Cable-stayed bridges have been widely used in high-speed railway infrastructure.The accurate determination of cable’s representative temperatures is vital during the intricate processes of design,construction,and mai...Cable-stayed bridges have been widely used in high-speed railway infrastructure.The accurate determination of cable’s representative temperatures is vital during the intricate processes of design,construction,and maintenance of cable-stayed bridges.However,the representative temperatures of stayed cables are not specified in the existing design codes.To address this issue,this study investigates the distribution of the cable temperature and determinates its representative temperature.First,an experimental investigation,spanning over a period of one year,was carried out near the bridge site to obtain the temperature data.According to the statistical analysis of the measured data,it reveals that the temperature distribution is generally uniform along the cable cross-section without significant temperature gradient.Then,based on the limited data,the Monte Carlo,the gradient boosted regression trees(GBRT),and univariate linear regression(ULR)methods are employed to predict the cable’s representative temperature throughout the service life.These methods effectively overcome the limitations of insufficient monitoring data and accurately predict the representative temperature of the cables.However,each method has its own advantages and limitations in terms of applicability and accuracy.A comprehensive evaluation of the performance of these methods is conducted,and practical recommendations are provided for their application.The proposed methods and representative temperatures provide a good basis for the operation and maintenance of in-service long-span cable-stayed bridges.展开更多
The degree of numerical linear independence is proposed and discussed. Based on this linear independence theory, a modified limited memory BFGS method is deve loped. Similar to the standard limited memory method, thi...The degree of numerical linear independence is proposed and discussed. Based on this linear independence theory, a modified limited memory BFGS method is deve loped. Similar to the standard limited memory method, this new method determines the new update by applying the updating formula m times to an initial positive diagonal matrix using the m previous pairs of the change in iteration and gradient. Besides the most recent pair of the change, which guarantees the quadratic termination, the choice of the other ( m -1) pairs of the change in the new method is dependent on the degree of numerical linear independence of previous search directions. In addition, the numerical linear independence theory is further discussed and the computation of the degree of linear independence is simplified. Theoretical and numerical results show that this new modified method improves efficiently the standard limited memory method.展开更多
We study how to use the SR1 update to realize minimization methods for problems where the storage is critical. We give an update formula which generates matrices using information from the last m iterations. The numer...We study how to use the SR1 update to realize minimization methods for problems where the storage is critical. We give an update formula which generates matrices using information from the last m iterations. The numerical tests show that the method is efficent.展开更多
Rubber isolation is the most mature control technology in practical application, and is widely used by short rigid buildings. However, many high isolation buildings have been built around the world in recent years, wh...Rubber isolation is the most mature control technology in practical application, and is widely used by short rigid buildings. However, many high isolation buildings have been built around the world in recent years, which do not follow the existing criterions and codes. Many researchers began to research the special problems caused by larger height-width ratio isolation structures. The overturning effect of high height-width ratio structures with rubber bearing is firstly studied. Considering the main factors, such as the height-width ratio of structures, type of site, the designed basic acceleration of ground motion and the decouple factor in horizon, computing experiment is defined with the Uniform Design Method, which is also known as designing isolation structure. The forces of the bearing under edge of structures based on the position of the rubber bearing are calculated. The result indicates that the rubber bearings will lose its functionality under very high tension and compressing force of earthquake motion in horizon and vertical, when the height-width ratio is over a certain value. Thus, based on the calculation result of isolation structures defined in the uniform design method, regression analysis is conducted, and also the rubber edge force regression formula are gotten, which has higher correlation and smaller standard deviation. This formula can be used to roughly calculate whether the pull force occurs at the edge of the building. By the edge bearings of isolation structure minimum force formula, the height-width ratio limited value of the isolation structure is deducted when rubber bearing has minimum force of zero.展开更多
Toppling failure of rock mass/soil slope is an important geological and environmental problem.Clarifying its failure mechanism under different conditions has great significance in engineering.The toppling failure of a...Toppling failure of rock mass/soil slope is an important geological and environmental problem.Clarifying its failure mechanism under different conditions has great significance in engineering.The toppling failure of a cutting slope occurred in a hydropower station in Kyushu,Japan illustrates that the joint characteristic played a significant role in the occurrence of rock slope tipping failure.Thus,in order to consider the mechanical properties of jointed rock mass and the influence of geometric conditions,a simplified analytical approach based on the limit equilibrium method for modeling the flexural toppling of cut rock slopes is proposed to consider the influence of the mechanical properties and geometry condition of jointed rock mass.The theoretical solution is compared with the numerical solution taking Kyushu Hydropower Station in Japan as one case,and it is found that the theoretical solution obtained by the simplified analysis method is consistent with the numerical analytical solution,thus verifying the accuracy of the simplified method.Meanwhile,the Goodman-Bray approach conventionally used in engineering practice is improved according to the analytical results.The results show that the allowable slope angle may be obtained by the improved Goodman-Bray approach considering the joint spacing,the joint frictional angle and the tensile strength of rock mass together.展开更多
