Silicon(Si)is a competitive anode material owing to its high theoretical capacity and low electrochemical potential.Recently,the prospect of Si anodes in solid-state batteries(SSBs)has been proposed due to less solid ...Silicon(Si)is a competitive anode material owing to its high theoretical capacity and low electrochemical potential.Recently,the prospect of Si anodes in solid-state batteries(SSBs)has been proposed due to less solid electrolyte interphase(SEI)formation and particle pulverization.However,major challenges arise for Si anodes in SSBs at elevated temperatures.In this work,the failure mechanisms of Si-Li_(6)PS_(5)Cl(LPSC)composite anodes above 80℃are thoroughly investigated from the perspectives of interface stability and(electro)chemo-mechanical effect.The chemistry and growth kinetics of Lix Si|LPSC interphase are demonstrated by combining electrochemical,chemical and computational characterizations.Si and/or Si–P compound formed at Lix Si|LPSC interface prove to be detrimental to interface stability at high temperatures.On the other hand,excessive volume expansion and local stress caused by Si lithiation at high temperatures damage the mechanical structure of Si-LPSC composite anodes.This work elucidates the behavior and failure mechanisms of Si-based anodes in SSBs at high temperatures and provides insights into upgrading Si-based anodes for application in SSBs.展开更多
BiVO_(4)porous spheres modified by ZnO were designed and synthesized using a facile two-step method.The resulting ZnO/BiVO_(4)composite catalysts have shown remarkable efficiency as piezoelectric catalysts for degradi...BiVO_(4)porous spheres modified by ZnO were designed and synthesized using a facile two-step method.The resulting ZnO/BiVO_(4)composite catalysts have shown remarkable efficiency as piezoelectric catalysts for degrading Rhodamine B(RhB)unde mechanical vibrations,they exhibit superior activity compared to pure ZnO.The 40wt%ZnO/BiVO_(4)heterojunction composite displayed the highest activity,along with good stability and recyclability.The enhanced piezoelectric catalytic activity can be attributed to the form ation of an I-scheme heterojunction structure,which can effectively inhibit the electron-hole recombination.Furthermore,hole(h+)and superoxide radical(·O_(2)^(-))are proved to be the primary active species.Therefore,ZnO/BiVO_(4)stands as an efficient and stable piezoelectric catalyst with broad potential application in the field of environmental water pollution treatment.展开更多
Although poly(lactic acid)(PLA)is a good environmentally-friendly bio-degradable polymer which is used to substitute traditional petrochemical-based polymer packaging films,the barrier properties of PLA films are stil...Although poly(lactic acid)(PLA)is a good environmentally-friendly bio-degradable polymer which is used to substitute traditional petrochemical-based polymer packaging films,the barrier properties of PLA films are still insufficient for high-barrier packaging applications.In this study,oxygen scavenger hydroxyl-terminated polybutadiene(HTPB)and cobalt salt catalyst were incorporated into the PLA/poly(butylene adipate-co-terephthalate)(PLA/PBAT),followed by melting extrusion and three-layer co-extrusion blown film process to prepare the composite films.The oxygen permeability coefficient of the composite film combined with 6 wt%oxygen scavenger and 0.4 wt%catalyst was decreased significantly from 377.00 cc·mil·m^(-2)·day^(-1)·0.1 MPa^(-1) to 0.98 cc·mil·m^(-2)·day^(-1)·0.1 MPa^(-1),showing a remarkable enhancement of 384.69 times compared with the PLA/PBAT composite film.Meanwhile,the degradation behavior of the composite film was also accelerated,exhibiting a mass loss of nearly 60%of the original mass after seven days of degradation in an alkaline environment,whereas PLA/PBAT composite film only showed a mass loss of 32%.This work has successfully prepared PLA/PBAT composite films with simultaneously improved oxygen barrier property and degradation behavior,which has great potential for high-demanding green chemistry packaging industries,including food,agricultural,and military packaging.展开更多
Cells,tissues,and organs are constantly subjected to the action of mechanical forces from the extracellular environment-and the nervous system is no exception.Cell-intrinsic properties such as membrane lipid compositi...Cells,tissues,and organs are constantly subjected to the action of mechanical forces from the extracellular environment-and the nervous system is no exception.Cell-intrinsic properties such as membrane lipid composition,abundance of mechanosensors,and cytoskeletal dynamics make cells more or less likely to sense these forces.Intrinsic and extrinsic cues are integrated by cells and this combined information determines the rate and dynamics of membrane protrusion growth or retraction(Yamada and Sixt,2019).Cell protrusions are extensions of the plasma membrane that play crucial roles in diverse contexts such as cell migration and neuronal synapse formation.In the nervous system,neurons are highly dynamic cells that can change the size and number of their pre-and postsynaptic elements(called synaptic boutons and dendritic spines,respectively),in response to changes in the levels of synaptic activity through a process called plasticity.Synaptic plasticity is a hallmark of the nervous system and is present throughout our lives,being required for functions like memory formation or the learning of new motor skills(Minegishi et al.,2023;Pillai and Franze,2024).展开更多
Although solar steam generation strategy is efficient in desalinating seawater,it is still challenging to achieve continuous solar-thermal desalination of seawater and catalytic degradation of organic pollutants.Herei...Although solar steam generation strategy is efficient in desalinating seawater,it is still challenging to achieve continuous solar-thermal desalination of seawater and catalytic degradation of organic pollutants.Herein,dynamic regulations of hydrogen bonding networks and solvation structures are realized by designing an asymmetric bilayer membrane consisting of a bacterial cellulose/carbon nanotube/Co_(2)(OH)_(2)CO_(3)nanorod top layer and a bacterial cellulose/Co_(2)(OH)_(2)CO_(3)nanorod(BCH)bottom layer.Crucially,the hydrogen bonding networks inside the membrane can be tuned by the rich surface–OH groups of the bacterial cellulose and Co_(2)(OH)_(2)CO_(3)as well as the ions and radicals in situ generated during the catalysis process.Moreover,both SO_(4)^(2−)and HSO_(5)−can regulate the solvation structure of Na^(+)and be adsorbed more preferentially on the evaporation surface than Cl^(−),thus hindering the de-solvation of the solvated Na^(+)and subsequent nucleation/growth of NaCl.Furthermore,the heat generated by the solar-thermal energy conversion can accelerate the reaction kinetics and enhance the catalytic degradation efficiency.This work provides a flow-bed water purification system with an asymmetric solar-thermal and catalytic membrane for synergistic solar thermal desalination of seawater/brine and catalytic degradation of organic pollutants.展开更多
Retinal aging has been recognized as a significant risk factor for various retinal disorders,including diabetic retinopathy,age-related macular degeneration,and glaucoma,following a growing understanding of the molecu...Retinal aging has been recognized as a significant risk factor for various retinal disorders,including diabetic retinopathy,age-related macular degeneration,and glaucoma,following a growing understanding of the molecular underpinnings of their development.This comprehensive review explores the mechanisms of retinal aging and investigates potential neuroprotective approaches,focusing on the activation of transcription factor EB.Recent meta-analyses have demonstrated promising outcomes of transcription factor EB-targeted strategies,such as exercise,calorie restriction,rapamycin,and metformin,in patients and animal models of these common retinal diseases.The review critically assesses the role of transcription factor EB in retinal biology during aging,its neuroprotective effects,and its therapeutic potential for retinal disorders.The impact of transcription factor EB on retinal aging is cell-specific,influencing metabolic reprogramming and energy homeostasis in retinal neurons through the regulation of mitochondrial quality control and nutrient-sensing pathways.In vascular endothelial cells,transcription factor EB controls important processes,including endothelial cell proliferation,endothelial tube formation,and nitric oxide levels,thereby influencing the inner blood-retinal barrier,angiogenesis,and retinal microvasculature.Additionally,transcription factor EB affects vascular smooth muscle cells,inhibiting vascular calcification and atherogenesis.In retinal pigment epithelial cells,transcription factor EB modulates functions such as autophagy,lysosomal dynamics,and clearance of the aging pigment lipofuscin,thereby promoting photoreceptor survival and regulating vascular endothelial growth factor A expression involved in neovascularization.These cell-specific functions of transcription factor EB significantly impact retinal aging mechanisms encompassing proteostasis,neuronal synapse plasticity,energy metabolism,microvasculature,and inflammation,ultimately offering protection against retinal aging and diseases.The review emphasizes transcription factor EB as a potential therapeutic target for retinal diseases.Therefore,it is imperative to obtain well-controlled direct experimental evidence to confirm the efficacy of transcription factor EB modulation in retinal diseases while minimizing its risk of adverse effects.展开更多
