The Application Value of Ultrasound Imaging in the Differential Diagnosis of Benign and Malignant Breast Nodules of BI-RADS 3 and Above

Objective:To explore the diagnostic value of ultrasound imaging for breast nodules of breast imaging-reporting and data system(BI-RADS)category 3 and above.Methods:From June 2021 to July 2022,163 patients with breast nodules of BI-RADS 3 or above were selected as the research subjects.After pathological diagnosis,24 cases were malignant breast nodules of BI-RADS 3 or above,while 139 cases were benign breast nodules of BI-RADS 3 or above.The diagnosis rate of malignant and benign breast nodules of BI-RADS 3 or above,including 95%CI,was observed and analyzed.Results:The malignant and benign detection rates of conventional ultrasound were 88.63%and 75.00%,respectively,and the malignant and benign detection rates of ultrasound imaging were 93.18%and 87.50%,respectively,with 95%CIs greater than 0.7.Conclusion:Ultrasound imaging can help improve the diagnostic accuracy of benign and malignant breast nodules of BI-RADS 3 and above and reduce the misdiagnosis rate.

Biological Databases for Human Research

The completion of the Human Genome Project lays a foundation for systematically studying the human genome from evolutionary history to precision medicine against diseases.With the explosive growth of biological data, there is an increasing number of biological databases that have been developed in aid of human-related research. Here we present a collection of humanrelated biological databases and provide a mini-review by classifying them into different categories according to their data types. As human-related databases continue to grow not only in count but also in volume, challenges are ahead in big data storage, processing, exchange and curation.

Numerical Study of the Impacts of Urban Expansion on Meiyu Precipitation over Eastern China

The Yangtze River Delta（YRD） has experienced significant urban expansion in recent years, while the Meiyu belt of China has demonstrated a decadal northward shifting trend. Thus, it is of interest to assess how urban expansion affects Meiyu precipitation and hopefully to reveal the underlying physical mechanisms involved. In this study, the urban extents over the YRD in 2001 and 2010 are derived based on land use/land cover（LULC） category data and nighttime light image data. Two parallel groups of10-summer（2001-2010） numerical simulations are carried out with the urban extents over the YRD in2001 and 2010, respectively. The results show that the urban expansion in the YRD tends to result in increased（decreased） Meiyu precipitation over the Huaihe River（Yangtze River） basin with intensities of0.2-1.2 mm day-1. Further analysis indicates that the spatiotemporal pattern of the Meiyu precipitation change induced by the urban expansion resembles the third empirical orthogonal function（EOF） mode of the observed Meiyu precipitation. Analyses of the possible underlying physical mechanisms reveal that urban expansion in the YRD leads to changes in the surface energy balance and warming（cooling） of tropospheric（stratospheric） air temperature over eastern China. Anomalous upward（downward） motion and moisture convergence（divergence） over the Huaihe River（Yangtze River） basin occur, corresponding to the increases（decreases） of the Meiyu precipitation over the Huaihe River（Yangtze River） basin.