Pattern adaptation is one of the fundamental sensory processes in the visual system. In this study, we compared pattern adaptation induced by two types of sinu-soidal drifting grating in dLGN cells of cat. The two typ...Pattern adaptation is one of the fundamental sensory processes in the visual system. In this study, we compared pattern adaptation induced by two types of sinu-soidal drifting grating in dLGN cells of cat. The two types of grating have the same parameters (e.g. spatial frequency, temporal frequency and contrast) except their pattern shapes, one of which is normal grating and the other annular grating. The results suggested that the annular grating elic-ited stronger response and stronger pattern adaptation than the normal grating. This is consistent with the adaptation and aftereffect to the two types of drifting gratings seen in psychology and may reflect the subcortical neural mecha-nism underlying these psychological phenomena.展开更多
Eye-specific segregation in the dorsal lateral geniculate nucleus(dLGN) and superior colliculus(SC) starts from the embryonic stage and continues to develop postnatally until eye-opening in mice. However, there have b...Eye-specific segregation in the dorsal lateral geniculate nucleus(dLGN) and superior colliculus(SC) starts from the embryonic stage and continues to develop postnatally until eye-opening in mice. However, there have been few systematic studies on the details of this developmental process. Here, we carried out time-dependent studies of eye-specific segregation in the dLGN and SC. Our results demonstrated that the development of eye-specific segregation in the SC is completed before postnatal day 12(P12), which is earlier than in the dLGN(P20). During the whole period, ipsilateral and overlapping axonal projections decreased continuously in both the dLGN and SC. On the other hand, contralateral axonal projections showed little change, except for a slight decrease between P8 and P20 in the dLGN.展开更多
70%-80% of our sensory input comes from vision. Light hit the retina at the back of our eyes and the visual information is relayed into the dorsal lateral geniculate nuclei （dLGN） and primary visual cortex （V1） th...70%-80% of our sensory input comes from vision. Light hit the retina at the back of our eyes and the visual information is relayed into the dorsal lateral geniculate nuclei （dLGN） and primary visual cortex （V1） thereafter, constituting the image-forming visual circuit. Molecular cues are one of the key factors to guide the wiring and refinement of the image-forming visual circuit during pre- and post-embryonic stages. Distinct molecular cues are involved in different developmental stages and nucleus, suggesting diverse guidance mechanisms. In this review, we summarize molecular guidance cues throughout the image-forming visual circuit, including chiasm determination, eye-specific segregation and refinement in the dLGN, and at last the reciprocal con- nections between the dLGN and VI.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.30070257)the Foundation of the Chinese Academy of Sciences(Grant No.KGCX2-SW-101)Visual Information Processing Laboratory of Institute of Biophysics,the Chinese Academy of Sciences.
文摘Pattern adaptation is one of the fundamental sensory processes in the visual system. In this study, we compared pattern adaptation induced by two types of sinu-soidal drifting grating in dLGN cells of cat. The two types of grating have the same parameters (e.g. spatial frequency, temporal frequency and contrast) except their pattern shapes, one of which is normal grating and the other annular grating. The results suggested that the annular grating elic-ited stronger response and stronger pattern adaptation than the normal grating. This is consistent with the adaptation and aftereffect to the two types of drifting gratings seen in psychology and may reflect the subcortical neural mecha-nism underlying these psychological phenomena.
基金Project supported by the Shanghai Postdoctoral Scientific Program,the National Natural Science Foundation of China(No.31271158)the Doctoral Program of Higher Education from Ministry of Education of China+2 种基金the Innovation Program of Shanghai Municipal Education Commission(No.13ZZ002)the Shanghai Municipal Commission of Health and Family Planning,Science and Technology Commission of Shanghai Municipality(Nos.12ZR1441000 and 13PJ1401000)the Young 1000 Plan
文摘Eye-specific segregation in the dorsal lateral geniculate nucleus(dLGN) and superior colliculus(SC) starts from the embryonic stage and continues to develop postnatally until eye-opening in mice. However, there have been few systematic studies on the details of this developmental process. Here, we carried out time-dependent studies of eye-specific segregation in the dLGN and SC. Our results demonstrated that the development of eye-specific segregation in the SC is completed before postnatal day 12(P12), which is earlier than in the dLGN(P20). During the whole period, ipsilateral and overlapping axonal projections decreased continuously in both the dLGN and SC. On the other hand, contralateral axonal projections showed little change, except for a slight decrease between P8 and P20 in the dLGN.
文摘70%-80% of our sensory input comes from vision. Light hit the retina at the back of our eyes and the visual information is relayed into the dorsal lateral geniculate nuclei （dLGN） and primary visual cortex （V1） thereafter, constituting the image-forming visual circuit. Molecular cues are one of the key factors to guide the wiring and refinement of the image-forming visual circuit during pre- and post-embryonic stages. Distinct molecular cues are involved in different developmental stages and nucleus, suggesting diverse guidance mechanisms. In this review, we summarize molecular guidance cues throughout the image-forming visual circuit, including chiasm determination, eye-specific segregation and refinement in the dLGN, and at last the reciprocal con- nections between the dLGN and VI.
