BACKGROUND Within the normal range,elevated alanine aminotransferase(ALT)levels are associated with an increased risk of metabolic dysfunction-associated fatty liver disease(MAFLD).AIM To investigate the associations ...BACKGROUND Within the normal range,elevated alanine aminotransferase(ALT)levels are associated with an increased risk of metabolic dysfunction-associated fatty liver disease(MAFLD).AIM To investigate the associations between repeated high-normal ALT measurements and the risk of new-onset MAFLD prospectively.METHODS A cohort of 3553 participants followed for four consecutive health examinations over 4 years was selected.The incidence rate,cumulative times,and equally and unequally weighted cumulative effects of excess high-normal ALT levels(ehALT)were measured.Cox proportional hazards regression was used to analyse the association between the cumulative effects of ehALT and the risk of new-onset MAFLD.RESULTS A total of 83.13%of participants with MAFLD had normal ALT levels.The incidence rate of MAFLD showed a linear increasing trend in the cumulative ehALT group.Compared with those in the low-normal ALT group,the multivariate adjusted hazard ratios of the equally and unequally weighted cumulative effects of ehALT were 1.651[95%confidence interval(CI):1.199-2.273]and 1.535(95%CI:1.119-2.106)in the third quartile and 1.616(95%CI:1.162-2.246)and 1.580(95%CI:1.155-2.162)in the fourth quartile,respectively.CONCLUSION Most participants with MAFLD had normal ALT levels.Long-term high-normal ALT levels were associated with a cumulative increased risk of new-onset MAFLD.展开更多
Repeated blast impacts on personnel in explosive environments can exacerbate craniocerebral trauma.Most existing studies focus on the injury effects of a single blast,lacking in-depth analysis on the injury effects an...Repeated blast impacts on personnel in explosive environments can exacerbate craniocerebral trauma.Most existing studies focus on the injury effects of a single blast,lacking in-depth analysis on the injury effects and cumulative effects of repeated blasts.Therefore,rats were used as the experimental samples to suffer from explosion blasts with different peak air overpressures(167 kPa~482 kPa)and varying number of repeated blasts.The cumulative effect of craniocerebral trauma was most pronounced for moderate repeated blast,showing approximately 95%increase of trauma severity with penta blast,and an approximately 85%increase of trauma severity with penta minor blast.The cumulative effect of craniocerebral trauma from severe,repeated blast has a smaller rate of change compared to the other two conditions.The severity of trauma from penta blast increased by approximately 69%compared to a single blast.Comprehensive physiological,pathological and biochemical analysis show that the degree of neurological trauma caused by repeated blasts is higher than that of single blasts,and the pathological trauma to brain tissue is more extensive and severe.The trauma degree remains unchanged after double blast,increases by one grade after triple or quadruple blast,and increases by two grades after penta blast.展开更多
In the present study, a rat model of chronic neuropathic pain was established by ligation of the sciatic nerve and a model of learning and memory impairment was established by ovariectomy to investigate the analgesic ...In the present study, a rat model of chronic neuropathic pain was established by ligation of the sciatic nerve and a model of learning and memory impairment was established by ovariectomy to investigate the analgesic effect of repeated electroacupuncture stimulation at bilateral Zusanfi (ST36) and Yanglingquan (GB34). In addition, associated synaptic changes in neurons in the paraventricular nucleus of the hypothalamus were examined. Results indicate that the thermal pain threshold (paw withdrawal latency) was significantly increased in rats subjected to 2-week electroacupuncture intervention compared with 2-day electroacupuncture, but the analgesic effect was weakened remarkably in ovariectomized rats with chronic constrictive injury. 2-week electroacupuncture intervention substantially reversed the chronic constrictive injury-induced increase in the synaptic cleft width and thinning of the postsynaptic density. These findings indicate that repeated electroacupuncture at bilateral Zusanfi and Yanglingquan has a cumulative analgesic effect and can effectively relieve chronic neuropathic pain by remodeling the synaptic structure of the hypothalamic paraventricular nucleus.展开更多
Starting in mid-November,China was hit by several cold events during the early winter of 2020/21.The lowest temperature observed at Beijing station on 7 January reached−19.6°C.In this paper,we show that the outbr...Starting in mid-November,China was hit by several cold events during the early winter of 2020/21.The lowest temperature observed at Beijing station on 7 January reached−19.6°C.In this paper,we show that the outbreak of the record-breaking extreme cold event can be attributed to a huge merging Ural blocking(UB)ridge over the Eurasian region.The sea-ice cover in the Kara and East Siberia Seas(KESS)in autumn was at its lowest value since 1979,which could have served as a precursor signal.Further analysis shows that several successive UB episodes occurred from 1 September 2020 to 10 January 2021.The persistent UB that occurred in late September/early October 2020 may have made an important contribution to the October historical minimum of sea ice in the KESS region.Our results also show that,after each UB episode in winter,significant upward propagation of wave activity occurred around 60°E,which resulted in weakening the stratospheric vortex.Meanwhile,each UB episode also caused a significant reduction in sea-ice extent in KESS and a significant weakening of the westerly jet in mid-high-latitude Eurasia.Results suggest that the Arctic vortex,which is supposed to enhance seasonally,became weaker and more unstable than the climatic mean under the seasonal cumulative effects of UB episodes,KESS warming,and long-lasting negative-phase North Atlantic Oscillation(NAO-).Those seasonal cumulative effects,combined with the impact of La Niña winter,led to the frequent occurrence of extreme cold events.展开更多
In the present study, we examined the analgesic effect of repeated electroacupuncture at bilateral Zusanfi (ST36) and Yanglingquan (GB34) once a day for 14 consecutive days in a rat model of chronic sciatic nerve ...In the present study, we examined the analgesic effect of repeated electroacupuncture at bilateral Zusanfi (ST36) and Yanglingquan (GB34) once a day for 14 consecutive days in a rat model of chronic sciatic nerve constriction injury-induced neuropathic pain. In addition, concomitant changes in calcium/calmodulin-dependent protein kinase II expression and synaptic ultrastructure of neurons in the hippocampal CA3 region were examined. The thermal pain threshold (paw withdrawal latency) was increased significantly in both groups at 2 weeks after electroacupuncture intervention compared with 2 days of electroacupuncture. In ovariectomized rats with chronic constriction injury, the analgesic effect was significantly reduced. Electroacupuncture for 2 weeks significantly diminished the injury-induced increase in synaptJc cleft width and thinning of the postsynaptJc density, and it significantly suppressed the down-regulation of intracellular calcium/ calmodulin-dependent protein kinase II expression in the hippocampal CA3 region. Repeated electroacupuncture intervention had a cumulative analgesic effect on injury-induced neuropathic pain reactions, and it led to synaptic remodeling of hippocampal neurons and upregulated calcium/calmodulin-dependent protein kJnase II expression in the hippocampal CA3 region.展开更多
