In this work,we aim to introduce some modifications to the Anam-Net deep neural network(DNN)model for segmenting optic cup(OC)and optic disc(OD)in retinal fundus images to estimate the cup-to-disc ratio(CDR).The CDR i...In this work,we aim to introduce some modifications to the Anam-Net deep neural network(DNN)model for segmenting optic cup(OC)and optic disc(OD)in retinal fundus images to estimate the cup-to-disc ratio(CDR).The CDR is a reliable measure for the early diagnosis of Glaucoma.In this study,we developed a lightweight DNN model for OC and OD segmentation in retinal fundus images.Our DNN model is based on modifications to Anam-Net,incorporating an anamorphic depth embedding block.To reduce computational complexity,we employ a fixed filter size for all convolution layers in the encoder and decoder stages as the network deepens.This modification significantly reduces the number of trainable parameters,making the model lightweight and suitable for resource-constrained applications.We evaluate the performance of the developed model using two publicly available retinal image databases,namely RIM-ONE and Drishti-GS.The results demonstrate promising OC segmentation performance across most standard evaluation metrics while achieving analogous results for OD segmentation.We used two retinal fundus image databases named RIM-ONE and Drishti-GS that contained 159 images and 101 retinal images,respectively.For OD segmentation using the RIM-ONE we obtain an f1-score(F1),Jaccard coefficient(JC),and overlapping error(OE)of 0.950,0.9219,and 0.0781,respectively.Similarly,for OC segmentation using the same databases,we achieve scores of 0.8481(F1),0.7428(JC),and 0.2572(OE).Based on these experimental results and the significantly lower number of trainable parameters,we conclude that the developed model is highly suitable for the early diagnosis of glaucoma by accurately estimating the CDR.展开更多
Background:The incidence of lumbar disc herniation(LDH)is notably high.Consensus among experts highlights non-surgical treatments as the primary therapeutic approach for LDH.Contemporary medicine frequently employs ph...Background:The incidence of lumbar disc herniation(LDH)is notably high.Consensus among experts highlights non-surgical treatments as the primary therapeutic approach for LDH.Contemporary medicine frequently employs pharmacotherapy and epidural injections in such treatments,which are associated with numerous adverse effects.Prolonged use can severely impair the liver and kidney functions of patients.Hence,the role of safe and effective traditional Chinese medicine techniques becomes pivotal.Among various traditional Chinese medicine approaches for treating LDH,fire dragon cupping,renowned for its remarkable efficacy,cost-effectiveness,and ease of application,is extensively utilised in clinical settings for managing LDH.Nonetheless,there is a scarcity of systematic and standardised evidence from evidence-based medicine studies.Therefore,conducting a meta-analysis is imperative.Methods:A comprehensive computerised search was conducted in databases including China National Knowledge Infrastructure,WanFang Data,VIP,China Biology Medicine disc,PubMed,EMbase,The Cochrane Library,Web of Science,and CINAHL.The search aimed to gather randomised controlled trials on fire dragon cupping therapy for LDH,spanning from the inception of these databases until December 2023.Two researchers independently screened the literature according to inclusion and exclusion criteria,extracted data,and assessed the methodological quality of the studies included,utilising RevMan 5.3 software for meta-analysis.Results:The results show that the fire dragon cupping therapy group had better clinical effectiveness(relative risk=1.23,95%confidence interval(CI)(1.14,1.33),P<0.00001),less pain(standardized mean difference=–1.33,95%CI(–1.49,–1.16),P<0.00001),and some improvement in lumbar function(Japanese Orthopaedic Association scores:mean difference=3.37,95%CI(2.31,4.43),P<0.00001.Conclusion:The fire dragon cupping therapy significantly alleviates LDH,warranting its extensive application.However,considering the limitations in the number and quality of studies included,the aforementioned conclusion necessitates further validation through more high-quality research.展开更多
