Global Stability and Hopf Bifurcation for a Virus Dynamics Model with General Incidence Rate and Delayed CTL Immune Response

In this work, we investigate an HIV-1 infection model with a general incidence rate and delayed CTL immune response. The model admits three possible equilibria, an infection-free equilibrium E*0, CTL-inactivated infection equilibrium E*1 and CTL-activated infection equilibrium E*2. We prove that in the absence of CTL immune delay, the model has exactly the basic behaviour model, for all positive intracellular delays, the global dynamics are determined by two threshold parameters R0 and R1, if R0 ≤ 1, E*0 is globally asymptotically stable, if R1 ≤ 1 < R0, E*1 is globally asymptotically stable and if R1 >1, E*2 is globally asymptotically stable. But if the CTL immune response delay is different from zero, then the behaviour of the model at E*2 changes completely, although R1 > 1, a Hopf bifurcation at E*2 is established. In the end, we present some numerical simulations.

Stability and Hopf bifurcation of a nonlinear electromechanical coupling system with time delay feedback

The stability and the Hopf bifurcation of a nonlinear electromechanical coupling system with time delay feedback are studied. By considering the energy in the air-gap field of the AC motor, the dynamical equation of the electromechanical coupling transmission system is deduced and a time delay feedback is introduced to control the dynamic behaviors of the system. The characteristic roots and the stable regions of time delay are determined by the direct method, and the relationship between the feedback gain and the length summation of stable regions is analyzed. Choosing the time delay as a bifurcation parameter, we find that the Hopf bifurcation occurs when the time delay passes through a critical value.A formula for determining the direction of the Hopf bifurcation and the stability of the bifurcating periodic solutions is given by using the normal form method and the center manifold theorem. Numerical simulations are also performed, which confirm the analytical results.

Stability and Hopf bifurcation of a delayed ratio-dependent predator-prey system

Since the ratio-dependent theory reflects the fact that predators must share and compete for food, it is suitable for describing the relationship between predators and their preys and has recently become a very important theory put forward by biologists. In order to investigate the dynamical relationship between predators and their preys, a so-called Michaelis-Menten ratio-dependent predator-prey model is studied in this paper with gestation time delays of predators and preys taken into consideration. The stability of the positive equilibrium is investigated by the Nyquist criteria, and the existence of the local Hopf bifurcation is analyzed by employing the theory of Hopf bifurcation. By means of the center manifold and the normal form theories, explicit formulae are derived to determine the stability, direction and other properties of bifurcating periodic solutions. The above theoretical results are validated by numerical simulations with the help of dynamical software WinPP. The results show that if both the gestation delays are small enough, their sizes will keep stable in the long run, but if the gestation delays of predators are big enough, their sizes will periodically fluc-tuate in the long term. In order to reveal the effects of time delays on the ratio-dependent predator-prey model, a ratiodependent predator-prey model without time delays is considered. By Hurwitz criteria, the local stability of positive equilibrium of this model is investigated. The conditions under which the positive equilibrium is locally asymptotically stable are obtained. By comparing the results with those of the model with time delays, it shows that the dynamical behaviors of ratio-dependent predator-prey model with time delays are more complicated. Under the same conditions, namely, with the same parameters, the stability of positive equilibrium of ratio-dependent predator-prey model would change due to the introduction of gestation time delays for predators and preys. Moreover, with the variation of time delays, the positive equilibrium of the ratio-dependent predator-prey model subjects to Hopf bifurcation.

Stability and Hopf Bifurcation of a Virus Infection Model with a Delayed CTL Immune Response

In this paper, a virus infection model with standard incidence rate and delayed CTL immune response is investigated. By analyzing corresponding characteristic equations,the local stability of each of feasible equilibria and the existence of Hopf bifurcations at the CTL-activated infection equilibrium are established, respectively. By means of comparison arguments, it is verified that the infection-free equilibrium is globally asymptotically stable if the basic reproduction ratio is less than unity. By using suitable Lyapunov functional and LaSalle's invariance principle, it is shown that the CTL-inactivated infection equilibrium of the system is globally asymptotically stable if the immune response reproduction ratio is less than unity and the basic reproduction ratio is greater than unity. Numerical simulations are carried out to illustrate the theoretical result.

