Deep tectonics and seismogenic mechanisms of the seismic source zone of the Jishishan M_(s)6.2 earthquake on December 18,2023,at the northeast margin of the Tibetan Plateau

On December 18,2023,an M_(s)6.2 earthquake occurred in Jishishan,Gansu Province,China.This earthquake happened in the eastern region of the Qilian Orogenic Belt,which is situated at the forefront of the NE margin of the Tibetan Plateau(i.e.,Qinghai-Tibet Plateau),encompassing a rhombic-shaped area that intersects the Qilian-Qaidam Basin,Alxa Block,Ordos Block,and South China Block.In this study,we analyzed the deep tectonic pattern of the Jishishan earthquake by incorporating data on the crustal thickness,velocity structure,global navigation satellite system(GNSS)strain field,and anisotropy.We discovered that the location of the earthquake was related to changes in the crustal structure.The results showed that the Jishishan M_(s)6.2 earthquake occurred in a unique position,with rapid changes in the crustal thickness,Vp/Vs,phase velocity,and S-wave velocity.The epicenter of the earthquake was situated at the transition zone between high and low velocities and was in proximity to a low-velocity region.Additionally,the source area is flanked by two high-velocity anomalies from the east and west.The principal compressive strain orientation near the Lajishan Fault is primarily in the NNE and NE directions,which align with the principal compressive stress direction in this region.In some areas of the Lajishan Fault,the principal compressive strain orientations show the NNW direction,consistent with the direction of the upper crustal fast-wave polarization from local earthquakes and the phase velocity azimuthal anisotropy.These features underscore the relationship between the occurrence of the Jishishan M_(s)6.2 earthquake and the deep inhomogeneous structure and deep tectonic characteristics.The NE margin of the Tibetan Plateau was thickened by crustal extension in the process of northeastward expansion,and the middle and lower crustal materials underwent structural deformation and may have been filled with salt-containing fluids during the extension process.The presence of this weak layer makes it easier for strong earthquakes to occur through the release of overlying rigid crustal stresses.However,it is unlikely that an earthquake of comparable or larger magnitude would occur in the short term(e.g.,in one year)at the Jishishan east margin fault.

Marginal zone lymphoma with severe rashes: A case report

BACKGROUND Marginal zone lymphoma(MZL)is an indolent subtype of non-Hodgkin lymphoma(NHL),which is rare clinically with severe rashes as the initial symptom.CASE SUMMARY This study reports a case of MZL with generalized skin rashes accompanied by pruritus and purulent discharge.First-line treatment with rituximab combined with zanubrutinib had poor effects.However,after switching to obinutuzumab combined with zanubrutinib,the case was alleviated,and the rashes disappeared.CONCLUSION For patients with advanced stage MZL not benefiting from type I anti-CD20 monoclonal antibody(mAb)combination therapy,switching to a type II anti-CD20 mAb combination regimen may be considered.This approach may provide a new perspective in the treatment of MZL.

The largest CPIES array in the marginal sea:abundant dynamics in the northeast South China Sea

The South China Sea(SCS)is a marginal sea connecting the Pacific and Indian oceans and has gained much attention in recent decades.The dynamics in the northeast SCS are considerably influenced by topography,monsoons,tropical cyclones,the Kuroshio intrusion,and water exchange through the Luzon Strait(LS).

Distal margin distance in radical resection of locally advanced rectal cancer after neoadjuvant therapy

Colorectal cancer has a high incidence and mortality rate in China, with the majority of cases being middle and low rectal cancer. Surgical intervention is currently the main treatment modality for locally advanced rectal cancer, with the common goal of improving oncological outcomes while preserving function. The controversy regarding the circumferential resection margin distance in rectal cancer surgery has been resolved. With the promotion of neoadjuvant therapy concepts and advancements in technology, treatment strategies have become more diverse.Following tumor downstaging, there is an increasing trend towards extending the safe distance of distal rectal margin. This provides more opportunities for patients with low rectal cancer to preserve their anal function.However, there is currently no consensus on the specific distance of distal resection margin.

