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Web Layout Design of Large Cavity Structures Based on Topology Optimization 被引量:1
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作者 Xiaoqiao Yang Jialiang Sun Dongping Jin 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第3期2665-2689,共25页
Large cavity structures are widely employed in aerospace engineering, such as thin-walled cylinders, blades andwings. Enhancing performance of aerial vehicles while reducing manufacturing costs and fuel consumptionhas... Large cavity structures are widely employed in aerospace engineering, such as thin-walled cylinders, blades andwings. Enhancing performance of aerial vehicles while reducing manufacturing costs and fuel consumptionhas become a focal point for contemporary researchers. Therefore, this paper aims to investigate the topologyoptimization of large cavity structures as a means to enhance their performance, safety, and efficiency. By usingthe variable density method, lightweight design is achieved without compromising structural strength. Theoptimization model considers both concentrated and distributed loads, and utilizes techniques like sensitivityfiltering and projection to obtain a robust optimized configuration. The mechanical properties are checked bycomparing the stress distribution and displacement of the unoptimized and optimized structures under the sameload. The results confirm that the optimized structures exhibit improved mechanical properties, thus offering keyinsights for engineering lightweight, high-strength large cavity structures. 展开更多
关键词 Topology optimization lightweight design web layout design cavity structure
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OptoGPT: A foundation model for inverse design in optical multilayer thin film structures 被引量:1
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作者 Taigao Ma Haozhu Wang L.Jay Guo 《Opto-Electronic Advances》 SCIE EI CAS CSCD 2024年第7期4-16,共13页
Optical multilayer thin film structures have been widely used in numerous photonic applications.However,existing inverse design methods have many drawbacks because they either fail to quickly adapt to different design... Optical multilayer thin film structures have been widely used in numerous photonic applications.However,existing inverse design methods have many drawbacks because they either fail to quickly adapt to different design targets,or are difficult to suit for different types of structures,e.g.,designing for different materials at each layer.These methods also cannot accommodate versatile design situations under different angles and polarizations.In addition,how to benefit practical fabrications and manufacturing has not been extensively considered yet.In this work,we introduce OptoGPT(Opto Generative Pretrained Transformer),a decoder-only transformer,to solve all these drawbacks and issues simultaneously. 展开更多
关键词 multilayer thin film structure inverse design foundation models deep learning structural color
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Resistive switching behavior and mechanism of HfO_(x) films with large on/off ratio by structure design
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作者 黄香林 王英 +2 位作者 黄慧香 段理 郭婷婷 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第1期660-665,共6页
Different bilayer structures of HfO_(x)/Ti(TiO_(x)) are designed for hafnium-based memory to investigate the switching characteristics. The chemical states in the films and near the interface are characterized by x-ra... Different bilayer structures of HfO_(x)/Ti(TiO_(x)) are designed for hafnium-based memory to investigate the switching characteristics. The chemical states in the films and near the interface are characterized by x-ray photoelectron spectroscopy,and the oxygen vacancies are analyzed. Highly improved on/off ratio(~104) and much uniform switching parameters are observed for bilayer structures compared to single layer HfO_(x) sample, which can be attributed to the modulation of oxygen vacancies at the interface and better control of the growth of filaments. Furthermore, the reliability of the prepared samples is investigated. The carrier conduction behaviors of HfO_(x)-based samples can be attributed to the trapping and de-trapping process of oxygen vacancies and a filamentary model is proposed. In addition, the rupture of filaments during the reset process for the bilayer structures occur at the weak points near the interface by the recovery of oxygen vacancies accompanied by the variation of barrier height. The re-formation of fixed filaments due to the residual filaments as lightning rods results in the better switching performance of the bilayer structure. 展开更多
关键词 HfO_(x)film resistive switching structure design interface modulation
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Design,preparation,application of advanced array structured materials and their action mechanism analyses for high performance lithium-sulfur batteries
