The precise detection and segmentation of tumor lesions are very important for lung cancer computer-aided diagnosis.However,in PET/CT(Positron Emission Tomography/Computed Tomography)lung images,the lesion shapes are ...The precise detection and segmentation of tumor lesions are very important for lung cancer computer-aided diagnosis.However,in PET/CT(Positron Emission Tomography/Computed Tomography)lung images,the lesion shapes are complex,the edges are blurred,and the sample numbers are unbalanced.To solve these problems,this paper proposes a Multi-branch Cross-scale Interactive Feature fusion Transformer model(MCIF-Transformer Mask RCNN)for PET/CT lung tumor instance segmentation,The main innovative works of this paper are as follows:Firstly,the ResNet-Transformer backbone network is used to extract global feature and local feature in lung images.The pixel dependence relationship is established in local and non-local fields to improve the model perception ability.Secondly,the Cross-scale Interactive Feature Enhancement auxiliary network is designed to provide the shallow features to the deep features,and the cross-scale interactive feature enhancement module(CIFEM)is used to enhance the attention ability of the fine-grained features.Thirdly,the Cross-scale Interactive Feature fusion FPN network(CIF-FPN)is constructed to realize bidirectional interactive fusion between deep features and shallow features,and the low-level features are enhanced in deep semantic features.Finally,4 ablation experiments,3 comparison experiments of detection,3 comparison experiments of segmentation and 6 comparison experiments with two-stage and single-stage instance segmentation networks are done on PET/CT lung medical image datasets.The results showed that APdet,APseg,ARdet and ARseg indexes are improved by 5.5%,5.15%,3.11%and 6.79%compared with Mask RCNN(resnet50).Based on the above research,the precise detection and segmentation of the lesion region are realized in this paper.This method has positive significance for the detection of lung tumors.展开更多
Preventive maintenance in the transformer is performed through a dif-ferential relay protection system,and it protects the transformer from internal and external faults.However,the Current Transformer(CT)in the differ...Preventive maintenance in the transformer is performed through a dif-ferential relay protection system,and it protects the transformer from internal and external faults.However,the Current Transformer(CT)in the differential protec-tion system mal-operates during inrush currents.CT saturates due to magnetizing inrush currents and causes false tripping of the differential relays.Moreover,iden-tification of tripping in protection relay either due to inrush current or internal faults needs to be diagnosed.For the above problem,continuous monitoring of transformer breather and CT terminals with thermal camera helps detect the trip-ping in relay due to inrush or internal fault.The transformer’s internal fault leads to high breathing process in the transformer breather,never for inrush currents.During inrush currents,CT temperature is increased.Continuous monitoring of breather and CT of the transformer through thermal imaging and radiometric pix-els detect the causes of CT saturation and differentiates maloperation.Hybrid wavelet threshold image analytics(HWT-IA)based radiometric pixels analysis of the transformer breather and CT after de-noising provides an accurate result of about 95%for identification of the false tripping of differential protection system of transformer.展开更多
For actively modulated In-line Sagnac interferential all optic fiber current transformers (AOFCTs), the accuracies are directly affected by the amplitude of the modulation signal. In order to deeply undertand the func...For actively modulated In-line Sagnac interferential all optic fiber current transformers (AOFCTs), the accuracies are directly affected by the amplitude of the modulation signal. In order to deeply undertand the function of the modulator, a theoretical model of modulation effect to AOFCTs is built up in this paper. The effect of the amplitude of the modulation signal to the output intensity of AOFCTs is theoretically formulated and numerical calculated. The results show that the modulation voltage variation could affect the output accuracies significantly. This might be some references on the investigation for practical applications of AOFCTs.展开更多