An accurate long-term energy demand forecasting is essential for energy planning and policy making. However, due to the immature energy data collecting and statistical methods, the available data are usually limited i...An accurate long-term energy demand forecasting is essential for energy planning and policy making. However, due to the immature energy data collecting and statistical methods, the available data are usually limited in many regions. In this paper, on the basis of comprehensive literature review, we proposed a hybrid model based on the long-range alternative energy planning (LEAP) model to improve the accuracy of energy demand forecasting in these regions. By taking Hunan province, China as a typical case, the proposed hybrid model was applied to estimating the possible future energy demand and energy-saving potentials in different sectors. The structure of LEAP model was estimated by Sankey energy flow, and Leslie matrix and autoregressive integrated moving average (ARIMA) models were used to predict the population, industrial structure and transportation turnover, respectively. Monte-Carlo method was employed to evaluate the uncertainty of forecasted results. The results showed that the hybrid model combined with scenario analysis provided a relatively accurate forecast for the long-term energy demand in regions with limited statistical data, and the average standard error of probabilistic distribution in 2030 energy demand was as low as 0.15. The prediction results could provide supportive references to identify energy-saving potentials and energy development pathways.展开更多
In this paper, a modified variation of the Limited SQP method is presented for constrained optimization. This method possesses not only the information of gradient but also the information of function value. Moreover,...In this paper, a modified variation of the Limited SQP method is presented for constrained optimization. This method possesses not only the information of gradient but also the information of function value. Moreover, the proposed method requires no more function or derivative evaluations and hardly more storage or arithmetic operations. Under suitable conditions, the global convergence is established.展开更多
Applied statisticians are often confronted with statistical inference problems dealing with situations in which there appear to be no data,or data of only limited usefulness.For example,when attempting to find a confi...Applied statisticians are often confronted with statistical inference problems dealing with situations in which there appear to be no data,or data of only limited usefulness.For example,when attempting to find a confidence interval for a binomial proportion,the sample may contain no successes.Such a scenario could be encountered when attempting to estimate the incidence of an extremely rare side effect associated with the administration of a newly developed drug.In this article,we use examples for our experiences working with scientific investigators and describe several scenarios in which there appeared to be no useful data,or data of only limited usefulness.We describe the methods we prefer for analyzing the data in these situations and illustrate their application using the actual data from the investigations we participated in.展开更多
[Objective] This study was conducted to establish a microbial limit test method for Bupi Qiangli Ointment. [Method] The conventional method and medium dilution method were used for bacterial, mold and yeast counting i...[Objective] This study was conducted to establish a microbial limit test method for Bupi Qiangli Ointment. [Method] The conventional method and medium dilution method were used for bacterial, mold and yeast counting in sample recovery test. [Result] The medium dilution method (1:10 test solution, 0.5 ml/plate) could effectively eliminate the inhibition effect of the Bupi Qiangli Ointment, and the recovery of Staphylococcus aureus was greater than 70% in the 3 batches of samples; and the conventional method exhibited the recoveries of E. coil, Bacillus subtilis, Candida albicans and Aspergillus greater than 70% in the 3 batches of samples. [Conclusion] Due to Bupi Qiangli Ointment has strongly antibacterial effect on Staphylococcus au- reus, the medium dilution method was used for bacterial counting, and the conventional method was used for mold and yeast counting; and the conventional method was used for controlled bacterium examination of E. coll.展开更多
A new strategy for elastic modulus adjustment is proposed based on the element bearing ratio (EBR),and the elastic modulus reduction method (EMRM) is proposed for limit load evaluation of frame structures. The EBR...A new strategy for elastic modulus adjustment is proposed based on the element bearing ratio (EBR),and the elastic modulus reduction method (EMRM) is proposed for limit load evaluation of frame structures. The EBR is defined employing the generalized yield criterion,and the reference EBR is determined by introducing the extrema and the degree of uniformity of EBR in the structure. The elastic modulus in the element with an EBR greater than the reference one is reduced based on the linear elastic finite element analysis and the equilibrium of strain energy. The lower-bound of limit-loads of frame structures are analyzed and the numerical example demonstrates the flexibility,accuracy and effciency of the proposed method.展开更多