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作者 Nanping Deng Xiaofan Feng +7 位作者 Yongbing Jin Zhaozhao Peng Yang Feng Ying Tian Yong Liu Lu Gao Weimin Kang Bowen Cheng 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2024年第2期266-303,I0007,共39页
Lithium-sulfur battery(LSB)has brought much attention and concern because of high theoretical specific capacity and energy density as one of main competitors for next-generation energy storage systems.The widely comme... Lithium-sulfur battery(LSB)has brought much attention and concern because of high theoretical specific capacity and energy density as one of main competitors for next-generation energy storage systems.The widely commercial application and development of LSB is mainly hindered by serious“shuttle effect”of lithium polysulfides(Li PSs),slow reaction kinetics,notorious lithium dendrites,etc.In various structures of LSB materials,array structured materials,possessing the composition of ordered micro units with the same or similar characteristics of each unit,present excellent application potential for various secondary cells due to some merits such as immobilization of active substances,high specific surface area,appropriate pore sizes,easy modification of functional material surface,accommodated huge volume change,enough facilitated transportation for electrons/lithium ions,and special functional groups strongly adsorbing Li PSs.Thus many novel array structured materials are applied to battery for tackling thorny problems mentioned above.In this review,recent progresses and developments on array structured materials applied in LSBs including preparation ways,collaborative structural designs based on array structures,and action mechanism analyses in improving electrochemical performance and safety are summarized.Meanwhile,we also have detailed discussion for array structured materials in LSBs and constructed the structure-function relationships between array structured materials and battery performances.Lastly,some directions and prospects about preparation ways,functional modifications,and practical applications of array structured materials in LSBs are generalized.We hope the review can attract more researchers'attention and bring more studying on array structured materials for other secondary batteries including LSB. 展开更多
关键词 Array structured materials Preparation methods and structural designs Action mechanism analyses Advanced Li-S batteries Excellent electrochemical performances and safety
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A Hybrid Level Set Optimization Design Method of Functionally Graded Cellular Structures Considering Connectivity
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作者 Yan Dong Kang Zhao +1 位作者 Liang Gao Hao Li 《Computers, Materials & Continua》 SCIE EI 2024年第4期1-18,共18页
With the continuous advancement in topology optimization and additive manufacturing(AM)technology,the capability to fabricate functionally graded materials and intricate cellular structures with spatially varying micr... With the continuous advancement in topology optimization and additive manufacturing(AM)technology,the capability to fabricate functionally graded materials and intricate cellular structures with spatially varying microstructures has grown significantly.However,a critical challenge is encountered in the design of these structures–the absence of robust interface connections between adjacent microstructures,potentially resulting in diminished efficiency or macroscopic failure.A Hybrid Level Set Method(HLSM)is proposed,specifically designed to enhance connectivity among non-uniform microstructures,contributing to the design of functionally graded cellular structures.The HLSM introduces a pioneering algorithm for effectively blending heterogeneous microstructure interfaces.Initially,an interpolation algorithm is presented to construct transition microstructures seamlessly connected on both sides.Subsequently,the algorithm enables the morphing of non-uniform unit cells to seamlessly adapt to interconnected adjacent microstructures.The method,seamlessly integrated into a multi-scale topology optimization framework using the level set method,exhibits its efficacy through numerical examples,showcasing its prowess in optimizing 2D and 3D functionally graded materials(FGM)and multi-scale topology optimization.In essence,the pressing issue of interface connections in complex structure design is not only addressed but also a robust methodology is introduced,substantiated by numerical evidence,advancing optimization capabilities in the realm of functionally graded materials and cellular structures. 展开更多
关键词 Hybrid level set method functionally graded cellular structure CONNECTIVITY interpolated transition optimization design
