The purpose of this paper is to examine the development of a curriculum in Japan to foster the agency(OECD Student Agency)necessary for children living in the future,as outlined in the OECD Education2030 Project,and t...The purpose of this paper is to examine the development of a curriculum in Japan to foster the agency(OECD Student Agency)necessary for children living in the future,as outlined in the OECD Education2030 Project,and the role of teachers who implement this curriculum.Therefore,I aim to achieve this goal by taking an overview of educational thought,educational systems and history,and examining several initiatives in the OECD Project and the situation of a Japanese high school that practices science and mathematics education.As a result of analyzing previous research and the narratives obtained from interviews with Teacher A(pseudonym)of a certain F High School(pseudonym),it was found that school education should not simply teach subjects,but should aim to enable student to help student exercise agency in the future.It was suggested that it is not necessary to add content to the curriculum,but rather to prepare to provide students with competencies that will enable them to use the content in various contexts,situations,and circumstances,suggesting that in order to discover such important competencies,teachers and other related parties are required to implement curricula that allow students to slowly and carefully explore the competencies surrounding the content,and to conceive and build curricula that include both hidden and intended curriculum that allows student to reflect on the curriculum they have achieved.展开更多
Using methods such as questionnaire survey and literature review,a survey was conducted on the professional development of physical education teachers in Huaiji County under the background of the new curriculum standa...Using methods such as questionnaire survey and literature review,a survey was conducted on the professional development of physical education teachers in Huaiji County under the background of the new curriculum standards.The research results found that physical education teachers in Huaiji County have a relatively good distribution structure in terms of teaching experience,age,and education level,but the gender ratio and professional title ratio need to be improved.In terms of professional competence,teachers have shown good performance in teaching implementation ability,but there is still room for improvement in teaching design ability.A certain proportion of teachers still express dissatisfaction with professional title promotion,hardware configuration satisfaction,salary and benefits,and school reward mechanisms.Based on this,this study proposes some measures to improve the professional development level of county-level physical education teachers,such as enhancing teachers teaching design and implementation abilities,strengthening the cultivation of technical action demonstration abilities,improving hardware configuration satisfaction and teaching effectiveness reflection level,strengthening guidance and support for teachers professional development,and enhancing the promotion and implementation of post employment training.展开更多
As a nation with an extensive coastline,China has regions that have flourished and prospered due to the sea,and marine culture has developed vigorously,with marine literature being an indispensable component.In the ne...As a nation with an extensive coastline,China has regions that have flourished and prospered due to the sea,and marine culture has developed vigorously,with marine literature being an indispensable component.In the new era,the youth in higher education institutions should focus on the ocean,listen to,inherit,and promote marine literature,aligning with policies to establish confidence in marine culture.Research indicates that the integration of marine literature offers numerous benefits to students’learning and future development,playing a crucial role in education.This paper will analyze the significance of marine literature in education,its current development status,and explore the application value of Chinese marine literature in educational settings.展开更多
Under the background of“new engineering”construction,software engineering teaching pays more attention to cultivating students’engineering practice and innovation ability.In view of the inconsistency between develo...Under the background of“new engineering”construction,software engineering teaching pays more attention to cultivating students’engineering practice and innovation ability.In view of the inconsistency between development and demand design,team division of labor,difficult measurement of individual contribution,single assessment method,and other problems in traditional practice teaching,this paper proposes that under the guidance of agile development methods,software engineering courses should adopt Scrum framework to organize course project practice,use agile collaboration platform to implement individual work,follow up experiment progress,and ensure effective project advancement.The statistical data of curriculum“diversity”assessment show that there is an obvious improvement effect on students’software engineering ability and quality.展开更多
The technological revolution and the explosion of information have created a diverse world.More and more so-called advanced cultures are entering kindergartens,prompting us to think about how to correctly develop the ...The technological revolution and the explosion of information have created a diverse world.More and more so-called advanced cultures are entering kindergartens,prompting us to think about how to correctly develop the existing local cultures in the cultural context,while simultaneously accepting and absorbing the appropriate parts of foreign cultures.It is also necessary to maintain a balance between diversity and localization to prevent kindergartens from becoming a“colony”of foreign cultures.The development of suitable,cultural,and life-oriented kindergarten curricula from different perspectives is the focus of such a balance.Only in this way can kindergartens truly fulfill their educational functions and provide a vibrant and colorful environment for children.展开更多
