Study on The Current Status and Progress of Clinical Application of Ciprofol

Ciprofol,as a new type of short-acting intravenous anesthetic drug,belongs to the category of gamma-aminobutyric acid(GABA)receptor agonists.Its unique chemical structure,through the introduction of the cyclopropyl group in the isopropyl side chain of propofol,constructs a new type of chiral molecule,which significantly enhances the spatial effect,and improves the affinity for GABA receptors.Its pharmacological properties are characterized by high potency,rapid onset of action,rapid recovery,low accumulation,and minimal adverse reactions.Therefore,it has a wide range of applications in various endoscopic diagnostic and therapeutic operations,ICU sedation,and general anesthesia.In this paper,the related knowledge of ciprofol and the development of clinical application research are comprehensively sorted out and synthesized,to provide a solid theoretical basis for the rational application of ciprofol in clinical practice.At the same time,the future research direction of ciprofol will also be prospected to provide valuable references for research in related fields.

Gut microbiome and metabolic-associated fatty liver disease:Current status and potential applications

Metabolic-associated fatty liver disease(MAFLD)is one of the most common chronic liver diseases worldwide.In recent years,the occurrence rate of MAFLD has been on the rise,mainly due to lifestyle changes,high-calorie diets,and imbalanced dietary structures,thereby posing a threat to human health and creating heavy social and economic burdens.With the development of 16S sequencing and integrated multi-omics analysis,the role of the gut microbiota(GM)and its metabolites in MAFLD has been further recognized.The GM plays a role in digestion,energy metabolism,vitamin synthesis,the prevention of pathogenic bacteria colonisation,and immunoregulation.The gut-liver axis is one of the vital links between the GM and the liver.Toxic substances in the intestine can enter the liver through the portal vascular system when the intestinal barrier is severely damaged.The liver also influences the GM in various ways,such as bile acid circulation.The gut-liver axis is essential in maintaining the body’s normal physiological state and plays a role in the onset and prognosis of many diseases,including MAFLD.This article reviews the status of the GM and MAFLD and summarizes the GM characteristics in MAFLD.The relationship between the GM and MAFLD is discussed in terms of bile acid circulation,energy metabolism,micronutrients,and signalling pathways.Current MAFLD treat ments targeting the GM are also listed.

THE PROGRESS OF PHYTOCHEMISTRY AND ITS CURRENT RESEARCH STATUS IN CHINA

It is of strategical significance to exploit new medicines with Chinese features and with their patented rights phytechemistry will have great prospects in this aspect. This article briefly introduces the main research fields on phytochemistry and their significance, the present research situation in China, and suggests some concrete proposals on the development of the discipline in China.

Research Status and Application Prospect of Aluminum Matrix Composites

Aluminum matrix composite is one of the most attractive metal matrix composites.It is a kind of material with strong vitality emerging in response to the needs of modern scientific development.Compared with traditional materials,aluminum matrix composites have the advantages of low density,good electric conductivity and heat conductivity,good wear resistance and oxidation resistance,high specific strength and stiffness,high temperature resistance,good heat treatment performance and flexible preparation process,which make them widely used in the fields of aviation,aerospace,and automobile.In this paper,the factors affecting the properties of aluminum matrix composites,the strengthening mechanism,classification and preparation methods of aluminum matrix composites are summarized.The research status,development direction and application prospect of aluminum matrix composites are briefly introduced.

Current Status of Material Research and Development in CISRI

The full name of CISRI is Central Iron&Steel Research Institute under the Ministry of Metallurgical Industry in China.It is the largest institute of metallurgical process research in China(the word"large"here refers to various fields,large personnel and many research projects).It includes ironmaking,steel-making,cold and hot processing of steel,metallic product,ferroalloy,refractory,automatic metallurgy control,design

Current status and technology development tendency of research reactors in China

The current status and development history of domestic and abroad research reactors (RRs) are mentioned.The representative RRs and their respective technology characteristics are introduced.The utilizations of China's RRs,mainly included as nuclear engineering technology,basic research applications of nuclear technology,teaching and personnel training,are explained.