The complex morphological,anatomical,physiological,and chemical mechanisms within the aging brain have been the hot topic of research for centuries.The aging process alters the brain structure that affects functions a...The complex morphological,anatomical,physiological,and chemical mechanisms within the aging brain have been the hot topic of research for centuries.The aging process alters the brain structure that affects functions and cognitions,but the worsening of such processes contributes to the pathogenesis of neurodegenerative disorders,such as Alzheimer's disease.Beyond these observable,mild morphological shifts,significant functional modifications in neurotransmission and neuronal activity critically influence the aging brain.Understanding these changes is important for maintaining cognitive health,especially given the increasing prevalence of age-related conditions that affect cognition.This review aims to explore the age-induced changes in brain plasticity and molecular processes,differentiating normal aging from the pathogenesis of Alzheimer's disease,thereby providing insights into predicting the risk of dementia,particularly Alzheimer's disease.展开更多
Regulated cell death is a form of cell death that is actively controlled by biomolecules.Several studies have shown that regulated cell death plays a key role after spinal cord injury.Pyroptosis and ferroptosis are ne...Regulated cell death is a form of cell death that is actively controlled by biomolecules.Several studies have shown that regulated cell death plays a key role after spinal cord injury.Pyroptosis and ferroptosis are newly discovered types of regulated cell deaths that have been shown to exacerbate inflammation and lead to cell death in damaged spinal cords.Autophagy,a complex form of cell death that is interconnected with various regulated cell death mechanisms,has garnered significant attention in the study of spinal cord injury.This injury triggers not only cell death but also cellular survival responses.Multiple signaling pathways play pivotal roles in influencing the processes of both deterioration and repair in spinal cord injury by regulating pyroptosis,ferroptosis,and autophagy.Therefore,this review aims to comprehensively examine the mechanisms underlying regulated cell deaths,the signaling pathways that modulate these mechanisms,and the potential therapeutic targets for spinal cord injury.Our analysis suggests that targeting the common regulatory signaling pathways of different regulated cell deaths could be a promising strategy to promote cell survival and enhance the repair of spinal cord injury.Moreover,a holistic approach that incorporates multiple regulated cell deaths and their regulatory pathways presents a promising multi-target therapeutic strategy for the management of spinal cord injury.展开更多
This article discusses the coexistence of prostate adenocarcinoma and prostate urothelial carcinoma.Combining existing literature and research results,the potential mechanisms of the co-occurrence of these two cancers...This article discusses the coexistence of prostate adenocarcinoma and prostate urothelial carcinoma.Combining existing literature and research results,the potential mechanisms of the co-occurrence of these two cancers are explored,including the role of androgen receptor,gene mutations,and their complex interactions in cell signaling pathways,etc.Also,the hypothesis of prostate cancer transformation into urothelial carcinoma is explained from some perspectives,including tumor multipotent stem cell differentiation,epithelial-mesenchymal transition,mesenchymal-epithelial transition,and other mechanisms.Ultimately,the goal is to provide more accurate diagnoses and more personalized treatments in clinical practice,as well as to lay the foundation for improving patient prognoses in the future.展开更多
Postoperative ileus(POI)remains a prevalent and significant challenge following abdominal surgeries,precipitating patient distress,prolonged hospital stays,and escalated medical expenditures.Conventionally addressed v...Postoperative ileus(POI)remains a prevalent and significant challenge following abdominal surgeries,precipitating patient distress,prolonged hospital stays,and escalated medical expenditures.Conventionally addressed via pharmacological interventions,POI is increasingly being explored through adjunctive therapeutic strategies,with acupuncture gaining recognition as a promising option.Acupuncture has demonstrated encouraging potential in promoting gastrointestinal motility in patients with POI.Moreover,recent research has shed light on the therapeutic mechanisms underlying its efficacy.This article aims to present a comprehensive overview of acupuncture as a treatment for POI,highlighting advancements in clinical research and recent elucidations of its mechanistic underpinnings.It aspires to contribute a pivotal reference point for scholars and enthusiasts keen on garnering a deeper understanding of acupuncture’s role in managing POI.展开更多
Fruit trees face various adverse environmental factors,such as extreme hydrothermal changes,soil salinization and low precipitation,leading to different types of stress.High temperature is one of the main factors affe...Fruit trees face various adverse environmental factors,such as extreme hydrothermal changes,soil salinization and low precipitation,leading to different types of stress.High temperature is one of the main factors affecting the growth of fruit trees,and an appropriate ambient temperature is a necessary condition for the normal growth and development of fruit trees.Since the 20th century,due to the intensification of the greenhouse effect and global warming,there has been a significant increase in the occurrence and duration of extreme hot weather in summer has been occurring frequently and for longer durations.Thus,the growth and production of fruit trees are affected by severe hightemperature stress.Therefore,this paper primarily summarized the impacts of high-temperature stress on fruit growth and development,flowering,fruiting,fruit setting and quality.It also discussed the physiological and biochemical responses of fruit trees to high-temperature stress,research progress on the molecular mechanisms and signal transduction pathways underlying fruit tree resistance to heat or high temperature,and research on the investigation of relevant metabolites of fruit trees under stress conditions.The future research directions were discussed,and prospects and potential difficulties were proposed to serve a reference for further investigation on the high-temperature tolerance of fruit trees.展开更多