In eukaryotic cells,organelles in the secretory,lysosomal,and endocytic pathways actively exchange biological materials with each other through intracellular membrane trafficking,which is the process of transporting t...In eukaryotic cells,organelles in the secretory,lysosomal,and endocytic pathways actively exchange biological materials with each other through intracellular membrane trafficking,which is the process of transporting the cargo of proteins,lipids,and other molecules to appropriate compartments via transport vesicles or intermediates.These processes are strictly regulated by various small GTPases such as the RAS-like in rat brain(RAB)protein family,which is the largest subfamily of the RAS superfamily.Dysfunction of membrane trafficking affects tissue homeostasis and leads to a wide range of diseases,including neurological disorders and neurodegenerative diseases.Therefore,it is important to understand the physiological and pathological roles of RAB proteins in brain function.RAB35,a member of the RAB family,is an evolutionarily conserved protein in metazoans.A wide range of studies using cultured mammalian cells and model organisms have revealed that RAB35 mediates various processes such as cytokinesis,endocytic recycling,actin bundling,and cell migration.RAB35 is also involved in neurite outgrowth and turnover of synaptic vesicles.We generated brain-specific Rab35 knockout mice to study the physiological roles of RAB35 in brain development and function.These mice exhibited defects in anxiety-related behaviors and spatial memory.Strikingly,RAB35 is required for the precise positioning of pyramidal neurons during hippocampal development,and thereby for normal hippocampal lamination.In contrast,layer formation in the cerebral cortex occurred superficially,even in the absence of RAB35,suggesting a predominant role for RAB35 in hippocampal development rather than in cerebral cortex development.Recent studies have suggested an association between RAB35 and neurodegenerative diseases,including Parkinson's disease and Alzheimer's disease.In this review,we provide an overview of the current understanding of subcellular functions of RAB35.We also provide insights into the physiological role of RAB35 in mammalian brain development and function,and discuss the involvement of RAB35 dysfunction in neurodegenerative diseases.展开更多
The theoretical and applied characteristics of educational psychology courses in colleges and universities are prominent,and actively promoting curriculum reform is more conducive to promoting the implementation of ta...The theoretical and applied characteristics of educational psychology courses in colleges and universities are prominent,and actively promoting curriculum reform is more conducive to promoting the implementation of talent training goals,which is in line with the practical needs of social development for high-quality talents.However,curriculum reform is a systematic project,which involves the innovation of curriculum content systems,teaching methods,teaching evaluations,and so on.This paper mainly expounds on the curriculum reform path in the period of high-quality development of educational psychology in colleges and universities,hoping to play a reference role in improving the level of education management.展开更多
Human brain development is a complex process,and animal models often have significant limitations.To address this,researchers have developed pluripotent stem cell-derived three-dimensional structures,known as brain-li...Human brain development is a complex process,and animal models often have significant limitations.To address this,researchers have developed pluripotent stem cell-derived three-dimensional structures,known as brain-like organoids,to more accurately model early human brain development and disease.To enable more consistent and intuitive reproduction of early brain development,in this study,we incorporated forebrain organoid culture technology into the traditional unguided method of brain organoid culture.This involved embedding organoids in matrigel for only 7 days during the rapid expansion phase of the neural epithelium and then removing them from the matrigel for further cultivation,resulting in a new type of human brain organoid system.This cerebral organoid system replicated the temporospatial characteristics of early human brain development,including neuroepithelium derivation,neural progenitor cell production and maintenance,neuron differentiation and migration,and cortical layer patterning and formation,providing more consistent and reproducible organoids for developmental modeling and toxicology testing.As a proof of concept,we applied the heavy metal cadmium to this newly improved organoid system to test whether it could be used to evaluate the neurotoxicity of environmental toxins.Brain organoids exposed to cadmium for 7 or 14 days manifested severe damage and abnormalities in their neurodevelopmental patterns,including bursts of cortical cell death and premature differentiation.Cadmium exposure caused progressive depletion of neural progenitor cells and loss of organoid integrity,accompanied by compensatory cell proliferation at ectopic locations.The convenience,flexibility,and controllability of this newly developed organoid platform make it a powerful and affordable alternative to animal models for use in neurodevelopmental,neurological,and neurotoxicological studies.展开更多