On the basis of second-order perturbation approximate and modal expansion approach,we investigate the enhancement effect of cumulative second-harmonic generation(SHG)of circumferential guided waves(CGWs)in a circular ...On the basis of second-order perturbation approximate and modal expansion approach,we investigate the enhancement effect of cumulative second-harmonic generation(SHG)of circumferential guided waves(CGWs)in a circular tube,which is inherently induced by the closed propagation feature of CGWs.An appropriate mode pair of primary-and double-frequency CGWs satisfying the phase velocity matching and nonzero energy flux is selected to ensure that the second harmonic generated by primary CGW propagation can accumulate along the circumference.Using a coherent superposition of multi-waves,a model of unidirectional CGW propagation is established for analyzing the enhancement effect of cumulative SHG of primary CGW mode selected.The theoretical analyses and numerical simulations performed directly demonstrate that the second harmonic generated does have a cumulative effect along the circumferential direction and the closed propagation feature of CGWs does enhance the magnitude of cumulative second harmonic generated.Potential applications of the enhancement effect of cumulative SHG of CGWs are considered and discussed.The theoretical analysis and numerical simulation perspective presented here yield an insight previously unavailable into the physical mechanism of the enhancement effect of cumulative SHG by closed propagation feature of CGWs in a circular tube.展开更多
In order to reveal the rapid increase mechanism of particulate concentration in short time,a notion of short-term cumulative effect of air particulate is defined as the significant increase of pollutant concentration ...In order to reveal the rapid increase mechanism of particulate concentration in short time,a notion of short-term cumulative effect of air particulate is defined as the significant increase of pollutant concentration in a short time under the condition of breeze,stable weather and constant emission caused by human being's activities. Subsequently,an index of short-term cumulative effect is established with air diffusive equation,and then the macro-scale meteorological situation and micro-scale factors of forming the short-term cumulative effect are discussed with the observation data. The macro-scale meteorological variables contain upper-level weather situations and surface weather situations. The micro-scale factors mainly include the boundary-layer height and boundary-layer stability. The analyses show that boundary-layer factors and weather variables have a significant influence on the short-term cumulative effect. The notion of short-term cumulative effect will play an important role in interpreting the severe pollution weather.展开更多
To explore the cumulative deformation effect of the dynamic response of a tunnel crossing the hauling sliding surface under earthquakes,the shaking table test was conducted in this study.Combined with the numerical ca...To explore the cumulative deformation effect of the dynamic response of a tunnel crossing the hauling sliding surface under earthquakes,the shaking table test was conducted in this study.Combined with the numerical calculations,this study proposed magnification of the Arias intensity(MIa)to characterize the overall local deformation damage of the tunnel lining in terms of the deformation characteristics,frequency domain,and energy.Using the time‐domain analysis method,the plastic effect coefficient(PEC)was proposed to characterize the degree of plastic deformation,and the applicability of the seismic cumulative failure effect(SCFE)was discussed.The results show that the low‐frequency component(f1 and f2≤10 Hz)and the high‐frequency component(f3 and f4>10 Hz)acceleration mainly cause global and local deformation of the tunnel lining.The local deformation caused by the high‐frequency wave has an important effect on the seismic damage of the lining.The physical meaning of PEC is more clearly defined than that of the residual strain,and the SCFE of the tunnel lining can also be defined.The SCFE of the tunnel lining includes the elastic deformation effect stage(<0.15g),the elastic–plastic deformation effect stage(0.15g–0.30g),and the plastic deformation effect stage(0.30g–0.40g).This study can provide valuable theoretical and technical support for the construction of traffic tunnels in high‐intensity earthquake areas.展开更多
The principle of sonic wave measurement was introduced, and cumulative damage effects of underground engineering rock mass under blasting load were studied by in situ test, using RSM-SY5 intelligent sonic wave apparat...The principle of sonic wave measurement was introduced, and cumulative damage effects of underground engineering rock mass under blasting load were studied by in situ test, using RSM-SY5 intelligent sonic wave apparatus. The blasting test was carried out for ten times at some tunnels of Changba Lead-Zinc Mine. The damage depth of surrounding rock caused by old blasting excavation (0.8-1.2 m) was confirmed. The relation between the cumulative damage degree and blast times was obtained. The results show that the sonic velocity decreases gradually with increasing blast times, hut the damage degree (D) increases. The damage cumulative law is non-linear. The damage degree caused by blast decreases with increasing distance, and damage effects become indistinct. The blasting damage of rock mass is anisotropic. The damage degree of rock mass within charging range is maximal. And the more the charge is, the more severe the damage degree of rock mass is. The test results provide references for researches of mechanical parameters of rock mass and dynamic stability analysis of underground chambers.展开更多
Although the development of energy and mineral resources strongly supports China’s rapid industrialization and urbanization,it has led to a series of ecological and environmental problems.Strengthening the spatial re...Although the development of energy and mineral resources strongly supports China’s rapid industrialization and urbanization,it has led to a series of ecological and environmental problems.Strengthening the spatial regulation considering the ecological and environmental protection on energy and mineral resource development areas is an important aspect of realizing China’s sustainable development.In this study,we mapped,categorized,and analyzed the ecological cumulative effects of the Chinese 134 prefectural mining units based on the pressure-state-response model,which is demonstrated as impact of mining activities on ecological environment,ecological environmental fragility,and ecological function.This investigation developed a stress zoning typology of the mining units based on scores of three dimensions of the ecological cumulative effects and classified 134 prefectural mining units into eight types of stress zones.A series of regulation and policy suggestions have been proposed to different types of zones from three aspects:space control,intensity control,and development mode control.The application of this evaluation and spatial zoning system will contribute to the refined spatial management of China’s mining areas.展开更多
