Bichner reaction,as a unique type of expansive dearomatization,has become a practical strategy for the straightforward assembly of valuable functionalized cycloheptatrienes from ubiquitous aromatic precursors.Although...Bichner reaction,as a unique type of expansive dearomatization,has become a practical strategy for the straightforward assembly of valuable functionalized cycloheptatrienes from ubiquitous aromatic precursors.Although the asymmetric version has been investigated since the early 1990s,enantioselective Bichner reaction is still limited by the catalyst type and substrate scope.This review aims to propose the limitation and possible development direction of this field by summarizing the evolution of catalytic asymmetric Bichner reaction,which is organized on the basis of intra-and intermolecular reactions.Considering the different metal carbene precursors,the reactions are further classified by carbene sources.展开更多
A bicyclo[2.2.2]octane C/D ring system, with a lactonic ring at C-8 and C-9, of the atisine-type C20-diterpenoid alkaloids, was successfully synthesized, using an oxidative dearomatization/intramolecular Diels-Alder r...A bicyclo[2.2.2]octane C/D ring system, with a lactonic ring at C-8 and C-9, of the atisine-type C20-diterpenoid alkaloids, was successfully synthesized, using an oxidative dearomatization/intramolecular Diels-Alder reaction.展开更多
基金support from MoST(No.2021YFC2100100)the National Natural Science Foundation of China(No.22125108)Yunnan Normal University,and Applied Basic Research Projects of Yunnan Province(No.202101AT070217).
文摘Bichner reaction,as a unique type of expansive dearomatization,has become a practical strategy for the straightforward assembly of valuable functionalized cycloheptatrienes from ubiquitous aromatic precursors.Although the asymmetric version has been investigated since the early 1990s,enantioselective Bichner reaction is still limited by the catalyst type and substrate scope.This review aims to propose the limitation and possible development direction of this field by summarizing the evolution of catalytic asymmetric Bichner reaction,which is organized on the basis of intra-and intermolecular reactions.Considering the different metal carbene precursors,the reactions are further classified by carbene sources.
基金the financial support provided by the National Science Foundation of China(No.81273387)
文摘A bicyclo[2.2.2]octane C/D ring system, with a lactonic ring at C-8 and C-9, of the atisine-type C20-diterpenoid alkaloids, was successfully synthesized, using an oxidative dearomatization/intramolecular Diels-Alder reaction.