Bendamustine and rituximab as frontline therapy in extranodal marginal zone lymphoma:a single-institution experience

Extranodal marginal zone lymphoma(EMZL)encompasses 70%of cases of marginal zone lymphoma.Frontline bendamustine and rituximab(BR)were derived from trials involving other indolent non-Hodgkin’s lymphomas.Only one trial has evaluated frontline BR prospectively in EMZL.This retrospective study reports outcomes among EMZL patients receiving frontline BR.Twenty-five patients were included with a median age of 69 years(40–81).Five(20.0%)patients had stage Ⅰ/Ⅱ disease,and 20(80.0%)had stage Ⅲ/Ⅳ disease.The median number of cycles was 6.0(3.0–6.0).Maintenance rituximab was administered to 10(41.7%)individuals.Overall response rate(ORR)was 100.0%(60.0%complete response,40.0%partial response).Medians of overall survival and progression-free survival were not reached.The estimated 2-year progression-free survival was 85.2%and overall survival was 100.0%.Four(16.6%)patients had infections related to treatment;3(12.0%)transformed to diffuse large B-cell lymphoma;5(20.8%)had a relapse or progression of EMZL;and 3(12.0%)died unrelated to BR.BR is an efficacious and well-tolerated front-line regimen for EMZL with response data consistent with existing literature.

Depositional model of the Member Deng-2 marginal microbial mound-bank complex of the Dengying Formation in the southwestern Sichuan Basin, SW China: Implications for the Ediacaran microbial mound construction and hydrocarbon exploration

Recent advances in hydrocarbon exploration have been made in the Member Deng-2 marginal microbial mound-bank complex reservoirs of the Dengying Formation in the western Sichuan Basin, SW China,where the depositional process is regarded confusing. The microfacies, construction types, and depositional model of the Member Deng-2 marginal microbial mound-bank complex have been investigated using unmanned aerial vehicle photography, outcrop section investigation, thin section identification,and seismic reflections in the southwestern Sichuan Basin. The microbialite lithologic textures in this region include thrombolite, dendrolite, stromatolite, fenestral stromatolite, spongiostromata stone,oncolite, aggregated grainstone, and botryoidal grapestone. Based on the comprehensive analysis of“depositional fabrics-lithology-microfacies”, an association between a fore mound, mound framework,and back mound subfacies has been proposed based on water depth, current direction, energy level and lithologic assemblages. The microfacies of the mound base, mound core, mound flank, mound cap, and mound flat could be recognized among the mound framework subfacies. Two construction types of marginal microbial mound-bank complex have been determined based on deposition location, mound scale, migration direction, and sedimentary facies association. Type Jinkouhe microbial mound constructions(TJMMCs) develop along the windward margin owing to their proximity to the seaward subfacies fore mound, with a northeastwardly migrated microbial mound on top of the mud mound,exhibiting the characteristics of large-sized mounds and small-sized banks in the surrounding area. Type E'bian microbial mound constructions(TEMMCs) primarily occur on the leeward margin, resulting from the presence of onshore back mound subfacies, with the smaller southwestward migrated microbial mounds existing on a thicker microbial flat. The platform margin microbial mound depositional model can be correlated with certain lateral comparison profile and seismic reflection structures in the 2D seismic section, which can provide references for future worldwide exploration. Microbial mounds with larger buildups and thicker vertical reservoirs are typically targeted on the windward margin, while small-sized microbial mounds and flats with better lateral connections are typically focused on the leeward margin.

Three-dimensional constrained gravity inversion of Moho depth and crustal structural characteristics at Mozambique continental margin

Mozambique's continental margin in East Africa was formed during the break-off stage of the east and west Gondwana lands. Studying the geological structure and division of continent-ocean boundary(COB) in Mozambique's continental margin is considered of great significance to rebuild Gondwana land and understand its movement mode. Along these lines, in this work, the initial Moho was fit using the known Moho depth from reflection seismic profiles, and a 3D multi-point constrained gravity inversion was carried out. Thus, highaccuracy Moho depth and crustal thickness in the study area were acquired. According to the crustal structure distribution based on the inversion results, the continental crust at the narrowest position of the Mozambique Channel was detected. According to the analysis of the crustal thickness, the Mozambique ridge is generally oceanic crust and the COB of the whole Mozambique continental margin is divided.