The cumulative effect of cascade hydropower stations on river ecological environment has been widely concerned because of the significant streamflow hydrology change induced by dam constructions. The characteristics o...The cumulative effect of cascade hydropower stations on river ecological environment has been widely concerned because of the significant streamflow hydrology change induced by dam constructions. The characteristics of the change in the lower reaches of the Jinsha River, China are analyzed based on long-term(1952–2015) hydrological and sedimentological data. The averaging coefficient, reservoir regulation coefficient(RRC), incoming sediment coefficient(ISC), and sediment transport modulus(STM), which reflect the variation of streamflow and sediment regimes, are defined and calculated. The results show that the construction and regulation of reservoirs reduces flow in flood season, increases flow in dry season, significantly altering the monthly discharge regimes. These alterations also led directly to changes in the timing of extreme flows at Pingshan Station. The monthly flow records at the basin outlet are reconstructed using stepwise regression, to reduce reservoir impacts. Comparisons of observed and reconstructed monthly flows demonstrate that the previous studies overestimated the cumulative effects of cascade reservoirs on flow processes. Furthermore, this study clearly illustrates that the reduction in sediment trapping and sediment transportation capacity together lead to the sharp reduction in annual sediment yield at the Pingshan Station. The earlier constructed reservoirs have more obvious effects on the ISC and STM than the more recent reservoirs and the effect of sediment trapping is related to reservoir location, on the main stream versus tributaries.展开更多
Affected by external environmental factors and evolution of dam performance, dam seepage behavior shows nonlinear time-varying characteristics. In this study, to predict and evaluate the long-term development trend an...Affected by external environmental factors and evolution of dam performance, dam seepage behavior shows nonlinear time-varying characteristics. In this study, to predict and evaluate the long-term development trend and short-term fluctuation of the dam seepage behavior, two monitoring models were developed, one for the base flow effect and one for daily variation of dam seepage elements. In the first model, to avoid the influence of the time lag effect on the evaluation of seepage variation with the time effect component of seepage elements, the base values of the seepage element and the reservoir water level were extracted using the wavelet multi-resolution analysis method, and the time effect component was separated by the established base flow effect monitoring model. For the development of the daily variation monitoring model for dam seepage elements, all the previous factors, of which the measured time series prior to the dam seepage element monitoring time may have certain influence on the monitored results, were considered. Those factors that were positively correlated with the analyzed seepage element were initially considered to be the support vector machine(SVM) model input factors, and then the SVM kernel function-based sensitivity analysis was performed to optimize the input factor set and establish the optimized daily variation SVM model. The efficiency and rationality of the two models were verified by case studies of the water level of two piezometric tubes buried under the slope of a concrete gravity dam.Sensitivity analysis of the optimized SVM model shows that the influences of the daily variation of the upstream reservoir water level and rainfall on the daily variation of piezometric tube water level are processes subject to normal distribution.展开更多
Considering three longitudinal displacement functions and uniform axial displacement functions for shear lag effect and uniform axial deformation of thin-walled box girder with varying depths,a simple and efficient me...Considering three longitudinal displacement functions and uniform axial displacement functions for shear lag effect and uniform axial deformation of thin-walled box girder with varying depths,a simple and efficient method with high precision to analyze the shear lag effect of thin-walled box girders was proposed.The governing differential equations and boundary conditions of the box girder under lateral loading were derived based on the energy-variational method,and closed-form solutions to stress and deflection corresponding to lateral loading were obtained.Analysis and calculations were carried out with respect to a trapezoidal box girder under concentrated loading or uniform loading and a rectangular box girder under concentrated loading.The analytical results were compared with numerical solutions derived according to the high order finite strip element method and the experimental results.The investigation shows that the closed-form solution is in good agreement with the numerical solutions derived according to the high order finite strip method and the experimental results,and has good stability.Because of the shear lag effect,the stress in cross-section centroid is no longer zero,thus it is not reasonable enough to assume that the strain in cross-section centroid is zero without considering uniform axial deformation.展开更多
Based on the consideration of longitudinal warp caused by shear lag effects on concrete slabs and bottom plates of steel beams,shear deformation of steel beams and interface slip between steel beams and concrete slabs...Based on the consideration of longitudinal warp caused by shear lag effects on concrete slabs and bottom plates of steel beams,shear deformation of steel beams and interface slip between steel beams and concrete slabs,the governing differential equations and boundary conditions of the steel-concrete composite box beams under lateral loading were derived using energy-variational method.The closed-form solutions for stress,deflection and slip of box beams under lateral loading were obtained,and the comparison of the analytical results and the experimental results for steel-concrete composite box beams under concentrated loading or uniform loading verifies the closed-form solution.The investigation of the parameters of load effects on composite box beams shows that:1) Slip stiffness has considerable impact on mid-span deflection and end slip when it is comparatively small;the mid-span deflection and end slip decrease significantly with the increase of slip stiffness,but when the slip stiffness reaches a certain value,its impact on mid-span deflection and end slip decreases to be negligible.2) The shear deformation has certain influence on mid-span deflection,and the larger the load is,the greater the influence is.3) The impact of shear deformation on end slip can be neglected.4) The strain of bottom plate of steel beam decreases with the increase of slip stiffness,while the shear lag effect becomes more significant.展开更多