Over the past few decades,the usage of oxytetracycline(OTC),a kind of antibiotic,has increased with the development of aquaculture and livestock breeding.However,about 30–90%of the applied antibiotics are excreted as...Over the past few decades,the usage of oxytetracycline(OTC),a kind of antibiotic,has increased with the development of aquaculture and livestock breeding.However,about 30–90%of the applied antibiotics are excreted as the parent compounds into the environment,especially with the application of animal manure to agricultural fields.This large influx of antibiotics may lead to the destruction of the natural microbial ecological community and pose great threats to human beings through the food chain.Therefore,the fate and toxicity of OTC in the environment are issues of great concern.Degradation of OTC,including the non-biodegradation and biodegradation,and the biological toxicity of its degradation products or metabolites,are reviewed in this paper.The non-biodegradation pathways include hydroxylation,quinonization,demethylation,decarbonylation,dehydration and secondary alcohol oxidation.Light(particularly UV light),pH and oxidizing substances play important roles in non-biodegradation.Biodegradation products include 4-epi-OTC(EOTC),2-acetyl-2-decarboxy-amido-OTC(ADOTC),α-apo-OTC andβ-apo-OTC.EOTC is an epimer and identied except for the configuration of the C4 dimethylamino group of OTC.Temperature and pH are the main factors affecting biodegradation pathways of OTC.In addition,this review discusses concerns over the biological toxicity of OTC degradation products.展开更多
Amine-based absorption/stripping is one of the promising technology for CO2 capture from natural and industrial gas streams.During the process,amines and CO2 undergo irreversible reactions to produce undesired compoun...Amine-based absorption/stripping is one of the promising technology for CO2 capture from natural and industrial gas streams.During the process,amines and CO2 undergo irreversible reactions to produce undesired compounds,which cause corrosion,foaming,increased viscosity and breakdown of equipment,ultimately contributing to the economic loss and environmental pollution.In this study,the thermal degradation of aqueous diethanolamine in the presence and absence of dissolved CO2 was investigated.The experiments were performed in stainless steel cylinders.The results show that thermal degradation in the absence of CO2 was a slow process;triethanolamine,and tris(2-aminoethyl)amine were only the degradation products identified in the mixture In addition,the rate of degradation was very low,only 3%degradation was observed after 4 weeks.But in the presence of CO2,sixteen degradation products were identified,nine of which were new degradation products reported for the first time in this study.The 3-(2-hydroxyethyl)-2-oxazolidinone,1,4-bis(2-hydroxyethyl)piperazine and triethanolamine were the most abundant degradation products.The remaining DEA concentration after 4 weeks was about 20%of the total amine concentration.The most probable degradation reactions and their mechanisms are also proposed.展开更多
Spent IERs are released during the operation and decommissioning of nuclear facilities.The safe and efficient treatment of spent IERs is an emergent problem in nuclear industry.IRN77 is a typical ion exchange resin wi...Spent IERs are released during the operation and decommissioning of nuclear facilities.The safe and efficient treatment of spent IERs is an emergent problem in nuclear industry.IRN77 is a typical ion exchange resin widely used in many nuclear power plants.Fenton process can degrade organic resins and reduce the radioactive residues volume and the disposal cost significantly.In this work,the IRN77 resin was selected as a model ion exchange resin and its treatment via Fenton process was investigated.The influencing factors for resin degradation,including catalyst dosage,reaction time,initial pH,temperature and oxidant dosage were investigated and optimized via the single-factor experimental method.Under the reaction temperature of 100℃ and reaction time of 120 min at initial pH of 2,more than 97%COD was removed with 1.66 g H_(2)O_(2) and 32 mg FeSO_(4)·7H_(2)O added to per gram of wet resin.The catalyst dosage and H_(2)O_(2) dosage can decrease 78%and 50%respectively compared to previous results.SEM,FT-IR and ion chromatograph were employed to characterize the resin beads,soluble organics and intermediates during the degradation reaction.Based on the characterization results,the resin degradation pathway was discussed in detail and it is proposed to three stages including beads dissociation,styrene and divinylbenzene decomposition and carboxylic acids mineralization.During the IERs degradation,formic acid,acetic acid,propionic acid and oxalic acid were quantitatively monitored as main intermediates,and oxalic acid accounted for over 90%of COD in the final residue solution.Fenton process is suggested as a promising resin degradation method.展开更多
The accelerated degradation in the front ceils of a polymer electrolyte membrane fuel cell(PEMFC) stack seriously reduces the reliability and durability of the whole stack. Most researches only focus on the size and...The accelerated degradation in the front ceils of a polymer electrolyte membrane fuel cell(PEMFC) stack seriously reduces the reliability and durability of the whole stack. Most researches only focus on the size and configuration of the gas intake manifold, which may lead to the maldistribution of flow and pressure. In order to find out the mechanisms of the accelerated degradation in the front cells, an extensive program of experimental and simulation work is initiated and the results are reported. It is found that after long-term lifetime tests the accelerated degradation in the front cells occurs in all three fuel cell stacks with different flow-fields under the U-type feed configuration. Compared with the rear cells of the stack, the voltage of the front cells is much lower at the same current densities and the membrane electrode assembly(MEA) has smaller active area, more catalyst particle agglomeration and higher ohmic impedance. For further investigation, a series of three dimensional isothermal numerical models are built to investigate the degradation mechanisms based on the experimental data. The simulation results reveal that the dry working condition of the membrane and the effect of high-speed gas scouting the MEA are the main causes of the accelerated degradation in the front cells of a PEM fuel cell stack under the U-type feed configuration. Several mitigation strategies that would mitigate these phenomena are presented: removing cells that have failed and replacing them with those of the same aging condition as the average of the stack; choosing a Z-type feed pattern instead of a U-type one; putting several air flow-field plates without MEA in the front of the stack; or exchanging the gas inlet and outlet alternately at a certain interval. This paper specifies the causes of the accelerated degradation in the front cells and provides the mitigation strategies.展开更多
Bacillus thuringiensis(Bt)cotton production is challenged by two main problems,i.e.,the low concentration of Bt protein at the boll setting stage and the lowest insect resistance in bolls among all the cotton plant’s...Bacillus thuringiensis(Bt)cotton production is challenged by two main problems,i.e.,the low concentration of Bt protein at the boll setting stage and the lowest insect resistance in bolls among all the cotton plant’s organs.Therefore,increasing the Bt protein concentration at the boll stage,especially in bolls,has become the main goal for increasing insect resistance in cotton.In this study,two protein degradation inhibitors(ethylene diamine tetra acetic acid(EDTA)and leupeptin)were sprayed on the bolls,subtending leaves,and whole cotton plants at the peak flowering stage of two Bt cultivars(medium maturation Sikang 1(SK1))and early maturation Zhongmian 425(ZM425)in 2019 and 2020.The Bt protein content and protein degradation metabolism were assessed.The results showed that the Bt protein concentrations were enhanced by 21.3 to 38.8%and 25.0 to 38.6%in the treated bolls of SK1 and ZM425 respectively,while they were decreased in the subtending leaves of these treated bolls.In the treated leaves,the Bt protein concentrations increased by 7.6 to 23.5%and 11.2 to 14.9%in SK1 and ZM425,respectively.The combined application of EDTA and leupeptin to the whole cotton plant increased the Bt protein concentrations in both bolls and subtending leaves.The Bt protein concentrations in bolls were higher,increasing by 22.5 to 31.0%and 19.6 to 32.5%for SK1 and ZM425,respectively.The organs treated with EDTA or/and leupeptin showed reduced free amino acid contents,protease and peptidase activities and significant enhancements in soluble protein contents.These results indicated that inhibiting protein degradation could improve the protein content,thus increasing the Bt protein concentrations in the bolls or/and leaves of cotton plants.Therefore,the increase in the Bt protein concentration without yield reduction suggested that these two protein degradation inhibitors may be applicable for improving insect resistance in cotton production.展开更多