Linkage between precipitation isotopes and water vapor sources in the monsoon margin:Evidence from arid areas of Northwest China

The isotope composition in precipitation has been widely considered as a tracer of monsoon activity.Compared with the coastal region,the monsoon margin usually has limited precipitation with large fluctuation and is usually sensitive to climate change.The water resource management in the monsoon margin should be better planned by understanding the composition of precipitation isotope and its influencing factors.In this study,the precipitation samples were collected at five sampling sites(Baiyin City,Kongtong District,Maqu County,Wudu District,and Yinchuan City)of the monsoon margin in the northwest of China in 2022 to analyze the characteristics of stable hydrogen(δD)and oxygen(δ18O)isotopes.We analyzed the impact of meteorological factors(temperature,precipitation,and relative humidity)on the composition of precipitation isotope at daily level by regression analysis,utilized the Hybrid Single-Particle Lagrangian Integrated Trajectory(HYSPLIT)-based backward trajectory model to simulate the air mass trajectory of precipitation events,and adopted the potential source contribution function(PSCF)and concentration weighted trajectory(CWT)to analyze the water vapor sources.The results showed that compared with the global meteoric water line(GMWL),the slope of the local meteoric water line(LMWL;δD=7.34δ^(18)O-1.16)was lower,indicating the existence of strong regional evaporation in the study area.Temperature significantly contributed toδ18O value,while relative humidity had a significant negative effect onδ18O value.Through the backward trajectory analysis,we found eight primary locations that were responsible for the water vapor sources of precipitation in the study area,of which moisture from the Indian Ocean to South China Sea(ITSC)and the western continental(CW)had the greatest influence on precipitation in the study area.The hydrogen and oxygen isotopes in precipitation are significantly influenced by the sources and transportation paths of air mass.In addition,the results of PSCF and CWT analysis showed that the water vapor source areas were primarily distributed in the south and northwest direction of the study area.

Influences of burial process on diagenesis and high-quality reservoir development of deep-ultra-deep clastic rocks:A case study of Lower Cretaceous Qingshuihe Formation in southern margin of Junggar Basin,NW China

Taking the Lower Cretaceous Qingshuihe Formation in the southern margin of Junggar Basin as an example,the influences of the burial process in a foreland basin on the diagenesis and the development of high-quality reservoirs of deep and ultra-deep clastic rocks were investigated using thin section,scanning electron microscope,electron probe,stable isotopic composition and fluid inclusion data.The Qingshuihe Formation went through four burial stages of slow shallow burial,tectonic uplift,progressive deep burial and rapid deep burial successively.The stages of slow shallow burial and tectonic uplift not only can alleviate the mechanical compaction of grains,but also can maintain an open diagenetic system in the reservoirs for a long time,which promotes the dissolution of soluble components by meteoric freshwater and inhibits the precipitation of dissolution products in the reservoirs.The late rapid deep burial process contributed to the development of fluid overpressure,which effectively inhibits the destruction of primary pores by compaction and cementation.The fluid overpressure promotes the development of microfractures in the reservoir,which enhances the dissolution effect of organic acids.Based on the quantitative reconstruction of porosity evolution history,it is found that the long-term slow shallow burial and tectonic uplift processes make the greatest contribution to the development of deep-ultra-deep high-quality clastic rock reservoirs,followed by the late rapid deep burial process,and the progressive deep burial process has little contribution.

Transformation of marginal zone lymphoma into high-grade B-cell lymphoma expressing terminal deoxynucleotidyl transferase:A case report

BACKGROUND High-grade B-cell lymphoma(HGBL)is an unusual malignancy that includes myelocytomatosis viral oncogene(MYC),B-cell lymphoma-2(BCL-2),and/or BCL-6 rearrangements,termed double-hit or triple-hit lymphomas,and HGBL-not otherwise specific(HGBL-NOS),which are morphologically characteristic of HGBL but lack MYC,BCL-2,or BCL-6 rearrangements.HGBL is partially transformed by follicular lymphoma and other indolent lymphoma,with few cases of marginal zone lymphoma(MZL)transformation.HGBL often has a poor prognosis and intensive therapy is currently mainly advocated,but there is no good treatment for these patients who cannot tolerate chemotherapy.CASE SUMMARY We reported a case of MZL transformed into HGBL-NOS with TP53 mutation and terminal deoxynucleotidyl transferase expression.Gene analysis revealed the gene expression profile was identical in the pre-and post-transformed tissues,suggesting that the two diseases are homologous,not secondary tumors.The chemotherapy was ineffective and the side effect was severe,so we tried combination therapy including venetoclax and obinutuzumab.The patient tolerated treatment well,and reached partial response.The patient had recurrence of hepatocellular carcinoma and died of multifunctional organ failure.He survived for 12 months after diagnosis.CONCLUSION Venetoclax combined with obinutuzumab might improve the survival in some HGBL patients,who are unsuitable for chemotherapy.