The physical process of cumulative second-harmonic generation of Lamb waves propagating in a two-layered solid plate is presented by using the second-order perturbation and the technique of nonlinear reflection of aco...The physical process of cumulative second-harmonic generation of Lamb waves propagating in a two-layered solid plate is presented by using the second-order perturbation and the technique of nonlinear reflection of acoustic waves at an interface. In general, the cumulative second-harmonic generation of a dispersive guided wave propagation does not occur. However, the present paper shows that the second-harmonic of Lamb wave propagation arising from the nonlinear interaction of the partial bulk acoustic waves and the restriction of the three boundaries of the solid plates does have a cumulative growth effect if some conditions are satisfied. Through boundary condition and initial condition of excitation, the analytical expression of cumulative second-harmonic of Lamb waves propagation is determined. Numerical results show the cumulative effect of Lamb waves on second-harmonic field patterns.展开更多
In order to study the effect of time lag and stress loading rates on rock deformation,the conventional stepped stress loading mode was changed into a continuous mode to investigate the effect of effective pressure on ...In order to study the effect of time lag and stress loading rates on rock deformation,the conventional stepped stress loading mode was changed into a continuous mode to investigate the effect of effective pressure on permeability and porosity.The time lag effect of rock deformation illustrating the relationship between changes in permeability and steady time was studied.Permeability reduction ratios were measured under different stress loading rates which were achieved by different pump rate settings.The results show that permeability and porosity gradually decrease with increases in effective pressure.Permeability at high effective pressure attains stability quickly.Steady times at low effective pressure are very long.Reduction in permeability at lower stress loading rates is small,while,in contrast,it is large at high stress loading rates.展开更多
In order to resolve the traffic congestion problem, many cable-stayed bridges are designed with a large width to span ratio. This results in significant shear lag effect to cause nonuniform stress distribution along t...In order to resolve the traffic congestion problem, many cable-stayed bridges are designed with a large width to span ratio. This results in significant shear lag effect to cause nonuniform stress distribution along the flanges of the beam of bridge. This paper reports study on the shear lag effect of the Lanzhou Xiaoxihu Yellow River Bridge. A 3D finite element model of the bridge was developed and finite element analysis (FEA) was done to obtain the theoretical results. To evaluate the theoretical results, a scaled model was made to conduct static test in laboratory. The experiment results accorded with the results obtained by FEA. It is proved that FEA is an effective method to predict shear lag effect of bridges of this type.展开更多
This paper studies a kind of non-autonomous respiratory disease model with a lag effect.First of all,the permanence and extinction of the system are discussed by using the comparison principle and some differential in...This paper studies a kind of non-autonomous respiratory disease model with a lag effect.First of all,the permanence and extinction of the system are discussed by using the comparison principle and some differential inequality techniques.Second,it assumes that all coefficients of the system are periodic.The existence of positive periodic solutions of the system is proven,based on the continuation theorem in coincidence with the degree theory of Mawhin and Gaines.In the meantime,the global attractivity of positive periodic solutions of the system is obtained by constructing an appropriate Lyapunov functional and using the Razumikin theorem.In addition,the existence and uniform asymptotic stability of almost periodic solutions of the system are analyzed by assuming that all parameters in the model are almost periodic in time.Finally,the theoretical derivation is verified by a numerical simulation.展开更多
The Luanchuan molybdenum polymetallic mine concentration area is rich in mineral resources and has a long history of mining.The environmental impact of long-term mining activities cannot be ignored.It is of great sign...The Luanchuan molybdenum polymetallic mine concentration area is rich in mineral resources and has a long history of mining.The environmental impact of long-term mining activities cannot be ignored.It is of great significance to study the ecological risk and the accumulation trends of heavy metals in the soil of mining areas for scientific prevention and control of heavy metal pollution.Taking the Taowanbeigou River Basin in the mine concentration area as the research object,the ecological pollution risk and cumulative effect of heavy metals in the soil of the basin were studied by using the comprehensive pollution index method,potential ecological risk assessment method and geoaccumulation index method.On this basis,the cumulative exceeding years of specific heavy metals were predicted by using the early warning model.The comprehensive potential ecological risk of heavy metals in the soil near the Luanchuan mine concentration area is moderate,and the single element Cd is the main ecological risk factor,with a contribution rate of 53.6%.The overall cumulative degrees of Cu and Pb in the soil are“none-moderate”,Zn and Cd are moderate,Mo has reached an extremely strong cumulative level,Hg,As and Cr risks are not obvious,and the overall cumulative risks order is Mo>Cd>Zn>Cu>Pb>Hg.According to the current accumulation rate and taking the risk screening values for soil contamination of agricultural land as the reference standard,the locations over standard rates of Cu,Zn and Cd will exceed 78%in 90years,and the over standard rate of Pb will reach approximately 57%in 200 years.The cumulative exceeding standard periods of As,Cr and Hg are generally long,which basically indicates that these elements do not pose a significant potential threat to the ecological environment.Mining activities will accelerate the accumulation of heavy metals in soil.With the continuous development of mining activities,the potential pollution risk of heavy metals in the soil of mining areas will also increase.展开更多
基金National Natural Science Foundation of China,No.72101236China Postdoctoral Science Foundation,No.2022M722900+1 种基金Collaborative Innovation Project of Zhengzhou City,No.XTCX2023006Nursing Team Project of the First Affiliated Hospital of Zhengzhou University,No.HLKY2023005.