The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell cultures.However,the lack of systematic and contin...The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell cultures.However,the lack of systematic and continuous comparison between in vivo retinal development and the organotypic retinal explant culture makes this model controversial in postnatal retinal development studies.Thus,we aimed to verify the feasibility of using this model for postnatal retinal development studies by comparing it with the in vivo retina.In this study,we showed that postnatal retinal explants undergo normal development,and exhibit a consistent structure and timeline with retinas in vivo.Initially,we used SOX2 and PAX6 immunostaining to identify retinal progenitor cells.We then examined cell proliferation and migration by immunostaining with Ki-67 and doublecortin,respectively.Ki-67-and doublecortin-positive cells decreased in both in vivo and explants during postnatal retinogenesis,and exhibited a high degree of similarity in abundance and distribution between groups.Additionally,we used Ceh-10 homeodomain-containing homolog,glutamate-ammonia ligase(glutamine synthetase),neuronal nuclei,and ionized calcium-binding adapter molecule 1 immunostaining to examine the emergence of bipolar cells,Müller glia,mature neurons,and microglia,respectively.The timing and spatial patterns of the emergence of these cell types were remarkably consistent between in vivo and explant retinas.Our study showed that the organotypic retinal explant culture model had a high degree of consistency with the progression of in vivo early postnatal retina development.The findings confirm the accuracy and credibility of this model and support its use for long-term,systematic,and continuous observation.展开更多
Helps students to promote lifelong learning ability and giveing them outstanding and unique Melbourne Experience is the University of Melbourne' s commitment to the students.Ten years ago,the University of Melbour...Helps students to promote lifelong learning ability and giveing them outstanding and unique Melbourne Experience is the University of Melbourne' s commitment to the students.Ten years ago,the University of Melbourne announced a major institutional reform in order to grow esteem,to improve the quality and to take up some of the challenges of international higher education competition.The Melbourne Curriculum was characterized by distinctive Melbourne Experience which are contribute to excellent classroom experience,research experience,practice experience,e- learning experience as follows:undergraduate courses focus on flexibility and preliminary,postgraduate courses focus on diversity and feasibility,practical courses focus on applicability and situationality,online courses focus on timeliness and interactivity.The development of Melbourne Curriculum highlights that we should pay particular attention to improving the quality of talent training and promoting the development of university centered on the curriculum reform,to promoting lifelong learning ability and directing research throughout the teaching process,to developing career skill and guiding with employability skills framework,to improving the quality of online courses and establishing reputation of a famous university on a new platform.展开更多
Initial teacher preparation and teachers’ continuing professional development are two significant pillars of the teacher education enterprise. The former encompasses a wide range of teachereducation initiatives at th...Initial teacher preparation and teachers’ continuing professional development are two significant pillars of the teacher education enterprise. The former encompasses a wide range of teachereducation initiatives at the levels of diploma, bachelor’s degree, postgraduate diploma, and even master’s degree for teacher licensure purposes. These are widely documented in the literature.What is important is how teacher professional development contributes to bolstering the teachereducator force, which is relatively insufficiently documented due to the very fact that different educational systems have somewhat different expectations of such programs in relation to the ideologies and theories underpinning the teacher professional development program design and curriculum offering. Taking stock of a postgraduate diploma program in English language teaching(PGDELT) for teachers’ continuing professional development with a 31-year history housed at a premier teacher education institution in Singapore, which has successfully graduated over 1, 000 English language teachers for colleges and universities in China, I intend to highlight some of its key features, as a former student and then a lecturer on the program, in order to draw implications for sustainable growth of language teacher education programs, especially those whose main purposes are to prepare teachers of English as a second or foreign language(ESL/EFL) and provide continuing professional development opportunities for such inservice teachers.展开更多
Taking the application of virtual simulation technology of industrial robot in teaching as the researchobject, a detailed research is conducted on the importance of course, principles of curriculum development,curricu...Taking the application of virtual simulation technology of industrial robot in teaching as the researchobject, a detailed research is conducted on the importance of course, principles of curriculum development,curriculum objectives, teaching content, teaching methods, teaching process and assessment methods in severalaspects. And the actual teaching for a semester according to this research, through the virtual simulationteaching, improved teaching efficiency, improved the industrial robot application level and ability of thestudents, reduced the equipment failure rate, and laid a solid foundation for the subsequent course.展开更多