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Multi-Scale Design and Optimization of Composite Material Structure for Heavy-Duty Truck Protection Device
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作者 Yanhui Zhang Lianhua Ma +3 位作者 Hailiang Su Jirong Qin Zhining Chen Kaibiao Deng 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第5期1961-1980,共20页
In this paper,to present a lightweight-developed front underrun protection device(FUPD)for heavy-duty trucks,plain weave carbon fiber reinforced plastic(CFRP)is used instead of the original high-strength steel.First,t... In this paper,to present a lightweight-developed front underrun protection device(FUPD)for heavy-duty trucks,plain weave carbon fiber reinforced plastic(CFRP)is used instead of the original high-strength steel.First,the mechanical and structural properties of plain carbon fiber composite anti-collision beams are comparatively analyzed from a multi-scale perspective.For studying the design capability of carbon fiber composite materials,we investigate the effects of TC-33 carbon fiber diameter(D),fiber yarn width(W)and height(H),and fiber yarn density(N)on the front underrun protective beam of carbon fiber compositematerials.Based on the investigation,a material-structure matching strategy suitable for the front underrun protective beam of heavy-duty trucks is proposed.Next,the composite material structure is optimized by applying size optimization and stack sequence optimization methods to obtain the higher performance carbon fiber composite front underrun protection beam of commercial vehicles.The results show that the fiber yarn height(H)has the greatest influence on the protective beam,and theH1matching scheme for the front underrun protective beamwith a carbon fiber composite structure exhibits superior performance.The proposed method achieves a weight reduction of 55.21% while still meeting regulatory requirements,which demonstrates its remarkable weight reduction effect. 展开更多
关键词 structural optimization front underrun protection device carbon fiber reinforced plastic multi-scale model lightweight design
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Design of a Novel Robotic Fish Structure Utilizing PVC Gel Actuators
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作者 Ruyhan   Nazia Bibi +3 位作者 Sara Rahman Abdullah Al Hossain Newaz Abdul Kadir Nasir Uddin 《Modern Mechanical Engineering》 2024年第3期57-72,共16页
In this research work, it has been designed a bionic robot fish structure, can swim underwater. The active compact body is powered by eight sets of symmetric PVC gel actuators with a caudal fin. The robot’s 200 mm-lo... In this research work, it has been designed a bionic robot fish structure, can swim underwater. The active compact body is powered by eight sets of symmetric PVC gel actuators with a caudal fin. The robot’s 200 mm-long, fish structure design incorporates a 55.52 angle to optimize the fish dynamics movement. It’s a fast and smooth operation and can swim. The robot can swim fast and quietly by using the right positions and the appropriate actuators on PVC gel actuators. This design entails a unique architecture that enables the robot to move safely and unobtrusively at the same time, which makes it suitable equipment for different exploration and surveillance missions in the water with speed and silent operation as the foremost concern. 展开更多
关键词 Biomimetic Robotics structural design PVC Gel Actuators Swimming Mechanisms
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Design and Engineering of Urban Interchange Ramp Bridge Structure
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作者 Yuxiao Zhang Maode Yang 《Journal of Architectural Research and Development》 2024年第2期62-67,共6页
This paper analyzes the structural design of an urban interchange ramp bridge from four aspects,which are the superstructure,pier structure,foundation structure,and deck structure design to summarize the structural de... This paper analyzes the structural design of an urban interchange ramp bridge from four aspects,which are the superstructure,pier structure,foundation structure,and deck structure design to summarize the structural design ideas of this urban interchange ramp bridge,which can be used as a reference for future construction of the same bridge. 展开更多
关键词 Interchange ramp Bridge structure design Pier structure Foundation structure Bridge deck structure
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Optimization method of reef structure design based on hydrodynamic model
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作者 WANG Hong ZNANG Xue +4 位作者 ZHANG Jingwei GAO Yan FANG Enjun ZENG Xiangxi Dai Yuanyuan 《Marine Science Bulletin》 2024年第1期67-80,共14页
