Four ternary lanthanide complexes with unsaturated acid and 1,10-phenanthroline are prepared in methanol and characterized by elemental analysis, molar conductance, UV, IR, (()~1H) NMR and XPS. The results from this p...Four ternary lanthanide complexes with unsaturated acid and 1,10-phenanthroline are prepared in methanol and characterized by elemental analysis, molar conductance, UV, IR, (()~1H) NMR and XPS. The results from this paper show that the complexes Ln(phen)(SA)_3·2H_2O or Ln(phen)(CA)_3·H_2O (Ln=Ce(Ⅲ), Sm(Ⅲ) and Eu(Ⅲ), (phen=1,10-)phenanthroline, SA=Sorbate and CA=Cinnamate) has better anti-inflammatory effect than cerium nitrate and their gremores are steadier than cerium nitrate gremor. And there is a kind of medicament which can replace the cerium nitrate gremor completely in treating burn.展开更多
Two new complexes （Cp）2Ti （Sal）2 and（Cp）2Ti（Clo）2 （Cp=Cyclopentadienyl η^5-C5H5 ）, have been synthesized in anhydrous THF by the reaction of HSal（o-hydroxybenzoic acid, salicylate acid） or HClo[N-（ m-chl...Two new complexes （Cp）2Ti （Sal）2 and（Cp）2Ti（Clo）2 （Cp=Cyclopentadienyl η^5-C5H5 ）, have been synthesized in anhydrous THF by the reaction of HSal（o-hydroxybenzoic acid, salicylate acid） or HClo[N-（ m-chloro-phenyl） anthranili acid, acidum clofenamicum] with （Cp）2TiCl2 and characterized by means of elemental analyses, IR, H NMR, ^13C NMR, UV and molar conductivity. In complex （Cp）2Ti（Sal）2 or（Cp）2Ti（Clo）2, the oxygen atom of the carboxyl group coordinates to Ti（Ⅳ） in a monodentate manner. The inhibitory action of the complexes on mouse ear tumefaction caused by croton oil and rat foot granulation growth caused by cotton balls is higher than that of the corresponding ligands HSal, HClo and [ （Cp）2TiCl2 ], whereas their toxicity is lower than those of the free ligands.展开更多
Two new complexes (Cp) 2Ti(Cin) 2 and (Cp) 2Ti(Tzea) 2 (Cp= Cyclopentadienyl η 5 C 5H 5) have been synthesized in THF by the reaction of HCin (Cincofen, 2 phenylquinoline 4 carboxylic acid) or HTzea...Two new complexes (Cp) 2Ti(Cin) 2 and (Cp) 2Ti(Tzea) 2 (Cp= Cyclopentadienyl η 5 C 5H 5) have been synthesized in THF by the reaction of HCin (Cincofen, 2 phenylquinoline 4 carboxylic acid) or HTzea (5 phenyltetrazolyl 2 ethanoic acid) with (Cp) 2TiCl 2, and characterized by elemental analyses, IR, 1H NMR and 13 C NMR, UV spectra, molar conductivity, TG DTA. In the complexes the carboxyl groups are coordinated to Ti(IV) in a monodentate manner. The inhibitory actions of the complexes on mice ear tumefaction caused by croton oil and the rat foot granulation growth produced by cotton wool are higher than those of the corresponding ligands HCin, HTzea and [(Cp) 2TiCl 2], while their toxicities are lower than those of the free ligands.展开更多
Curcumin, the medically active component from Curcuma Tonga (Turmeric), is widely used to treat inflammatory diseases. Protein interaction network (PIN) analysis was used to predict its mechanisms of molecular action....Curcumin, the medically active component from Curcuma Tonga (Turmeric), is widely used to treat inflammatory diseases. Protein interaction network (PIN) analysis was used to predict its mechanisms of molecular action. Targets of curcumin were obtained based on ChEMBL and STITCH databases. Protein protein interactions (PPIs) were extracted from the String database. The PIN of curcumin was constructed by Cytoscape and the function modules identified by gene ontology (GO) enrichment analysis based on molecular complex detection (MCODE). A PIN of curcumin with 482 nodes and 1688 interactions was constructed, which has scale-free, small world and modular properties. Based on analysis of these function modules, the mechanism of curcumin is proposed. Two modules were found to be intimately associated with inflammation. With function modules analysis, the anti-inflammatory effects of curcumin were related to SMAD, ERG and mediation by the TLR family. TLR9 may be a potential target of curcumin to treat inflammation. (C) 2015 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.展开更多
I. INTRODUCTIONGlycyrrhizic acid, extracted from glycyrrhiza, having the adreno-corticotropic hormone (ACTH)-like effect, is used for anti-inflammation, detoxication etc.
