSTO 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2014年第6期1773-1778,共6页
Face centred cubic(FCC) TiB ceramic powder synthesized by Ti-boronizing method was used as conductive filler to make ceramic electrically conductive adhesives(ECAs) with the polymer matrix.Electrically conductive ... Face centred cubic(FCC) TiB ceramic powder synthesized by Ti-boronizing method was used as conductive filler to make ceramic electrically conductive adhesives(ECAs) with the polymer matrix.Electrically conductive properties of the ceramic ECAs were studied.The bulk electrical resistivity varied with the powder content of the FCC-TiB in ECAs.The FCC-TiB filled ECAs also showed the percolation behavior that usually occurred for the metal-filled ECAs,the percolation threshold was located at the content of 60%FCC-TiB.A minimum value of 0.1 Ω·cm was obtained at a content of 75%FCC-TiB.In order to check the reliability of mechanical property,tensile test was done to measure the shear strength,and the shear strength dropped with increasing the content of FCC-TiB powders.It is about 12.26 MPa at the content of 70%TiB powders.The Cu filled ECAs were also prepared for comparison.The properties of the oxidation resistance of the two ECAs were evaluated.The results show that the ceramic ECAs have excellent oxidation resistance and better stability compared with the Cu filled ECAs. 展开更多
关键词 ceramic powder face centred cubic TIB electrically conductive adhesives bulk resistivity OXIDATION shear strength
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Growth of Cubic GaN by MOCVD at High Temperature
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作者 付羿 孙元平 +5 位作者 沈晓明 李顺峰 冯志宏 段俐宏 王海 杨辉 《Journal of Semiconductors》 EI CAS CSCD 北大核心 2002年第2期120-123,共4页
High quality cubic GaN (c GaN) is grown by metalorganic vapor deposition (MOCVD) at an increased growth temperature of 900℃,with the growth rate of 1 6μm/h.The full width at half maximum (FWHM) of room temperature... High quality cubic GaN (c GaN) is grown by metalorganic vapor deposition (MOCVD) at an increased growth temperature of 900℃,with the growth rate of 1 6μm/h.The full width at half maximum (FWHM) of room temperature photoluminescence (PL) for the high temperature grown GaN film is 48meV.It is smaller than that of the sample grown at 830℃.In X ray diffraction (XRD) measurement,the high temperature grown GaN shows a (002) peak at 20° with a FWHM of 21′.It can be concluded that,although c GaN is of metastable phase,high growth temperature is still beneficial to the improvement in its crystal quality.The relationship between the growth rate and growth temperature is also discussed. 展开更多
关键词 cubic GAN MOCVD
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The burden of upper motor neuron involvement is correlated with the bilateral limb involvement interval in patients with amyotrophic lateral sclerosis:a retrospective observational study
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作者 Jieying Wu Shan Ye +2 位作者 Xiangyi Liu Yingsheng Xu Dongsheng Fan 《Neural Regeneration Research》 SCIE CAS 2025年第5期1505-1512,共8页
Amyotrophic lateral sclerosis is a rare neurodegenerative disease characterized by the involvement of both upper and lower motor neurons.Early bilateral limb involvement significantly affects patients'daily lives ... Amyotrophic lateral sclerosis is a rare neurodegenerative disease characterized by the involvement of both upper and lower motor neurons.Early bilateral limb involvement significantly affects patients'daily lives and may lead them to be confined to bed.However,the effect of upper and lower motor neuron impairment and other risk factors on bilateral limb involvement is unclear.To address this issue,we retrospectively collected data from 586 amyotrophic lateral sclerosis patients with limb onset diagnosed at Peking University Third Hospital between January 2020 and May 2022.A univariate analysis revealed no significant differences in the time intervals of spread in different directions between individuals with upper motor neuron-dominant amyotrophic lateral sclerosis and those with classic amyotrophic lateral sclerosis.We used causal directed acyclic graphs for risk factor determination and Cox proportional hazards models to investigate the association between the duration of bilateral limb involvement and clinical baseline characteristics in amyotrophic lateral sclerosis patients.Multiple factor analyses revealed that higher upper motor neuron scores(hazard ratio[HR]=1.05,95%confidence interval[CI]=1.01–1.09,P=0.018),onset in the left limb(HR=0.72,95%CI=0.58–0.89,P=0.002),and a horizontal pattern of progression(HR=0.46,95%CI=0.37–0.58,P<0.001)were risk factors for a shorter interval until bilateral limb involvement.The results demonstrated that a greater degree of upper motor neuron involvement might cause contralateral limb involvement to progress more quickly in limb-onset amyotrophic lateral sclerosis patients.These findings may improve the management of amyotrophic lateral sclerosis patients with limb onset and the prediction of patient prognosis. 展开更多
关键词 amyotrophic lateral sclerosis bilateral limb involvement Cox proportional hazards regression model horizontal spread restricted cubic spline analysis time interval upper motor neuron vertical spread
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