Background: As the deep influence of traditional medical education, many undergraduate nursing colleges and universities in China still keep the traditional disease-focused curriculum system. However, it became outda...Background: As the deep influence of traditional medical education, many undergraduate nursing colleges and universities in China still keep the traditional disease-focused curriculum system. However, it became outdated as the Chinese high nursing education developed. Meanwhile, the increasing demand of nursing human resources stimulates the enrollment expansion of colleges. All of these bring more difficulties and opportunities for nurse educators who are endeavoring to reform the undergraduate curriculum. Methods: The authors retrospectively reviewed the related literature, illustrated the existing challenges and opportunities during the curriculum renewal process in China. This paper also analyzed the ten- dencies of Chinese baccalaureate curriculum innovation. Results: Chinese current undergraduate nursing curriculum has larger proportion of basic medical courses, which brings great challenge for nursing educators. In the meantime, the expansion of enroll- ment brings conflicts with existing nursing education resources in China. Integration, humanization, internationalization and diversification are main tendencies leading the future nursing curriculum innovation in China. Conclusions: The more effective teaching innovations in the nursing education system are in great demand.展开更多
The significance and status of the teachers'professional development make the education system and the society pay more and more attentions.The article elaborates the internal contact of curriculum discourse and t...The significance and status of the teachers'professional development make the education system and the society pay more and more attentions.The article elaborates the internal contact of curriculum discourse and teachers'professional development from a few respects such as the rationality of curriculum discourse,the long-term nature of the teachers'professional development and many factors affecting the teachers'professional development.The article also analyzes the external and internal factors influencing Tibet foreign language teachers'professional development,and puts forward the corresponding countermeasures in the light of these problems.展开更多
This paper analyzes a total of 294 master thesis topics for students at Graduate School of Translation and Interpretation (GSTI), Beijing Foreign Studies University (BFSU) between years 2006-2010 and 160 topics at...This paper analyzes a total of 294 master thesis topics for students at Graduate School of Translation and Interpretation (GSTI), Beijing Foreign Studies University (BFSU) between years 2006-2010 and 160 topics at Graduate Institute of Interpretation and Translation (GIIT), Shanghai International Studies University (SH1SU) between years 2007-2013, with the purpose of establishing correlations between thesis topics and curriculum development, comparing and contrasting the topics between BFSU and SHISU. The study is both quantitative and qualitative. Over the years students of BFSU and SHISU have shown a progress of possessing more and more appropriate methodological expertise in selecting research topics. More and more students have examined relatively new translation theories. We also see a change from picking overdone topics to more and more original topics. Our progress in no small part thanks to our administrative measures. As for GSTI of BFSU, however there is a demand for elective courses to cover areas such as interdisciplinary approaches to translation and multimedia, which are untouched in the current courses that focus on professional translation and interpretation. We might also want to sharpen students' language skill in providing purposefully language-rich texts for practices and allowing for more diversified options, such as introducing texts in world literature, ethnic English literature, drama, poetry, and non classics. The GSTI's long term cooperation with well-known organizations, both domestic and international, especially with United Nations at Geneva and New York, and European Union, offers students many on site training and field experiences. We might also want to introduce functional research methods, thus students can learn how to transform their field experiences into academic work.展开更多
The curriculum development ability of secondary vocational school teachers is a necessary professional ability for teachers.It has important practical significance and practical value for promoting secondary vocationa...The curriculum development ability of secondary vocational school teachers is a necessary professional ability for teachers.It has important practical significance and practical value for promoting secondary vocational education curriculum and teaching reform.On the basis of analyzing the connotation and composition of curriculum development ability of teachers in secondary vocational schools,this article proposes three strategies to improve the curriculum development ability of teachers in secondary vocational schools.展开更多
This article aims to combine the connotation of Tianfu culture with primary school problem-based learning based on Sichuan Tianfu culture,producing problem-based curriculum as the output.We explore problem-based curri...This article aims to combine the connotation of Tianfu culture with primary school problem-based learning based on Sichuan Tianfu culture,producing problem-based curriculum as the output.We explore problem-based curriculum development and practical methods based on primary education.It shows the distinctive and charming regional culture,representing the mutual respect and inclusiveness of Tianfu cultural bonds.It is also the innovative expression of the characteristic schoolbased curriculum of the elementary school.展开更多
From the position setting of sightseeing agriculture businesses and ability analysis,this paper analyzes the career action field based on training objectives of sightseeing agriculture major and determines the typical...From the position setting of sightseeing agriculture businesses and ability analysis,this paper analyzes the career action field based on training objectives of sightseeing agriculture major and determines the typical tasks and career action field. According to the major teaching design of career action field,this paper introduces the systematic curriculum system of sightseeing agriculture major based on work flow.展开更多