Overhanging rock slopes(steeper than 90°) are typically avoided in rock engineering design, particularly where the scale of the slope exceeds the scale of fracturing present in the rock mass. This paper highlight...Overhanging rock slopes(steeper than 90°) are typically avoided in rock engineering design, particularly where the scale of the slope exceeds the scale of fracturing present in the rock mass. This paper highlights an integrated approach of designing overhanging rock slopes where the relative dimensions of the slope exceed the scale of fracturing and the rock mass failure needs to be considered rather than kinematic release of individual blocks. The key to the method is a simplified limit equilibrium(LE) tool that was used for the support design and analysis of a multi-faceted overhanging rock slope. The overhanging slopes required complex geometries with constantly changing orientations. The overhanging rock varied in height from 30 m to 66 m. Geomechanical modelling combined with discrete fracture network(DFN)representation of the rock mass was used to validate the rock mass strength assumptions and the failure mechanism assumed in the LE model. The advantage of the simplified LE method is that buttress and support design iterations(along with sensitivity analysis of design parameters) can be completed for various cross-sections along the proposed overhanging rock sections in an efficient manner, compared to the more time-intensive, sophisticated methods that were used for the initial validation. The method described presents the development of this design tool and assumptions made for a specific overhanging rock slope design. Other locations will have different geological conditions that can control the potential behaviour of rock slopes, however, the approach presented can be applied as a general guiding design principle for overhanging rock cut slope.展开更多
The modified suction caisson(MSC) adds a short-skirted structure around the regular suction caissons to increase the lateral bearing capacity and limit the deflection. The MSC is suitable for acting as the offshore wi...The modified suction caisson(MSC) adds a short-skirted structure around the regular suction caissons to increase the lateral bearing capacity and limit the deflection. The MSC is suitable for acting as the offshore wind turbine foundation subjected to larger lateral loads compared with the imposed vertical loads. Determination of the lateral bearing capacity is a key issue for the MSC design. The formula estimating the lateral bearing capacity of the MSC was proposed in terms of the limit equilibrium method and was verified by the test results. Parametric studies on the lateral bearing capacity were also carried out. It was found that the lateral bearing capacity of the MSC increases with the increasing length and radius of the external skirt, and the lateral bearing capacity increases linearly with the increasing coefficient of subgrade reaction. The maximum lateral bearing capacity of the MSC is attained when the ratio of the radii of the internal compartment to the external skirt equals 0.82 and the ratio of the lengths of the external skirt to the internal compartment equals 0.48, provided that the steel usage of the MSC is kept constant.展开更多
The forming limit curve (FLC) can be obtained by means of curve fitting the limit strain points of different strain paths. The theory of percent regression analysis is applied to the curve fitting of forming limit e...The forming limit curve (FLC) can be obtained by means of curve fitting the limit strain points of different strain paths. The theory of percent regression analysis is applied to the curve fitting of forming limit experimental data.Forecast intervals of FLC percentiles can be calculated. Thus reliability and confidence level can be considered. The theoretical method to get the limits of limit strain points distributing region is presented, and the FLC position can be adjusted according to practical requirement. Method for establishing FLC with high reliability using small samples is presented at the same time. This method can make full use of the current experimental data and the previous data.Compared with the traditional method that can only use current experimental data, fewer specimens are required in the present method to obtain the same precision and the result is more accurate with the same number of specimens.展开更多
In this paper, a generalized limit equilibrium method of solving the active earth pressure problem behind a retaining wall is proposed.Differing from other limit equilibrium methods, an arbitrary slip surface shape wi...In this paper, a generalized limit equilibrium method of solving the active earth pressure problem behind a retaining wall is proposed.Differing from other limit equilibrium methods, an arbitrary slip surface shape without any assumptions of pre-defined shapes is needed in the current framework, which is verified to find the most probable failure slip surface. Based on the current computational framework, numerical comparisons with experiment, discrete element method and other methods are carried out. In addition, the influences of the inclination of the wall, the soil cohesion, the angle of the internal friction of the soil, the slope inclination of the backfill soil on the critical pressure coefficient of the soil, the point of application of the resultant earth pressure and the shape of the slip surface are also carefully investigated. The results demonstrate that limit equilibrium solution from predefined slip plane assumption, including Coulomb solution, is a special case of current computational framework. It is well illustrated that the current method is feasible to evaluate the characteristics of earth pressure problem.展开更多
One of the critical aspects in mine design is slope stability analysis and the determination of stable slopes. In the Chador- Malu iron ore mine, one of the most important iron ore mines in central Iran, it was consid...One of the critical aspects in mine design is slope stability analysis and the determination of stable slopes. In the Chador- Malu iron ore mine, one of the most important iron ore mines in central Iran, it was considered vital to perform a comprehensive slope stability analysis. At first, we divided the existing rock hosting pit into six zones and a geotechnical map was prepared. Then, the value of MRMR (Mining Rock Mass Rating) was determined for each zone. Owing to the fact that the Chador-Malu iron ore mine is located in a highly tectonic area and the rock mass completely crushed, the Hoek-Brown failure criterion was found suitable to estimate geo-mechanical parameters. After that, the value of cohesion (c) and friction angle (tp) were calculated for different geotechnical zones and relative graphs and equations were derived as a function of slope height. The stability analyses using numerical and limit equilibrium methods showed that some instability problems might occur by increasing the slope height. Therefore, stable slopes for each geotechnical zone and prepared sections were calculated and presented as a function of slope height.展开更多
