BACKGROUND Breast cancer patients have a high skin metastasis rate.However,reports on treatment of cutaneous metastases of breast cancer are scarce.CASE SUMMARY We report the treatment process for one breast cancer ca...BACKGROUND Breast cancer patients have a high skin metastasis rate.However,reports on treatment of cutaneous metastases of breast cancer are scarce.CASE SUMMARY We report the treatment process for one breast cancer case with bone,lung,and skin metastases.The patient was a 43-year-old woman with advanced breast cancer and skin metastasis.She underwent pathological diagnosis by needle biopsy to guide the treatment.When the disease progressed,a new pathological diagnosis was determined by needle biopsy to guide the treatment.The patient received chemotherapy,endocrine therapy,and photodynamic dynamic therapy,followed by sonodynamic therapy.CONCLUSION Repeated puncture should be performed for advanced breast cancer with skin metastasis,in order to obtain the pathology and directly determine diagnosis when the disease progresses.The treatment should focus on controlling the systemic metastasis,rather than the local disease.展开更多
Only 1% - 12% of patients with lung cancer develop cutaneous metastases. While adenocarcinoma is incredibly common, it is rare for a cutaneous manifestation of the disease to be the initial presenting complaint. Skin ...Only 1% - 12% of patients with lung cancer develop cutaneous metastases. While adenocarcinoma is incredibly common, it is rare for a cutaneous manifestation of the disease to be the initial presenting complaint. Skin manifestations can be difficult to identify and can appear to be deceptively benign, leading to delays in diagnosis and treatment. ALK+ lung cancer specifically has an increased frequency of distant lymph node involvement and lymphangitic carcinomatosis relative to typical EGFR+ lung cancer. Herein we report a case of ALK-rearranged lung adenocarcinoma that initially presented as cutaneous skin metastases to the neck. Such skin lesions should be identified early, and considered as a potential manifestation of an internal malignancy. Given the poor prognosis associated with cutaneous metastases, further diagnostic tests, such as imaging or biopsy, should be done with urgency.展开更多
Introduction:Cutaneous metastasis is defined as invasion of the skin by malignant cells originating elsewhere in the body.Cutaneous metastasis of adenocarcinoma gall bladder is extremely rare.The skin can be involved ...Introduction:Cutaneous metastasis is defined as invasion of the skin by malignant cells originating elsewhere in the body.Cutaneous metastasis of adenocarcinoma gall bladder is extremely rare.The skin can be involved simultaneously or metachronously with the primary tumor.Here,we reported a case of cutaneous metastases as a clinical harbinger to an otherwise difficult to diagnose primary adenocarcinoma gallbladder.Case presentation:A 46-year-old male presented with multiple nodules on scalp,trunk,and limbs along with fever,weight loss,and lymphadenopathy.Histopathologic examination of the nodule revealed a malignant infiltrating glandular neoplasm in dermis,consistent with metastatic adenocarcinoma with intestinal metaplasia on immunohistochemistry.Radiological investigations further confirmed the primary tumor in gall bladder with metastases in liver and lymph nodes.Unfortunately,the patient succumbed to his disease.Discussion:Gallbladder adenocarcinoma is the most commonly seen tumor of the biliary tract.Skin involvement in malignancy helps determine the treatment course and has inevitable prognostic significance.Conclusion:We reported multiple cutaneous nodules as a remote manifestation of gallbladder adenocarcinoma.Biopsy of the skin lesion was easy to perform and quite reliably guided us toward the diagnosis of the primary tumor which would have been very difficult to diagnose otherwise.展开更多
文摘BACKGROUND Breast cancer patients have a high skin metastasis rate.However,reports on treatment of cutaneous metastases of breast cancer are scarce.CASE SUMMARY We report the treatment process for one breast cancer case with bone,lung,and skin metastases.The patient was a 43-year-old woman with advanced breast cancer and skin metastasis.She underwent pathological diagnosis by needle biopsy to guide the treatment.When the disease progressed,a new pathological diagnosis was determined by needle biopsy to guide the treatment.The patient received chemotherapy,endocrine therapy,and photodynamic dynamic therapy,followed by sonodynamic therapy.CONCLUSION Repeated puncture should be performed for advanced breast cancer with skin metastasis,in order to obtain the pathology and directly determine diagnosis when the disease progresses.The treatment should focus on controlling the systemic metastasis,rather than the local disease.
文摘Only 1% - 12% of patients with lung cancer develop cutaneous metastases. While adenocarcinoma is incredibly common, it is rare for a cutaneous manifestation of the disease to be the initial presenting complaint. Skin manifestations can be difficult to identify and can appear to be deceptively benign, leading to delays in diagnosis and treatment. ALK+ lung cancer specifically has an increased frequency of distant lymph node involvement and lymphangitic carcinomatosis relative to typical EGFR+ lung cancer. Herein we report a case of ALK-rearranged lung adenocarcinoma that initially presented as cutaneous skin metastases to the neck. Such skin lesions should be identified early, and considered as a potential manifestation of an internal malignancy. Given the poor prognosis associated with cutaneous metastases, further diagnostic tests, such as imaging or biopsy, should be done with urgency.
文摘Introduction:Cutaneous metastasis is defined as invasion of the skin by malignant cells originating elsewhere in the body.Cutaneous metastasis of adenocarcinoma gall bladder is extremely rare.The skin can be involved simultaneously or metachronously with the primary tumor.Here,we reported a case of cutaneous metastases as a clinical harbinger to an otherwise difficult to diagnose primary adenocarcinoma gallbladder.Case presentation:A 46-year-old male presented with multiple nodules on scalp,trunk,and limbs along with fever,weight loss,and lymphadenopathy.Histopathologic examination of the nodule revealed a malignant infiltrating glandular neoplasm in dermis,consistent with metastatic adenocarcinoma with intestinal metaplasia on immunohistochemistry.Radiological investigations further confirmed the primary tumor in gall bladder with metastases in liver and lymph nodes.Unfortunately,the patient succumbed to his disease.Discussion:Gallbladder adenocarcinoma is the most commonly seen tumor of the biliary tract.Skin involvement in malignancy helps determine the treatment course and has inevitable prognostic significance.Conclusion:We reported multiple cutaneous nodules as a remote manifestation of gallbladder adenocarcinoma.Biopsy of the skin lesion was easy to perform and quite reliably guided us toward the diagnosis of the primary tumor which would have been very difficult to diagnose otherwise.
