Analysis and Modeling of Mobile Phone Activity Data Using Interactive Cyber-Physical Social System

Mobile networks possess significant information and thus are considered a gold mine for the researcher’s community.The call detail records(CDR)of a mobile network are used to identify the network’s efficacy and the mobile user’s behavior.It is evident from the recent literature that cyber-physical systems(CPS)were used in the analytics and modeling of telecom data.In addition,CPS is used to provide valuable services in smart cities.In general,a typical telecom company hasmillions of subscribers and thus generatesmassive amounts of data.From this aspect,data storage,analysis,and processing are the key concerns.To solve these issues,herein we propose a multilevel cyber-physical social system(CPSS)for the analysis and modeling of large internet data.Our proposed multilevel system has three levels and each level has a specific functionality.Initially,raw Call Detail Data(CDR)was collected at the first level.Herein,the data preprocessing,cleaning,and error removal operations were performed.In the second level,data processing,cleaning,reduction,integration,processing,and storage were performed.Herein,suggested internet activity record measures were applied.Our proposed system initially constructs a graph and then performs network analysis.Thus proposed CPSS system accurately identifies different areas of internet peak usage in a city(Milan city).Our research is helpful for the network operators to plan effective network configuration,management,and optimization of resources.

Security Analysis in Smart Agriculture: Insights from a Cyber-Physical System Application

Smart agriculture modifies traditional farming practices,and offers innovative approaches to boost production and sustainability by leveraging contemporary technologies.In today’s world where technology is everything,these technologies are utilized to streamline regular tasks and procedures in agriculture,one of the largest and most significant industries in every nation.This research paper stands out from existing literature on smart agriculture security by providing a comprehensive analysis and examination of security issues within smart agriculture systems.Divided into three main sections-security analysis,system architecture and design and risk assessment of Cyber-Physical Systems(CPS)applications-the study delves into various elements crucial for smart farming,such as data sources,infrastructure components,communication protocols,and the roles of different stakeholders such as farmers,agricultural scientists and researchers,technology providers,government agencies,consumers and many others.In contrast to earlier research,this work analyzes the resilience of smart agriculture systems using approaches such as threat modeling,penetration testing,and vulnerability assessments.Important discoveries highlight the concerns connected to unsecured communication protocols,possible threats from malevolent actors,and vulnerabilities in IoT devices.Furthermore,the study suggests enhancements for CPS applications,such as strong access controls,intrusion detection systems,and encryption protocols.In addition,risk assessment techniques are applied to prioritize mitigation tactics and detect potential hazards,addressing issues like data breaches,system outages,and automated farming process sabotage.The research sets itself apart even more by presenting a prototype CPS application that makes use of a digital temperature sensor.This application was first created using a Tinkercad simulator and then using actual hardware with Arduino boards.The CPS application’s defenses against potential threats and vulnerabilities are strengthened by this integrated approach,which distinguishes this research for its depth and usefulness in the field of smart agriculture security.

A Review on Security and Privacy Issues Pertaining to Cyber-Physical Systems in the Industry 5.0 Era

The advent of Industry 5.0 marks a transformative era where Cyber-Physical Systems(CPSs)seamlessly integrate physical processes with advanced digital technologies.However,as industries become increasingly interconnected and reliant on smart digital technologies,the intersection of physical and cyber domains introduces novel security considerations,endangering the entire industrial ecosystem.The transition towards a more cooperative setting,including humans and machines in Industry 5.0,together with the growing intricacy and interconnection of CPSs,presents distinct and diverse security and privacy challenges.In this regard,this study provides a comprehensive review of security and privacy concerns pertaining to CPSs in the context of Industry 5.0.The review commences by providing an outline of the role of CPSs in Industry 5.0 and then proceeds to conduct a thorough review of the different security risks associated with CPSs in the context of Industry 5.0.Afterward,the study also presents the privacy implications inherent in these systems,particularly in light of the massive data collection and processing required.In addition,the paper delineates potential avenues for future research and provides countermeasures to surmount these challenges.Overall,the study underscores the imperative of adopting comprehensive security and privacy strategies within the context of Industry 5.0.