A novel class of weighted essentially nonoscillatory (WENO) schemes based on Hermite polynomi- als, termed as HWENO schemes, is developed and applied as limiters for high order discontinuous Galerkin (DG) method o...A novel class of weighted essentially nonoscillatory (WENO) schemes based on Hermite polynomi- als, termed as HWENO schemes, is developed and applied as limiters for high order discontinuous Galerkin (DG) method on triangular grids. The developed HWENO methodology utilizes high-order derivative information to keep WENO re- construction stencils in the von Neumann neighborhood. A simple and efficient technique is also proposed to enhance the smoothness of the existing stencils, making higher-order scheme stable and simplifying the reconstruction process at the same time. The resulting HWENO-based limiters are as compact as the underlying DG schemes and therefore easy to implement. Numerical results for a wide range of flow conditions demonstrate that for DG schemes of up to fourth order of accuracy, the designed HWENO limiters can simul- taneously obtain uniform high order accuracy and sharp, es- sentially non-oscillatory shock transition.展开更多
A new method is proposed for slope optimization design based on the limit curve method, where the slope is in the limit equilibrium state when the limit slope curve determined by the slip-line field theory and the slo...A new method is proposed for slope optimization design based on the limit curve method, where the slope is in the limit equilibrium state when the limit slope curve determined by the slip-line field theory and the slope intersect at the toe of the slope. Compared with the strength reduction (SR) method, finite element limit analysis method, and the SR method based on Davis algorithm, the new method is suitable for determining the slope stability and limit slope angle (LSA). The optimal slope shape is determined based on a series of slope heights and LSA values, which increases the LSA by 2.45°-11.14° and reduces an invalid overburden amount of rocks by 9.15%, compared with the space mechanics theory. The proposed method gives the objective quantification index of instability criterion, and results in a significant engineering economy.展开更多
It is widely recognized that assessments of the status of data-poor fish stocks are challenging and that Bayesian analysis is one of the methods which can be used to improve the reliability of stock assessments in dat...It is widely recognized that assessments of the status of data-poor fish stocks are challenging and that Bayesian analysis is one of the methods which can be used to improve the reliability of stock assessments in data-poor situations through borrowing strength from prior information deduced from species with good-quality data or other known information. Because there is considerable uncertainty remaining in the stock assessment of albacore tuna(Thunnus alalunga) in the Indian Ocean due to the limited and low-quality data, we investigate the advantages of a Bayesian method in data-poor stock assessment by using Indian Ocean albacore stock assessment as an example. Eight Bayesian biomass dynamics models with different prior assumptions and catch data series were developed to assess the stock. The results show(1) the rationality of choice of catch data series and assumption of parameters could be enhanced by analyzing the posterior distribution of the parameters;(2) the reliability of the stock assessment could be improved by using demographic methods to construct a prior for the intrinsic rate of increase(r). Because we can make use of more information to improve the rationality of parameter estimation and the reliability of the stock assessment compared with traditional statistical methods by incorporating any available knowledge into the informative priors and analyzing the posterior distribution based on Bayesian framework in data-poor situations, we suggest that the Bayesian method should be an alternative method to be applied in data-poor species stock assessment, such as Indian Ocean albacore.展开更多
This paper describes a precise method combining numerical analysis and limit equilibrium theory to determine potential slip surfaces in soil slopes. In this method, the direction of the critical slip surface at any po...This paper describes a precise method combining numerical analysis and limit equilibrium theory to determine potential slip surfaces in soil slopes. In this method, the direction of the critical slip surface at any point in a slope is determined using the Coulomb’s strength principle and the extremum principle based on the ratio of the shear strength to the shear stress at that point. The ratio, which is considered as an analysis index, can be computed once the stress field of the soil slope is obtained. The critical slip direction at any point in the slope must be the tangential direction of a potential slip surface passing through the point. Therefore, starting from a point on the top of the slope surface or on the horizontal segment outside the slope toe, the increment with a small distance into the slope is used to choose another point and the corresponding slip direction at the point is computed. Connecting all the points used in the computation forms a potential slip surface exiting at the starting point. Then the factor of safety for any potential slip surface can be computed using limit equilibrium method like Spencer method. After factors of safety for all the potential slip surfaces are obtained, the minimum one is the factor of safety for the slope and the corresponding potential slip surface is the critical slip surface of the slope. The proposed method does not need to pre-assume the shape of potential slip surfaces. Thus it is suitable for any shape of slip surfaces. Moreover the method is very simple to be applied. Examples are presented in this paper to illustrate the feasibility of the proposed method programmed in ANSYS software by macro commands.展开更多