There has been an increasing awareness in China's English language teaching profession that curriculum development should take account of the participants within the curriculum development process: the planners, the...There has been an increasing awareness in China's English language teaching profession that curriculum development should take account of the participants within the curriculum development process: the planners, the administrators, the institutions, the teachers, and the learners. This paper attempts to identify the underlying principles of the New English Curriculum in China (2001), based on which the roles of the learner, teacher, and institution that underpin the development of the new English curriculum in a secondary school in South-west China are critieaUy examined.展开更多
文摘The purpose of this paper is to examine the development of a curriculum in Japan to foster the agency(OECD Student Agency)necessary for children living in the future,as outlined in the OECD Education2030 Project,and the role of teachers who implement this curriculum.Therefore,I aim to achieve this goal by taking an overview of educational thought,educational systems and history,and examining several initiatives in the OECD Project and the situation of a Japanese high school that practices science and mathematics education.As a result of analyzing previous research and the narratives obtained from interviews with Teacher A(pseudonym)of a certain F High School(pseudonym),it was found that school education should not simply teach subjects,but should aim to enable student to help student exercise agency in the future.It was suggested that it is not necessary to add content to the curriculum,but rather to prepare to provide students with competencies that will enable them to use the content in various contexts,situations,and circumstances,suggesting that in order to discover such important competencies,teachers and other related parties are required to implement curricula that allow students to slowly and carefully explore the competencies surrounding the content,and to conceive and build curricula that include both hidden and intended curriculum that allows student to reflect on the curriculum they have achieved.
基金Key Education Research Project of Zhaoqing Education Development Research Institute in 2023(ZQJYY2023016)Key Education Research Project of Zhaoqing Education Development Research Institute in 2016(ZQJYY2016003).
文摘Using methods such as questionnaire survey and literature review,a survey was conducted on the professional development of physical education teachers in Huaiji County under the background of the new curriculum standards.The research results found that physical education teachers in Huaiji County have a relatively good distribution structure in terms of teaching experience,age,and education level,but the gender ratio and professional title ratio need to be improved.In terms of professional competence,teachers have shown good performance in teaching implementation ability,but there is still room for improvement in teaching design ability.A certain proportion of teachers still express dissatisfaction with professional title promotion,hardware configuration satisfaction,salary and benefits,and school reward mechanisms.Based on this,this study proposes some measures to improve the professional development level of county-level physical education teachers,such as enhancing teachers teaching design and implementation abilities,strengthening the cultivation of technical action demonstration abilities,improving hardware configuration satisfaction and teaching effectiveness reflection level,strengthening guidance and support for teachers professional development,and enhancing the promotion and implementation of post employment training.
基金supported by the 2023 Zhejiang Province College Students'Science and Technology Innovation Project,grant number 202312411032.
文摘As a nation with an extensive coastline,China has regions that have flourished and prospered due to the sea,and marine culture has developed vigorously,with marine literature being an indispensable component.In the new era,the youth in higher education institutions should focus on the ocean,listen to,inherit,and promote marine literature,aligning with policies to establish confidence in marine culture.Research indicates that the integration of marine literature offers numerous benefits to students’learning and future development,playing a crucial role in education.This paper will analyze the significance of marine literature in education,its current development status,and explore the application value of Chinese marine literature in educational settings.
文摘Under the background of“new engineering”construction,software engineering teaching pays more attention to cultivating students’engineering practice and innovation ability.In view of the inconsistency between development and demand design,team division of labor,difficult measurement of individual contribution,single assessment method,and other problems in traditional practice teaching,this paper proposes that under the guidance of agile development methods,software engineering courses should adopt Scrum framework to organize course project practice,use agile collaboration platform to implement individual work,follow up experiment progress,and ensure effective project advancement.The statistical data of curriculum“diversity”assessment show that there is an obvious improvement effect on students’software engineering ability and quality.
文摘The technological revolution and the explosion of information have created a diverse world.More and more so-called advanced cultures are entering kindergartens,prompting us to think about how to correctly develop the existing local cultures in the cultural context,while simultaneously accepting and absorbing the appropriate parts of foreign cultures.It is also necessary to maintain a balance between diversity and localization to prevent kindergartens from becoming a“colony”of foreign cultures.The development of suitable,cultural,and life-oriented kindergarten curricula from different perspectives is the focus of such a balance.Only in this way can kindergartens truly fulfill their educational functions and provide a vibrant and colorful environment for children.