The redistribution of three-dimensional(3D)geostress during underground tunnel excavation can easily induce to shear failure along rockmass structural plane,potentially resulting in engineering disasters.However,the c...The redistribution of three-dimensional(3D)geostress during underground tunnel excavation can easily induce to shear failure along rockmass structural plane,potentially resulting in engineering disasters.However,the current understanding of rockmass shear behavior is mainly based on shear tests under2D stress without lateral stress,the shear fracture under 3D stress is unclear,and the relevant 3D shear fracture theory research is deficient.Therefore,this study conducted true triaxial cyclic loading and unloading shear tests on intact and bedded limestone under different normal stress σ_(n) and lateral stressσ_(p)to investigate the shear strength,deformation,and failure characteristics.The results indicate that under differentσ_(n)and σ_(p),the stress–strain hysteresis loop area gradually increases from nearly zero in the pre-peak stage,becomes most significant in the post-peak stage,and then becomes very small in the residual stage as the number of shear test cycles increases.The shear peak strength and failure surface roughness almost linearly increase with the increase inσ_(n),while they first increase and then gradually decrease asσ_(p)increases,with the maximum increases of 12.9%for strength and 15.1%for roughness.The shear residual strength almost linearly increases withσ_(n),but shows no significant change withσ_(p).Based on the acoustic emission characteristic parameters during the test process,the shear fracture process and microscopic failure mechanism were analyzed.As the shear stressτincreases,the acoustic emission activity,main frequency,and amplitude gradually increase,showing a significant rise during the cycle near the peak strength,while remaining almost unchanged in the residual stage.The true triaxial shear fracture process presents tensile-shear mixture failure characteristics dominated by microscopic tensile failure.Based on the test results,a 3D shear strength criterion considering the lateral stress effect was proposed,and the determination methods and evolution of the shear modulus G,cohesion c_(jp),friction angleφ_(jp),and dilation angleψjpduring rockmass shear fracture process were studied.Under differentσ_(n)andσ_(p),G first rapidly decreases and then tends to stabilize;cjp,φ_(jp),andψjpfirst increase rapidly to the maximum value,then decrease slowly,and finally remain basically unchanged.A 3D shear mechanics model considering the effects of lateral stress and shear parameter degradation was further established,and a corresponding numerical calculation program was developed based on3D discrete element software.The proposed model effectively simulates the shear failure evolution process of rockmass under true triaxial shear test,and is further applied to successfully reveal the failure characteristics of surrounding rocks with structural planes under different combinations of tunnel axis and geostress direction.展开更多
Wnts are secreted,lipid-modified proteins that bind to different receptors on the cell surface to activate canonical or non-canonical Wnt signaling pathways,which control various biological processes throughout embryo...Wnts are secreted,lipid-modified proteins that bind to different receptors on the cell surface to activate canonical or non-canonical Wnt signaling pathways,which control various biological processes throughout embryonic development and adult life.Aberrant Wnt signaling pathway underlies a wide range of human disease pathogeneses.展开更多
Heart injury such as myocardial infarction leads to cardiomyocyte loss,fibrotic tissue deposition,and scar formation.These changes reduce cardiac contractility,resulting in heart failure,which causes a huge public hea...Heart injury such as myocardial infarction leads to cardiomyocyte loss,fibrotic tissue deposition,and scar formation.These changes reduce cardiac contractility,resulting in heart failure,which causes a huge public health burden.Military personnel,compared with civilians,is exposed to more stress,a risk factor for heart diseases,making cardiovascular health management and treatment innovation an important topic for military medicine.So far,medical intervention can slow down cardiovascular disease progression,but not yet induce heart regeneration.In the past decades,studies have focused on mechanisms underlying the regenerative capability of the heart and applicable approaches to reverse heart injury.Insights have emerged from studies in animal models and early clinical trials.Clinical interventions show the potential to reduce scar formation and enhance cardiomyocyte proliferation that counteracts the pathogenesis of heart disease.In this review,we discuss the signaling events controlling the regeneration of heart tissue and summarize current therapeutic approaches to promote heart regeneration after injury.展开更多
The synergistic reaction of photocatalysis and advanced oxidation is a valid strategy for the degradation of harmful antibiotic wastewater.Herein,carbon dots(CDs)modified MIL-101(Fe)octahedrons to form CDs/MIL-101(Fe)...The synergistic reaction of photocatalysis and advanced oxidation is a valid strategy for the degradation of harmful antibiotic wastewater.Herein,carbon dots(CDs)modified MIL-101(Fe)octahedrons to form CDs/MIL-101(Fe)composite photocatalyst was synthesized for visible light-driven photocatalytic/persulfate(PS)-activated tetracycline(TC)degradation.The electron spin resonance(ESR)spectra,scavenging experiment and electrochemical analysis were carried out to reveal that the high visible light-driven photocatalytic degradation activity of TC over CDs/MIL-101(Fe)photocatalysts is not only ascribed to the production of free active radicals in the CDs/MIL-101(Fe)/PS system(·OH,·SO_(4-),^(1)O_(2),h^(+)and·O_(2)^(-))but also attributed to the consumption of electrons caused by the PS,which can suppress the recombination of photo-generated carriers as well as strong light scattering and electron trapping effects of CDs.Finally,the possible degradation pathways were proposed by analyzing intermediates via liquid chromatography-mass spectrometry technique.This research presents a rational design conception to construct a CDs/PS-based photocatalysis/advanced oxidation technology with high-efficient degradation activity for the remediation of organic antibiotic pollutant wastewater and for the improvement of carrier transport kinetics of photocatalysts.展开更多
基金Project supported by the Major Program of the National Natural Science Foundation of China (Grant No.22393904)the National Key Research and Development Program of China (Grant No.2022YFB2502200)+1 种基金Beijing Municipal Science&Technology Commission (Grant No.Z221100006722015)the New Energy Vehicle Power Battery Life Cycle Testing and Verification Public Service Platform Project (Grant No.2022-235-224)。
文摘Silicon(Si)is a competitive anode material owing to its high theoretical capacity and low electrochemical potential.Recently,the prospect of Si anodes in solid-state batteries(SSBs)has been proposed due to less solid electrolyte interphase(SEI)formation and particle pulverization.However,major challenges arise for Si anodes in SSBs at elevated temperatures.In this work,the failure mechanisms of Si-Li_(6)PS_(5)Cl(LPSC)composite anodes above 80℃are thoroughly investigated from the perspectives of interface stability and(electro)chemo-mechanical effect.The chemistry and growth kinetics of Lix Si|LPSC interphase are demonstrated by combining electrochemical,chemical and computational characterizations.Si and/or Si–P compound formed at Lix Si|LPSC interface prove to be detrimental to interface stability at high temperatures.On the other hand,excessive volume expansion and local stress caused by Si lithiation at high temperatures damage the mechanical structure of Si-LPSC composite anodes.This work elucidates the behavior and failure mechanisms of Si-based anodes in SSBs at high temperatures and provides insights into upgrading Si-based anodes for application in SSBs.