基金Project(2017G006-N)supported by the Project of Science and Technology Research and Development Program of China Railway Corporation。
文摘Cable-stayed bridges have been widely used in high-speed railway infrastructure.The accurate determination of cable’s representative temperatures is vital during the intricate processes of design,construction,and maintenance of cable-stayed bridges.However,the representative temperatures of stayed cables are not specified in the existing design codes.To address this issue,this study investigates the distribution of the cable temperature and determinates its representative temperature.First,an experimental investigation,spanning over a period of one year,was carried out near the bridge site to obtain the temperature data.According to the statistical analysis of the measured data,it reveals that the temperature distribution is generally uniform along the cable cross-section without significant temperature gradient.Then,based on the limited data,the Monte Carlo,the gradient boosted regression trees(GBRT),and univariate linear regression(ULR)methods are employed to predict the cable’s representative temperature throughout the service life.These methods effectively overcome the limitations of insufficient monitoring data and accurately predict the representative temperature of the cables.However,each method has its own advantages and limitations in terms of applicability and accuracy.A comprehensive evaluation of the performance of these methods is conducted,and practical recommendations are provided for their application.The proposed methods and representative temperatures provide a good basis for the operation and maintenance of in-service long-span cable-stayed bridges.
文摘The degree of numerical linear independence is proposed and discussed. Based on this linear independence theory, a modified limited memory BFGS method is deve loped. Similar to the standard limited memory method, this new method determines the new update by applying the updating formula m times to an initial positive diagonal matrix using the m previous pairs of the change in iteration and gradient. Besides the most recent pair of the change, which guarantees the quadratic termination, the choice of the other ( m -1) pairs of the change in the new method is dependent on the degree of numerical linear independence of previous search directions. In addition, the numerical linear independence theory is further discussed and the computation of the degree of linear independence is simplified. Theoretical and numerical results show that this new modified method improves efficiently the standard limited memory method.
文摘We study how to use the SR1 update to realize minimization methods for problems where the storage is critical. We give an update formula which generates matrices using information from the last m iterations. The numerical tests show that the method is efficent.
文摘Rubber isolation is the most mature control technology in practical application, and is widely used by short rigid buildings. However, many high isolation buildings have been built around the world in recent years, which do not follow the existing criterions and codes. Many researchers began to research the special problems caused by larger height-width ratio isolation structures. The overturning effect of high height-width ratio structures with rubber bearing is firstly studied. Considering the main factors, such as the height-width ratio of structures, type of site, the designed basic acceleration of ground motion and the decouple factor in horizon, computing experiment is defined with the Uniform Design Method, which is also known as designing isolation structure. The forces of the bearing under edge of structures based on the position of the rubber bearing are calculated. The result indicates that the rubber bearings will lose its functionality under very high tension and compressing force of earthquake motion in horizon and vertical, when the height-width ratio is over a certain value. Thus, based on the calculation result of isolation structures defined in the uniform design method, regression analysis is conducted, and also the rubber edge force regression formula are gotten, which has higher correlation and smaller standard deviation. This formula can be used to roughly calculate whether the pull force occurs at the edge of the building. By the edge bearings of isolation structure minimum force formula, the height-width ratio limited value of the isolation structure is deducted when rubber bearing has minimum force of zero.
基金Project(52109132)supported by the National Natural Science Foundation of ChinaProject(ZR2020QE270)supported by the Natural Science Foundation of Shandong Province,China+1 种基金Project(JMDPC202204)supported by State Key Laboratory of Strata Intelligent Control,Green Mining Co-founded by Shandong Province and the Ministry of Science and TechnologyShandong University of Science and Technology,China。
文摘Toppling failure of rock mass/soil slope is an important geological and environmental problem.Clarifying its failure mechanism under different conditions has great significance in engineering.The toppling failure of a cutting slope occurred in a hydropower station in Kyushu,Japan illustrates that the joint characteristic played a significant role in the occurrence of rock slope tipping failure.Thus,in order to consider the mechanical properties of jointed rock mass and the influence of geometric conditions,a simplified analytical approach based on the limit equilibrium method for modeling the flexural toppling of cut rock slopes is proposed to consider the influence of the mechanical properties and geometry condition of jointed rock mass.The theoretical solution is compared with the numerical solution taking Kyushu Hydropower Station in Japan as one case,and it is found that the theoretical solution obtained by the simplified analysis method is consistent with the numerical analytical solution,thus verifying the accuracy of the simplified method.Meanwhile,the Goodman-Bray approach conventionally used in engineering practice is improved according to the analytical results.The results show that the allowable slope angle may be obtained by the improved Goodman-Bray approach considering the joint spacing,the joint frictional angle and the tensile strength of rock mass together.