文摘Four ternary lanthanide complexes with unsaturated acid and 1,10-phenanthroline are prepared in methanol and characterized by elemental analysis, molar conductance, UV, IR, (()~1H) NMR and XPS. The results from this paper show that the complexes Ln(phen)(SA)_3·2H_2O or Ln(phen)(CA)_3·H_2O (Ln=Ce(Ⅲ), Sm(Ⅲ) and Eu(Ⅲ), (phen=1,10-)phenanthroline, SA=Sorbate and CA=Cinnamate) has better anti-inflammatory effect than cerium nitrate and their gremores are steadier than cerium nitrate gremor. And there is a kind of medicament which can replace the cerium nitrate gremor completely in treating burn.
文摘Two new complexes （Cp）2Ti （Sal）2 and（Cp）2Ti（Clo）2 （Cp=Cyclopentadienyl η^5-C5H5 ）, have been synthesized in anhydrous THF by the reaction of HSal（o-hydroxybenzoic acid, salicylate acid） or HClo[N-（ m-chloro-phenyl） anthranili acid, acidum clofenamicum] with （Cp）2TiCl2 and characterized by means of elemental analyses, IR, H NMR, ^13C NMR, UV and molar conductivity. In complex （Cp）2Ti（Sal）2 or（Cp）2Ti（Clo）2, the oxygen atom of the carboxyl group coordinates to Ti（Ⅳ） in a monodentate manner. The inhibitory action of the complexes on mouse ear tumefaction caused by croton oil and rat foot granulation growth caused by cotton balls is higher than that of the corresponding ligands HSal, HClo and [ （Cp）2TiCl2 ], whereas their toxicity is lower than those of the free ligands.
文摘Two new complexes (Cp) 2Ti(Cin) 2 and (Cp) 2Ti(Tzea) 2 (Cp= Cyclopentadienyl η 5 C 5H 5) have been synthesized in THF by the reaction of HCin (Cincofen, 2 phenylquinoline 4 carboxylic acid) or HTzea (5 phenyltetrazolyl 2 ethanoic acid) with (Cp) 2TiCl 2, and characterized by elemental analyses, IR, 1H NMR and 13 C NMR, UV spectra, molar conductivity, TG DTA. In the complexes the carboxyl groups are coordinated to Ti(IV) in a monodentate manner. The inhibitory actions of the complexes on mice ear tumefaction caused by croton oil and the rat foot granulation growth produced by cotton wool are higher than those of the corresponding ligands HCin, HTzea and [(Cp) 2TiCl 2], while their toxicities are lower than those of the free ligands.
基金supported by grants from the National Natural Science Foundation of China(Grant No.81403103)Chinese Medicine Resources(Sichuan Province)Youth Science and Technology Innovation Team(Grant No.2015TD0028)+1 种基金Sichuan Province Science and Technology Support Plan(Grant No.2014SZ0156)Sichuan Province Education Department Project(Grant No.2013SZB0781)
文摘Curcumin, the medically active component from Curcuma Tonga (Turmeric), is widely used to treat inflammatory diseases. Protein interaction network (PIN) analysis was used to predict its mechanisms of molecular action. Targets of curcumin were obtained based on ChEMBL and STITCH databases. Protein protein interactions (PPIs) were extracted from the String database. The PIN of curcumin was constructed by Cytoscape and the function modules identified by gene ontology (GO) enrichment analysis based on molecular complex detection (MCODE). A PIN of curcumin with 482 nodes and 1688 interactions was constructed, which has scale-free, small world and modular properties. Based on analysis of these function modules, the mechanism of curcumin is proposed. Two modules were found to be intimately associated with inflammation. With function modules analysis, the anti-inflammatory effects of curcumin were related to SMAD, ERG and mediation by the TLR family. TLR9 may be a potential target of curcumin to treat inflammation. (C) 2015 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.
基金Project supported by the National Natural Science Foundation of China.
文摘I. INTRODUCTIONGlycyrrhizic acid, extracted from glycyrrhiza, having the adreno-corticotropic hormone (ACTH)-like effect, is used for anti-inflammation, detoxication etc.