Artificial fish reef is a kind of artificial structure in water,which provides a necessary and safe place for aquatic life such as fish to inhabit,grow,and breed,and creates an environment suitable for fish growth,so ... Artificial fish reef is a kind of artificial structure in water,which provides a necessary and safe place for aquatic life such as fish to inhabit,grow,and breed,and creates an environment suitable for fish growth,so as to protect and multiply fishery resources.In a large time scale,the physical process of sea area can deeply affect the chemical process and biological process,so the structure characteristics of artificial reef are the key factors affecting the flow field effect around the reef.In this study,through the hydrodynamic experiments of four kinds of reef models,including big windows box reef,big and small windows box reef,"(卐)"shaped reef and double-layer shellfish breeding reef,the influence of single reef structure on the flow field effect is analyzed,and the force conditions of different reefs under the same incoming current velocity are obtained.According to the simulation results,the safety research and calculation of five kinds of reef models are carried out,and the volumes of vortex area and upwelling area behind four kinds of reef are obtained.Using hydrodynamic model to simulate the flow field effect of reef area,optimizing the reef structure design,improving the maximum biological trapping and proliferation effect of reef,can provide theoretical guidance and scientific and technological support for the construction of reef area. 展开更多
关键词 HYDRODYNAMIC MODEL artificial reef structure design
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Research on the Course of Principles of Concrete Structure Design
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作者 Yuhuan Shi Jinping Hu +2 位作者 Xue Lin Zhinan Jiang Jialian Qi 《Journal of Contemporary Educational Research》 2024年第2期80-84,共5页
Nowadays,education and teaching have become a hot topic,and teaching in colleges and universities is facing a brand-new development direction.Principles of Concrete Structure Design,as one of the main courses,transmit... Nowadays,education and teaching have become a hot topic,and teaching in colleges and universities is facing a brand-new development direction.Principles of Concrete Structure Design,as one of the main courses,transmits professional knowledge for students,enhances the students’professional ability,and further carries out in-depth research on the course to bring a better teaching effect for students.The article mainly focuses on the research of the principles of concrete structure design course,conducts an analysis of the teaching characteristics of the principles of concrete structure design course,and reasonably sets the teaching content from the optimization of the course teaching objectives;innovative course teaching methods can deepen the effect of knowledge understanding;reform of experimental practice teaching can lay down the effect of the internalization of knowledge,etc.The in-depth description and discussion of the relevant aspects of the research aim to provide guidelines for related research. 展开更多
关键词 Concrete structure design principle Course characteristics Teaching innovation Course research
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An origami shield with supporting frame structures optimized by a feature-driven topology optimization method
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作者 Dongsheng Jia Pengcheng Feng +5 位作者 Liangdi Wang Longcan Chen Jun Wang Jihong Zhu Yingjie Xu Weihong Zhang 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第1期447-456,共10页
In this paper,the design,manufacture and testing of an origami protective shield with a supporting frame structure are presented.It consists of an origami shield surface and a deployable supporting frame structure tha... In this paper,the design,manufacture and testing of an origami protective shield with a supporting frame structure are presented.It consists of an origami shield surface and a deployable supporting frame structure that needs to be portable and sufficiently stiff.First,for the design of the shield surface,a threestage origami crease pattern is developed to reduce the shield size in the folded state.The shield surface consists of several stiff modular panels and layered with flexible fabric.The modular panels are made of a multi-layer composite where a ceramic layer is made of small pieces to improve durability as those small pieces enable restriction of crack propagation.Then,the supporting frame structure is designed as a chain-of-bars structure in order to fold into a highly compact state as a bundle of bars and deploy in sequence.Thus,a feature-driven topology structural optimization method preserving component sequence is developed where the inter-dependence of sub-structures is taken into account.A bar with semi-circular ends is used as a basic design feature.The positions of the bar’s end points are treated as design variables and the width of the bars is kept constant.Then,a constraint on the total length of the chain of bars is introduced.Finally,the modular panels made of multi-layer composite and the full-scale prototype of the origami shield are fabricated and tested to verify the bullet-proof performance. 展开更多