基金supported by the Japan Society for the Promotion of Science KAKENHI(grant Nos.23K05678 to IM,19H05711 and 20H00466 to KS)the Joint Research Program of Institute for Molecular and Cellular Regulation,Gunma University(to KS)。
文摘In eukaryotic cells,organelles in the secretory,lysosomal,and endocytic pathways actively exchange biological materials with each other through intracellular membrane trafficking,which is the process of transporting the cargo of proteins,lipids,and other molecules to appropriate compartments via transport vesicles or intermediates.These processes are strictly regulated by various small GTPases such as the RAS-like in rat brain(RAB)protein family,which is the largest subfamily of the RAS superfamily.Dysfunction of membrane trafficking affects tissue homeostasis and leads to a wide range of diseases,including neurological disorders and neurodegenerative diseases.Therefore,it is important to understand the physiological and pathological roles of RAB proteins in brain function.RAB35,a member of the RAB family,is an evolutionarily conserved protein in metazoans.A wide range of studies using cultured mammalian cells and model organisms have revealed that RAB35 mediates various processes such as cytokinesis,endocytic recycling,actin bundling,and cell migration.RAB35 is also involved in neurite outgrowth and turnover of synaptic vesicles.We generated brain-specific Rab35 knockout mice to study the physiological roles of RAB35 in brain development and function.These mice exhibited defects in anxiety-related behaviors and spatial memory.Strikingly,RAB35 is required for the precise positioning of pyramidal neurons during hippocampal development,and thereby for normal hippocampal lamination.In contrast,layer formation in the cerebral cortex occurred superficially,even in the absence of RAB35,suggesting a predominant role for RAB35 in hippocampal development rather than in cerebral cortex development.Recent studies have suggested an association between RAB35 and neurodegenerative diseases,including Parkinson's disease and Alzheimer's disease.In this review,we provide an overview of the current understanding of subcellular functions of RAB35.We also provide insights into the physiological role of RAB35 in mammalian brain development and function,and discuss the involvement of RAB35 dysfunction in neurodegenerative diseases.
文摘The theoretical and applied characteristics of educational psychology courses in colleges and universities are prominent,and actively promoting curriculum reform is more conducive to promoting the implementation of talent training goals,which is in line with the practical needs of social development for high-quality talents.However,curriculum reform is a systematic project,which involves the innovation of curriculum content systems,teaching methods,teaching evaluations,and so on.This paper mainly expounds on the curriculum reform path in the period of high-quality development of educational psychology in colleges and universities,hoping to play a reference role in improving the level of education management.
基金supported by the National Key R&D Program of China,No.2019YFA0110300(to ZG)the National Natural Science Foundation of China,Nos.81773302(to YF),32070862(to ZG).
文摘Human brain development is a complex process,and animal models often have significant limitations.To address this,researchers have developed pluripotent stem cell-derived three-dimensional structures,known as brain-like organoids,to more accurately model early human brain development and disease.To enable more consistent and intuitive reproduction of early brain development,in this study,we incorporated forebrain organoid culture technology into the traditional unguided method of brain organoid culture.This involved embedding organoids in matrigel for only 7 days during the rapid expansion phase of the neural epithelium and then removing them from the matrigel for further cultivation,resulting in a new type of human brain organoid system.This cerebral organoid system replicated the temporospatial characteristics of early human brain development,including neuroepithelium derivation,neural progenitor cell production and maintenance,neuron differentiation and migration,and cortical layer patterning and formation,providing more consistent and reproducible organoids for developmental modeling and toxicology testing.As a proof of concept,we applied the heavy metal cadmium to this newly improved organoid system to test whether it could be used to evaluate the neurotoxicity of environmental toxins.Brain organoids exposed to cadmium for 7 or 14 days manifested severe damage and abnormalities in their neurodevelopmental patterns,including bursts of cortical cell death and premature differentiation.Cadmium exposure caused progressive depletion of neural progenitor cells and loss of organoid integrity,accompanied by compensatory cell proliferation at ectopic locations.The convenience,flexibility,and controllability of this newly developed organoid platform make it a powerful and affordable alternative to animal models for use in neurodevelopmental,neurological,and neurotoxicological studies.