Practically,the load currents in three phases are asymmetric in the power system.It means that the impedances are different in all three phases.If the consumer’s transformer neutral cut off and/or was disconnected fr...Practically,the load currents in three phases are asymmetric in the power system.It means that the impedances are different in all three phases.If the consumer’s transformer neutral cut off and/or was disconnected from the neutral of power supply source,then there will be some trouble and failure occurred.The current in the neutral wire drops down to zero when the neutral wire is cut off and the phase currents of all three-phase equal to each other since there was no return wire.The currents are equal but the voltages at the phase consumers are different.Especially for residential single-phase consumers,the voltage at the consumers of the phase varies differently for three phase systems when the neutral wire was disconnected at consumer side and even the voltage at the consumers one or two of those three phases becomes over nominal voltage or reaches nearly line voltage.In this case,the electronic appliances in that phase will be fed by high voltage than the rated value and they can be broken down.In the power system of UB(Ulaanbaatar)city,there are some occasional such kind of failures every year.Obviously,many electronic appliances were broken down due to high voltage and the electricity utility companies respond for service charge of damaged parts.展开更多
Transforming growth factor-beta 1(TGF-β1)has been extensively studied for its pleiotropic effects on central nervous system diseases.The neuroprotective or neurotoxic effects of TGF-β1 in specific brain areas may de...Transforming growth factor-beta 1(TGF-β1)has been extensively studied for its pleiotropic effects on central nervous system diseases.The neuroprotective or neurotoxic effects of TGF-β1 in specific brain areas may depend on the pathological process and cell types involved.Voltage-gated sodium channels(VGSCs)are essential ion channels for the generation of action potentials in neurons,and are involved in various neuroexcitation-related diseases.However,the effects of TGF-β1 on the functional properties of VGSCs and firing properties in cortical neurons remain unclear.In this study,we investigated the effects of TGF-β1 on VGSC function and firing properties in primary cortical neurons from mice.We found that TGF-β1 increased VGSC current density in a dose-and time-dependent manner,which was attributable to the upregulation of Nav1.3 expression.Increased VGSC current density and Nav1.3 expression were significantly abolished by preincubation with inhibitors of mitogen-activated protein kinase kinase(PD98059),p38 mitogen-activated protein kinase(SB203580),and Jun NH2-terminal kinase 1/2 inhibitor(SP600125).Interestingly,TGF-β1 significantly increased the firing threshold of action potentials but did not change their firing rate in cortical neurons.These findings suggest that TGF-β1 can increase Nav1.3 expression through activation of the ERK1/2-JNK-MAPK pathway,which leads to a decrease in the firing threshold of action potentials in cortical neurons under pathological conditions.Thus,this contributes to the occurrence and progression of neuroexcitatory-related diseases of the central nervous system.展开更多
基金funded by National Natural Science Foundation of China No.62062003Ningxia Natural Science Foundation Project No.2023AAC03293.
文摘The precise detection and segmentation of tumor lesions are very important for lung cancer computer-aided diagnosis.However,in PET/CT(Positron Emission Tomography/Computed Tomography)lung images,the lesion shapes are complex,the edges are blurred,and the sample numbers are unbalanced.To solve these problems,this paper proposes a Multi-branch Cross-scale Interactive Feature fusion Transformer model(MCIF-Transformer Mask RCNN)for PET/CT lung tumor instance segmentation,The main innovative works of this paper are as follows:Firstly,the ResNet-Transformer backbone network is used to extract global feature and local feature in lung images.The pixel dependence relationship is established in local and non-local fields to improve the model perception ability.Secondly,the Cross-scale Interactive Feature Enhancement auxiliary network is designed to provide the shallow features to the deep features,and the cross-scale interactive feature enhancement module(CIFEM)is used to enhance the attention ability of the fine-grained features.Thirdly,the Cross-scale Interactive Feature fusion FPN network(CIF-FPN)is constructed to realize bidirectional interactive fusion between deep features and shallow features,and the low-level features are enhanced in deep semantic features.Finally,4 ablation experiments,3 comparison experiments of detection,3 comparison experiments of segmentation and 6 comparison experiments with two-stage and single-stage instance segmentation networks are done on PET/CT lung medical image datasets.The results showed that APdet,APseg,ARdet and ARseg indexes are improved by 5.5%,5.15%,3.11%and 6.79%compared with Mask RCNN(resnet50).Based on the above research,the precise detection and segmentation of the lesion region are realized in this paper.This method has positive significance for the detection of lung tumors.
