[Objective] The paper was to explore the therapeutic effect of traditional Chinese medicine on damp-heat diarrhea of piglets in summer.[Method] Three prescriptions were developed with a dozen of traditional Chinese me...[Objective] The paper was to explore the therapeutic effect of traditional Chinese medicine on damp-heat diarrhea of piglets in summer.[Method] Three prescriptions were developed with a dozen of traditional Chinese medicines,and in vitro antibacterial test against swine standard Escherichia coli [O149：K91,K88 ac（C83907）] was conducted.Moreover,106 natural cases of diarrhea piglets caused by coinfection of damp-heat and E.coli through clinical and laboratory diagnosis were then treated.[Result] The oral liquids prepared by three traditional Chinese medicine prescriptions had certain antibacterial effect on standard pathogenic E.coli.Prescription 2 presented the strongest inhibitory effects on swine E.coli in vitro,with the MIC of 31.25 mg/m L.It had better therapeutic effect,and the effective rate reached 94.74%.[Conclusion] The prescription 2 mainly consisted of Coptis chinensis and Prunus mume might be effective in treatment of piglet diarrhea caused by damp heat and E.coli in clinic.展开更多
BACKGROUND A patient with type Ⅲ Kummell’s disease had a ruptured posterior cortex of the fractured vertebral body, which caused spinal cord compression. An open surgery was considered the best choice of operation. ...BACKGROUND A patient with type Ⅲ Kummell’s disease had a ruptured posterior cortex of the fractured vertebral body, which caused spinal cord compression. An open surgery was considered the best choice of operation. However, the patient and her family refused open surgery and instead demanded a minimally invasive surgical treatment such as percutaneous vertebroplasty(PVP). After preoperative discussion, we finally adopted the novel therapy of traditional Chinese medicine manipulative reduction(TCMMR) combined with PVP.CASE SUMMARY A patient with type Ⅲ Kummell’s disease exhibiting bone block-induced spinal cord compression was admitted to our hospital. She suffered from a variety of medical disorders but refused open surgery, and instead asked for PVP surgery. TCMMR, in parallel with PVP, was used to restore the height of the compressed vertebral body and reduce the symptoms of spinal cord compression by the bone block in order to strengthen the vertebral body and prevent further collapse. The surgery was very successful. The height of the compressed vertebra was restored, and the symptom of spinal cord compression by bone block was reduced successfully via TCMMR. The fractured vertebra was solidified by the PVP. The pain visual analog score declined from preoperative 7 scores to postoperative 2 scores, and the Frankel spinal cord scale increased from preoperative D degree to postoperative E degree.CONCLUSION The new method has advantages in treating patients with type Ⅲ Kummell’s disease who cannot be treated with open surgery.展开更多
Objective Based on intra-set correlation analysis, this paper deconstructs the clinical medical records of traditional Chinese medicine(TCM) Master ZHOU Zhongying in treating thyroid cancer, and analyzes the experienc...Objective Based on intra-set correlation analysis, this paper deconstructs the clinical medical records of traditional Chinese medicine(TCM) Master ZHOU Zhongying in treating thyroid cancer, and analyzes the experience in “mechanism-syndrome-medicine-prescription” for thyroid cancer.Methods Through Medcase data processing platform, based on Frequent Pattern(FP)-Growth enhanced correlation analysis algorithm, the medical records of Professor ZHOU Zhongying for the treatment of thyroid cancer from June 1, 2001 to February 28, 2015 were analyzed within the set.Results This study involved 43 medical records, 43 patients, and 167 visits. After processing intra-set correlations, 28 groups of highly correlated symptoms, 21 groups of highly correlated tongue images, 10 groups of highly correlated pulse conditions, 28 groups of highly correlated pathogenesis, 34 groups of highly correlated herbs, and 26 groups of highly correlated western medicine diagnosis were selected. Professor ZHOU Zhongying treats thyroid cancer according to syndrome differentiation. Symptoms with more association rules included neck swelling, neck pain, cough, and dry mouth;tongue images with more association rules included dark purple tongue, dark red tongue, and fissured tongue;pulse conditions with more association rules were wiry pulse, thready pulse, small pulse, and slippery pulse;the pathogenesis with more association rules