基金supported by the National Natural Science Foundation of China,Nos.81901156(to ZZ),82271200(to ZZ),82171308(to XC)the Fundamental Research Funds for the Central Universities,No.xzy012022035(to ZZ)+1 种基金the Natural Science Foundation of Shaanxi Province,Nos.2021JM-261(to QK),2023-YBSF-303(to ZZ)Traditional Chinese Medicine Project of Shaanxi Province,No.2019-ZZ-JC047(to QK)。
文摘The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell cultures.However,the lack of systematic and continuous comparison between in vivo retinal development and the organotypic retinal explant culture makes this model controversial in postnatal retinal development studies.Thus,we aimed to verify the feasibility of using this model for postnatal retinal development studies by comparing it with the in vivo retina.In this study,we showed that postnatal retinal explants undergo normal development,and exhibit a consistent structure and timeline with retinas in vivo.Initially,we used SOX2 and PAX6 immunostaining to identify retinal progenitor cells.We then examined cell proliferation and migration by immunostaining with Ki-67 and doublecortin,respectively.Ki-67-and doublecortin-positive cells decreased in both in vivo and explants during postnatal retinogenesis,and exhibited a high degree of similarity in abundance and distribution between groups.Additionally,we used Ceh-10 homeodomain-containing homolog,glutamate-ammonia ligase(glutamine synthetase),neuronal nuclei,and ionized calcium-binding adapter molecule 1 immunostaining to examine the emergence of bipolar cells,Müller glia,mature neurons,and microglia,respectively.The timing and spatial patterns of the emergence of these cell types were remarkably consistent between in vivo and explant retinas.Our study showed that the organotypic retinal explant culture model had a high degree of consistency with the progression of in vivo early postnatal retina development.The findings confirm the accuracy and credibility of this model and support its use for long-term,systematic,and continuous observation.
文摘Helps students to promote lifelong learning ability and giveing them outstanding and unique Melbourne Experience is the University of Melbourne' s commitment to the students.Ten years ago,the University of Melbourne announced a major institutional reform in order to grow esteem,to improve the quality and to take up some of the challenges of international higher education competition.The Melbourne Curriculum was characterized by distinctive Melbourne Experience which are contribute to excellent classroom experience,research experience,practice experience,e- learning experience as follows:undergraduate courses focus on flexibility and preliminary,postgraduate courses focus on diversity and feasibility,practical courses focus on applicability and situationality,online courses focus on timeliness and interactivity.The development of Melbourne Curriculum highlights that we should pay particular attention to improving the quality of talent training and promoting the development of university centered on the curriculum reform,to promoting lifelong learning ability and directing research throughout the teaching process,to developing career skill and guiding with employability skills framework,to improving the quality of online courses and establishing reputation of a famous university on a new platform.
文摘Initial teacher preparation and teachers’ continuing professional development are two significant pillars of the teacher education enterprise. The former encompasses a wide range of teachereducation initiatives at the levels of diploma, bachelor’s degree, postgraduate diploma, and even master’s degree for teacher licensure purposes. These are widely documented in the literature.What is important is how teacher professional development contributes to bolstering the teachereducator force, which is relatively insufficiently documented due to the very fact that different educational systems have somewhat different expectations of such programs in relation to the ideologies and theories underpinning the teacher professional development program design and curriculum offering. Taking stock of a postgraduate diploma program in English language teaching(PGDELT) for teachers’ continuing professional development with a 31-year history housed at a premier teacher education institution in Singapore, which has successfully graduated over 1, 000 English language teachers for colleges and universities in China, I intend to highlight some of its key features, as a former student and then a lecturer on the program, in order to draw implications for sustainable growth of language teacher education programs, especially those whose main purposes are to prepare teachers of English as a second or foreign language(ESL/EFL) and provide continuing professional development opportunities for such inservice teachers.
基金supported by Teaching Research Subjec of LiaoNing Mechatronics College(JYLX2017014)Educational science "13th Five-Year" planning subject of Liaoning province(JG18EB090)
文摘Taking the application of virtual simulation technology of industrial robot in teaching as the researchobject, a detailed research is conducted on the importance of course, principles of curriculum development,curriculum objectives, teaching content, teaching methods, teaching process and assessment methods in severalaspects. And the actual teaching for a semester according to this research, through the virtual simulationteaching, improved teaching efficiency, improved the industrial robot application level and ability of thestudents, reduced the equipment failure rate, and laid a solid foundation for the subsequent course.