基金financially supported by the National Natural Science Foundation of China(No.22272151)Public Welfare Technology Application Research Project of Jinhua City,China(No.2023-4-022)。
文摘BiVO_(4)porous spheres modified by ZnO were designed and synthesized using a facile two-step method.The resulting ZnO/BiVO_(4)composite catalysts have shown remarkable efficiency as piezoelectric catalysts for degrading Rhodamine B(RhB)unde mechanical vibrations,they exhibit superior activity compared to pure ZnO.The 40wt%ZnO/BiVO_(4)heterojunction composite displayed the highest activity,along with good stability and recyclability.The enhanced piezoelectric catalytic activity can be attributed to the form ation of an I-scheme heterojunction structure,which can effectively inhibit the electron-hole recombination.Furthermore,hole(h+)and superoxide radical(·O_(2)^(-))are proved to be the primary active species.Therefore,ZnO/BiVO_(4)stands as an efficient and stable piezoelectric catalyst with broad potential application in the field of environmental water pollution treatment.
基金financial support of this work by the National Natural Science Foundation of China(Nos.22378332,52003219)the Open Fund of Zhejiang Key Laboratory of Flexible Electronics(No.2022FE008)+1 种基金the Natural Science Foundation of Ningbo(NO.2022J058)Ministry of Industry and Information Technology high quality development project(TC220A04A-206).
文摘Although poly(lactic acid)(PLA)is a good environmentally-friendly bio-degradable polymer which is used to substitute traditional petrochemical-based polymer packaging films,the barrier properties of PLA films are still insufficient for high-barrier packaging applications.In this study,oxygen scavenger hydroxyl-terminated polybutadiene(HTPB)and cobalt salt catalyst were incorporated into the PLA/poly(butylene adipate-co-terephthalate)(PLA/PBAT),followed by melting extrusion and three-layer co-extrusion blown film process to prepare the composite films.The oxygen permeability coefficient of the composite film combined with 6 wt%oxygen scavenger and 0.4 wt%catalyst was decreased significantly from 377.00 cc·mil·m^(-2)·day^(-1)·0.1 MPa^(-1) to 0.98 cc·mil·m^(-2)·day^(-1)·0.1 MPa^(-1),showing a remarkable enhancement of 384.69 times compared with the PLA/PBAT composite film.Meanwhile,the degradation behavior of the composite film was also accelerated,exhibiting a mass loss of nearly 60%of the original mass after seven days of degradation in an alkaline environment,whereas PLA/PBAT composite film only showed a mass loss of 32%.This work has successfully prepared PLA/PBAT composite films with simultaneously improved oxygen barrier property and degradation behavior,which has great potential for high-demanding green chemistry packaging industries,including food,agricultural,and military packaging.
基金supported by PTDC-01778/2022-NeuroDev3D,iNOVA4Health(UIDB/04462/2020 and UIDP/04462/2020)LS4FUTURE(LA/P/0087/2020)。
文摘Cells,tissues,and organs are constantly subjected to the action of mechanical forces from the extracellular environment-and the nervous system is no exception.Cell-intrinsic properties such as membrane lipid composition,abundance of mechanosensors,and cytoskeletal dynamics make cells more or less likely to sense these forces.Intrinsic and extrinsic cues are integrated by cells and this combined information determines the rate and dynamics of membrane protrusion growth or retraction(Yamada and Sixt,2019).Cell protrusions are extensions of the plasma membrane that play crucial roles in diverse contexts such as cell migration and neuronal synapse formation.In the nervous system,neurons are highly dynamic cells that can change the size and number of their pre-and postsynaptic elements(called synaptic boutons and dendritic spines,respectively),in response to changes in the levels of synaptic activity through a process called plasticity.Synaptic plasticity is a hallmark of the nervous system and is present throughout our lives,being required for functions like memory formation or the learning of new motor skills(Minegishi et al.,2023;Pillai and Franze,2024).
基金Financial support from the National Natural Science Foundation of China(51972016)the Fundamental Research Funds for the Central Universities(JD2417)is gratefully acknowledged.
文摘Although solar steam generation strategy is efficient in desalinating seawater,it is still challenging to achieve continuous solar-thermal desalination of seawater and catalytic degradation of organic pollutants.Herein,dynamic regulations of hydrogen bonding networks and solvation structures are realized by designing an asymmetric bilayer membrane consisting of a bacterial cellulose/carbon nanotube/Co_(2)(OH)_(2)CO_(3)nanorod top layer and a bacterial cellulose/Co_(2)(OH)_(2)CO_(3)nanorod(BCH)bottom layer.Crucially,the hydrogen bonding networks inside the membrane can be tuned by the rich surface–OH groups of the bacterial cellulose and Co_(2)(OH)_(2)CO_(3)as well as the ions and radicals in situ generated during the catalysis process.Moreover,both SO_(4)^(2−)and HSO_(5)−can regulate the solvation structure of Na^(+)and be adsorbed more preferentially on the evaporation surface than Cl^(−),thus hindering the de-solvation of the solvated Na^(+)and subsequent nucleation/growth of NaCl.Furthermore,the heat generated by the solar-thermal energy conversion can accelerate the reaction kinetics and enhance the catalytic degradation efficiency.This work provides a flow-bed water purification system with an asymmetric solar-thermal and catalytic membrane for synergistic solar thermal desalination of seawater/brine and catalytic degradation of organic pollutants.
基金supported by the Start-up Fund for new faculty from the Hong Kong Polytechnic University(PolyU)(A0043215)(to SA)the General Research Fund and Research Impact Fund from the Hong Kong Research Grants Council(15106018,R5032-18)(to DYT)+1 种基金the Research Center for SHARP Vision in PolyU(P0045843)(to SA)the InnoHK scheme from the Hong Kong Special Administrative Region Government(to DYT).