文摘BACKGROUND Within the normal range,elevated alanine aminotransferase(ALT)levels are associated with an increased risk of metabolic dysfunction-associated fatty liver disease(MAFLD).AIM To investigate the associations between repeated high-normal ALT measurements and the risk of new-onset MAFLD prospectively.METHODS A cohort of 3553 participants followed for four consecutive health examinations over 4 years was selected.The incidence rate,cumulative times,and equally and unequally weighted cumulative effects of excess high-normal ALT levels(ehALT)were measured.Cox proportional hazards regression was used to analyse the association between the cumulative effects of ehALT and the risk of new-onset MAFLD.RESULTS A total of 83.13%of participants with MAFLD had normal ALT levels.The incidence rate of MAFLD showed a linear increasing trend in the cumulative ehALT group.Compared with those in the low-normal ALT group,the multivariate adjusted hazard ratios of the equally and unequally weighted cumulative effects of ehALT were 1.651[95%confidence interval(CI):1.199-2.273]and 1.535(95%CI:1.119-2.106)in the third quartile and 1.616(95%CI:1.162-2.246)and 1.580(95%CI:1.155-2.162)in the fourth quartile,respectively.CONCLUSION Most participants with MAFLD had normal ALT levels.Long-term high-normal ALT levels were associated with a cumulative increased risk of new-onset MAFLD.
基金supported by the National Natural Science Foundation of China(Grant No.12372356)Postgraduate Scientific Research In-novation Project of Hunan Province(Grant No.CX20221044).
文摘Repeated blast impacts on personnel in explosive environments can exacerbate craniocerebral trauma.Most existing studies focus on the injury effects of a single blast,lacking in-depth analysis on the injury effects and cumulative effects of repeated blasts.Therefore,rats were used as the experimental samples to suffer from explosion blasts with different peak air overpressures(167 kPa~482 kPa)and varying number of repeated blasts.The cumulative effect of craniocerebral trauma was most pronounced for moderate repeated blast,showing approximately 95%increase of trauma severity with penta blast,and an approximately 85%increase of trauma severity with penta minor blast.The cumulative effect of craniocerebral trauma from severe,repeated blast has a smaller rate of change compared to the other two conditions.The severity of trauma from penta blast increased by approximately 69%compared to a single blast.Comprehensive physiological,pathological and biochemical analysis show that the degree of neurological trauma caused by repeated blasts is higher than that of single blasts,and the pathological trauma to brain tissue is more extensive and severe.The trauma degree remains unchanged after double blast,increases by one grade after triple or quadruple blast,and increases by two grades after penta blast.
基金supported by the Strategic Priority Research Program of Chinese Academy of Sciences[grant numbers XDA23090102]the National Natural Science Foundation of China[grant numbers 42175078 and 42075040]+1 种基金the Health Meteorological Project of Hebei Province[grant number FW202150]the National Key Research and Development Program of China[grant number 2018YFA0606203].
基金supported by the National Natural Science Foundation of China,No.30472241,90709031 and 30973796the National Basic Research Program of China for Traditional Chinese Medicine Theory("973" Program),No.2007CB512505+1 种基金the Natural Foundation of Hainan Province(No.310054)a grant from the Health Department of Hainan Province(QiongWei 2010-45)
文摘In the present study, a rat model of chronic neuropathic pain was established by ligation of the sciatic nerve and a model of learning and memory impairment was established by ovariectomy to investigate the analgesic effect of repeated electroacupuncture stimulation at bilateral Zusanfi (ST36) and Yanglingquan (GB34). In addition, associated synaptic changes in neurons in the paraventricular nucleus of the hypothalamus were examined. Results indicate that the thermal pain threshold (paw withdrawal latency) was significantly increased in rats subjected to 2-week electroacupuncture intervention compared with 2-day electroacupuncture, but the analgesic effect was weakened remarkably in ovariectomized rats with chronic constrictive injury. 2-week electroacupuncture intervention substantially reversed the chronic constrictive injury-induced increase in the synaptic cleft width and thinning of the postsynaptic density. These findings indicate that repeated electroacupuncture at bilateral Zusanfi and Yanglingquan has a cumulative analgesic effect and can effectively relieve chronic neuropathic pain by remodeling the synaptic structure of the hypothalamic paraventricular nucleus.
基金the financial support from the National Natural Science Foundation of China(Grants Nos. 41975068, 41790473, and 41975099)the Chinese Academy of Sciences Strategic Priority Research Program (Grant No. XDA19070403).
文摘Starting in mid-November,China was hit by several cold events during the early winter of 2020/21.The lowest temperature observed at Beijing station on 7 January reached−19.6°C.In this paper,we show that the outbreak of the record-breaking extreme cold event can be attributed to a huge merging Ural blocking(UB)ridge over the Eurasian region.The sea-ice cover in the Kara and East Siberia Seas(KESS)in autumn was at its lowest value since 1979,which could have served as a precursor signal.Further analysis shows that several successive UB episodes occurred from 1 September 2020 to 10 January 2021.The persistent UB that occurred in late September/early October 2020 may have made an important contribution to the October historical minimum of sea ice in the KESS region.Our results also show that,after each UB episode in winter,significant upward propagation of wave activity occurred around 60°E,which resulted in weakening the stratospheric vortex.Meanwhile,each UB episode also caused a significant reduction in sea-ice extent in KESS and a significant weakening of the westerly jet in mid-high-latitude Eurasia.Results suggest that the Arctic vortex,which is supposed to enhance seasonally,became weaker and more unstable than the climatic mean under the seasonal cumulative effects of UB episodes,KESS warming,and long-lasting negative-phase North Atlantic Oscillation(NAO-).Those seasonal cumulative effects,combined with the impact of La Niña winter,led to the frequent occurrence of extreme cold events.