Hopf Bifurcation and Stability Analysis for a Predator-prey Model with Time-delay

In this paper, a predator-prey model of three species is investigated, the necessary and sucient of the stable equilibrium point for this model is studied. Further, by introduc-ing a delay as a bifurcation parameter, it is found that Hopf bifurcation occurs when τ cross some critical values. And, the stability and direction of hopf bifurcation are determined by applying the normal form theory and center manifold theory. numerical simulation results are given to support the theoretical predictions. At last, the periodic solution of this system is computed.

Anti-control of Hopf Bifurcation in a Delayed Predator-prey Gompertz Model

A delayed predator-prey Gompertz model is investigated. The stability is analyzed. Anti-control of Hopf bifurcation for the model is presented. Numerical simulations are performed to confirm that the new feedback controller using time delay is efficient in creating Hopf bifurcation. Finally, main conclusions are included.

A Nonstandard Finite Difference Scheme for SIS Epidemic Model with Delay: Stability and Bifurcation Analysis

A numerical scheme for a SIS epidemic model with a delay is constructed by applying a nonstandard finite difference (NSFD) method. The dynamics of the obtained discrete system is investigated. First we show that the discrete system has equilibria which are exactly the same as those of continuous model. By studying the distribution of the roots of the characteristics equations related to the linearized system, we can provide the stable regions in the appropriate parameter plane. It is shown that the conditions for those equilibria to be asymptotically stable are consistent with the continuous model for any size of numerical time-step. Furthermore, we also establish the existence of Neimark-Sacker bifurcation (also called Hopf bifurcation for map) which is controlled by the time delay. The analytical results are confirmed by some numerical simulations.

HOPF BIFURCATION OF AN OSCILLATOR WITH QUADRATIC AND CUBIC NONLINEARITIES AND WITH DELAYED VELOCITY FEEDBACK

This paper studies the local dynamics of an SDOF system with quadratic and cubic stiffness terms,and with linear delayed velocity feedback.The analysis indicates that for a sufficiently large velocity feedback gain,the equilibrium of the system may undergo a number of stability switches with an increase of time delay,and then becomes unstable forever.At each critical value of time delay for which the system changes its stability,a generic Hopf bifurcation occurs and a periodic motion emerges in a one-sided neighbourhood of the critical time delay.The method of Fredholm alternative is applied to determine the bifurcating periodic motions and their stability.It stresses on the effect of the system parameters on the stable regions and the amplitudes of the bifurcating periodic solutions.

The stability and Hopf bifurcation for an HIV model with saturated infection rate and double delays

An HIV infection model with saturated infection rate and double delays is investigated. First, the existence of the infection-free equilibrium E0, the immune-exhausted equilibrium E1 and the infected equilibrium E2 with immunity in different conditions is shown. By analyzing the characteristic equation, we study the locally asymptotical stability of the trivial equilibrium, and the existence of Hopf bifurcations when two delays are used as the bifurcation parameter. Furthermore, we apply the Nyquist criterion to estimate the length of delay for which stability continues to hold. Then with suitable Lyapunov function and LaSalle＇s invariance principle, the global stability of the three equilibriums is obtained. Finally, numerical simulations are presented to illustrate the main mathematical results.

Global stability and Hopf bifurcation of an eco-epidemiological model with time delay

In this paper,an eco-epidemiological model with time delay representing the gestation period of the predator is investigated.In the model,it is assumed that the predator population suffers a transmissible disease and the infected predators may recover from the disease and become susceptible again.By analyzing corresponding characteristic equations,the local stability of each of feasible equilibria and the existence of Hopf bifurcations at the disease-free and coexistence equilibria are established,respectively.By means of Lyapunov functionals and LaSalle’s invariance principle,sufficient condi tions are obtained for the global stability of the coexistence equilibrium,the disease-free equilibrium and the predator-extinct equilibrium of the system,respectively.