Purpose: The aim of this study is early detection of increased cup to disc ratio and a survey study of cup-disc ratio in Egyptian children age group less than 15 years. Methods: Three hundred and eighty-two (382) chil...Purpose: The aim of this study is early detection of increased cup to disc ratio and a survey study of cup-disc ratio in Egyptian children age group less than 15 years. Methods: Three hundred and eighty-two (382) children were enrolled in this study. They were classified into three age groups;infants’ Group (1) from 0-2 years, preschool Group (2) from 2-6 years and school children Group (3) from 6-15 years old. C/D ratio was measured for each child. Results: In Group (1), normal C/D ratio ranged from 0 to 0.1. The C/D ratio > 0.3 or a binocular difference of >0.2 could be regarded as one of the criteria of newborn glaucoma. Group (2): the normal ratio ranged from 0.1-0.2. Group (3): the normal ratio ranged from 0.2-0.3. The highest ratio 0.7 was found in two eyes. An asymmetry of 0.2 or more in the C/D ratios of the eyes was found in 4.8% of the children. Conclusion: C/D ratio > 0.3 and asymmetry of 0.2 is suggestive of glaucoma especially in infants of lower age group.展开更多
The machining surface integrity of aero-engine turbine disc slots has a significant impact on their fatigue life and service performance,and achieving efficiency and high-precision machining is still a great challenge...The machining surface integrity of aero-engine turbine disc slots has a significant impact on their fatigue life and service performance,and achieving efficiency and high-precision machining is still a great challenge.The high machining requirements of future aeroengine turbine disc slots will be difficult to satisfy using the broaching method.In addition,existing methods of slot machin-ing face difficulties in ensuring surface integrity.This study explored a cup shaped electroplated Cubic Boron Nitride(CBN)abrasive wheel for profile grinding the turbine disc slots of FGH96 powder metallurgy superalloy.The matrix structure of the cup shaped abrasive wheel was designed and verified.A profile grinding experiment was conducted for fir-tree slots on a five-axis machining center.The accuracy and the surface integrity were analyzed.Results show that the key dimension detection results of the slots were within the allowable tolerance range.Meanwhile,an average sur-face roughness Ra of 0.55μm was achieved,the residual stress was compressive,the plastic defor-mation layer thickness was less than 5μm,and the hardening layer thickness was less than 20μm.The research findings provide a new approach to machining the slots of aviation engine turbine discs and guidance for the high-quality processing of complex components.展开更多
基金funded byResearchers Supporting Project Number(RSPD2024R 553),King Saud University,Riyadh,Saudi Arabia.
文摘In this work,we aim to introduce some modifications to the Anam-Net deep neural network(DNN)model for segmenting optic cup(OC)and optic disc(OD)in retinal fundus images to estimate the cup-to-disc ratio(CDR).The CDR is a reliable measure for the early diagnosis of Glaucoma.In this study,we developed a lightweight DNN model for OC and OD segmentation in retinal fundus images.Our DNN model is based on modifications to Anam-Net,incorporating an anamorphic depth embedding block.To reduce computational complexity,we employ a fixed filter size for all convolution layers in the encoder and decoder stages as the network deepens.This modification significantly reduces the number of trainable parameters,making the model lightweight and suitable for resource-constrained applications.We evaluate the performance of the developed model using two publicly available retinal image databases,namely RIM-ONE and Drishti-GS.The results demonstrate promising OC segmentation performance across most standard evaluation metrics while achieving analogous results for OD segmentation.We used two retinal fundus image databases named RIM-ONE and Drishti-GS that contained 159 images and 101 retinal images,respectively.For OD segmentation using the RIM-ONE we obtain an f1-score(F1),Jaccard coefficient(JC),and overlapping error(OE)of 0.950,0.9219,and 0.0781,respectively.Similarly,for OC segmentation using the same databases,we achieve scores of 0.8481(F1),0.7428(JC),and 0.2572(OE).Based on these experimental results and the significantly lower number of trainable parameters,we conclude that the developed model is highly suitable for the early diagnosis of glaucoma by accurately estimating the CDR.
基金supported by the 2022 study on the effectiveness of Fire Dragon Cupping in treating cold-dampness obstructive type shoulder stiffness,funded by the Bao'an District Healthcare Research Project in Shenzhen(Shen Bao Ke[2023]No.13,Project No.2022JD237)2023 study on the therapeutic observation and mechanism exploration of Fire Dragon Cupping in cold-dampness obstructive type acute gout,funded by the Guangdong Provincial Administration of Traditional Chinese Medicine(Yue Zhong Yi Han[2023]No.205,Project No.20242077)+1 种基金National Clinical Key Specialty(Traditional Chinese Medicine)Construction Project(2013-239)Sanming Project of Medicine in Shenzhen(No.SZZYSM202206014).