基金supported by the National Natural Science Foundation of China,No.30472241,90709031 and 30973796the Ministry of Science and Technology of China("973"Project),No.2007CB512505+1 种基金provided by the Foundation of Hainan Province,No.310054the Health Department of Hainan Province,Qiong-Wei-45
文摘In the present study, we examined the analgesic effect of repeated electroacupuncture at bilateral Zusanfi (ST36) and Yanglingquan (GB34) once a day for 14 consecutive days in a rat model of chronic sciatic nerve constriction injury-induced neuropathic pain. In addition, concomitant changes in calcium/calmodulin-dependent protein kinase II expression and synaptic ultrastructure of neurons in the hippocampal CA3 region were examined. The thermal pain threshold (paw withdrawal latency) was increased significantly in both groups at 2 weeks after electroacupuncture intervention compared with 2 days of electroacupuncture. In ovariectomized rats with chronic constriction injury, the analgesic effect was significantly reduced. Electroacupuncture for 2 weeks significantly diminished the injury-induced increase in synaptJc cleft width and thinning of the postsynaptJc density, and it significantly suppressed the down-regulation of intracellular calcium/ calmodulin-dependent protein kinase II expression in the hippocampal CA3 region. Repeated electroacupuncture intervention had a cumulative analgesic effect on injury-induced neuropathic pain reactions, and it led to synaptic remodeling of hippocampal neurons and upregulated calcium/calmodulin-dependent protein kJnase II expression in the hippocampal CA3 region.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11834008,11704410,11632004,11474361,and U1930202).
文摘On the basis of second-order perturbation approximate and modal expansion approach,we investigate the enhancement effect of cumulative second-harmonic generation(SHG)of circumferential guided waves(CGWs)in a circular tube,which is inherently induced by the closed propagation feature of CGWs.An appropriate mode pair of primary-and double-frequency CGWs satisfying the phase velocity matching and nonzero energy flux is selected to ensure that the second harmonic generated by primary CGW propagation can accumulate along the circumference.Using a coherent superposition of multi-waves,a model of unidirectional CGW propagation is established for analyzing the enhancement effect of cumulative SHG of primary CGW mode selected.The theoretical analyses and numerical simulations performed directly demonstrate that the second harmonic generated does have a cumulative effect along the circumferential direction and the closed propagation feature of CGWs does enhance the magnitude of cumulative second harmonic generated.Potential applications of the enhancement effect of cumulative SHG of CGWs are considered and discussed.The theoretical analysis and numerical simulation perspective presented here yield an insight previously unavailable into the physical mechanism of the enhancement effect of cumulative SHG by closed propagation feature of CGWs in a circular tube.
基金Supported by the National Science Foundation of China(41675046)
文摘In order to reveal the rapid increase mechanism of particulate concentration in short time,a notion of short-term cumulative effect of air particulate is defined as the significant increase of pollutant concentration in a short time under the condition of breeze,stable weather and constant emission caused by human being's activities. Subsequently,an index of short-term cumulative effect is established with air diffusive equation,and then the macro-scale meteorological situation and micro-scale factors of forming the short-term cumulative effect are discussed with the observation data. The macro-scale meteorological variables contain upper-level weather situations and surface weather situations. The micro-scale factors mainly include the boundary-layer height and boundary-layer stability. The analyses show that boundary-layer factors and weather variables have a significant influence on the short-term cumulative effect. The notion of short-term cumulative effect will play an important role in interpreting the severe pollution weather.
基金National Key R&D Program of China,Grant/Award Number:2018YFC1504901Science and technology program of Gansu Province,Grant/Award Numbers:21JR7RA738,21JR7RA739+1 种基金Science and Technology Development Project of China Railway Research Institute Co.Ltd,Grant/Award Number:2017‐KJ008‐Z008‐XBNatural Science Foundation of Gansu Province,Grant/Award Number:145RJZA068。
文摘To explore the cumulative deformation effect of the dynamic response of a tunnel crossing the hauling sliding surface under earthquakes,the shaking table test was conducted in this study.Combined with the numerical calculations,this study proposed magnification of the Arias intensity(MIa)to characterize the overall local deformation damage of the tunnel lining in terms of the deformation characteristics,frequency domain,and energy.Using the time‐domain analysis method,the plastic effect coefficient(PEC)was proposed to characterize the degree of plastic deformation,and the applicability of the seismic cumulative failure effect(SCFE)was discussed.The results show that the low‐frequency component(f1 and f2≤10 Hz)and the high‐frequency component(f3 and f4>10 Hz)acceleration mainly cause global and local deformation of the tunnel lining.The local deformation caused by the high‐frequency wave has an important effect on the seismic damage of the lining.The physical meaning of PEC is more clearly defined than that of the residual strain,and the SCFE of the tunnel lining can also be defined.The SCFE of the tunnel lining includes the elastic deformation effect stage(<0.15g),the elastic–plastic deformation effect stage(0.15g–0.30g),and the plastic deformation effect stage(0.30g–0.40g).This study can provide valuable theoretical and technical support for the construction of traffic tunnels in high‐intensity earthquake areas.
基金Project (50490272) supported by the National Natural Science Foundation of ChinaProject(040109) supported by the Doctor Degree Paper Innovation Engineering of Central South University
文摘The principle of sonic wave measurement was introduced, and cumulative damage effects of underground engineering rock mass under blasting load were studied by in situ test, using RSM-SY5 intelligent sonic wave apparatus. The blasting test was carried out for ten times at some tunnels of Changba Lead-Zinc Mine. The damage depth of surrounding rock caused by old blasting excavation (0.8-1.2 m) was confirmed. The relation between the cumulative damage degree and blast times was obtained. The results show that the sonic velocity decreases gradually with increasing blast times, hut the damage degree (D) increases. The damage cumulative law is non-linear. The damage degree caused by blast decreases with increasing distance, and damage effects become indistinct. The blasting damage of rock mass is anisotropic. The damage degree of rock mass within charging range is maximal. And the more the charge is, the more severe the damage degree of rock mass is. The test results provide references for researches of mechanical parameters of rock mass and dynamic stability analysis of underground chambers.