关键词 ORIGAMI Deployable structure structure design SHIELD Composite materials
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Bioinspired directional structures for inhibiting wetting on super-melt-philic surfaces above 1200°C
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作者 Hujun Wang Xiuyuan Zhao +4 位作者 Zhengcan Xie Biao Yang Jing Zheng Kai Yin Zhongrong Zhou 《International Journal of Extreme Manufacturing》 SCIE EI CAS CSCD 2024年第4期337-346,共10页
Over the past two decades,superhydrophobic surfaces that are easily created have aroused considerable attention for their superior performances in various applications at room temperature.Nowadays,there is a growing d... Over the past two decades,superhydrophobic surfaces that are easily created have aroused considerable attention for their superior performances in various applications at room temperature.Nowadays,there is a growing demand in special fields for the development of surfaces that can resist wetting by high-temperature molten droplets(>1200°C)using facile design and fabrication strategies.Herein,bioinspired directional structures(BDSs)were prepared on Y2O3-stabilized ZrO2(YSZ)surfaces using femtosecond laser ablation.Benefiting from the anisotropic energy barriers,the BDSs featured with no additional modifiers showed a remarkable increase from 9.2°to 60°in the contact angle of CaO–MgO–Al2O3–SiO2(CMAS)melt and a 70.1%reduction in the spreading area of CMAS at 1250°C,compared with polished super-CMAS-melt-philic YSZ surfaces.Moreover,the BDSs demonstrated exceptional wetting inhibition even at 1400°C,with an increase from 3.3°to 31.3°in contact angle and a 67.9%decrease in spreading area.This work provides valuable insight and a facile preparation strategy for effectively inhibiting the wetting of molten droplets on super-melt-philic surfaces at extremely high temperatures. 展开更多
关键词 directional structures bioinspired design inhibiting wetting super-melt-philic SUPERHYDROPHOBIC
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Experimental research on the launching system of auxiliary charge with filter cartridge structure
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作者 Zi-Jun Chen Ze He +2 位作者 Hong-Hao Ma Lu-Qing Wang Zhao-Wu Shen 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第1期41-48,共8页
A launching system with a filter cartridge structure was proposed to improve the muzzle velocity of the projectile.The combustion chamber of the launching system is divided into two fixed chambers,one is located in th... A launching system with a filter cartridge structure was proposed to improve the muzzle velocity of the projectile.The combustion chamber of the launching system is divided into two fixed chambers,one is located in the breech chamber,and the other is arranged in the barrel.The breech chamber charge was ignited first,and the charges in the auxiliary chambers were ignited by the high-temperature,highpressure combustible gas trailing the projectile.In this way,the combustible gas in the auxiliary chambers could compensate for the pressure drop caused by the movement of the projectile.The proposed device features the advantage of launching a projectile with high muzzle velocity without exceeding the maximum pressure in the chamber.In order to obtain some internal ballistic characteristics of the launch system,some critical structure,such as the length of the filter cartridge auxiliary charge,the combustion degree of the propellant in the chamber,and the length of the barrel,are discussed.The experimental results show that with the increased auxiliary charge length,a pressure plateau or even a secondary peak pressure can be formed,which is less than the peak pressure.The projectile velocity increased by 23.57%,14.64%,and 7.65%when the diaphragm thickness was 0 mm,1 mm,and2 mm,respectively.The muzzle velocity of the projectile can be increased by 13.42%by increasing the length of the barrel.Under the same charge condition,with the increase of barrel length,the energy utilization rate of propellant increases by 28.64%. 展开更多
关键词 Interior ballistics Charge structures Launch system Charge design
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Vibration Control of the Rail Grinding Vehicle with Abrasive Belt Based on Structural Optimization and Lightweight Design
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作者 Wengang Fan Shuai Zhang +2 位作者 Zhiwei Wu Yi Liu Jiangnan Yu 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2024年第3期311-337,共27页