文摘Retinal aging has been recognized as a significant risk factor for various retinal disorders,including diabetic retinopathy,age-related macular degeneration,and glaucoma,following a growing understanding of the molecular underpinnings of their development.This comprehensive review explores the mechanisms of retinal aging and investigates potential neuroprotective approaches,focusing on the activation of transcription factor EB.Recent meta-analyses have demonstrated promising outcomes of transcription factor EB-targeted strategies,such as exercise,calorie restriction,rapamycin,and metformin,in patients and animal models of these common retinal diseases.The review critically assesses the role of transcription factor EB in retinal biology during aging,its neuroprotective effects,and its therapeutic potential for retinal disorders.The impact of transcription factor EB on retinal aging is cell-specific,influencing metabolic reprogramming and energy homeostasis in retinal neurons through the regulation of mitochondrial quality control and nutrient-sensing pathways.In vascular endothelial cells,transcription factor EB controls important processes,including endothelial cell proliferation,endothelial tube formation,and nitric oxide levels,thereby influencing the inner blood-retinal barrier,angiogenesis,and retinal microvasculature.Additionally,transcription factor EB affects vascular smooth muscle cells,inhibiting vascular calcification and atherogenesis.In retinal pigment epithelial cells,transcription factor EB modulates functions such as autophagy,lysosomal dynamics,and clearance of the aging pigment lipofuscin,thereby promoting photoreceptor survival and regulating vascular endothelial growth factor A expression involved in neovascularization.These cell-specific functions of transcription factor EB significantly impact retinal aging mechanisms encompassing proteostasis,neuronal synapse plasticity,energy metabolism,microvasculature,and inflammation,ultimately offering protection against retinal aging and diseases.The review emphasizes transcription factor EB as a potential therapeutic target for retinal diseases.Therefore,it is imperative to obtain well-controlled direct experimental evidence to confirm the efficacy of transcription factor EB modulation in retinal diseases while minimizing its risk of adverse effects.
文摘The complex morphological,anatomical,physiological,and chemical mechanisms within the aging brain have been the hot topic of research for centuries.The aging process alters the brain structure that affects functions and cognitions,but the worsening of such processes contributes to the pathogenesis of neurodegenerative disorders,such as Alzheimer's disease.Beyond these observable,mild morphological shifts,significant functional modifications in neurotransmission and neuronal activity critically influence the aging brain.Understanding these changes is important for maintaining cognitive health,especially given the increasing prevalence of age-related conditions that affect cognition.This review aims to explore the age-induced changes in brain plasticity and molecular processes,differentiating normal aging from the pathogenesis of Alzheimer's disease,thereby providing insights into predicting the risk of dementia,particularly Alzheimer's disease.
基金supported by the Natural Science Foundation of Fujian Province,No.2021J02035(to WX).
文摘Regulated cell death is a form of cell death that is actively controlled by biomolecules.Several studies have shown that regulated cell death plays a key role after spinal cord injury.Pyroptosis and ferroptosis are newly discovered types of regulated cell deaths that have been shown to exacerbate inflammation and lead to cell death in damaged spinal cords.Autophagy,a complex form of cell death that is interconnected with various regulated cell death mechanisms,has garnered significant attention in the study of spinal cord injury.This injury triggers not only cell death but also cellular survival responses.Multiple signaling pathways play pivotal roles in influencing the processes of both deterioration and repair in spinal cord injury by regulating pyroptosis,ferroptosis,and autophagy.Therefore,this review aims to comprehensively examine the mechanisms underlying regulated cell deaths,the signaling pathways that modulate these mechanisms,and the potential therapeutic targets for spinal cord injury.Our analysis suggests that targeting the common regulatory signaling pathways of different regulated cell deaths could be a promising strategy to promote cell survival and enhance the repair of spinal cord injury.Moreover,a holistic approach that incorporates multiple regulated cell deaths and their regulatory pathways presents a promising multi-target therapeutic strategy for the management of spinal cord injury.
文摘This article discusses the coexistence of prostate adenocarcinoma and prostate urothelial carcinoma.Combining existing literature and research results,the potential mechanisms of the co-occurrence of these two cancers are explored,including the role of androgen receptor,gene mutations,and their complex interactions in cell signaling pathways,etc.Also,the hypothesis of prostate cancer transformation into urothelial carcinoma is explained from some perspectives,including tumor multipotent stem cell differentiation,epithelial-mesenchymal transition,mesenchymal-epithelial transition,and other mechanisms.Ultimately,the goal is to provide more accurate diagnoses and more personalized treatments in clinical practice,as well as to lay the foundation for improving patient prognoses in the future.
基金Supported by Clinical Key Project of Peking University Third Hospital,No.BYSY2023049Funding from State Key Laboratory of Female Fertility Promotion,Center for Reproductive Medicine,Department of Obstetrics and Gynecology,Peking University Third Hospital,No.BYSYSZKF2023027.
文摘Postoperative ileus(POI)remains a prevalent and significant challenge following abdominal surgeries,precipitating patient distress,prolonged hospital stays,and escalated medical expenditures.Conventionally addressed via pharmacological interventions,POI is increasingly being explored through adjunctive therapeutic strategies,with acupuncture gaining recognition as a promising option.Acupuncture has demonstrated encouraging potential in promoting gastrointestinal motility in patients with POI.Moreover,recent research has shed light on the therapeutic mechanisms underlying its efficacy.This article aims to present a comprehensive overview of acupuncture as a treatment for POI,highlighting advancements in clinical research and recent elucidations of its mechanistic underpinnings.It aspires to contribute a pivotal reference point for scholars and enthusiasts keen on garnering a deeper understanding of acupuncture’s role in managing POI.
基金supported by the“JBGS”Project of Seed Industry Revitalization in Jiangsu Province[Grant No.JBGS(2021)021]the Earmarked Fund for Jiangsu Agricultural Industry Technology System[Grant No.JATS(2022)510]。
文摘Fruit trees face various adverse environmental factors,such as extreme hydrothermal changes,soil salinization and low precipitation,leading to different types of stress.High temperature is one of the main factors affecting the growth of fruit trees,and an appropriate ambient temperature is a necessary condition for the normal growth and development of fruit trees.Since the 20th century,due to the intensification of the greenhouse effect and global warming,there has been a significant increase in the occurrence and duration of extreme hot weather in summer has been occurring frequently and for longer durations.Thus,the growth and production of fruit trees are affected by severe hightemperature stress.Therefore,this paper primarily summarized the impacts of high-temperature stress on fruit growth and development,flowering,fruiting,fruit setting and quality.It also discussed the physiological and biochemical responses of fruit trees to high-temperature stress,research progress on the molecular mechanisms and signal transduction pathways underlying fruit tree resistance to heat or high temperature,and research on the investigation of relevant metabolites of fruit trees under stress conditions.The future research directions were discussed,and prospects and potential difficulties were proposed to serve a reference for further investigation on the high-temperature tolerance of fruit trees.