基金Under the auspices of the Strategic Priority Research Program(A)of the Chinese Academy of Sciences(No.XDA19040403)National Natural Science Foundation of China(No.42071158,72050001)。
文摘Although the development of energy and mineral resources strongly supports China’s rapid industrialization and urbanization,it has led to a series of ecological and environmental problems.Strengthening the spatial regulation considering the ecological and environmental protection on energy and mineral resource development areas is an important aspect of realizing China’s sustainable development.In this study,we mapped,categorized,and analyzed the ecological cumulative effects of the Chinese 134 prefectural mining units based on the pressure-state-response model,which is demonstrated as impact of mining activities on ecological environment,ecological environmental fragility,and ecological function.This investigation developed a stress zoning typology of the mining units based on scores of three dimensions of the ecological cumulative effects and classified 134 prefectural mining units into eight types of stress zones.A series of regulation and policy suggestions have been proposed to different types of zones from three aspects:space control,intensity control,and development mode control.The application of this evaluation and spatial zoning system will contribute to the refined spatial management of China’s mining areas.
基金financially supported by the National 973 Program of China (2015CB452701)the National Natural Science Foundation of China (Grant No. 51579161)
文摘The cumulative effect of cascade hydropower stations on river ecological environment has been widely concerned because of the significant streamflow hydrology change induced by dam constructions. The characteristics of the change in the lower reaches of the Jinsha River, China are analyzed based on long-term(1952–2015) hydrological and sedimentological data. The averaging coefficient, reservoir regulation coefficient(RRC), incoming sediment coefficient(ISC), and sediment transport modulus(STM), which reflect the variation of streamflow and sediment regimes, are defined and calculated. The results show that the construction and regulation of reservoirs reduces flow in flood season, increases flow in dry season, significantly altering the monthly discharge regimes. These alterations also led directly to changes in the timing of extreme flows at Pingshan Station. The monthly flow records at the basin outlet are reconstructed using stepwise regression, to reduce reservoir impacts. Comparisons of observed and reconstructed monthly flows demonstrate that the previous studies overestimated the cumulative effects of cascade reservoirs on flow processes. Furthermore, this study clearly illustrates that the reduction in sediment trapping and sediment transportation capacity together lead to the sharp reduction in annual sediment yield at the Pingshan Station. The earlier constructed reservoirs have more obvious effects on the ISC and STM than the more recent reservoirs and the effect of sediment trapping is related to reservoir location, on the main stream versus tributaries.
基金supported by the National Natural Science Foundation of China(Grant No.51709021)the Open Foundation of the State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering(Grant No.2016491111)
文摘Affected by external environmental factors and evolution of dam performance, dam seepage behavior shows nonlinear time-varying characteristics. In this study, to predict and evaluate the long-term development trend and short-term fluctuation of the dam seepage behavior, two monitoring models were developed, one for the base flow effect and one for daily variation of dam seepage elements. In the first model, to avoid the influence of the time lag effect on the evaluation of seepage variation with the time effect component of seepage elements, the base values of the seepage element and the reservoir water level were extracted using the wavelet multi-resolution analysis method, and the time effect component was separated by the established base flow effect monitoring model. For the development of the daily variation monitoring model for dam seepage elements, all the previous factors, of which the measured time series prior to the dam seepage element monitoring time may have certain influence on the monitored results, were considered. Those factors that were positively correlated with the analyzed seepage element were initially considered to be the support vector machine(SVM) model input factors, and then the SVM kernel function-based sensitivity analysis was performed to optimize the input factor set and establish the optimized daily variation SVM model. The efficiency and rationality of the two models were verified by case studies of the water level of two piezometric tubes buried under the slope of a concrete gravity dam.Sensitivity analysis of the optimized SVM model shows that the influences of the daily variation of the upstream reservoir water level and rainfall on the daily variation of piezometric tube water level are processes subject to normal distribution.
基金Projects(51078355,50938008) supported by the National Natural Science Foundation of ChinaProject(CX2011B093) supported by the Doctoral Candidate Research Innovation Program of Hunan Province, ChinaProject(20117Q008) supported by the Basic Scientific Research Funds for Central Universities of China
文摘Considering three longitudinal displacement functions and uniform axial displacement functions for shear lag effect and uniform axial deformation of thin-walled box girder with varying depths,a simple and efficient method with high precision to analyze the shear lag effect of thin-walled box girders was proposed.The governing differential equations and boundary conditions of the box girder under lateral loading were derived based on the energy-variational method,and closed-form solutions to stress and deflection corresponding to lateral loading were obtained.Analysis and calculations were carried out with respect to a trapezoidal box girder under concentrated loading or uniform loading and a rectangular box girder under concentrated loading.The analytical results were compared with numerical solutions derived according to the high order finite strip element method and the experimental results.The investigation shows that the closed-form solution is in good agreement with the numerical solutions derived according to the high order finite strip method and the experimental results,and has good stability.Because of the shear lag effect,the stress in cross-section centroid is no longer zero,thus it is not reasonable enough to assume that the strain in cross-section centroid is zero without considering uniform axial deformation.
基金Projects(51078355,50938008) supported by the National Natural Science Foundation of ChinaProject(094801020) supported by the Academic Scholarship for Doctoral Candidates of the Ministry of Education,China+1 种基金Project(CX2011B093) supported by the Doctoral Candidate Research Innovation Project of Hunan Province, ChinaProject(20117Q008) supported by the Central University Basic Scientific Research Business Expenses Special Fund of China
文摘Based on the consideration of longitudinal warp caused by shear lag effects on concrete slabs and bottom plates of steel beams,shear deformation of steel beams and interface slip between steel beams and concrete slabs,the governing differential equations and boundary conditions of the steel-concrete composite box beams under lateral loading were derived using energy-variational method.The closed-form solutions for stress,deflection and slip of box beams under lateral loading were obtained,and the comparison of the analytical results and the experimental results for steel-concrete composite box beams under concentrated loading or uniform loading verifies the closed-form solution.The investigation of the parameters of load effects on composite box beams shows that:1) Slip stiffness has considerable impact on mid-span deflection and end slip when it is comparatively small;the mid-span deflection and end slip decrease significantly with the increase of slip stiffness,but when the slip stiffness reaches a certain value,its impact on mid-span deflection and end slip decreases to be negligible.2) The shear deformation has certain influence on mid-span deflection,and the larger the load is,the greater the influence is.3) The impact of shear deformation on end slip can be neglected.4) The strain of bottom plate of steel beam decreases with the increase of slip stiffness,while the shear lag effect becomes more significant.