As a new grinding and maintenance technology,rail belt grinding shows significant advantages in many applications The dynamic characteristics of the rail belt grinding vehicle largely determines its grinding performan... As a new grinding and maintenance technology,rail belt grinding shows significant advantages in many applications The dynamic characteristics of the rail belt grinding vehicle largely determines its grinding performance and service life.In order to explore the vibration control method of the rail grinding vehicle with abrasive belt,the vibration response changes in structural optimization and lightweight design are respectively analyzed through transient response and random vibration simulations in this paper.Firstly,the transient response simulation analysis of the rail grinding vehicle with abrasive belt is carried out under operating conditions and non-operating conditions.Secondly,the vibration control of the grinding vehicle is implemented by setting vibration isolation elements,optimizing the structure,and increasing damping.Thirdly,in order to further explore the dynamic characteristics of the rail grinding vehicle,the random vibration simulation analysis of the grinding vehicle is carried out under the condition of the horizontal irregularity of the American AAR6 track.Finally,by replacing the Q235 steel frame material with 7075 aluminum alloy and LA43M magnesium alloy,both vibration control and lightweight design can be achieved simultaneously.The results of transient dynamic response analysis show that the acceleration of most positions in the two working conditions exceeds the standard value in GB/T 17426-1998 standard.By optimizing the structure of the grinding vehicle in three ways,the average vibration acceleration of the whole car is reduced by about 55.1%from 15.6 m/s^(2) to 7.0 m/s^(2).The results of random vibration analysis show that the grinding vehicle with Q235 steel frame does not meet the safety conditions of 3σ.By changing frame material,the maximum vibration stress of the vehicle can be reduced from 240.7 MPa to 160.0 MPa and the weight of the grinding vehicle is reduced by about 21.7%from 1500 kg to 1175 kg.The modal analysis results indicate that the vibration control of the grinding vehicle can be realized by optimizing the structure and replacing the materials with lower stiffness under the premise of ensuring the overall strength.The study provides the basis for the development of lightweight,diversified and efficient rail grinding equipment. 展开更多
关键词 Vibration control Dynamic characteristics structural optimization Lightweight design Modal analysis
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Advances in the structure design of substrate materials for zinc anode of aqueous zinc ion batteries 被引量:5
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作者 Sinian Yang Hongxia Du +5 位作者 Yuting Li Xiangsi Wu Bensheng Xiao Zhangxing He Qiaobao Zhang Xianwen Wu 《Green Energy & Environment》 SCIE EI CAS CSCD 2023年第6期1531-1552,共22页
Aqueous zinc ion batteries(AZIBs) demonstrate tremendous competitiveness and application prospects because of their abundant resources,low cost, high safety, and environmental friendliness. Although the advanced elect... Aqueous zinc ion batteries(AZIBs) demonstrate tremendous competitiveness and application prospects because of their abundant resources,low cost, high safety, and environmental friendliness. Although the advanced electrochemical energy storage systems based on zinc ion batteries have been greatly developed, many severe problems associated with Zn anode impede its practical application, such as the dendrite formation,hydrogen evolution, corrosion and passivation phenomenon. To address these drawbacks, electrolytes, separators, zinc alloys, interfacial modification and structural design of Zn anode have been employed at present by scientists. Among them, the structural design for zinc anode is relatively mature, which is generally believed to enhance the electroactive surface area of zinc anode, reduce local current density, and promote the uniform distribution of zinc ions on the surface of anode. In order to explore new research directions, it is crucial to systematically summarize the structural design of anode materials. Herein, this review focuses on the challenges in Zn anode, modification strategies and the three-dimensional(3D) structure design of substrate materials for Zn anode including carbon substrate materials, metal substrate materials and other substrate materials. Finally, future directions and perspectives about the Zn anode are presented for developing high-performance AZIBs. 展开更多
关键词 Zinc ion battery structure design of substrate materials Dendrite-free 3D Zn anode
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Experimental study of solid-liquid origami composite structures with improved impact resistance
