Synovial osteochondromatosis is a rare, benign condition of unknown etiology in which the synovium undergoes metaplasia, leading to cartilaginous nodules that ultimately break free, mineralize, and even ossify. The mo...Synovial osteochondromatosis is a rare, benign condition of unknown etiology in which the synovium undergoes metaplasia, leading to cartilaginous nodules that ultimately break free, mineralize, and even ossify. The most commonly involved joint is the knee. Typically, radiographs can be diagnostic and mineralized nodules are pathognomonic. In as many as one-third of cases, however, no calcification or ossification of the cartilage occurs in the early stage of the disease because mineralization is time-dependent. In such cases, gadolinium-enhanced MRI can be useful. Unmineralized nodules are typically peripherally enhanced because they are attached to and derive a vascular supply from the synovium. We experienced an unmineralized case of synovial osteochondromatosis of the right knee joint, in which imaging diagnosis was difficult. Neither calcification nor ossification was observed, but all nodules were released from the synovium as loose bodies and there was no vascular supply. Therefore, MRI did not show a typical appearance. These findings suggest that synovial osteochondromatosis should be considered as a differential diagnosis in a case in which unmineralized loose bodies without a synovial lesion are found in an imaging examination.展开更多
Objective: The aim of this prospective study is <span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">to </span>...Objective: The aim of this prospective study is <span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">to </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">evaluate how much damage the patellar cartilage presents during a total knee replacement. Methods: The damage of the articular patellar surface was analysed by visual inspection and photographs in 354 primary total knee replacement</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">s</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">. The authors graded the degree of cartilage lesion in five groups. The cartilage status was analyzed and correlated with age, gender, side, body mass index (BMI), Kellgren-Lawrence radiographic scale and axial deviation. Results: After statistical analysis, we concluded: there was no evidence of an association between patellar arthrosis and age gender, side, weight and deformity. Conclusions: Articular cartilage was damaged in all 354 knees. Important subchondral bone exposure occurred in 274 knees (77</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">.</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">4%). Obese patients had more severe patellar osteoarthritis.</span></span></span>展开更多
BACKGROUND The incidence of primary osteoarthritis knee is gradually increasing among young individuals.The increasing prevalence of obesity,sedentary lifestyle,sporting activity,and vitamin D deficiency(VDD)has been ...BACKGROUND The incidence of primary osteoarthritis knee is gradually increasing among young individuals.The increasing prevalence of obesity,sedentary lifestyle,sporting activity,and vitamin D deficiency(VDD)has been hypothesized for this shifting disease trend.This study was designed to look for the association of serum vitamin D among these young arthritic patients.AIM To look for the association of serum vitamin D in younger knee osteoarthritis(KOA)patients.METHODS In a 2-year observational study,146 non-obese KOA patients of 35-60 years were evaluated clinically(Knee injury and Osteoarthritis Outcome Score,KOOS)and radiologically(Kellegren-Lawrence stage,KL).The serum 25(OH)D level of these patients and 146 normal healthy individuals of same age group were