基金Project supported by the Shanghai Leading Academic Discipline Project, China (Grant No B503)
文摘The physical process of cumulative second-harmonic generation of Lamb waves propagating in a two-layered solid plate is presented by using the second-order perturbation and the technique of nonlinear reflection of acoustic waves at an interface. In general, the cumulative second-harmonic generation of a dispersive guided wave propagation does not occur. However, the present paper shows that the second-harmonic of Lamb wave propagation arising from the nonlinear interaction of the partial bulk acoustic waves and the restriction of the three boundaries of the solid plates does have a cumulative growth effect if some conditions are satisfied. Through boundary condition and initial condition of excitation, the analytical expression of cumulative second-harmonic of Lamb waves propagation is determined. Numerical results show the cumulative effect of Lamb waves on second-harmonic field patterns.
基金Projects 2008ZX05009-004 supported by the National Key Sci-Tech Major Special Item2006CB705805 by the National Basic Research Program of Chinasupported by the National Basic Research Program of China and "enhanced oil recovery basic theory for low permeability reservoirs" under grant 2002CCA00700
文摘In order to study the effect of time lag and stress loading rates on rock deformation,the conventional stepped stress loading mode was changed into a continuous mode to investigate the effect of effective pressure on permeability and porosity.The time lag effect of rock deformation illustrating the relationship between changes in permeability and steady time was studied.Permeability reduction ratios were measured under different stress loading rates which were achieved by different pump rate settings.The results show that permeability and porosity gradually decrease with increases in effective pressure.Permeability at high effective pressure attains stability quickly.Steady times at low effective pressure are very long.Reduction in permeability at lower stress loading rates is small,while,in contrast,it is large at high stress loading rates.
文摘In order to resolve the traffic congestion problem, many cable-stayed bridges are designed with a large width to span ratio. This results in significant shear lag effect to cause nonuniform stress distribution along the flanges of the beam of bridge. This paper reports study on the shear lag effect of the Lanzhou Xiaoxihu Yellow River Bridge. A 3D finite element model of the bridge was developed and finite element analysis (FEA) was done to obtain the theoretical results. To evaluate the theoretical results, a scaled model was made to conduct static test in laboratory. The experiment results accorded with the results obtained by FEA. It is proved that FEA is an effective method to predict shear lag effect of bridges of this type.
基金supported by the National Natural ScienceFoundation of China(11401002,11771001)the Natural Science Foundation of Anhui Province(2008085MA02)+3 种基金the Natural Science Fund for Colleges and Universities in Anhui Province(KJ2018A0029)the Teaching Research Project of Anhui University(ZLTS2016065)the Quality engineering project of colleges and universities in Anhui Province(2020jyxm0103)the Science Foundation of Anhui Province Universities(KJ2019A005)。
文摘This paper studies a kind of non-autonomous respiratory disease model with a lag effect.First of all,the permanence and extinction of the system are discussed by using the comparison principle and some differential inequality techniques.Second,it assumes that all coefficients of the system are periodic.The existence of positive periodic solutions of the system is proven,based on the continuation theorem in coincidence with the degree theory of Mawhin and Gaines.In the meantime,the global attractivity of positive periodic solutions of the system is obtained by constructing an appropriate Lyapunov functional and using the Razumikin theorem.In addition,the existence and uniform asymptotic stability of almost periodic solutions of the system are analyzed by assuming that all parameters in the model are almost periodic in time.Finally,the theoretical derivation is verified by a numerical simulation.
基金supported by the Science and Technology Research Project to Henan Provincial Department of Natural Resources(Henan Natural Resources Letter[2019]373–10)。
文摘The Luanchuan molybdenum polymetallic mine concentration area is rich in mineral resources and has a long history of mining.The environmental impact of long-term mining activities cannot be ignored.It is of great significance to study the ecological risk and the accumulation trends of heavy metals in the soil of mining areas for scientific prevention and control of heavy metal pollution.Taking the Taowanbeigou River Basin in the mine concentration area as the research object,the ecological pollution risk and cumulative effect of heavy metals in the soil of the basin were studied by using the comprehensive pollution index method,potential ecological risk assessment method and geoaccumulation index method.On this basis,the cumulative exceeding years of specific heavy metals were predicted by using the early warning model.The comprehensive potential ecological risk of heavy metals in the soil near the Luanchuan mine concentration area is moderate,and the single element Cd is the main ecological risk factor,with a contribution rate of 53.6%.The overall cumulative degrees of Cu and Pb in the soil are“none-moderate”,Zn and Cd are moderate,Mo has reached an extremely strong cumulative level,Hg,As and Cr risks are not obvious,and the overall cumulative risks order is Mo>Cd>Zn>Cu>Pb>Hg.According to the current accumulation rate and taking the risk screening values for soil contamination of agricultural land as the reference standard,the locations over standard rates of Cu,Zn and Cd will exceed 78%in 90years,and the over standard rate of Pb will reach approximately 57%in 200 years.The cumulative exceeding standard periods of As,Cr and Hg are generally long,which basically indicates that these elements do not pose a significant potential threat to the ecological environment.Mining activities will accelerate the accumulation of heavy metals in soil.With the continuous development of mining activities,the potential pollution risk of heavy metals in the soil of mining areas will also increase.