基金Project(51606225) supported by the National Natural Science Foundation of ChinaProject(2016JJ2144) supported by Hunan Provincial Natural Science Foundation of ChinaProject(502221703) supported by Graduate Independent Explorative Innovation Foundation of Central South University,China
文摘An accurate long-term energy demand forecasting is essential for energy planning and policy making. However, due to the immature energy data collecting and statistical methods, the available data are usually limited in many regions. In this paper, on the basis of comprehensive literature review, we proposed a hybrid model based on the long-range alternative energy planning (LEAP) model to improve the accuracy of energy demand forecasting in these regions. By taking Hunan province, China as a typical case, the proposed hybrid model was applied to estimating the possible future energy demand and energy-saving potentials in different sectors. The structure of LEAP model was estimated by Sankey energy flow, and Leslie matrix and autoregressive integrated moving average (ARIMA) models were used to predict the population, industrial structure and transportation turnover, respectively. Monte-Carlo method was employed to evaluate the uncertainty of forecasted results. The results showed that the hybrid model combined with scenario analysis provided a relatively accurate forecast for the long-term energy demand in regions with limited statistical data, and the average standard error of probabilistic distribution in 2030 energy demand was as low as 0.15. The prediction results could provide supportive references to identify energy-saving potentials and energy development pathways.
文摘In this paper, a modified variation of the Limited SQP method is presented for constrained optimization. This method possesses not only the information of gradient but also the information of function value. Moreover, the proposed method requires no more function or derivative evaluations and hardly more storage or arithmetic operations. Under suitable conditions, the global convergence is established.
文摘Applied statisticians are often confronted with statistical inference problems dealing with situations in which there appear to be no data,or data of only limited usefulness.For example,when attempting to find a confidence interval for a binomial proportion,the sample may contain no successes.Such a scenario could be encountered when attempting to estimate the incidence of an extremely rare side effect associated with the administration of a newly developed drug.In this article,we use examples for our experiences working with scientific investigators and describe several scenarios in which there appeared to be no useful data,or data of only limited usefulness.We describe the methods we prefer for analyzing the data in these situations and illustrate their application using the actual data from the investigations we participated in.
基金Supported by Traditional Chinese Medicine and Ethnic Minority Medicine Technology Research Subject of Guizhou Administrative Bureau(QZYY2013-70,QZYY-2014-026)Joint Application of Basic Research Fund of Science and Technology Department o Yunnan Province-Guiyang University of Chinese Medicine(QKHLHZ[2014]7323)~~
文摘[Objective] This study was conducted to establish a microbial limit test method for Bupi Qiangli Ointment. [Method] The conventional method and medium dilution method were used for bacterial, mold and yeast counting in sample recovery test. [Result] The medium dilution method (1:10 test solution, 0.5 ml/plate) could effectively eliminate the inhibition effect of the Bupi Qiangli Ointment, and the recovery of Staphylococcus aureus was greater than 70% in the 3 batches of samples; and the conventional method exhibited the recoveries of E. coil, Bacillus subtilis, Candida albicans and Aspergillus greater than 70% in the 3 batches of samples. [Conclusion] Due to Bupi Qiangli Ointment has strongly antibacterial effect on Staphylococcus au- reus, the medium dilution method was used for bacterial counting, and the conventional method was used for mold and yeast counting; and the conventional method was used for controlled bacterium examination of E. coll.
基金supported by the National Natural Science Foundation of China (No. 50768001)the Foundation of New Century Excellent Talents in University (No. NCET-04-0834)the Guangxi Natural Science Foundation (No. 0728026)
文摘A new strategy for elastic modulus adjustment is proposed based on the element bearing ratio (EBR),and the elastic modulus reduction method (EMRM) is proposed for limit load evaluation of frame structures. The EBR is defined employing the generalized yield criterion,and the reference EBR is determined by introducing the extrema and the degree of uniformity of EBR in the structure. The elastic modulus in the element with an EBR greater than the reference one is reduced based on the linear elastic finite element analysis and the equilibrium of strain energy. The lower-bound of limit-loads of frame structures are analyzed and the numerical example demonstrates the flexibility,accuracy and effciency of the proposed method.