estimated.RESULTS Both the groups were comparable in terms of age and sex.The average serum 25(OH)D level in healthy individuals and KOA patients was 45.83 ng/mL and 34.58 ng/mL,respectively(P<0.001).Inadequate serum 25(OH)D level(<30 ng/mL)was found in 46.57%of KOA patients and 24%of normal healthy participants indicating a significant positive association(odds ratio 2.77,95%CI:1.67-4.54,P<0.001).The 25(OH)D level in KL grade I,II,III and IV was 43.40,30.59,31.56 and 33.93 ng/mL respectively(no difference,P=0.47).Similarly,the KOOS score in sufficient,insufficient and deficient groups were 65.31,60.36 and 65.31,respectively(no difference,P=0.051).CONCLUSION The serum 25(OH)D level is significantly low in younger KOA patients.However,the clinical and radiological severities have no association with serum vitamin D level.展开更多
Autologous fat-derived stromal vascular fraction(SVF) is a mixed cell population that has been used for many years in regenerative plastic surgery.In terms of animal and clinical research,this concise review was perfo...Autologous fat-derived stromal vascular fraction(SVF) is a mixed cell population that has been used for many years in regenerative plastic surgery.In terms of animal and clinical research,this concise review was performed to evaluate the efficacy of SVF in knee degenerative joint disease(KDJD),which could cause pain,disability and severely affect patients’ lives.Thirteen studies retrieved and screened from the databases were included,including six animal studies and seven clinical trials.The metaanalysis of clinical research shows that intra-articular injection of SVF,in combination with adjuvant surgery,could alleviate pain and improve early functional recovery for patients with KDJD at Kellgren-Lawrence(KL) grades Ⅱ–Ⅲ.展开更多
目的:探讨桃红四物汤对退行性半月板损伤患者膝关节镜术后关节功能恢复的影响。方法:选取2022年1月—2023年12月在广州市增城区中医医院行膝关节镜手术治疗的100例退行性半月板损伤患者作为研究对象,按照随机数表法将患者分为对照组与...目的:探讨桃红四物汤对退行性半月板损伤患者膝关节镜术后关节功能恢复的影响。方法:选取2022年1月—2023年12月在广州市增城区中医医院行膝关节镜手术治疗的100例退行性半月板损伤患者作为研究对象,按照随机数表法将患者分为对照组与观察组,各50例。对照组膝关节镜术后予以常规处理,观察组在对照组基础上予以桃红四物汤,比较两组疗效、凝血功能、膝关节活动度、疼痛度及膝关节功能。结果:观察组优良率为96.00%,高于对照组的80.00%,差异有统计学意义(P<0.05);观察组术后1周凝血酶原时间(prothrombin time,PT)、活化部分凝血酶时间(activated partial thrombin time,APTT)长于对照组,术后4周Lysholm评估法(Lysholm knee function score,LKSS)评分、美国特种外科医院膝关节评估表(knee joint assessment form of American Hospital for Special Surgery,HSS)评分高于对照组,差异有统计学意义(P<0.05);观察组术后2周、4周膝关节活动度大于对照组,膝关节视觉模拟评分法(visual analogue scale,VAS)评分低于对照组,差异有统计学意义(P<0.05)。结论:桃红四物汤用于退行性半月板损伤患者膝关节镜术后的辅治效果显著,能有效改善凝血功能,增大膝关节活动度,加快缓解疼痛,促进膝关节功能恢复。展开更多
文摘Synovial osteochondromatosis is a rare, benign condition of unknown etiology in which the synovium undergoes metaplasia, leading to cartilaginous nodules that ultimately break free, mineralize, and even ossify. The most commonly involved joint is the knee. Typically, radiographs can be diagnostic and mineralized nodules are pathognomonic. In as many as one-third of cases, however, no calcification or ossification of the cartilage occurs in the early stage of the disease because mineralization is time-dependent. In such cases, gadolinium-enhanced MRI can be useful. Unmineralized nodules are typically peripherally enhanced because they are attached to and derive a vascular supply from the synovium. We experienced an unmineralized case of synovial osteochondromatosis of the right knee joint, in which imaging diagnosis was difficult. Neither calcification nor ossification was observed, but all nodules were released from the synovium as loose bodies and there was no vascular supply. Therefore, MRI did not show a typical appearance. These findings suggest that synovial osteochondromatosis should be considered as a differential diagnosis in a case in which unmineralized loose bodies without a synovial lesion are found in an imaging examination.