Novel cyber-physical collaborative detection and localization method against dynamic load altering attacks in smart energy grids

Owing to the integration of energy digitization and artificial intelligence technology,smart energy grids can realize the stable,efficient and clean operation of power systems.However,the emergence of cyber-physical attacks,such as dynamic load-altering attacks(DLAAs)has introduced great challenges to the security of smart energy grids.Thus,this study developed a novel cyber-physical collaborative security framework for DLAAs in smart energy grids.The proposed framework integrates attack prediction in the cyber layer with the detection and localization of attacks in the physical layer.First,a data-driven method was proposed to predict the DLAA sequence in the cyber layer.By designing a double radial basis function network,the influence of disturbances on attack prediction can be eliminated.Based on the prediction results,an unknown input observer-based detection and localization method was further developed for the physical layer.In addition,an adaptive threshold was designed to replace the traditional precomputed threshold and improve the detection performance of the DLAAs.Consequently,through the collaborative work of the cyber-physics layer,injected DLAAs were effectively detected and located.Compared with existing methodologies,the simulation results on IEEE 14-bus and 118-bus power systems verified the superiority of the proposed cyber-physical collaborative detection and localization against DLAAs.

On Zero Dynamics and Controllable Cyber-Attacks in Cyber-Physical Systems and Dynamic Coding Schemes as Their Countermeasures

In this paper, we study stealthy cyber-attacks on actuators of cyber-physical systems(CPS), namely zero dynamics and controllable attacks. In particular, under certain assumptions, we investigate and propose conditions under which one can execute zero dynamics and controllable attacks in the CPS. The above conditions are derived based on the Markov parameters of the CPS and elements of the system observability matrix. Consequently, in addition to outlining the number of required actuators to be attacked, these conditions provide one with the minimum system knowledge needed to perform zero dynamics and controllable cyber-attacks. As a countermeasure against the above stealthy cyber-attacks, we develop a dynamic coding scheme that increases the minimum number of the CPS required actuators to carry out zero dynamics and controllable cyber-attacks to its maximum possible value. It is shown that if at least one secure input channel exists, the proposed dynamic coding scheme can prevent adversaries from executing the zero dynamics and controllable attacks even if they have complete knowledge of the coding system. Finally, two illustrative numerical case studies are provided to demonstrate the effectiveness and capabilities of our derived conditions and proposed methodologies.

Risk-Balanced Routing Strategy for Service Function Chains of Cyber-Physical Power System Considering Cross-Space Cascading Failure

Cyber-physical power system(CPPS)has significantly improved the operational efficiency of power systems.However,cross-space cascading failures may occur due to the coupling characteristics,which poses a great threat to the safety and reliability of CPPS,and there is an acute need to reduce the probability of these failures.Towards this end,this paper first proposes a cascading failure index to identify and quantify the importance of different information in the same class of communication services.On this basis,a joint improved risk-balanced service function chain routing strategy(SFC-RS)is proposed,which is modeled as a robust optimization problem and solved by column-and-constraint generation(C-CG)algorithm.Compared with the traditional shortest-path routing algorithm,the superiority of SFC-RS is verified in the IEEE 30-bus system.The results demonstrate that SFC-RS effectively mitigates the risk associated with information transmission in the network,enhances information transmission accessibility,and effectively limits communication disruption from becoming the cause of cross-space cascading failures.

Cyber-Physical-Social System Between a Humanoid Robot and a Virtual Human Through a Shared Platform for Adaptive Agent Ecology

Two artificial agents(a humanoid robot and a virtual human) are enriched with various similar intelligence,autonomy, functionalities and interaction modalities. The agents are integrated in the form of a cyber-physical-social system(CPSS) through a shared communication platform to create a social ecology. In the ecology, the agents collaborate(assist each other) to perform a real-world task(search for a hidden object)for the benefits of humans. A robot-virtual human bilateral trust model is derived and a real-time trust measurement method is developed. The role of taking initiative in the collaboration is switched between the agents following a finite state machine model triggered by bilateral trust, which results in a mixedinitiative collaboration. A scheme is developed to evaluate the performance of the agents in the ecology through the CPSS.The results show that the robot and the virtual human perform satisfactorily in the collaboration through the CPSS. The results thus prove the effectiveness of the real-world ecology between artificial agents of heterogeneous realities through a shared platform based on trust-triggered mixed-initiatives. The results can help develop adaptive social ecology comprising intelligent agents of heterogeneous realities to assist humans in various tasks through collaboration between the agents in the form of a CPSS.