文摘Overhanging rock slopes(steeper than 90°) are typically avoided in rock engineering design, particularly where the scale of the slope exceeds the scale of fracturing present in the rock mass. This paper highlights an integrated approach of designing overhanging rock slopes where the relative dimensions of the slope exceed the scale of fracturing and the rock mass failure needs to be considered rather than kinematic release of individual blocks. The key to the method is a simplified limit equilibrium(LE) tool that was used for the support design and analysis of a multi-faceted overhanging rock slope. The overhanging slopes required complex geometries with constantly changing orientations. The overhanging rock varied in height from 30 m to 66 m. Geomechanical modelling combined with discrete fracture network(DFN)representation of the rock mass was used to validate the rock mass strength assumptions and the failure mechanism assumed in the LE model. The advantage of the simplified LE method is that buttress and support design iterations(along with sensitivity analysis of design parameters) can be completed for various cross-sections along the proposed overhanging rock sections in an efficient manner, compared to the more time-intensive, sophisticated methods that were used for the initial validation. The method described presents the development of this design tool and assumptions made for a specific overhanging rock slope design. Other locations will have different geological conditions that can control the potential behaviour of rock slopes, however, the approach presented can be applied as a general guiding design principle for overhanging rock cut slope.
基金financially supported by the National Natural Science Foundation of China(Grant Nos.51639002 and 51379118)Shandong University of Science and Technology Scientific Found(Grant No.2015TDJH104)
文摘The modified suction caisson(MSC) adds a short-skirted structure around the regular suction caissons to increase the lateral bearing capacity and limit the deflection. The MSC is suitable for acting as the offshore wind turbine foundation subjected to larger lateral loads compared with the imposed vertical loads. Determination of the lateral bearing capacity is a key issue for the MSC design. The formula estimating the lateral bearing capacity of the MSC was proposed in terms of the limit equilibrium method and was verified by the test results. Parametric studies on the lateral bearing capacity were also carried out. It was found that the lateral bearing capacity of the MSC increases with the increasing length and radius of the external skirt, and the lateral bearing capacity increases linearly with the increasing coefficient of subgrade reaction. The maximum lateral bearing capacity of the MSC is attained when the ratio of the radii of the internal compartment to the external skirt equals 0.82 and the ratio of the lengths of the external skirt to the internal compartment equals 0.48, provided that the steel usage of the MSC is kept constant.
文摘The forming limit curve (FLC) can be obtained by means of curve fitting the limit strain points of different strain paths. The theory of percent regression analysis is applied to the curve fitting of forming limit experimental data.Forecast intervals of FLC percentiles can be calculated. Thus reliability and confidence level can be considered. The theoretical method to get the limits of limit strain points distributing region is presented, and the FLC position can be adjusted according to practical requirement. Method for establishing FLC with high reliability using small samples is presented at the same time. This method can make full use of the current experimental data and the previous data.Compared with the traditional method that can only use current experimental data, fewer specimens are required in the present method to obtain the same precision and the result is more accurate with the same number of specimens.
基金Financial support from the Key Research Program of Chinese Academy of Sciences (Grant No. KZZD-EW-05-01)the NSFC (Grant Nos. 41101008, 41272346)the Youth Talent Team Program of the Institute of Mountain Hazards and Environment, Chinese Academy of Sciences, Opening Fund of State Key Laboratory of Geohazard Prevention and Geoenvironment Protection (Chengdu University of Technology) (Grant No. SKLGP2011K010)
文摘In this paper, a generalized limit equilibrium method of solving the active earth pressure problem behind a retaining wall is proposed.Differing from other limit equilibrium methods, an arbitrary slip surface shape without any assumptions of pre-defined shapes is needed in the current framework, which is verified to find the most probable failure slip surface. Based on the current computational framework, numerical comparisons with experiment, discrete element method and other methods are carried out. In addition, the influences of the inclination of the wall, the soil cohesion, the angle of the internal friction of the soil, the slope inclination of the backfill soil on the critical pressure coefficient of the soil, the point of application of the resultant earth pressure and the shape of the slip surface are also carefully investigated. The results demonstrate that limit equilibrium solution from predefined slip plane assumption, including Coulomb solution, is a special case of current computational framework. It is well illustrated that the current method is feasible to evaluate the characteristics of earth pressure problem.
文摘One of the critical aspects in mine design is slope stability analysis and the determination of stable slopes. In the Chador- Malu iron ore mine, one of the most important iron ore mines in central Iran, it was considered vital to perform a comprehensive slope stability analysis. At first, we divided the existing rock hosting pit into six zones and a geotechnical map was prepared. Then, the value of MRMR (Mining Rock Mass Rating) was determined for each zone. Owing to the fact that the Chador-Malu iron ore mine is located in a highly tectonic area and the rock mass completely crushed, the Hoek-Brown failure criterion was found suitable to estimate geo-mechanical parameters. After that, the value of cohesion (c) and friction angle (tp) were calculated for different geotechnical zones and relative graphs and equations were derived as a function of slope height. The stability analyses using numerical and limit equilibrium methods showed that some instability problems might occur by increasing the slope height. Therefore, stable slopes for each geotechnical zone and prepared sections were calculated and presented as a function of slope height.
