A generalized mathematical model of human body current threshold for perception was established and the current flowing through human body could be arbitrary cyclical waveforms.The relationship between human body curr...A generalized mathematical model of human body current threshold for perception was established and the current flowing through human body could be arbitrary cyclical waveforms.The relationship between human body current threshold for perception and current frequency, true root mean square(RMS) value and influence factor was described.A test system was established based on electroencephalogram(EEG) to study the relationship between human body current threshold for perception and current waveform, frequency ...展开更多
Objective： To quantitatively identify and grade trigeminal sensory functions after 3 major surgical procedures of trigeminal neuralgia using a newly developed quantitative sensory testing technique, current perceptio...Objective： To quantitatively identify and grade trigeminal sensory functions after 3 major surgical procedures of trigeminal neuralgia using a newly developed quantitative sensory testing technique, current perception threshold measurement （CPTM）. Methods： In the current study, there were 48 trigeminal neuralgia patients without history of prior surgical treatment. These patients received one of the following 3 surgical procedures, microvascular decompression （MVD）, peripheral nerve block with alcohol （PNB）, or percutaneous radiofrequency thermocoagulation （PRFT）. The quantitative sensory testing measurement, CPTM, and conventional qualitative sensory testing measurements were performed preoperatively and postoperatively to evaluate and grade the trigeminal sensory functions All 3 major cutaneous sensory fiber types, large myelinated fibers （A beta）, small myelinated fibers （A delta） and unmyelinated fibers（C） were allowed to quantitatively evaluate and grade by CPTM. The results of the measurements were statistically analyzed using a one-way analysis of variance （single factor）. Each subject was his/her own control for comparison of the preoperative to postoperative state on the asymptomatic and symptomatic sides. Subjects were tested 48 h preoperatively and 4 weeks postoperatively. Results： PNB with alcohol and PRFT caused significant sensory dysfunction postoperatively in every fiber type, indicating damage to all fibers. On the contrary, the sensory function in all 3 fiber types was unchanged after MVD management. Conclusion： Among the 3 major surgical procedures tested, only MVD preserves sensory function in trigeminal system. CPTM is of quantitative nature on the evaluation of sensory functions of nerve fibers展开更多
目的探讨电流感觉阈值(CPT)测定对三叉神经痛患者感觉定量的评估作用。方法选择2017年1月—2018年10月江西省人民医院神经内科住院部或门诊临床确诊为原发性三叉神经痛下颌支受累的患者26例,所有患者均常规给予营养神经的药物治疗。在...目的探讨电流感觉阈值(CPT)测定对三叉神经痛患者感觉定量的评估作用。方法选择2017年1月—2018年10月江西省人民医院神经内科住院部或门诊临床确诊为原发性三叉神经痛下颌支受累的患者26例,所有患者均常规给予营养神经的药物治疗。在治疗前、治疗后7、14 d对患者进行CPT测定和简化麦吉尔(McGill)疼痛问卷评分表(SF-MPQ)测评,比较CPT和SF-MPQ疼痛评分,评价CPT在三叉神经痛患者治疗前后的感觉功能中的应用价值。结果治疗前用5、250 Hz刺激,患侧CPT高于健侧,差异均有统计学意义(均P<0.05),而用2000 Hz刺激,两侧CPT比较,差异无统计学意义(P>0.05)。患侧治疗后7、14 d CPT与治疗前比较,5、250 Hz刺激下的CPT均有所下降,差异均有统计学意义(均P<0.05),而2000 Hz刺激下患侧治疗后7、14 d CPT与治疗前比较,差异无统计学意义(P>0.05)。治疗后7、14 d SF-MPQ疼痛评分低于治疗前,差异均有统计学意义(均P<0.05)。Pearson相关分析显示,治疗前,治疗后7、14 d的SF-MPQ疼痛评分与患侧下颌支5 Hz刺激下CPT呈正相关(r=0.656、0.418、0.697,P<0.05)。结论CPT可量化地检测三叉神经痛患者治疗前后的感觉功能,客观地评估治疗前后病情程度及治疗效果。展开更多
基金Supported by the Ministry of Science and Technology of China (No. NCSTE-2006-JKZX-167)Beijing Key Laboratory (Measurement and Control of Electro-mechanical Systems) (No. 82063005)
文摘A generalized mathematical model of human body current threshold for perception was established and the current flowing through human body could be arbitrary cyclical waveforms.The relationship between human body current threshold for perception and current frequency, true root mean square(RMS) value and influence factor was described.A test system was established based on electroencephalogram(EEG) to study the relationship between human body current threshold for perception and current waveform, frequency ...
文摘Objective： To quantitatively identify and grade trigeminal sensory functions after 3 major surgical procedures of trigeminal neuralgia using a newly developed quantitative sensory testing technique, current perception threshold measurement （CPTM）. Methods： In the current study, there were 48 trigeminal neuralgia patients without history of prior surgical treatment. These patients received one of the following 3 surgical procedures, microvascular decompression （MVD）, peripheral nerve block with alcohol （PNB）, or percutaneous radiofrequency thermocoagulation （PRFT）. The quantitative sensory testing measurement, CPTM, and conventional qualitative sensory testing measurements were performed preoperatively and postoperatively to evaluate and grade the trigeminal sensory functions All 3 major cutaneous sensory fiber types, large myelinated fibers （A beta）, small myelinated fibers （A delta） and unmyelinated fibers（C） were allowed to quantitatively evaluate and grade by CPTM. The results of the measurements were statistically analyzed using a one-way analysis of variance （single factor）. Each subject was his/her own control for comparison of the preoperative to postoperative state on the asymptomatic and symptomatic sides. Subjects were tested 48 h preoperatively and 4 weeks postoperatively. Results： PNB with alcohol and PRFT caused significant sensory dysfunction postoperatively in every fiber type, indicating damage to all fibers. On the contrary, the sensory function in all 3 fiber types was unchanged after MVD management. Conclusion： Among the 3 major surgical procedures tested, only MVD preserves sensory function in trigeminal system. CPTM is of quantitative nature on the evaluation of sensory functions of nerve fibers
文摘目的探讨电流感觉阈值(CPT)测定对三叉神经痛患者感觉定量的评估作用。方法选择2017年1月—2018年10月江西省人民医院神经内科住院部或门诊临床确诊为原发性三叉神经痛下颌支受累的患者26例,所有患者均常规给予营养神经的药物治疗。在治疗前、治疗后7、14 d对患者进行CPT测定和简化麦吉尔(McGill)疼痛问卷评分表(SF-MPQ)测评,比较CPT和SF-MPQ疼痛评分,评价CPT在三叉神经痛患者治疗前后的感觉功能中的应用价值。结果治疗前用5、250 Hz刺激,患侧CPT高于健侧,差异均有统计学意义(均P<0.05),而用2000 Hz刺激,两侧CPT比较,差异无统计学意义(P>0.05)。患侧治疗后7、14 d CPT与治疗前比较,5、250 Hz刺激下的CPT均有所下降,差异均有统计学意义(均P<0.05),而2000 Hz刺激下患侧治疗后7、14 d CPT与治疗前比较,差异无统计学意义(P>0.05)。治疗后7、14 d SF-MPQ疼痛评分低于治疗前,差异均有统计学意义(均P<0.05)。Pearson相关分析显示,治疗前,治疗后7、14 d的SF-MPQ疼痛评分与患侧下颌支5 Hz刺激下CPT呈正相关(r=0.656、0.418、0.697,P<0.05)。结论CPT可量化地检测三叉神经痛患者治疗前后的感觉功能,客观地评估治疗前后病情程度及治疗效果。