A Triple Human-Digital Twin Architecture for Cyber-Physical Systems

With the development of information and communication technology and the advent of the Internet of Things(IoT)era,cyber-physical system(CPS)is becoming the trend of products or systems.The deep integration and real-time interaction between the physical world and the virtual world expand system functions.Although there are some CPS implementation guidelines,the virtual world is still relatively abstract compared to the concrete physical world that can be touched through the IoT.Besides that,human is a non-negligible CPS endogenous interactive intelligent component.In this paper,we propose a triple human-digital twin architecture,where the physical objects and the digital twins that are the projections of the physical entities establish the cornerstone of human functioning together.And the hierarchically distributed digital twins grow dynamically with the physical entities along the lifecycle.Furthermore,the interaction and collaboration among the physical objects,the digital twins,and the humans in their respective worlds(the expected world,the interpreted world,and the physical world)integrate the full value chain of the products in anticipation of seamless synergy.Finally,we present a power management digital companion platform for the lunar probe to demonstrate the efficacy of the architecture.

Call for Paper from Food Science and Human Wellness

Food Science and Human Wellness(FSHW ISSN:2213-4530,CN 10-1750/TS)publishes original research papers demonstrating the latest advancement of multidisci-plinary subjects related to food science and human health.Topics may include but not limited to:nutriology,biochemistry,microbiology,immunology and toxicology.

Call for Paper from Food Science and Human Wellness

Food Science and Human Wellness(FSHW ISSN:2213-4530,CN 10-1750/TS)publishes original research papers demonstrating the latest advancement of multidisci-plinary subjects related to food science and human health.Topics may include but not limited to:nutriology,bio-chemistry,microbiology,immunology and toxicology.

Commentary on:“Human neural stem cell-derived artificial organelles to improve oxidative phosphorylation”

Mitochondrial function is fundamental to neuroregeneration,particularly in neurons,where high energy demands are essential for repair and recovery(Patrón and Zinsmaier,2016;Beckervordersandforth et al.,2017;Iwata et al.,2023).Mitochondrial dysfunction,characterized by an imbalance in ATP levels and excessive production of mitochondrial reactive oxygen species,is a key factor that impedes neural regeneration in neurodegenerative diseases and after neuronal injury(Han et al.,2016,2020;Zheng et al.,2016;Zong et al.,2024).

Human endogenous retrovirus type-W and multiple sclerosis–related smoldering neuroinflammation

Introduction to human endogenous retrovirus type-W(HERV-W): Genomic inheritance from the past includes retroviral sequences that have been stably incorporated into our genomes and account for up to 8% of human DNA.

Treatment of spinal cord injury with biomaterials and stem cell therapy in non-human primates and humans

Spinal cord injury results in the loss of sensory,motor,and autonomic functions,which almost always produces permanent physical disability.Thus,in the search for more effective treatments than those already applied for years,which are not entirely efficient,researches have been able to demonstrate the potential of biological strategies using biomaterials to tissue manufacturing through bioengineering and stem cell therapy as a neuroregenerative approach,seeking to promote neuronal recovery after spinal cord injury.Each of these strategies has been developed and meticulously evaluated in several animal models with the aim of analyzing the potential of interventions for neuronal repair and,consequently,boosting functional recovery.Although the majority of experimental research has been conducted in rodents,there is increasing recognition of the importance,and need,of evaluating the safety and efficacy of these interventions in non-human primates before moving to clinical trials involving therapies potentially promising in humans.This article is a literature review from databases(PubMed,Science Direct,Elsevier,Scielo,Redalyc,Cochrane,and NCBI)from 10 years ago to date,using keywords(spinal cord injury,cell therapy,non-human primates,humans,and bioengineering in spinal cord injury).From 110 retrieved articles,after two selection rounds based on inclusion and exclusion criteria,21 articles were analyzed.Thus,this review arises from the need to recognize the experimental therapeutic advances applied in non-human primates and even humans,aimed at deepening these strategies and identifying the advantages and influence of the results on extrapolation for clinical applicability in humans.

Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the axon.TAU is missorted and aggregated in an array of diseases known as tauopathies.Microtubules are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing enzymes.As impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule dynamics.We therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to microtubules.To investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-KO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic littermates.In sum,P301L-TAU results in changes in microtubule PTMs,suggestive of impairment of microtubule stability.This is accompanied by missorting and aggregation of TAU in mice but not in i Neurons.Microtubule PTMs/impairment may be of key importance in tauopathies.

Spatial transcriptomics combined with single-nucleus RNA sequencing reveals glial cell heterogeneity in the human spinal cord

Glial cells play crucial roles in regulating physiological and pathological functions,including sensation,the response to infection and acute injury,and chronic neurodegenerative disorders.Glial cells include astrocytes,microglia,and oligodendrocytes in the central nervous system,and satellite glial cells and Schwann cells in the peripheral nervous system.Despite the greater understanding of glial cell types and functional heterogeneity achieved through single-cell and single-nucleus RNA sequencing in animal models,few studies have investigated the transcriptomic profiles of glial cells in the human spinal cord.Here,we used high-throughput single-nucleus RNA sequencing and spatial transcriptomics to map the cellular and molecular heterogeneity of astrocytes,microglia,and oligodendrocytes in the human spinal cord.To explore the conservation and divergence across species,we compared these findings with those from mice.In the human spinal cord,astrocytes,microglia,and oligodendrocytes were each divided into six distinct transcriptomic subclusters.In the mouse spinal cord,astrocytes,microglia,and oligodendrocytes were divided into five,four,and five distinct transcriptomic subclusters,respectively.The comparative results revealed substantial heterogeneity in all glial cell types between humans and mice.Additionally,we detected sex differences in gene expression in human spinal cord glial cells.Specifically,in all astrocyte subtypes,the levels of NEAT1 and CHI3L1 were higher in males than in females,whereas the levels of CST3 were lower in males than in females.In all microglial subtypes,all differentially expressed genes were located on the sex chromosomes.In addition to sex-specific gene differences,the levels of MT-ND4,MT2A,MT-ATP6,MT-CO3,MT-ND2,MT-ND3,and MT-CO_(2) in all spinal cord oligodendrocyte subtypes were higher in females than in males.Collectively,the present dataset extensively characterizes glial cell heterogeneity and offers a valuable resource for exploring the cellular basis of spinal cordrelated illnesses,including chronic pain,amyotrophic lateral sclerosis,and multiple sclerosis.

Incorporation of human β-defensin-1 into immunoliposomes to facilitate targeted autophagy therapy of colon carcinoma

Based on the discovery that humanβ-defensin-1(hBD-1)triggers autophagy in colon cancer cells and inhibits proliferation,we proposed the consideration of its druggability.As a protein,its stability,targetability and bioavailability must be improved.Compared with the traditional medicinal chemistry technology,nano-technology is more economical for increasing the druggability of hBD-1 and can be readily scaled up.Here,we propose an immunoliposome system containing hBD-1 to improve its stability and bioavailability.To enhance its targetability,anti-epidermal growth factor receptor(EGFR)antibodies were conjugated to the liposomal bilayer to produce immunoliposomes that can target EGFR,which is highly expressed in colon cancer cells.Although more studies are needed to su-pport clinical trials and large-scale manufacturing,these immunoliposomes have great potential as therapeutics.Thus,immunoliposomes are suitable nanovesicles to improve the druggability of hBD-1;however,additional basic and translational research of these systems is warranted.