基金supported by the National Basic Research Program of China (2009CB724104)the National Natural Science Foundation of China (90716010)
文摘A novel class of weighted essentially nonoscillatory (WENO) schemes based on Hermite polynomi- als, termed as HWENO schemes, is developed and applied as limiters for high order discontinuous Galerkin (DG) method on triangular grids. The developed HWENO methodology utilizes high-order derivative information to keep WENO re- construction stencils in the von Neumann neighborhood. A simple and efficient technique is also proposed to enhance the smoothness of the existing stencils, making higher-order scheme stable and simplifying the reconstruction process at the same time. The resulting HWENO-based limiters are as compact as the underlying DG schemes and therefore easy to implement. Numerical results for a wide range of flow conditions demonstrate that for DG schemes of up to fourth order of accuracy, the designed HWENO limiters can simul- taneously obtain uniform high order accuracy and sharp, es- sentially non-oscillatory shock transition.
基金Project(JJKH20180450KJ)supported by Education Department of Jilin Province,ChinaProject(20166008)supported by the Science and Technology Bureau of Jilin Province,China
文摘A new method is proposed for slope optimization design based on the limit curve method, where the slope is in the limit equilibrium state when the limit slope curve determined by the slip-line field theory and the slope intersect at the toe of the slope. Compared with the strength reduction (SR) method, finite element limit analysis method, and the SR method based on Davis algorithm, the new method is suitable for determining the slope stability and limit slope angle (LSA). The optimal slope shape is determined based on a series of slope heights and LSA values, which increases the LSA by 2.45°-11.14° and reduces an invalid overburden amount of rocks by 9.15%, compared with the space mechanics theory. The proposed method gives the objective quantification index of instability criterion, and results in a significant engineering economy.
基金The Innovation Program of Shanghai Municipal Education Commission under contract No.14ZZ147the Opening Project of Key Laboratory of Sustainable Exploitation of Oceanic Fisheries Resources(Shanghai Ocean University),Ministry of Education under contract No.A1-0209-15-0503-1
文摘It is widely recognized that assessments of the status of data-poor fish stocks are challenging and that Bayesian analysis is one of the methods which can be used to improve the reliability of stock assessments in data-poor situations through borrowing strength from prior information deduced from species with good-quality data or other known information. Because there is considerable uncertainty remaining in the stock assessment of albacore tuna(Thunnus alalunga) in the Indian Ocean due to the limited and low-quality data, we investigate the advantages of a Bayesian method in data-poor stock assessment by using Indian Ocean albacore stock assessment as an example. Eight Bayesian biomass dynamics models with different prior assumptions and catch data series were developed to assess the stock. The results show(1) the rationality of choice of catch data series and assumption of parameters could be enhanced by analyzing the posterior distribution of the parameters;(2) the reliability of the stock assessment could be improved by using demographic methods to construct a prior for the intrinsic rate of increase(r). Because we can make use of more information to improve the rationality of parameter estimation and the reliability of the stock assessment compared with traditional statistical methods by incorporating any available knowledge into the informative priors and analyzing the posterior distribution based on Bayesian framework in data-poor situations, we suggest that the Bayesian method should be an alternative method to be applied in data-poor species stock assessment, such as Indian Ocean albacore.
文摘This paper describes a precise method combining numerical analysis and limit equilibrium theory to determine potential slip surfaces in soil slopes. In this method, the direction of the critical slip surface at any point in a slope is determined using the Coulomb’s strength principle and the extremum principle based on the ratio of the shear strength to the shear stress at that point. The ratio, which is considered as an analysis index, can be computed once the stress field of the soil slope is obtained. The critical slip direction at any point in the slope must be the tangential direction of a potential slip surface passing through the point. Therefore, starting from a point on the top of the slope surface or on the horizontal segment outside the slope toe, the increment with a small distance into the slope is used to choose another point and the corresponding slip direction at the point is computed. Connecting all the points used in the computation forms a potential slip surface exiting at the starting point. Then the factor of safety for any potential slip surface can be computed using limit equilibrium method like Spencer method. After factors of safety for all the potential slip surfaces are obtained, the minimum one is the factor of safety for the slope and the corresponding potential slip surface is the critical slip surface of the slope. The proposed method does not need to pre-assume the shape of potential slip surfaces. Thus it is suitable for any shape of slip surfaces. Moreover the method is very simple to be applied. Examples are presented in this paper to illustrate the feasibility of the proposed method programmed in ANSYS software by macro commands.