文摘Preventive maintenance in the transformer is performed through a dif-ferential relay protection system,and it protects the transformer from internal and external faults.However,the Current Transformer(CT)in the differential protec-tion system mal-operates during inrush currents.CT saturates due to magnetizing inrush currents and causes false tripping of the differential relays.Moreover,iden-tification of tripping in protection relay either due to inrush current or internal faults needs to be diagnosed.For the above problem,continuous monitoring of transformer breather and CT terminals with thermal camera helps detect the trip-ping in relay due to inrush or internal fault.The transformer’s internal fault leads to high breathing process in the transformer breather,never for inrush currents.During inrush currents,CT temperature is increased.Continuous monitoring of breather and CT of the transformer through thermal imaging and radiometric pix-els detect the causes of CT saturation and differentiates maloperation.Hybrid wavelet threshold image analytics(HWT-IA)based radiometric pixels analysis of the transformer breather and CT after de-noising provides an accurate result of about 95%for identification of the false tripping of differential protection system of transformer.
文摘For actively modulated In-line Sagnac interferential all optic fiber current transformers (AOFCTs), the accuracies are directly affected by the amplitude of the modulation signal. In order to deeply undertand the function of the modulator, a theoretical model of modulation effect to AOFCTs is built up in this paper. The effect of the amplitude of the modulation signal to the output intensity of AOFCTs is theoretically formulated and numerical calculated. The results show that the modulation voltage variation could affect the output accuracies significantly. This might be some references on the investigation for practical applications of AOFCTs.
文摘Practically,the load currents in three phases are asymmetric in the power system.It means that the impedances are different in all three phases.If the consumer’s transformer neutral cut off and/or was disconnected from the neutral of power supply source,then there will be some trouble and failure occurred.The current in the neutral wire drops down to zero when the neutral wire is cut off and the phase currents of all three-phase equal to each other since there was no return wire.The currents are equal but the voltages at the phase consumers are different.Especially for residential single-phase consumers,the voltage at the consumers of the phase varies differently for three phase systems when the neutral wire was disconnected at consumer side and even the voltage at the consumers one or two of those three phases becomes over nominal voltage or reaches nearly line voltage.In this case,the electronic appliances in that phase will be fed by high voltage than the rated value and they can be broken down.In the power system of UB(Ulaanbaatar)city,there are some occasional such kind of failures every year.Obviously,many electronic appliances were broken down due to high voltage and the electricity utility companies respond for service charge of damaged parts.
基金supported by the Natural Science Foundation of Guangdong Province,Nos.2019A1515010649(to WC),2022A1515012044(to JS)the China Postdoctoral Science Foundation,No.2018M633091(to JS).
文摘Transforming growth factor-beta 1(TGF-β1)has been extensively studied for its pleiotropic effects on central nervous system diseases.The neuroprotective or neurotoxic effects of TGF-β1 in specific brain areas may depend on the pathological process and cell types involved.Voltage-gated sodium channels(VGSCs)are essential ion channels for the generation of action potentials in neurons,and are involved in various neuroexcitation-related diseases.However,the effects of TGF-β1 on the functional properties of VGSCs and firing properties in cortical neurons remain unclear.In this study,we investigated the effects of TGF-β1 on VGSC function and firing properties in primary cortical neurons from mice.We found that TGF-β1 increased VGSC current density in a dose-and time-dependent manner,which was attributable to the upregulation of Nav1.3 expression.Increased VGSC current density and Nav1.3 expression were significantly abolished by preincubation with inhibitors of mitogen-activated protein kinase kinase(PD98059),p38 mitogen-activated protein kinase(SB203580),and Jun NH2-terminal kinase 1/2 inhibitor(SP600125).Interestingly,TGF-β1 significantly increased the firing threshold of action potentials but did not change their firing rate in cortical neurons.These findings suggest that TGF-β1 can increase Nav1.3 expression through activation of the ERK1/2-JNK-MAPK pathway,which leads to a decrease in the firing threshold of action potentials in cortical neurons under pathological conditions.Thus,this contributes to the occurrence and progression of neuroexcitatory-related diseases of the central nervous system.