was phlegm and blood stasis, damp-heat accumulation,and impairment of both Qi and Yin;herbs with more association rules were Chaihu(Bupleuri Radix), Zeqi(Sun Euphoribiae Herb), and Tiandong(Asparagi Radix);western medicine diagnosis with more association rules included thyroid cancer, insomnia, and chronic gastritis.Conclusion Thyroid cancer mostly presents as deficiency in origin and excess in manifestations. The basic pathogenesis is phlegm and blood stasis, damp-heat accumulation, and impairment of both Qi and Yin, which are closely related to liver, kidney, and spleen. Professor ZHOU Zhongying adopts both attack and supplement approaches as the general treatment principle, with a strong emphasis on regulating Qi and relieving depression, eliminating phlegm and resolving stagnation, eliminating dampness and turbidity, clearing fire and destroying poison, moistening dryness and softening hard mass, invigorating Qi and nourishing Yin, and paying attention to nourishing liver and kidney, invigorating spleen and stomach,while protecting the heart and lungs.展开更多
目的:探讨谷红注射液联合中药热敷治疗卒中后认知障碍的临床效果。方法:前瞻性选取2020年8月—2022年8月无锡市康复医院收治的88例卒中后认知障碍患者。根据抽签法将其分为研究组和对照组,各44例。两组均给予常规治疗,对照组给予谷红注...目的:探讨谷红注射液联合中药热敷治疗卒中后认知障碍的临床效果。方法:前瞻性选取2020年8月—2022年8月无锡市康复医院收治的88例卒中后认知障碍患者。根据抽签法将其分为研究组和对照组,各44例。两组均给予常规治疗,对照组给予谷红注射液,研究组在对照组基础上给予中药热敷。比较两组治疗后临床效果、治疗前后神经功能、认知功能、血清学指标、脑血流动力学。结果:研究组总有效率为95.45%,显著高于对照组的79.55%,差异有统计学意义(P<0.05)。治疗后,研究组蒙特利尔认知评估量表(Montreal cognitive assessment,MoCA)、简易智能精神状态检查量表(mini-mental state examination,MMSE)评分均高于对照组,美国国立卫生研究院卒中量表(National Institute of Health stroke scale,NIHSS)评分明显低于对照组,差异有统计学意义(P<0.05)。治疗后,研究组S-100钙结合蛋白β(S-100 calcium binding protein β,S-100β)、视锥蛋白样蛋白-l(visinin like protein 1,VILIP-1)水平均低于对照组,胰岛素样生长因子1(insulin-like growth factor 1,IGF-1)水平高于对照组,差异有统计学意义(P<0.05)。治疗后,研究组收缩期峰值流速(peak flow velocity of systole,Vp)、平均血流速度(mean velocity,Vm)均高于对照组,搏动指数(pulse index,PI)低于对照组,差异有统计学意义(P<0.05)。结论:谷红注射液联合中药热敷治疗卒中后认知障碍患者能促进神经功能恢复,改善认知功能,改善脑血流动力学,提高治疗效果。展开更多
基金Supported by Special Fund for Agro-scientific Research in the Public Interest(201303040-06)
文摘[Objective] The paper was to explore the therapeutic effect of traditional Chinese medicine on damp-heat diarrhea of piglets in summer.[Method] Three prescriptions were developed with a dozen of traditional Chinese medicines,and in vitro antibacterial test against swine standard Escherichia coli [O149：K91,K88 ac（C83907）] was conducted.Moreover,106 natural cases of diarrhea piglets caused by coinfection of damp-heat and E.coli through clinical and laboratory diagnosis were then treated.[Result] The oral liquids prepared by three traditional Chinese medicine prescriptions had certain antibacterial effect on standard pathogenic E.coli.Prescription 2 presented the strongest inhibitory effects on swine E.coli in vitro,with the MIC of 31.25 mg/m L.It had better therapeutic effect,and the effective rate reached 94.74%.[Conclusion] The prescription 2 mainly consisted of Coptis chinensis and Prunus mume might be effective in treatment of piglet diarrhea caused by damp heat and E.coli in clinic.
文摘BACKGROUND A patient with type Ⅲ Kummell’s disease had a ruptured posterior cortex of the fractured vertebral body, which caused spinal cord compression. An open surgery was considered the best choice of operation. However, the patient and her family refused open surgery and instead demanded a minimally invasive surgical treatment such as percutaneous vertebroplasty(PVP). After preoperative discussion, we finally adopted the novel therapy of traditional Chinese medicine manipulative reduction(TCMMR) combined with PVP.CASE SUMMARY A patient with type Ⅲ Kummell’s disease exhibiting bone block-induced spinal cord compression was admitted to our hospital. She suffered from a variety of medical disorders but refused open surgery, and instead asked for PVP surgery. TCMMR, in parallel with PVP, was used to restore the height of the compressed vertebral body and reduce the symptoms of spinal cord compression by the bone block in order to strengthen the vertebral body and prevent further collapse. The surgery was very successful. The height of the compressed vertebra was restored, and the symptom of spinal cord compression by bone block was reduced successfully via TCMMR. The fractured vertebra was solidified by the PVP. The pain visual analog score declined from preoperative 7 scores to postoperative 2 scores, and the Frankel spinal cord scale increased from preoperative D degree to postoperative E degree.CONCLUSION The new method has advantages in treating patients with type Ⅲ Kummell’s disease who cannot be treated with open surgery.
