BACKGROUND Eosinophilic solid and cystic(ESC)renal cell carcinoma(RCC),a unique and emerging subtype of RCC,has an indolent nature;in some rare instances,it may exhibit metastatic potential.Current cases are inadequat...BACKGROUND Eosinophilic solid and cystic(ESC)renal cell carcinoma(RCC),a unique and emerging subtype of RCC,has an indolent nature;in some rare instances,it may exhibit metastatic potential.Current cases are inadequate to precisely predict the clinical outcome of ESC RCC and determine treatment choices.CASE SUMMARY Herein,we report two patients with ESC RCC.Patient 1 was a young woman with classical pathological characteristics.Patient 2 was a 52-year-old man with multifocal metastases,involving the pulmonary hilar and mediastinal lymph nodes,liver,brain,mesosternum,vertebra,rib,femur,and symphysis pubis.Awareness of ESC RCC,along with its characteristic architecture and immunophenotype,would contribute to making a definitive diagnosis,even on core biopsy samples.CONCLUSION The discovery of ESC RCC molecular signatures may provide new therapeutic strategies in the future.展开更多
Objective:Cystic lesions of the pancreas have been increasingly recognized.Some lesions exhibit benign behavior,while others have unequivocal malignant potential.Thus,accurate identification of malignancy in patients ...Objective:Cystic lesions of the pancreas have been increasingly recognized.Some lesions exhibit benign behavior,while others have unequivocal malignant potential.Thus,accurate identification of malignancy in patients diagnosed with pancreatic cystic neoplasms(PCNs)remains a major challenge.The aim of this study was to define a combined criterion to better predict malignant lesions in patients with PCNs.Methods:We retrospectively analyzed 165 patients who underwent resection of PCNs from October 2011 to May 2017.The relationship among malignancy and serum carbohydrate antigen 19-9(CA19-9),preoperative neutrophil-to-lymphocyte ratio(NLR),and the presence of enhanced solid component on imaging was analyzed.Results:NLR before surgery in patients with malignant PCNs(2.81±2.14)was significantly higher than that in patients diagnosed with pancreatic neuroendocrine tumor(1.90±0.69,P=0.013)or healthy volunteers(1.40±0.48;P<0.001).Serum CA19-9≥39U/m L,NLR>1.976 and presence of enhanced solid component were independent predictors of PCN malignancy.A combined criterion meeting any two or more of the three elements including CA19-9≥39 U/m L,NLR>1.976,and presence of enhanced solid component on computed tomography imaging is an indicator with a high positive predictive value of 80.5%and a high negative predictive value of 87.9%,and thus,represents a highly accurate test(86.1%).Conclusions:The new combined criterion is an effective predictor of tumor malignancy in patients with PCNs.展开更多
目的:探讨多模态超声特征分型在乳腺囊实混合性肿块良恶性鉴别诊断中的价值。方法:回顾性分析106例经病理证实的乳腺囊实混合性肿块(108个),术前行常规超声、萤火虫成像、超微血管三维成像(Smart 3D SMI)及应变弹性成像(SE)。应用多模...目的:探讨多模态超声特征分型在乳腺囊实混合性肿块良恶性鉴别诊断中的价值。方法:回顾性分析106例经病理证实的乳腺囊实混合性肿块(108个),术前行常规超声、萤火虫成像、超微血管三维成像(Smart 3D SMI)及应变弹性成像(SE)。应用多模态超声对肿块特征分型,并对常规超声的乳腺影像报告和数据系统(BI-RADS)分类结果进行校正。以术后病理为金标准,比较分析校正前后的鉴别诊断效能。结果:106例中良性61例(62个病灶),恶性45例(46个病灶)。常规超声BI-RADS分类结果校正后的诊断敏感度、特异度、准确率、阳性预测值、阴性预测值、AUC分别为89.13%、80.65%、84.26%、77.36%、90.91%、0.849,均高于校正前。结论:常规超声BI-RADS分类经多模态超声校正后,可提高对乳腺囊实混合性肿块良恶性的鉴别诊断效能。展开更多
文摘BACKGROUND Eosinophilic solid and cystic(ESC)renal cell carcinoma(RCC),a unique and emerging subtype of RCC,has an indolent nature;in some rare instances,it may exhibit metastatic potential.Current cases are inadequate to precisely predict the clinical outcome of ESC RCC and determine treatment choices.CASE SUMMARY Herein,we report two patients with ESC RCC.Patient 1 was a young woman with classical pathological characteristics.Patient 2 was a 52-year-old man with multifocal metastases,involving the pulmonary hilar and mediastinal lymph nodes,liver,brain,mesosternum,vertebra,rib,femur,and symphysis pubis.Awareness of ESC RCC,along with its characteristic architecture and immunophenotype,would contribute to making a definitive diagnosis,even on core biopsy samples.CONCLUSION The discovery of ESC RCC molecular signatures may provide new therapeutic strategies in the future.
文摘Objective:Cystic lesions of the pancreas have been increasingly recognized.Some lesions exhibit benign behavior,while others have unequivocal malignant potential.Thus,accurate identification of malignancy in patients diagnosed with pancreatic cystic neoplasms(PCNs)remains a major challenge.The aim of this study was to define a combined criterion to better predict malignant lesions in patients with PCNs.Methods:We retrospectively analyzed 165 patients who underwent resection of PCNs from October 2011 to May 2017.The relationship among malignancy and serum carbohydrate antigen 19-9(CA19-9),preoperative neutrophil-to-lymphocyte ratio(NLR),and the presence of enhanced solid component on imaging was analyzed.Results:NLR before surgery in patients with malignant PCNs(2.81±2.14)was significantly higher than that in patients diagnosed with pancreatic neuroendocrine tumor(1.90±0.69,P=0.013)or healthy volunteers(1.40±0.48;P<0.001).Serum CA19-9≥39U/m L,NLR>1.976 and presence of enhanced solid component were independent predictors of PCN malignancy.A combined criterion meeting any two or more of the three elements including CA19-9≥39 U/m L,NLR>1.976,and presence of enhanced solid component on computed tomography imaging is an indicator with a high positive predictive value of 80.5%and a high negative predictive value of 87.9%,and thus,represents a highly accurate test(86.1%).Conclusions:The new combined criterion is an effective predictor of tumor malignancy in patients with PCNs.
文摘目的:探讨多模态超声特征分型在乳腺囊实混合性肿块良恶性鉴别诊断中的价值。方法:回顾性分析106例经病理证实的乳腺囊实混合性肿块(108个),术前行常规超声、萤火虫成像、超微血管三维成像(Smart 3D SMI)及应变弹性成像(SE)。应用多模态超声对肿块特征分型,并对常规超声的乳腺影像报告和数据系统(BI-RADS)分类结果进行校正。以术后病理为金标准,比较分析校正前后的鉴别诊断效能。结果:106例中良性61例(62个病灶),恶性45例(46个病灶)。常规超声BI-RADS分类结果校正后的诊断敏感度、特异度、准确率、阳性预测值、阴性预测值、AUC分别为89.13%、80.65%、84.26%、77.36%、90.91%、0.849,均高于校正前。结论:常规超声BI-RADS分类经多模态超声校正后,可提高对乳腺囊实混合性肿块良恶性的鉴别诊断效能。