基金supported by the National Key R&D Program of China (2018YFD0500206)the National Natural Science Foundation of China (31772395)the Fundamental Research Funds for Central Non-profit Scientific Institution of Institute of Agricultural Resources and Regional Planning, Chinese Academy of Agricultural Sciences (IARRP-2017-13)
文摘Over the past few decades,the usage of oxytetracycline(OTC),a kind of antibiotic,has increased with the development of aquaculture and livestock breeding.However,about 30–90%of the applied antibiotics are excreted as the parent compounds into the environment,especially with the application of animal manure to agricultural fields.This large influx of antibiotics may lead to the destruction of the natural microbial ecological community and pose great threats to human beings through the food chain.Therefore,the fate and toxicity of OTC in the environment are issues of great concern.Degradation of OTC,including the non-biodegradation and biodegradation,and the biological toxicity of its degradation products or metabolites,are reviewed in this paper.The non-biodegradation pathways include hydroxylation,quinonization,demethylation,decarbonylation,dehydration and secondary alcohol oxidation.Light(particularly UV light),pH and oxidizing substances play important roles in non-biodegradation.Biodegradation products include 4-epi-OTC(EOTC),2-acetyl-2-decarboxy-amido-OTC(ADOTC),α-apo-OTC andβ-apo-OTC.EOTC is an epimer and identied except for the configuration of the C4 dimethylamino group of OTC.Temperature and pH are the main factors affecting biodegradation pathways of OTC.In addition,this review discusses concerns over the biological toxicity of OTC degradation products.
基金Supported by the University of Malaya Research Grant(RP038C15HTM,RP020C-14AFR,RP031B-15AFR,IPPP(PG209-2014B))the High Impact Research Grant of the University of Malaya(UM.C/625/1/HIR/123).
文摘Amine-based absorption/stripping is one of the promising technology for CO2 capture from natural and industrial gas streams.During the process,amines and CO2 undergo irreversible reactions to produce undesired compounds,which cause corrosion,foaming,increased viscosity and breakdown of equipment,ultimately contributing to the economic loss and environmental pollution.In this study,the thermal degradation of aqueous diethanolamine in the presence and absence of dissolved CO2 was investigated.The experiments were performed in stainless steel cylinders.The results show that thermal degradation in the absence of CO2 was a slow process;triethanolamine,and tris(2-aminoethyl)amine were only the degradation products identified in the mixture In addition,the rate of degradation was very low,only 3%degradation was observed after 4 weeks.But in the presence of CO2,sixteen degradation products were identified,nine of which were new degradation products reported for the first time in this study.The 3-(2-hydroxyethyl)-2-oxazolidinone,1,4-bis(2-hydroxyethyl)piperazine and triethanolamine were the most abundant degradation products.The remaining DEA concentration after 4 weeks was about 20%of the total amine concentration.The most probable degradation reactions and their mechanisms are also proposed.
文摘Spent IERs are released during the operation and decommissioning of nuclear facilities.The safe and efficient treatment of spent IERs is an emergent problem in nuclear industry.IRN77 is a typical ion exchange resin widely used in many nuclear power plants.Fenton process can degrade organic resins and reduce the radioactive residues volume and the disposal cost significantly.In this work,the IRN77 resin was selected as a model ion exchange resin and its treatment via Fenton process was investigated.The influencing factors for resin degradation,including catalyst dosage,reaction time,initial pH,temperature and oxidant dosage were investigated and optimized via the single-factor experimental method.Under the reaction temperature of 100℃ and reaction time of 120 min at initial pH of 2,more than 97%COD was removed with 1.66 g H_(2)O_(2) and 32 mg FeSO_(4)·7H_(2)O added to per gram of wet resin.The catalyst dosage and H_(2)O_(2) dosage can decrease 78%and 50%respectively compared to previous results.SEM,FT-IR and ion chromatograph were employed to characterize the resin beads,soluble organics and intermediates during the degradation reaction.Based on the characterization results,the resin degradation pathway was discussed in detail and it is proposed to three stages including beads dissociation,styrene and divinylbenzene decomposition and carboxylic acids mineralization.During the IERs degradation,formic acid,acetic acid,propionic acid and oxalic acid were quantitatively monitored as main intermediates,and oxalic acid accounted for over 90%of COD in the final residue solution.Fenton process is suggested as a promising resin degradation method.
基金supported by National Basic Research Program of China(973 Program,Grant No.2012CB215500)National Hi-tech Research and Development Program of China(863 Program,Grant Nos.2012AA1106012,2012AA053402)+1 种基金National Natural Science Foundation of China(Grant No.20976095)the Specialized Research Fund for the Doctoral Program of Higher Education,China(Grant No.20090002110074)
文摘The accelerated degradation in the front ceils of a polymer electrolyte membrane fuel cell(PEMFC) stack seriously reduces the reliability and durability of the whole stack. Most researches only focus on the size and configuration of the gas intake manifold, which may lead to the maldistribution of flow and pressure. In order to find out the mechanisms of the accelerated degradation in the front cells, an extensive program of experimental and simulation work is initiated and the results are reported. It is found that after long-term lifetime tests the accelerated degradation in the front cells occurs in all three fuel cell stacks with different flow-fields under the U-type feed configuration. Compared with the rear cells of the stack, the voltage of the front cells is much lower at the same current densities and the membrane electrode assembly(MEA) has smaller active area, more catalyst particle agglomeration and higher ohmic impedance. For further investigation, a series of three dimensional isothermal numerical models are built to investigate the degradation mechanisms based on the experimental data. The simulation results reveal that the dry working condition of the membrane and the effect of high-speed gas scouting the MEA are the main causes of the accelerated degradation in the front cells of a PEM fuel cell stack under the U-type feed configuration. Several mitigation strategies that would mitigate these phenomena are presented: removing cells that have failed and replacing them with those of the same aging condition as the average of the stack; choosing a Z-type feed pattern instead of a U-type one; putting several air flow-field plates without MEA in the front of the stack; or exchanging the gas inlet and outlet alternately at a certain interval. This paper specifies the causes of the accelerated degradation in the front cells and provides the mitigation strategies.
基金supported by the National Natural Science Foundation of China (31901462 and 31671613).
文摘Bacillus thuringiensis(Bt)cotton production is challenged by two main problems,i.e.,the low concentration of Bt protein at the boll setting stage and the lowest insect resistance in bolls among all the cotton plant’s organs.Therefore,increasing the Bt protein concentration at the boll stage,especially in bolls,has become the main goal for increasing insect resistance in cotton.In this study,two protein degradation inhibitors(ethylene diamine tetra acetic acid(EDTA)and leupeptin)were sprayed on the bolls,subtending leaves,and whole cotton plants at the peak flowering stage of two Bt cultivars(medium maturation Sikang 1(SK1))and early maturation Zhongmian 425(ZM425)in 2019 and 2020.The Bt protein content and protein degradation metabolism were assessed.The results showed that the Bt protein concentrations were enhanced by 21.3 to 38.8%and 25.0 to 38.6%in the treated bolls of SK1 and ZM425 respectively,while they were decreased in the subtending leaves of these treated bolls.In the treated leaves,the Bt protein concentrations increased by 7.6 to 23.5%and 11.2 to 14.9%in SK1 and ZM425,respectively.The combined application of EDTA and leupeptin to the whole cotton plant increased the Bt protein concentrations in both bolls and subtending leaves.The Bt protein concentrations in bolls were higher,increasing by 22.5 to 31.0%and 19.6 to 32.5%for SK1 and ZM425,respectively.The organs treated with EDTA or/and leupeptin showed reduced free amino acid contents,protease and peptidase activities and significant enhancements in soluble protein contents.These results indicated that inhibiting protein degradation could improve the protein content,thus increasing the Bt protein concentrations in the bolls or/and leaves of cotton plants.Therefore,the increase in the Bt protein concentration without yield reduction suggested that these two protein degradation inhibitors may be applicable for improving insect resistance in cotton production.