基金funded by Guangxi Higher Education Reform Project(No.2015JGB332 and No.2017JGB329)
文摘Background: As the deep influence of traditional medical education, many undergraduate nursing colleges and universities in China still keep the traditional disease-focused curriculum system. However, it became outdated as the Chinese high nursing education developed. Meanwhile, the increasing demand of nursing human resources stimulates the enrollment expansion of colleges. All of these bring more difficulties and opportunities for nurse educators who are endeavoring to reform the undergraduate curriculum. Methods: The authors retrospectively reviewed the related literature, illustrated the existing challenges and opportunities during the curriculum renewal process in China. This paper also analyzed the ten- dencies of Chinese baccalaureate curriculum innovation. Results: Chinese current undergraduate nursing curriculum has larger proportion of basic medical courses, which brings great challenge for nursing educators. In the meantime, the expansion of enroll- ment brings conflicts with existing nursing education resources in China. Integration, humanization, internationalization and diversification are main tendencies leading the future nursing curriculum innovation in China. Conclusions: The more effective teaching innovations in the nursing education system are in great demand.
文摘The significance and status of the teachers'professional development make the education system and the society pay more and more attentions.The article elaborates the internal contact of curriculum discourse and teachers'professional development from a few respects such as the rationality of curriculum discourse,the long-term nature of the teachers'professional development and many factors affecting the teachers'professional development.The article also analyzes the external and internal factors influencing Tibet foreign language teachers'professional development,and puts forward the corresponding countermeasures in the light of these problems.
文摘This paper analyzes a total of 294 master thesis topics for students at Graduate School of Translation and Interpretation (GSTI), Beijing Foreign Studies University (BFSU) between years 2006-2010 and 160 topics at Graduate Institute of Interpretation and Translation (GIIT), Shanghai International Studies University (SH1SU) between years 2007-2013, with the purpose of establishing correlations between thesis topics and curriculum development, comparing and contrasting the topics between BFSU and SHISU. The study is both quantitative and qualitative. Over the years students of BFSU and SHISU have shown a progress of possessing more and more appropriate methodological expertise in selecting research topics. More and more students have examined relatively new translation theories. We also see a change from picking overdone topics to more and more original topics. Our progress in no small part thanks to our administrative measures. As for GSTI of BFSU, however there is a demand for elective courses to cover areas such as interdisciplinary approaches to translation and multimedia, which are untouched in the current courses that focus on professional translation and interpretation. We might also want to sharpen students' language skill in providing purposefully language-rich texts for practices and allowing for more diversified options, such as introducing texts in world literature, ethnic English literature, drama, poetry, and non classics. The GSTI's long term cooperation with well-known organizations, both domestic and international, especially with United Nations at Geneva and New York, and European Union, offers students many on site training and field experiences. We might also want to introduce functional research methods, thus students can learn how to transform their field experiences into academic work.
基金School-level scientific research development fund project of Jilin Engineering Normal University"Research on the current situation and promotion strategy of curriculum development ability of secondary vocational teachers in Jilin Province"(X2015046).
文摘The curriculum development ability of secondary vocational school teachers is a necessary professional ability for teachers.It has important practical significance and practical value for promoting secondary vocational education curriculum and teaching reform.On the basis of analyzing the connotation and composition of curriculum development ability of teachers in secondary vocational schools,this article proposes three strategies to improve the curriculum development ability of teachers in secondary vocational schools.
文摘This article aims to combine the connotation of Tianfu culture with primary school problem-based learning based on Sichuan Tianfu culture,producing problem-based curriculum as the output.We explore problem-based curriculum development and practical methods based on primary education.It shows the distinctive and charming regional culture,representing the mutual respect and inclusiveness of Tianfu cultural bonds.It is also the innovative expression of the characteristic schoolbased curriculum of the elementary school.
基金Supported by Excellent New Major (Sightseeing Agriculture Major) Construction Project of Suzhou Higher Vocational Colleges in 2013
文摘From the position setting of sightseeing agriculture businesses and ability analysis,this paper analyzes the career action field based on training objectives of sightseeing agriculture major and determines the typical tasks and career action field. According to the major teaching design of career action field,this paper introduces the systematic curriculum system of sightseeing agriculture major based on work flow.
文摘There has been an increasing awareness in China's English language teaching profession that curriculum development should take account of the participants within the curriculum development process: the planners, the administrators, the institutions, the teachers, and the learners. This paper attempts to identify the underlying principles of the New English Curriculum in China (2001), based on which the roles of the learner, teacher, and institution that underpin the development of the new English curriculum in a secondary school in South-west China are critieaUy examined.