Current Status and Prospect of Process Research in CISRI

The Central Iron and Steel Research Institute(CISRI),directly under the Ministry of Metallurgical Industry(MMI),is a comprehensive research institute mainly engaged in the research and development of new metallic materials and new iron and steel process.With the rapid development of China’s iron and steel industry,CISRI has also made a great progress since it was established more than 40 years ago.In 1994,the steel output of

Research and Application of Hypobaric Storage Technology in Agriculture and Food Industry in China

In recent ten years in China,the application research of hypobaric storage was extended to the non-freeze preservation of cooked food,fresh-cut vegetables,edible fungi and fruits,preliminary processing of growing area and vacuum cold fresh chain to the cold chain breakage for horticultural products,and also to the investigation of principle and theory but the investigation results would have some evident difference. This paper will simply summarize the basic conception,principle,two withdrawing air type hypobaric storage technologies,and introduce many examples as mentioned above extending in China. This paper thinks that the master mechanism of preservation of LP for fresh horticultural products effectively inhibits the activity change of manifold enzymes,which are PAL,POD,PPO,CAT,CAD,SOD et al.,affecting the maturation and caducity of fresh horticultural products during LP storage for a short period,as a result,to reduce both risk of physiology obstacle and disease and to prolong their postharvest life; for the foreseeable future Burg's hypobaric storage technology and hypobaric short period treatment technology will play an important role in the preservation on fresh agricultural products and food preservation in storage and transportation,the preliminary processing of growing area,fresh logistics,establishing the operating platform of perishable food and high business value,fresh e-business,and fresh delivery for scattered families,establishing the operating platform of fresh-cut vegetables including edible fungi and so on in China or in the world.

Analysis of status quo and research progress in nursing of postpartum fatigue: a literature review

Postpartum fatigue is an important issue that threatens women’s health.The incidence of postpartum fatigue is high.Failure to intervene in time may lead to adverse outcomes such as postpartum depression,premature termination of breastfeeding,child abuse,and low infant development.This article reviews the concepts,characteristics,related factors,adverse effects,and interventions of postpartum fatigue.The aim is to improve doctors’and nurses’awareness of on postpartum fatigue in pregnant women,enrich the research content and methods,stimulate the interest of nurses,and actively carry out targeted intervention research to prevent or reduce the occurrence of adverse outcomes.

Current Status of Forest Medicine Research in China

In recent years,due to regional pollution and deteriorating environment,combined with intense social competition and heavier life pressure,an increasing number of people are affected by lifestyle-related diseases and remain in a state of being sub-healthy.Therefore,health issue has been receiving unprecedented attention.

Research of E-commerce Application in Small and Medium Enterprises——A Case Study of Wenzhou

The paper analyzes the status quo of E-commerce application in Wenzhou＇s small and medium enterprises. This survey selects the 100 prominent small and medium enterprises covering chemical engineering, shoes, apparel, machinery, furniture, glasses, lighters, pen and pencil, electric and electronics as the investigating targets and issues the questionnaires to them. The result indicates that, the status quo of E-commerce application in Wenzhou＇s small and medium enterprises are worrisome, which is obviously way behind other cities. Based on that, the paper analyzes the reasons in combination with visiting them, and also proposes the corresponding strategies and predicts its prospect in the end.

Functions and Application of Ornamental Aromatic Plants in Garden Landscaping

The application history of ornamental aromatic plants in garden landscaping both in China and abroad is introduced as well as their function and categories.The application form of the ornamental aromatic plants in garden landscaping is analyzed,and the application prospect is put forward.

Application Progress of Fructus Ligustri Lucidi( FLL) in Animal Husbandry

Fructus Ligustri Lucidi （ FLL）, a well-known and commonly used Chinese herbal medicine in clinical practice, is often applied in animal husbandry in the form of monomer or compound. The chemical composition, pharmacological effects of FLL and its application progress in animal husbandry are reviewed.

