A novel one-pot protocol for the synthesis of valuable 3,4-dihydropyridin-2-ones from the condensation of al- dehyde with cyanoacetamide and 1,3-dicarbonyl compounds in the presence of imidazole was developed. A serie...A novel one-pot protocol for the synthesis of valuable 3,4-dihydropyridin-2-ones from the condensation of al- dehyde with cyanoacetamide and 1,3-dicarbonyl compounds in the presence of imidazole was developed. A series of aldehydes and 1,3-dicarbonyl compounds were employed to examine the scope of substrates for this protocol. This reaction proceeded through the formation of one ring and four new bonds （two C-C, one C-N, one C=C） via the sequence involving Knoevenagel condensation, Michael addition and intramolecular cyclization with moderate to excellent yields. All new compounds were characterized by IR, 1H NMR, 13C NMR and HRMS.展开更多
基金The financial support from the National Natural Science Foundation of China （No. 21072172） and the Zhejiang Provincial Natural Science Foundation （No. 2010-Z4090225） is gratefully acknowledged.
文摘A novel one-pot protocol for the synthesis of valuable 3,4-dihydropyridin-2-ones from the condensation of al- dehyde with cyanoacetamide and 1,3-dicarbonyl compounds in the presence of imidazole was developed. A series of aldehydes and 1,3-dicarbonyl compounds were employed to examine the scope of substrates for this protocol. This reaction proceeded through the formation of one ring and four new bonds （two C-C, one C-N, one C=C） via the sequence involving Knoevenagel condensation, Michael addition and intramolecular cyclization with moderate to excellent yields. All new compounds were characterized by IR, 1H NMR, 13C NMR and HRMS.