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作者 Shuheng Wang Zhanyu Wang +5 位作者 Bei Wang Zhi Liu Yunzhu Ni Wuxing Lai Shan Jiang Yong An Huang 《Theoretical & Applied Mechanics Letters》 CAS CSCD 2024年第2期118-123,共6页
In this paper,a liquid-solid origami composite design is proposed for the improvement of impact resistance.Employing this design strategy,Kresling origami composite structures with different fillings were designed and... In this paper,a liquid-solid origami composite design is proposed for the improvement of impact resistance.Employing this design strategy,Kresling origami composite structures with different fillings were designed and fabricated,namely air,water,and shear thickening fluid(STF).Quasi-static compression and drop-weight impact experiments were carried out to compare and reveal the static and dynamic mechanical behavior of these structures.The results from drop-weight impact experiments demonstrated that the solid-liquid Kresling origami composite structures exhibited superior yield strength and reduced peak force when compared to their empty counterparts.Notably,the Kresling origami structures filled with STF exhibited significantly heightened yield strength and reduced peak force.For example,at an impact velocity of 3 m/s,the yield strength of single-layer STF-filled Kresling origami structures increased by 772.7%and the peak force decreased by 68.6%.This liquid-solid origami composite design holds the potential to advance the application of origami structures in critical areas such as aerospace,intelligent protection and other important fields.The demonstrated improvements in impact resistance underscore the practical viability of this approach in enhancing structural performance for a range of applications. 展开更多
关键词 Solid-liquid design Origami structure Impact resistance Shear thickening fluid
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Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease
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作者 Yinglong Miao Michael S.Wolfe 《Neural Regeneration Research》 SCIE CAS 2025年第1期174-180,共7页
γ-Secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the ... γ-Secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface receptors.Mutations inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-Secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as well.However,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-secretase.In this review,we focus on recent studies of structural dynamic mechanisms ofγ-secretase.Different mechanisms,including the“Fit-Stay-Trim,”“Sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics simulations.While an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental findings.The approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-secretase.In addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is discussed.Finally,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations of theγ-secretase-substrate complexes.Comprehensive understanding of the functional mechanisms ofγ-secretase will greatly facilitate the rational design of effective drug molecules for treating familial Alzheimer’s disease and perhaps Alzheimer’s disease in general. 展开更多
关键词 Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics NOTCH
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A symmetric substructuring method for analyzing the natural frequencies of conical origami structures
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作者 Chenhao Lu Yao Chen +2 位作者 Weiying Fan Jian Feng Pooya Sareh 《Theoretical & Applied Mechanics Letters》 CAS CSCD 2024年第3期203-210,共8页
Conical origami structures are characterized by their substantial out-of-plane stiffness and energy-absorptioncapacity.Previous investigations have commonly focused on the static characteristics of these lightweight s... Conical origami structures are characterized by their substantial out-of-plane stiffness and energy-absorptioncapacity.Previous investigations have commonly focused on the static characteristics of these lightweight struc-tures.However,the efficient analysis of the natural vibrations of these structures is pivotal for designing conicalorigami structures with programmable stiffness and mass.In this paper,we propose a novel method to analyzethe natural vibrations of such structures by combining a symmetric substructuring method(SSM)and a gener-alized eigenvalue analysis.SSM exploits the inherent symmetry of the structure to decompose it into a finiteset of repetitive substructures.In doing so,we reduce the dimensions of matrices and improve computationalefficiency by adopting the stiffness and mass matrices of the substructures in the generalized eigenvalue analysis.Finite element simulations of pin-jointed models are used to validate the computational results of the proposedapproach.Moreover,the parametric analysis of the structures demonstrates the influences of the number of seg-ments along the circumference and the radius of the cone on the structural mass and natural frequencies of thestructures.Furthermore,we present a comparison between six-fold and four-fold conical origami structures anddiscuss the influence of various geometric parameters on their natural frequencies.This study provides a strategyfor efficiently analyzing the natural vibration of symmetric origami structures and has the potential to contributeto the efficient design and customization of origami metastructures with programmable stiffness. 展开更多