Moho反射波噪声干涉方法及其在青藏高原东北缘地壳结构成像的应用初探

基于南北地震带北段布设的密集流动地震台阵的连续波形记录,采用台阵噪声干涉技术获得了青藏高原东北缘Moho面PmP反射波,利用已有的区域三维地壳速度模型,采用沉积层校正方法建立研究区域的三维地壳初始模型,进而对噪声互相关函数进行基准面校正,然后采用共中心点叠加方法获得了研究区的地壳厚度分布.结果显示,青藏高原东北缘及周边不同块体地壳厚度差异显著,沿青藏高原北东向的扩展方向,地壳厚度逐渐变薄.祁连造山带中、西段地壳厚度约55~65 km,西秦岭造山带地壳厚度从西至东从53 km左右减小至42 km上下,阿拉善块体地壳厚度约50 km,鄂尔多斯块体西缘地壳厚度约40~45 km.六盘山断裂、海原断裂与天景山断裂附近呈现局部的地壳增厚,并且出现脉冲状Moho面反射震相,表明断裂带附近可能存在速度跃变较大的Moho面结构.祁连山北缘断裂出现叠置的反射震相,推测下地壳的逆冲形成了此类Moho结构.

基于不同Margin的人脸特征选择及识别方法

Margin在机器学习中具有很重要的意义,基于margin的特征选择方法就是从分类的角度对特征集各特征的权重进行分析。该文对不同的margin进行了分析,提出将sample-margin和hypothesis-margin分别作为特征选择标准对SBS特征选择方法进行改进,然后设计具有最佳超参数的SVM多项式分类器进行人脸识别。实验在FRERT人脸图像库上进行并与Relief特征选择方法进行了比较,对SVM和NN分类器的实验结果也进行了分析。实验结果显示:该文提出的人脸识别特征选择及识别方法是有效、适用的。

建筑设计生成方法教学研究——“ceiling Margin”生成工具工程实践

计算机生成方法通过相关算法对建筑元素自组织优化组合,借助传统设计方法不易获得的艺术灵感,它将生成系统作为全新建筑设计方法并趋向艺术实践的程序创作系统。介绍了东南大学2007毕业班建筑生成设计研究组的教学探索及工程实践,通过"ceiling Margin"吊顶生成工具的程序开发、加工及安装,阐述全新建筑设计生成方法。

快速Marginalized粒子滤波器在纯方位跟踪中的应用

为提高纯方位跟踪性能,降低粒子滤波方法的运算量,在原有Marginalized粒子滤波器(MPF)的基础上,对线性部分处理方法进行简化,提出了快速Marginalized粒子滤波器(FMPF),并结合纯方位跟踪模型,推导了FMPF应用的具体算法步骤,使用机动目标纯方位跟踪仿真实例,与其他滤波器进行了仿真对比,分析了跟踪性能和计算量。仿真结果表明,与标准粒子滤波器相比,FMPF可以提高线性部分的计算精度,同时减少MPF所需的计算量。

Temporal-Spatial Variances of Holocene Precipitation at the Marginal Area of the East Asian Monsoon Influences from Pollen Evidence

The woodland-steppe ecotone in the. southern Nei Mongol Plateau is located at the northern edge of the east Asian monsoon influences. A marked southeastern - northwestern (SE - NW) precipitation gradient exists in this region. Quantitative reconstruction of palaeo-precipitation of this region is helpful to reveal the development of monsoon climate and to predict die future desertification. Based on modern vegetation and surface pollen studies, a pollen-precipitation transfer function in the study region was established. Pollen data from three sediment sequences within the ecotone were used to reconstruct palaeo-precipitation during the Holocene. The processes of precipitation changes in the three sequences were quite different. There was a tendency of precipitation declined from the onset of the Holocene to 1 100 a BP in Haoluku. But, in Liuzhouwan and Xiaoniuchang, both located south of Haoluku, the annual precipitation reached highest values during 7 800 - 6 200 a BP and 7 200 - 5 000 a BP, respectively. The influences of southwestern (SW) monsoon and the variances of topographical conditions have possibly caused these temporal-spatial variances.

