Background Fibrinogen-depleting agents are promising in the treatment of cerebral ischemic disease. They were studied by many trials, and the outcomes were different because of different regimens and different doses. ...Background Fibrinogen-depleting agents are promising in the treatment of cerebral ischemic disease. They were studied by many trials, and the outcomes were different because of different regimens and different doses. In this study, we assessed the efficacy and safety of defibrase on acute cerebral infarction in China. Methods A search using Chinese hospital knowledge database （CHKD） and MEDLINE database for randomized controlled trials was carded out. A CHKD （1994 June 2005） search was performed with the keyword ＂defibrase＂, then a second search for the keyword ＂acute cerebral infarction＂; a MEDLINE search （1950 June 2005） was performed with the following keywords： [（cerebral ischemia）, OR （acute cerebral infarction）, OR （stroke）], AND [defibrase]. Meta-analysis was performed with RevMan software 4.2. Results Included were 14 studies comparing the efficiency and safety of defibrase with other drugs in the treatment of acute cerebral infarction. Patients＇ records were pooled （total 646 patients; defibrase, n=328, no defibrase n=318）. Neurological deficit score （NDS） before treatment showed weighted mean differences （WMD）=0.95, 95% confidence interval （CI）= （-0.60, 2.50）, P=0.23; NDS after treatment showed WMD=- 2.20, 95% CI= （-4.21, -0.18）, P=0.03; Barthel index at 3 months showed WMD=4.45, 95% CI= （-0.13, 9.03）, P=0.06; the plasma fibrinogen level before treatment showed WMD=0.02, 95% CI= （-0.16, 0.19）, P=0.86; plasma fibrinogen level after treatment showed WMD=- 1.51, 95% CI= （- 1.88, - 1.15）, P〈0.00 001.Conclusions With the given dose and regimen of defibrase in China, defibrase may play a role of anticoagulation. It might inhibit the progression of stroke and prevent the recurrence of stroke.展开更多
Objective:To study the risk factors of hemorrhagic transformation in patients with acute cerebral infarction and to analyze the risk factors.Methods: A total of 96 patients with acute cerebral infarction after the thr...Objective:To study the risk factors of hemorrhagic transformation in patients with acute cerebral infarction and to analyze the risk factors.Methods: A total of 96 patients with acute cerebral infarction after the thrombolysis in our hospital from June 2016 to December 2017 were selected as the research object. And they were divided into bleeding group 48 cases and hemorrhage transformation group 48 cases according to whether with hemorrhage occurs transformation. Then the lipid metabolism, atrial fibrillation, history of smoking and drinking, history of hypertension and diabetes, blood pressure, treatment time after onset and infarction area of two groups were compared, and the relationship between those factors and the disease were analyzed by the multi-factor Logistic regression analysis.Results: The atrial fibrillation, history of smoking and drinking of two groups had significant differences;The hospital fasting plasma glucose and LDL-C level of two groups had significant differences;the treatment time after onset and infarction area of two groups had significant differences;The multi-factor Logistic regression analysis showed that atrial fibrillation, blood glucose on admission, LDL-C and large area of infarction are the factors affecting the risk of bleeding in patients with acute cerebral infarction transformation.Conclusion:Atrial fibrillation, blood glucose on admission, LDL-C, treatment time after onset and large area of infarction belongs to the patients with acute cerebral infarction after the thrombolysis transformation of bleeding risk factors.展开更多
文摘Background Fibrinogen-depleting agents are promising in the treatment of cerebral ischemic disease. They were studied by many trials, and the outcomes were different because of different regimens and different doses. In this study, we assessed the efficacy and safety of defibrase on acute cerebral infarction in China. Methods A search using Chinese hospital knowledge database （CHKD） and MEDLINE database for randomized controlled trials was carded out. A CHKD （1994 June 2005） search was performed with the keyword ＂defibrase＂, then a second search for the keyword ＂acute cerebral infarction＂; a MEDLINE search （1950 June 2005） was performed with the following keywords： [（cerebral ischemia）, OR （acute cerebral infarction）, OR （stroke）], AND [defibrase]. Meta-analysis was performed with RevMan software 4.2. Results Included were 14 studies comparing the efficiency and safety of defibrase with other drugs in the treatment of acute cerebral infarction. Patients＇ records were pooled （total 646 patients; defibrase, n=328, no defibrase n=318）. Neurological deficit score （NDS） before treatment showed weighted mean differences （WMD）=0.95, 95% confidence interval （CI）= （-0.60, 2.50）, P=0.23; NDS after treatment showed WMD=- 2.20, 95% CI= （-4.21, -0.18）, P=0.03; Barthel index at 3 months showed WMD=4.45, 95% CI= （-0.13, 9.03）, P=0.06; the plasma fibrinogen level before treatment showed WMD=0.02, 95% CI= （-0.16, 0.19）, P=0.86; plasma fibrinogen level after treatment showed WMD=- 1.51, 95% CI= （- 1.88, - 1.15）, P〈0.00 001.Conclusions With the given dose and regimen of defibrase in China, defibrase may play a role of anticoagulation. It might inhibit the progression of stroke and prevent the recurrence of stroke.
文摘Objective:To study the risk factors of hemorrhagic transformation in patients with acute cerebral infarction and to analyze the risk factors.Methods: A total of 96 patients with acute cerebral infarction after the thrombolysis in our hospital from June 2016 to December 2017 were selected as the research object. And they were divided into bleeding group 48 cases and hemorrhage transformation group 48 cases according to whether with hemorrhage occurs transformation. Then the lipid metabolism, atrial fibrillation, history of smoking and drinking, history of hypertension and diabetes, blood pressure, treatment time after onset and infarction area of two groups were compared, and the relationship between those factors and the disease were analyzed by the multi-factor Logistic regression analysis.Results: The atrial fibrillation, history of smoking and drinking of two groups had significant differences;The hospital fasting plasma glucose and LDL-C level of two groups had significant differences;the treatment time after onset and infarction area of two groups had significant differences;The multi-factor Logistic regression analysis showed that atrial fibrillation, blood glucose on admission, LDL-C and large area of infarction are the factors affecting the risk of bleeding in patients with acute cerebral infarction transformation.Conclusion:Atrial fibrillation, blood glucose on admission, LDL-C, treatment time after onset and large area of infarction belongs to the patients with acute cerebral infarction after the thrombolysis transformation of bleeding risk factors.