Deep Learning Based Attack Detection for Cyber-Physical System Cybersecurity:A Survey

With the booming of cyber attacks and cyber criminals against cyber-physical systems(CPSs),detecting these attacks remains challenging.It might be the worst of times,but it might be the best of times because of opportunities brought by machine learning(ML),in particular deep learning(DL).In general,DL delivers superior performance to ML because of its layered setting and its effective algorithm for extract useful information from training data.DL models are adopted quickly to cyber attacks against CPS systems.In this survey,a holistic view of recently proposed DL solutions is provided to cyber attack detection in the CPS context.A six-step DL driven methodology is provided to summarize and analyze the surveyed literature for applying DL methods to detect cyber attacks against CPS systems.The methodology includes CPS scenario analysis,cyber attack identification,ML problem formulation,DL model customization,data acquisition for training,and performance evaluation.The reviewed works indicate great potential to detect cyber attacks against CPS through DL modules.Moreover,excellent performance is achieved partly because of several highquality datasets that are readily available for public use.Furthermore,challenges,opportunities,and research trends are pointed out for future research.

Blockchain-Assisted Secure Fine-Grained Searchable Encryption for a Cloud-Based Healthcare Cyber-Physical System

The concept of sharing of personal health data over cloud storage in a healthcare-cyber physical system has become popular in recent times as it improves access quality.The privacy of health data can only be preserved by keeping it in an encrypted form,but it affects usability and flexibility in terms of effective search.Attribute-based searchable encryption(ABSE)has proven its worth by providing fine-grained searching capabilities in the shared cloud storage.However,it is not practical to apply this scheme to the devices with limited resources and storage capacity because a typical ABSE involves serious computations.In a healthcare cloud-based cyber-physical system(CCPS),the data is often collected by resource-constraint devices;therefore,here also,we cannot directly apply ABSE schemes.In the proposed work,the inherent computational cost of the ABSE scheme is managed by executing the computationally intensive tasks of a typical ABSE scheme on the blockchain network.Thus,it makes the proposed scheme suitable for online storage and retrieval of personal health data in a typical CCPS.With the assistance of blockchain technology,the proposed scheme offers two main benefits.First,it is free from a trusted authority,which makes it genuinely decentralized and free from a single point of failure.Second,it is computationally efficient because the computational load is now distributed among the consensus nodes in the blockchain network.Specifically,the task of initializing the system,which is considered the most computationally intensive,and the task of partial search token generation,which is considered as the most frequent operation,is now the responsibility of the consensus nodes.This eliminates the need of the trusted authority and reduces the burden of data users,respectively.Further,in comparison to existing decentralized fine-grained searchable encryption schemes,the proposed scheme has achieved a significant reduction in storage and computational cost for the secret key associated with users.It has been verified both theoretically and practically in the performance analysis section.

Cyber-Physical Production Systems for Data-Driven,Decentralized,and Secure Manufacturing-A Perspective

With the concepts of Industry 4.0 and smart manufacturing gaining popularity,there is a growing notion that conventional manufacturing will witness a transition toward a new paradigm,targeting innovation,automation,better response to customer needs,and intelligent systems.Within this context,this review focuses on the concept of cyber–physical production system(CPPS)and presents a holistic perspective on the role of the CPPS in three key and essential drivers of this transformation:data-driven manufacturing,decentralized manufacturing,and integrated blockchains for data security.The paper aims to connect these three aspects of smart manufacturing and proposes that through the application of data-driven modeling,CPPS will aid in transforming manufacturing to become more intuitive and automated.In turn,automated manufacturing will pave the way for the decentralization of manufacturing.Layering blockchain technologies on top of CPPS will ensure the reliability and security of data sharing and integration across decentralized systems.Each of these claims is supported by relevant case studies recently published in the literature and from the industry;a brief on existing challenges and the way forward is also provided.

Smart Cities as Cyber-Physical Social Systems

The emerging prototype for a Smart City is one of an urban environment with a new generation of inno- vative services for transportation, energy distribution, healthcare, environmental monitoring, business, commerce, emergency response, and social activities. Enabling the technology for such a setting re- quires a viewpoint of Smart Cities as cyber-physical systems （CPSs） that include new software platforms and strict requirements for mobility, security, safety, privacy, and the processing of massive amounts of information. This paper identifies some key defining characteristics of a Smart City, discusses some lessons learned from viewing them as CPSs, and outlines some fundamental research issues that remain largely open.