基于权重一致性优化的实时Marginalized粒子滤波算法

针对Marginalized粒子滤波中随机量测噪声对于非线性状态估计精度的不利影响以及线性状态估计中计算量较大问题,提出了一种基于权重一致性优化的实时Marginalized粒子滤波算法.首先,结合量测系统建模中先验信息的提取和利用,通过粒子权重间一致性距离和一致性矩阵的构建,提出了量测提升策略下权重的一致性优化方法,以改善粒子滤波在非线性状态估计中的滤波精度.其次,通过对Marginalized粒子滤波实现中时间更新和量测更新环节的结构优化,给出了实时Marginalized粒子滤波,以降低蒙特卡罗仿真实现下卡尔曼滤波在状态线性估计中的计算复杂度.最后,在两者的动态结合基础上给出了新算法具体实现步骤.利用基于单站雷达目标跟踪仿真场景,分析了算法性能.理论分析和仿真实验结果验证了算法的可行性和有效性.

The 3D magnetic structure beneath the continental margin of the northeastern South China Sea

Understanding the continental margin of the Northeastern South China Sea is critical to the study of deep structures, tectonic evolution, and dynamics of the region. One set of important data for this endeavor is the total-field magnetic data. Given the challenges associated with the magnetic data at low latitudes and with remanent magnetism in this area, we combine the equivalent-source technique and magnetic amplitude inversion to recover 3D subsurface magnetic structures. The inversion results show that this area is characterized by a north-south block division and east-west zonation. Magnetic regions strike in EW, NE and NW direction and are consistent with major tectonic trends in the region. The highly magnetic zone recovered from inversion in the continental margin differs visibly from that of the magnetically quiet zones to the south. The magnetic anomaly zone strikes in NE direction, covering an area of about 500 km × 60 km, and extending downward to a depth of 25 km or more. In combination with other geophysical data, we suggest that this strongly magnetic zone was produced by deep underplating of magma associated with plate subduction in Mesozoic period. The magnetically quiet zone in the south is an EW trending unit underlain by broad and gentle magnetic layers of lower crust. Its magnetic structure bears a clear resemblance to oceanic crust, assumed to be related to the presence of ancient oceanic crust there.

基于CSS盒子模型的margin属性解析

以盒子模型为基础分析盒子外边距(margin)属性的特征,着重分析了盒子与盒子之间的关系和盒子之间距离的设置规则,并通过实例讨论了CSS的"塌陷"现象以及解决"塌陷"现象的方法,从而掌握应用CSS技术对网页元素进行精确定位的基本方法。

Analyzing our educational resource deployment of compulsory education by marginal utility

In the base of utility and marginal utility,the article put forwardthe concept of utility and marginal utilityof educational outlay and the theory of them,and analyzed the actuality of educational resource deployment in ourcountry,gave some advice about howtoi mprove our educational resource deployment of compulsory education.

Effects of Sowing Rate on Marginal Superiority and Yield of Wheat in Wheat-cotton Intercropping System

In the wheat-cotton intercropping system, total 6 sowing rates （187.5, 225.0, 262.5, 300.0, 337.5 and 375.0 kg/hm2） were arranged, and the effects of sowing rate on marginal superiority and yield of wheat were investigated. The re- sults showed that the effect of sowing rate on inner-line wheat was greater than that on side-line wheat; with the increased sowing rate, the marginal superiority of panicle number was reduced in overall, and the difference in panicle number be- tween inner and side lines was decreased from 9.0×10^5/hm2 （sowing rate of 187.5 kg/hm2） to 7.8×10^5/hm2 （sowing rate of 375.0 kg/hm2）; the marginal superiority of grains per spike was increased first and then reduced, and the largest difference in grains per spike between the inner and side lines reached 4.6 under the sowing rate of 300.0 kg/hm2; the marginal superiority of 1 000-grain weight and yield was gradually increased, and the largest difference in 1 000-grain weight between the inner and side lines reached 3.9 g under the sowing rate of 337.5 kg/hm2, and in yield reached 3 136.5 kg/hm2under the sowing rate of 375.0 kg/hm2. The effects of sowing rate on the three yield factors of intercropped wheat ranked as panicle number 〉 grains per spike 〉 1 000-grain weight. The appropriate sowing rate of wheat was 225.0-262.0 kg/hm2 in the wheat-cotton intercropping system.