关键词 Natural structural vibration Origami design Group theory Symmetric substructuring method(SSM) Generalized eigenvalue analysis
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Multifunctional Perovskite Photodetectors: From Molecular-Scale Crystal Structure Design to Micro/Nano-scale Morphology Manipulation 被引量:2
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作者 Yingjie Zhao Xing Yin +4 位作者 Pengwei Li Ziqiu Ren Zhenkun Gu Yiqiang Zhang Yanlin Song 《Nano-Micro Letters》 SCIE EI CAS CSCD 2023年第10期565-594,共30页
Multifunctional photodetectors boost the development of traditional optical communication technology and emerging artificial intelligence fields, such as robotics and autonomous driving. However, the current implement... Multifunctional photodetectors boost the development of traditional optical communication technology and emerging artificial intelligence fields, such as robotics and autonomous driving. However, the current implementation of multifunctional detectors is based on the physical combination of optical lenses, gratings, and multiple photodetectors, the large size and its complex structure hinder the miniaturization, lightweight, and integration of devices. In contrast, perovskite materials have achieved remarkable progress in the field of multifunctional photodetectors due to their diverse crystal structures, simple morphology manipulation, and excellent optoelectronic properties. In this review, we first overview the crystal structures and morphology manipulation techniques of perovskite materials and then summarize the working mechanism and performance parameters of multifunctional photodetectors. Furthermore, the fabrication strategies of multifunctional perovskite photodetectors and their advancements are highlighted, including polarized light detection, spectral detection, angle-sensing detection, and selfpowered detection. Finally, the existing problems of multifunctional detectors and the perspectives of their future development are presented. 展开更多
关键词 Perovskite materials Crystal structure design Micro/nano-structure manipulation Working mechanism Multifunctional photodetectors
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Inhibiting Voltage Decay in Li-Rich Layered Oxide Cathode:From O3-Type to O2-Type Structural Design
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作者 Guohua Zhang Xiaohui Wen +2 位作者 Yuheng Gao Renyuan Zhang Yunhui Huang 《Nano-Micro Letters》 SCIE EI CAS CSCD 2024年第12期81-102,共22页
Li-rich layered oxide(LRLO)cathodes have been regarded as promising candidates for next-generation Li-ion batteries due to their exceptionally high energy density,which combines cationic and anionic redox activities.H... Li-rich layered oxide(LRLO)cathodes have been regarded as promising candidates for next-generation Li-ion batteries due to their exceptionally high energy density,which combines cationic and anionic redox activities.However,continuous voltage decay during cycling remains the primary obstacle for practical applications,which has yet to be fundamentally addressed.It is widely acknowledged that voltage decay originates from the irreversible migration of transition metal ions,which usually further exacerbates structural evolution and aggravates the irreversible oxygen redox reactions.Recently,constructing O2-type structure has been considered one of the most promising approaches for inhibiting voltage decay.In this review,the relationship between voltage decay and structural evolution is systematically elucidated.Strategies to suppress voltage decay are systematically summarized.Additionally,the design of O2-type structure and the corresponding mechanism of suppressing voltage decay are comprehensively discussed.Unfortunately,the reported O2-type LRLO cathodes still exhibit partially disordered structure with extended cycles.Herein,the factors that may cause the irreversible transition metal migrations in O2-type LRLO materials are also explored,while the perspectives and challenges for designing high-performance O2-type LRLO cathodes without voltage decay are proposed. 展开更多
关键词 Lithium-ion batteries Li-rich layered oxide Voltage decay Migration of transition metal ions O2-type structural design
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