基金Six Talent Peak Projects in Jiangsu Province (RJFW-40)Jiangsu Province “333 High-level Talent Training Project”(2018Ⅲ-0121)+2 种基金Technology Innovation Fund of Science and Technology Enterprises in Jiangsu Province (BC2015022)Representative Project of Intangible Cultural Heritage in Pukou District,Nanjing (PKIX-4)The Construction and Application of Thyroid Disease Differentiation and Treatment Rule Mining and Clinical Decision Support System by Traditional Chinese Medicine Master ZHOU Zhongying (012071003583)。
文摘Objective Based on intra-set correlation analysis, this paper deconstructs the clinical medical records of traditional Chinese medicine(TCM) Master ZHOU Zhongying in treating thyroid cancer, and analyzes the experience in “mechanism-syndrome-medicine-prescription” for thyroid cancer.Methods Through Medcase data processing platform, based on Frequent Pattern(FP)-Growth enhanced correlation analysis algorithm, the medical records of Professor ZHOU Zhongying for the treatment of thyroid cancer from June 1, 2001 to February 28, 2015 were analyzed within the set.Results This study involved 43 medical records, 43 patients, and 167 visits. After processing intra-set correlations, 28 groups of highly correlated symptoms, 21 groups of highly correlated tongue images, 10 groups of highly correlated pulse conditions, 28 groups of highly correlated pathogenesis, 34 groups of highly correlated herbs, and 26 groups of highly correlated western medicine diagnosis were selected. Professor ZHOU Zhongying treats thyroid cancer according to syndrome differentiation. Symptoms with more association rules included neck swelling, neck pain, cough, and dry mouth;tongue images with more association rules included dark purple tongue, dark red tongue, and fissured tongue;pulse conditions with more association rules were wiry pulse, thready pulse, small pulse, and slippery pulse;the pathogenesis with more association rules was phlegm and blood stasis, damp-heat accumulation,and impairment of both Qi and Yin;herbs with more association rules were Chaihu(Bupleuri Radix), Zeqi(Sun Euphoribiae Herb), and Tiandong(Asparagi Radix);western medicine diagnosis with more association rules included thyroid cancer, insomnia, and chronic gastritis.Conclusion Thyroid cancer mostly presents as deficiency in origin and excess in manifestations. The basic pathogenesis is phlegm and blood stasis, damp-heat accumulation, and impairment of both Qi and Yin, which are closely related to liver, kidney, and spleen. Professor ZHOU Zhongying adopts both attack and supplement approaches as the general treatment principle, with a strong emphasis on regulating Qi and relieving depression, eliminating phlegm and resolving stagnation, eliminating dampness and turbidity, clearing fire and destroying poison, moistening dryness and softening hard mass, invigorating Qi and nourishing Yin, and paying attention to nourishing liver and kidney, invigorating spleen and stomach,while protecting the heart and lungs.
文摘目的:探讨谷红注射液联合中药热敷治疗卒中后认知障碍的临床效果。方法:前瞻性选取2020年8月—2022年8月无锡市康复医院收治的88例卒中后认知障碍患者。根据抽签法将其分为研究组和对照组,各44例。两组均给予常规治疗,对照组给予谷红注射液,研究组在对照组基础上给予中药热敷。比较两组治疗后临床效果、治疗前后神经功能、认知功能、血清学指标、脑血流动力学。结果:研究组总有效率为95.45%,显著高于对照组的79.55%,差异有统计学意义(P<0.05)。治疗后,研究组蒙特利尔认知评估量表(Montreal cognitive assessment,MoCA)、简易智能精神状态检查量表(mini-mental state examination,MMSE)评分均高于对照组,美国国立卫生研究院卒中量表(National Institute of Health stroke scale,NIHSS)评分明显低于对照组,差异有统计学意义(P<0.05)。治疗后,研究组S-100钙结合蛋白β(S-100 calcium binding protein β,S-100β)、视锥蛋白样蛋白-l(visinin like protein 1,VILIP-1)水平均低于对照组,胰岛素样生长因子1(insulin-like growth factor 1,IGF-1)水平高于对照组,差异有统计学意义(P<0.05)。治疗后,研究组收缩期峰值流速(peak flow velocity of systole,Vp)、平均血流速度(mean velocity,Vm)均高于对照组,搏动指数(pulse index,PI)低于对照组,差异有统计学意义(P<0.05)。结论:谷红注射液联合中药热敷治疗卒中后认知障碍患者能促进神经功能恢复,改善认知功能,改善脑血流动力学,提高治疗效果。