Current Research Situation and Development Countermeasures for Digital Orchards

With the rapid development of modern information technology, digital technology has gradually penetrated into all fields and links of the agricultural industry. Digital orchard reflects the comprehensive application of digital technology in orchard management. This study surveys and analyzes the current development of digital orchard, clarifies the development status and existing problems, and comes up with reasonable recommendations, to provide a certain reference and guidance for the construction of digital orchard in Zibo City of Shandong Province.

Current status and future directions of the Tibetan Plateau ecosystem research

The Tibetan Plateau (TP) encompasses Xizang and Qinghai and parts of northern Yunnan and Sichuan provinces, with a total area of circa 2.6 millions km2. The 2013 satellite data showed that grasslands, forests, wetlands, agricultural lands, and deserts account for 60%, 7.7%, 1.4%, 0.3%, and 30%, respectively, of total TP land (1)Due to its existence in dry, high altitude and cold environments, the TP ecosystem is extremely vulnerable to global climate change and studies on the TP ecosystem can be utilized as a pre-warning for other ecosystems.

Quadrivalvar Rheumatic Cardiopathy in Tetralogy of Fallot in an Adult—A Case Report

Rheumatic involvement of all four heart valves is uncommon and its association with congenital heart disease is very rare. Tetralogy of Fallot is a frequent cyanotic congenital heart disease with a survival beyond middle age. Background of this case report described the rheumatic involvement of all four heart valves (quadrivalvar rheumatic cardiopathy) with stenotic lesions of semilunar valves (aortic and pulmonary valves) and regurgitant lesions of atrioventricular valves (mitral and tricuspid valves) in Tetralogy of Fallot in a 48-year old asymptomatic female, detected by transthoracic two dimensional echocardiography in Thoothukudi region of India.

Recent advance in synthesis and application of heteroatom zeolites

Incorporation of heteroatoms into the framewo rk of zeolites has become a significant strategy to improve their performance in catalysis and adsorption,because the obtained heteroatom zeolites exhibit quite different properties from the conventional aluminosilicate zeolites in aspects of surface acidity,pore structures,particle size and so on.In this review,the progress on the heteroatom zeolites including their synthesis and application is highlighted.First,the recent advance on the design and synthesis of different heteroatom zeolites is summarized.Special emphasis is placed on the introduction and comparison of three typical methods,including the direct synthesis,post synthesis and improved direct synthesis,for the traditional heteroatom zeolites(such as TS-1,Sn-MFI,Sn-β) and newly-reported heteroatom zeolites(such as W-MFI,Mo-MFI).According to their intrinsic characteristics,the application of heteroatom zeolites in diverse fields,such as production of fine chemicals,air pollution control and biomass conversion is then discussed.Finally,the challenges and perspective on the future development of heteroatom zeolites in low-cost preparation and practical application are proposed.

包皮环切术的研究进展及应用现状

包皮环切术是治疗男性包皮过长、包茎等疾病最简单、最常用和最有效的方法。包皮环切术也从传统方法向着更简单、快速、微创的“器械式”方法转变。本文就包皮环切术的手术方式(传统包皮环切术、电刀包皮环切术、激光包皮环切术、袖套式包皮环切术和阴茎根部皮肤环切术、商环、Gomco钳、Mogen夹、PlastiBell、PrePex、Alisklamp和一次性包皮环切缝合器)进行综述,希望能够为临床医生给患者选择合适的包皮环切方法提供参考依据。

国内外加热电缆的发展现状

按照发热元件的不同对加热电缆进行分类介绍,从加热电缆的研究进展、应用现状和市场现状等方面对目前加热电缆的发展进行了概述。对国内外现行加热电缆标准进行了整理,按照适用范围对其进行分类,并分析了国内外加热电缆的标准在制定中存在的一些差距(引用文献69篇)。

真空预冷技术的现状和发展前景

概述了国内外真空预冷技术的研究现状和应用情况,总结了该技术目前存在的问题,提出了今后研究的方向和建议。