文摘Objective: The aim of this prospective study is <span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">to </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">evaluate how much damage the patellar cartilage presents during a total knee replacement. Methods: The damage of the articular patellar surface was analysed by visual inspection and photographs in 354 primary total knee replacement</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">s</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">. The authors graded the degree of cartilage lesion in five groups. The cartilage status was analyzed and correlated with age, gender, side, body mass index (BMI), Kellgren-Lawrence radiographic scale and axial deviation. Results: After statistical analysis, we concluded: there was no evidence of an association between patellar arthrosis and age gender, side, weight and deformity. Conclusions: Articular cartilage was damaged in all 354 knees. Important subchondral bone exposure occurred in 274 knees (77</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">.</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">4%). Obese patients had more severe patellar osteoarthritis.</span></span></span>
文摘BACKGROUND The incidence of primary osteoarthritis knee is gradually increasing among young individuals.The increasing prevalence of obesity,sedentary lifestyle,sporting activity,and vitamin D deficiency(VDD)has been hypothesized for this shifting disease trend.This study was designed to look for the association of serum vitamin D among these young arthritic patients.AIM To look for the association of serum vitamin D in younger knee osteoarthritis(KOA)patients.METHODS In a 2-year observational study,146 non-obese KOA patients of 35-60 years were evaluated clinically(Knee injury and Osteoarthritis Outcome Score,KOOS)and radiologically(Kellegren-Lawrence stage,KL).The serum 25(OH)D level of these patients and 146 normal healthy individuals of same age group were estimated.RESULTS Both the groups were comparable in terms of age and sex.The average serum 25(OH)D level in healthy individuals and KOA patients was 45.83 ng/mL and 34.58 ng/mL,respectively(P<0.001).Inadequate serum 25(OH)D level(<30 ng/mL)was found in 46.57%of KOA patients and 24%of normal healthy participants indicating a significant positive association(odds ratio 2.77,95%CI:1.67-4.54,P<0.001).The 25(OH)D level in KL grade I,II,III and IV was 43.40,30.59,31.56 and 33.93 ng/mL respectively(no difference,P=0.47).Similarly,the KOOS score in sufficient,insufficient and deficient groups were 65.31,60.36 and 65.31,respectively(no difference,P=0.051).CONCLUSION The serum 25(OH)D level is significantly low in younger KOA patients.However,the clinical and radiological severities have no association with serum vitamin D level.
基金supported by the National Natural Science Foundation of China (81974347)the National Clinical Research Center for Geriatrics,West China Hospital Sichuan University(Z2021JC002)the “1.3.5 Program for Disciplines of Excellence”,West China Hospital,Sichuan University (ZYJC18002,2018HXFH040)。
文摘Autologous fat-derived stromal vascular fraction(SVF) is a mixed cell population that has been used for many years in regenerative plastic surgery.In terms of animal and clinical research,this concise review was performed to evaluate the efficacy of SVF in knee degenerative joint disease(KDJD),which could cause pain,disability and severely affect patients’ lives.Thirteen studies retrieved and screened from the databases were included,including six animal studies and seven clinical trials.The metaanalysis of clinical research shows that intra-articular injection of SVF,in combination with adjuvant surgery,could alleviate pain and improve early functional recovery for patients with KDJD at Kellgren-Lawrence(KL) grades Ⅱ–Ⅲ.
文摘目的:探讨桃红四物汤对退行性半月板损伤患者膝关节镜术后关节功能恢复的影响。方法:选取2022年1月—2023年12月在广州市增城区中医医院行膝关节镜手术治疗的100例退行性半月板损伤患者作为研究对象,按照随机数表法将患者分为对照组与观察组,各50例。对照组膝关节镜术后予以常规处理,观察组在对照组基础上予以桃红四物汤,比较两组疗效、凝血功能、膝关节活动度、疼痛度及膝关节功能。结果:观察组优良率为96.00%,高于对照组的80.00%,差异有统计学意义(P<0.05);观察组术后1周凝血酶原时间(prothrombin time,PT)、活化部分凝血酶时间(activated partial thrombin time,APTT)长于对照组,术后4周Lysholm评估法(Lysholm knee function score,LKSS)评分、美国特种外科医院膝关节评估表(knee joint assessment form of American Hospital for Special Surgery,HSS)评分高于对照组,差异有统计学意义(P<0.05);观察组术后2周、4周膝关节活动度大于对照组,膝关节视觉模拟评分法(visual analogue scale,VAS)评分低于对照组,差异有统计学意义(P<0.05)。结论:桃红四物汤用于退行性半月板损伤患者膝关节镜术后的辅治效果显著,能有效改善凝血功能,增大膝关节活动度,加快缓解疼痛,促进膝关节功能恢复。