Cyclopropylamine is synthesized with γ butyrolactone and isopropanol by five steps of ring opening esterification, cyclization, hydrolysis, acylation and Hofmann degradation. Cyclization and hydrolysis are key steps ...Cyclopropylamine is synthesized with γ butyrolactone and isopropanol by five steps of ring opening esterification, cyclization, hydrolysis, acylation and Hofmann degradation. Cyclization and hydrolysis are key steps in the process, and Phase Transfer Catalysis (PTC) is used in the two steps respectively. In the cyclization reaction, because solid liquid PTC, sodium hydroxide is applied instead of expensive sodium alcoholate, the reaction can be carried out in mild conditions. The optimum re action conditions are as follows: 0.03∶1∶1.5 mole ratio of BTEAC to ester to sodium hydroxide, reacting at 50 ℃ for 2 h with yield of 92%. Hydrolysis of isopropyl cyclopropanecarboxylate is accelerated by liquid liquid PTC, and the order of catalytic activity is BTEAC>BTMAC>CTMAB>TBAB. The results show that the new synthesis method is superior to those from literature and feasible for production with simple routes, mild reaction conditions, cheap materials and total yield of 52.6%.展开更多
Synthesis of N6-cyclopropy1-2.6-diamino-9 β-D-arabinofuranosyl-purine has beenaccomplished by treatment silylated 2-amino-6-chloro-purine 4 with 2.3.5-tri-O-benzyl- β-Darabinofuranosyl chloride 3 in the presence of ...Synthesis of N6-cyclopropy1-2.6-diamino-9 β-D-arabinofuranosyl-purine has beenaccomplished by treatment silylated 2-amino-6-chloro-purine 4 with 2.3.5-tri-O-benzyl- β-Darabinofuranosyl chloride 3 in the presence of molecular sieves. followed by reaction withcyclopropylamine and debenzyl reaction to give the β-anomeric nucleoside. The structures ofall products were confirmed by UV. 'H-NMR and elemental analysis.展开更多
基金The Science and Research Foundation of Education Commission of Hunan Province
文摘Cyclopropylamine is synthesized with γ butyrolactone and isopropanol by five steps of ring opening esterification, cyclization, hydrolysis, acylation and Hofmann degradation. Cyclization and hydrolysis are key steps in the process, and Phase Transfer Catalysis (PTC) is used in the two steps respectively. In the cyclization reaction, because solid liquid PTC, sodium hydroxide is applied instead of expensive sodium alcoholate, the reaction can be carried out in mild conditions. The optimum re action conditions are as follows: 0.03∶1∶1.5 mole ratio of BTEAC to ester to sodium hydroxide, reacting at 50 ℃ for 2 h with yield of 92%. Hydrolysis of isopropyl cyclopropanecarboxylate is accelerated by liquid liquid PTC, and the order of catalytic activity is BTEAC>BTMAC>CTMAB>TBAB. The results show that the new synthesis method is superior to those from literature and feasible for production with simple routes, mild reaction conditions, cheap materials and total yield of 52.6%.
文摘Synthesis of N6-cyclopropy1-2.6-diamino-9 β-D-arabinofuranosyl-purine has beenaccomplished by treatment silylated 2-amino-6-chloro-purine 4 with 2.3.5-tri-O-benzyl- β-Darabinofuranosyl chloride 3 in the presence of molecular sieves. followed by reaction withcyclopropylamine and debenzyl reaction to give the β-anomeric nucleoside. The structures ofall products were confirmed by UV. 'H-NMR and elemental analysis.