基金the National Natural Science Foundation of China(Nos.52469019,52109119,and 52274145)the Chinese Postdoctoral Science Fund Project(No.2022M723408)+1 种基金the Major Project of Guangxi Science and Technology(No.AA23023016)the Technology Project of China Power Engineering Consulting Group Co.,Ltd.(No.DG2-T01-2023)。
文摘The redistribution of three-dimensional(3D)geostress during underground tunnel excavation can easily induce to shear failure along rockmass structural plane,potentially resulting in engineering disasters.However,the current understanding of rockmass shear behavior is mainly based on shear tests under2D stress without lateral stress,the shear fracture under 3D stress is unclear,and the relevant 3D shear fracture theory research is deficient.Therefore,this study conducted true triaxial cyclic loading and unloading shear tests on intact and bedded limestone under different normal stress σ_(n) and lateral stressσ_(p)to investigate the shear strength,deformation,and failure characteristics.The results indicate that under differentσ_(n)and σ_(p),the stress–strain hysteresis loop area gradually increases from nearly zero in the pre-peak stage,becomes most significant in the post-peak stage,and then becomes very small in the residual stage as the number of shear test cycles increases.The shear peak strength and failure surface roughness almost linearly increase with the increase inσ_(n),while they first increase and then gradually decrease asσ_(p)increases,with the maximum increases of 12.9%for strength and 15.1%for roughness.The shear residual strength almost linearly increases withσ_(n),but shows no significant change withσ_(p).Based on the acoustic emission characteristic parameters during the test process,the shear fracture process and microscopic failure mechanism were analyzed.As the shear stressτincreases,the acoustic emission activity,main frequency,and amplitude gradually increase,showing a significant rise during the cycle near the peak strength,while remaining almost unchanged in the residual stage.The true triaxial shear fracture process presents tensile-shear mixture failure characteristics dominated by microscopic tensile failure.Based on the test results,a 3D shear strength criterion considering the lateral stress effect was proposed,and the determination methods and evolution of the shear modulus G,cohesion c_(jp),friction angleφ_(jp),and dilation angleψjpduring rockmass shear fracture process were studied.Under differentσ_(n)andσ_(p),G first rapidly decreases and then tends to stabilize;cjp,φ_(jp),andψjpfirst increase rapidly to the maximum value,then decrease slowly,and finally remain basically unchanged.A 3D shear mechanics model considering the effects of lateral stress and shear parameter degradation was further established,and a corresponding numerical calculation program was developed based on3D discrete element software.The proposed model effectively simulates the shear failure evolution process of rockmass under true triaxial shear test,and is further applied to successfully reveal the failure characteristics of surrounding rocks with structural planes under different combinations of tunnel axis and geostress direction.
基金supported by the National Natural Science Foundation of China (81772017 to[L.F.H.],and 82072106 and 32371371 to[A.R.Q.])The Project Supported by Natural Science Basic Research Plan in Shaanxi Province of China (2023-JC-YB-163 to[L.F.H.])the National Institutes of Health[AR-070135 and AG-056438 to W.C.,and AR075735,DE023813,AR074954,and DE028264 to Y.P.L.]。
文摘Wnts are secreted,lipid-modified proteins that bind to different receptors on the cell surface to activate canonical or non-canonical Wnt signaling pathways,which control various biological processes throughout embryonic development and adult life.Aberrant Wnt signaling pathway underlies a wide range of human disease pathogeneses.
基金supported by the Natural Science Foundation of Beijing,China(7214223,7212027)the Beijing Hospitals Authority Youth Programme(QML20210601)+3 种基金the Chinese Scholarship Council(CSC)scholarship(201706210415)the National Key Research and Development Program of China(2017YFC0908800)the Beijing Municipal Health Commission(PXM2020_026272_000002,PXM2020_026272_000014)the National Natural Science Foundation of China(82070293).
文摘Heart injury such as myocardial infarction leads to cardiomyocyte loss,fibrotic tissue deposition,and scar formation.These changes reduce cardiac contractility,resulting in heart failure,which causes a huge public health burden.Military personnel,compared with civilians,is exposed to more stress,a risk factor for heart diseases,making cardiovascular health management and treatment innovation an important topic for military medicine.So far,medical intervention can slow down cardiovascular disease progression,but not yet induce heart regeneration.In the past decades,studies have focused on mechanisms underlying the regenerative capability of the heart and applicable approaches to reverse heart injury.Insights have emerged from studies in animal models and early clinical trials.Clinical interventions show the potential to reduce scar formation and enhance cardiomyocyte proliferation that counteracts the pathogenesis of heart disease.In this review,we discuss the signaling events controlling the regeneration of heart tissue and summarize current therapeutic approaches to promote heart regeneration after injury.
基金the funding support from the National Natural Science Foundation of China(21906072,22006057)the Natural Science Foundation of Jiangsu Province(BK20190982)“Doctor of Mass entrepreneurship and innovation”Project in Jiangsu Province。
文摘The synergistic reaction of photocatalysis and advanced oxidation is a valid strategy for the degradation of harmful antibiotic wastewater.Herein,carbon dots(CDs)modified MIL-101(Fe)octahedrons to form CDs/MIL-101(Fe)composite photocatalyst was synthesized for visible light-driven photocatalytic/persulfate(PS)-activated tetracycline(TC)degradation.The electron spin resonance(ESR)spectra,scavenging experiment and electrochemical analysis were carried out to reveal that the high visible light-driven photocatalytic degradation activity of TC over CDs/MIL-101(Fe)photocatalysts is not only ascribed to the production of free active radicals in the CDs/MIL-101(Fe)/PS system(·OH,·SO_(4-),^(1)O_(2),h^(+)and·O_(2)^(-))but also attributed to the consumption of electrons caused by the PS,which can suppress the recombination of photo-generated carriers as well as strong light scattering and electron trapping effects of CDs.Finally,the possible degradation pathways were proposed by analyzing intermediates via liquid chromatography-mass spectrometry technique.This research presents a rational design conception to construct a CDs/PS-based photocatalysis/advanced oxidation technology with high-efficient degradation activity for the remediation of organic antibiotic pollutant wastewater and for the improvement of carrier transport kinetics of photocatalysts.