文摘Background:The incidence of lumbar disc herniation(LDH)is notably high.Consensus among experts highlights non-surgical treatments as the primary therapeutic approach for LDH.Contemporary medicine frequently employs pharmacotherapy and epidural injections in such treatments,which are associated with numerous adverse effects.Prolonged use can severely impair the liver and kidney functions of patients.Hence,the role of safe and effective traditional Chinese medicine techniques becomes pivotal.Among various traditional Chinese medicine approaches for treating LDH,fire dragon cupping,renowned for its remarkable efficacy,cost-effectiveness,and ease of application,is extensively utilised in clinical settings for managing LDH.Nonetheless,there is a scarcity of systematic and standardised evidence from evidence-based medicine studies.Therefore,conducting a meta-analysis is imperative.Methods:A comprehensive computerised search was conducted in databases including China National Knowledge Infrastructure,WanFang Data,VIP,China Biology Medicine disc,PubMed,EMbase,The Cochrane Library,Web of Science,and CINAHL.The search aimed to gather randomised controlled trials on fire dragon cupping therapy for LDH,spanning from the inception of these databases until December 2023.Two researchers independently screened the literature according to inclusion and exclusion criteria,extracted data,and assessed the methodological quality of the studies included,utilising RevMan 5.3 software for meta-analysis.Results:The results show that the fire dragon cupping therapy group had better clinical effectiveness(relative risk=1.23,95%confidence interval(CI)(1.14,1.33),P<0.00001),less pain(standardized mean difference=–1.33,95%CI(–1.49,–1.16),P<0.00001),and some improvement in lumbar function(Japanese Orthopaedic Association scores:mean difference=3.37,95%CI(2.31,4.43),P<0.00001.Conclusion:The fire dragon cupping therapy significantly alleviates LDH,warranting its extensive application.However,considering the limitations in the number and quality of studies included,the aforementioned conclusion necessitates further validation through more high-quality research.
文摘Purpose: The aim of this study is early detection of increased cup to disc ratio and a survey study of cup-disc ratio in Egyptian children age group less than 15 years. Methods: Three hundred and eighty-two (382) children were enrolled in this study. They were classified into three age groups;infants’ Group (1) from 0-2 years, preschool Group (2) from 2-6 years and school children Group (3) from 6-15 years old. C/D ratio was measured for each child. Results: In Group (1), normal C/D ratio ranged from 0 to 0.1. The C/D ratio > 0.3 or a binocular difference of >0.2 could be regarded as one of the criteria of newborn glaucoma. Group (2): the normal ratio ranged from 0.1-0.2. Group (3): the normal ratio ranged from 0.2-0.3. The highest ratio 0.7 was found in two eyes. An asymmetry of 0.2 or more in the C/D ratios of the eyes was found in 4.8% of the children. Conclusion: C/D ratio > 0.3 and asymmetry of 0.2 is suggestive of glaucoma especially in infants of lower age group.
基金supported by the National Natural Science Foundation of China (Nos.52305477,52375447,52305474)Major Special Projects of Aero-engine and Gas Turbine (No.2017-VII-0002-0095)+4 种基金the Special Fund of Taishan Scholars Project (No.tsqn202211179)the Youth Talent Promotion Project in Shandong (No.SDAST2021qt12)the Natural Science Foundation of Shandong Province (Nos.ZR2023QE057,ZR2022QE028,ZR2021QE116,and ZR2020KE027)Qingdao Science and Technology Planning Park Cultivation Plan (No.23-1-5-yqpy-17-qy)the Natural Science Foundation of Jiangsu Province (No.BK20210407).
文摘The machining surface integrity of aero-engine turbine disc slots has a significant impact on their fatigue life and service performance,and achieving efficiency and high-precision machining is still a great challenge.The high machining requirements of future aeroengine turbine disc slots will be difficult to satisfy using the broaching method.In addition,existing methods of slot machin-ing face difficulties in ensuring surface integrity.This study explored a cup shaped electroplated Cubic Boron Nitride(CBN)abrasive wheel for profile grinding the turbine disc slots of FGH96 powder metallurgy superalloy.The matrix structure of the cup shaped abrasive wheel was designed and verified.A profile grinding experiment was conducted for fir-tree slots on a five-axis machining center.The accuracy and the surface integrity were analyzed.Results show that the key dimension detection results of the slots were within the allowable tolerance range.Meanwhile,an average sur-face roughness Ra of 0.55μm was achieved,the residual stress was compressive,the plastic defor-mation layer thickness was less than 5μm,and the hardening layer thickness was less than 20μm.The research findings provide a new approach to machining the slots of aviation engine turbine discs and guidance for the high-quality processing of complex components.
