New progresses are introduced briefly about the water cycle study on atmosphere of China made in recent years. The introduction includes eight aspects as follows: 1) precipitation characteristics, 2) stability of clim...New progresses are introduced briefly about the water cycle study on atmosphere of China made in recent years. The introduction includes eight aspects as follows: 1) precipitation characteristics, 2) stability of climatic system, 3) precipitation sensitive region, 4) regional evaporation and evapotranspiration, 5) water surface evaporation, 6) vegetation transpiration, 7) cloud physics, and 8) vapor source.展开更多
MicroRNAs(miRNAs)encoded by latency-associated transcript are associated with both latent and acute stages of herpes simplex virus 2(HSV-2)infection.In this study,miRNA-H4-5p and miRNA-H4-3p were ectopically expressed...MicroRNAs(miRNAs)encoded by latency-associated transcript are associated with both latent and acute stages of herpes simplex virus 2(HSV-2)infection.In this study,miRNA-H4-5p and miRNA-H4-3p were ectopically expressed in HeLa cells to explore potential cellular targets of viral miRNAs and demonstrate their potential biological functions.The results showed that miRNA-H4-5p could reverse apoptosis induced by actinomycin D(Act-D)and promote cell cycle progression,but miRNA-H4-3p had no such obvious functions.Bioinformatics analysis,luciferase report assay,quantitative reverse transcription polymerase chain reaction(qRT-PCR),and Western blotting demonstrated that miRNA-H4-5p could bind to the 3-′untranslated region(UTR)of cyclin-dependent kinase inhibitor 2A(CDKN2A)and cyclin-dependent kinase-like 2(CDKL2)to negatively regulate their expression.We verified that these two targeted genes were associated with cell apoptosis and cell cycle.Furthermore,in HeLa cells infected with HSV-2,we detected significantly reduced expression of CDKN2A and CDKL2 and demonstrated the negative regulation effect of miRNA-H4-5p on these two target genes.Our findings show that viral miRNAs play a vital role in regulating the expression of the host's cellular genes that participate in cell apoptosis and progression to reshape the cellular environment in response to HSV-2 infection,providing further information on the roles of encoded herpesvirus miRNAs in pathogen-host interaction.展开更多
With the support by the National Natural Science Foundation of China and the Ministry of Science and Technology of China,the research team led by Prof.Wu HuiJian(伍会健)at the School of Life Science and Biotechnology,...With the support by the National Natural Science Foundation of China and the Ministry of Science and Technology of China,the research team led by Prof.Wu HuiJian(伍会健)at the School of Life Science and Biotechnology,Dalian University of Technology published their recent research result"DEC1regu-展开更多
The research on the tire industry cluster based on life cycle theory can be carried out by a four stage periods,namely initial period,growth period,maturity period,and recession period.This paper analyzes on the possi...The research on the tire industry cluster based on life cycle theory can be carried out by a four stage periods,namely initial period,growth period,maturity period,and recession period.This paper analyzes on the possible risks taken in each life cycle period as well as proposes corresponding suggestions to strengthen the research by looking into the conditions and factors of the continuous sustainable development process in a tire industry.展开更多
文章基于新黎曼理论三和弦进行提出一个理论框架,以“平行”和“导音转换”两种仅涉及半音进行的三和弦变换架构六音系统和超六音系统,并通过在这一理论框架下分析瓦格纳、弗朗克、理查·施特劳斯等作曲家作品中的半音化和声,演示...文章基于新黎曼理论三和弦进行提出一个理论框架,以“平行”和“导音转换”两种仅涉及半音进行的三和弦变换架构六音系统和超六音系统,并通过在这一理论框架下分析瓦格纳、弗朗克、理查·施特劳斯等作曲家作品中的半音化和声,演示晚期浪漫主义音乐中三和弦在六音空间及自然音级空间中独特的进行方式。该理论框架的完整与自洽性、其与浪漫主义晚期创作实践的紧密联系,及其对游离于传统调性理论边缘的和声进行引发的思考,使该文成为新黎曼理论最具开创性的研究之一,以及该领域迄今引用量最高的文章(据web of science及谷歌学术数据)。展开更多
基金Knowledge Innovation Program of CAS No. KZCX1-10-07+3 种基金 National Natural Science Foundation of China No. 49971078 Knowledge Innovation Project of CAS No. KZCX2-314
文摘New progresses are introduced briefly about the water cycle study on atmosphere of China made in recent years. The introduction includes eight aspects as follows: 1) precipitation characteristics, 2) stability of climatic system, 3) precipitation sensitive region, 4) regional evaporation and evapotranspiration, 5) water surface evaporation, 6) vegetation transpiration, 7) cloud physics, and 8) vapor source.
基金supported by the National Natural Science Foundation of China (81371749) and (81171511)
文摘MicroRNAs(miRNAs)encoded by latency-associated transcript are associated with both latent and acute stages of herpes simplex virus 2(HSV-2)infection.In this study,miRNA-H4-5p and miRNA-H4-3p were ectopically expressed in HeLa cells to explore potential cellular targets of viral miRNAs and demonstrate their potential biological functions.The results showed that miRNA-H4-5p could reverse apoptosis induced by actinomycin D(Act-D)and promote cell cycle progression,but miRNA-H4-3p had no such obvious functions.Bioinformatics analysis,luciferase report assay,quantitative reverse transcription polymerase chain reaction(qRT-PCR),and Western blotting demonstrated that miRNA-H4-5p could bind to the 3-′untranslated region(UTR)of cyclin-dependent kinase inhibitor 2A(CDKN2A)and cyclin-dependent kinase-like 2(CDKL2)to negatively regulate their expression.We verified that these two targeted genes were associated with cell apoptosis and cell cycle.Furthermore,in HeLa cells infected with HSV-2,we detected significantly reduced expression of CDKN2A and CDKL2 and demonstrated the negative regulation effect of miRNA-H4-5p on these two target genes.Our findings show that viral miRNAs play a vital role in regulating the expression of the host's cellular genes that participate in cell apoptosis and progression to reshape the cellular environment in response to HSV-2 infection,providing further information on the roles of encoded herpesvirus miRNAs in pathogen-host interaction.
文摘With the support by the National Natural Science Foundation of China and the Ministry of Science and Technology of China,the research team led by Prof.Wu HuiJian(伍会健)at the School of Life Science and Biotechnology,Dalian University of Technology published their recent research result"DEC1regu-
文摘The research on the tire industry cluster based on life cycle theory can be carried out by a four stage periods,namely initial period,growth period,maturity period,and recession period.This paper analyzes on the possible risks taken in each life cycle period as well as proposes corresponding suggestions to strengthen the research by looking into the conditions and factors of the continuous sustainable development process in a tire industry.
文摘文章基于新黎曼理论三和弦进行提出一个理论框架,以“平行”和“导音转换”两种仅涉及半音进行的三和弦变换架构六音系统和超六音系统,并通过在这一理论框架下分析瓦格纳、弗朗克、理查·施特劳斯等作曲家作品中的半音化和声,演示晚期浪漫主义音乐中三和弦在六音空间及自然音级空间中独特的进行方式。该理论框架的完整与自洽性、其与浪漫主义晚期创作实践的紧密联系,及其对游离于传统调性理论边缘的和声进行引发的思考,使该文成为新黎曼理论最具开创性的研究之一,以及该领域迄今引用量最高的文章(据web of science及谷歌学术数据)。