Hopf bifurcation analysis of Chen circuit with direct time delay feedback

Direct time delay feedback can make non-chaotic Chen circuit chaotic. The chaotic Chen circuit with direct time delay feedback possesses rich and complex dynamical behaviours. To reach a deep and clear understanding of the dynamics of such circuits described by delay differential equations, Hopf bifurcation in the circuit is analysed using the Hopf bifurcation theory and the central manifold theorem in this paper. Bifurcation points and bifurcation directions are derived in detail, which prove to be consistent with the previous bifurcation diagram. Numerical simulations and experimental results are given to verify the theoretical analysis. Hopf bifurcation analysis can explain and predict the periodical orbit （oscillation） in Chen circuit with direct time delay feedback. Bifurcation boundaries are derived using the Hopf bifurcation analysis, which will be helpful for determining the parameters in the stabilisation of the originally chaotic circuit.

Hopf Bifurcation of a Positive Feedback Delay Differential Equation

Under some minor technical hypotheses, for each T larger than a certain rS > 0, Krisztin, Walther and Wu showed the existence of a periodic orbit for the positive feedback delay differential equation x(t) = -rμx(t) + rf(x(t-1)), where r and μ are positive constants and f : R → R satisfies f(0) = 0 and f' > 0. Combining this with a unique result of Krisztin and Walther, we know that this periodic orbit is the one branched out from 0 through Hopf bifurcation. Using the normal form theory for delay differential equations, we show the same result under the condition that f ∈ C3(R,R) is such that f''(0) = 0 and f'''(0) < 0, which is weaker than those of Krisztin and Walther.

Bifurcation and Chaos in Delayed Cellular Neural Network Model

This paper deals with control of chaotic behavior of a delayed Cellular Neural Network (DCNN) model which is a one-dimensional regular array of four cells with continuous activation function. We investigate different dynamical behaviors including limit cycle, torus, and chaos for different range of weight parameters of the system. Regarding synaptic weight as parameter, Hopf bifurcations are obtained in the system without delay. In the delayed model condition for the Global asymptotic stability of the equilibrium point is presented. Numerical simulation and results are given to show the role of delay in chaos control of the CNNs.

Hopf Bifurcation Analysis for a Delayed SIRS Epidemic Model with a Nonlinear Incidence Rate

This paper is concerned with a delayed SIRS epidemic model with a nonlinear incidence rate. The main results are given in terms of local stability and Hopf bifurcation. Sufficient conditions for the local stability of the positive equilibrium and existence of Hopf bifurcation are obtained by regarding the time delay as the bifurcation parameter. Further,the properties of Hopf bifurcation such as the direction and stability are investigated by using the normal form theory and center manifold argument. Finally,some numerical simulations are presented to verify the theoretical analysis.

Hopf Bifurcations in a Predator-Prey System of Population Allelopathy with Discrete Delay

A delayed Lotka-Volterra two-species predator-prey system of population allelopathy with discrete delay is considered. By linearizing the system at the positive equilibrium and analyzing the associated characteristic equation, the asymptotic stability of the positive equilibrium is investigated and Hopf bifurcations are demonstrated. Furthermore, the direction of Hopf bifurcation and the stability of the bifurcating periodic solutions are determined by the normal form theory and the center manifold theorem for functional differential equations (FDEs). Finally, some numerical simulations are carried out for illustrating the theoretical results.

Stability and multi-parametric Hopf bifurcation analyses of viral infection model with time delay

Ever since HIV was first diagnosed in human, a great number of scientific works have been undertaken to explore the biological mechanisms involved in the infection and progression of the disease. This paper deals with stability and bifurcation analyses of mathematical model that represents the dynamics of HIV infection of thymus. The existence and stability of the equilibria are investigated. The model is described by a system of delay differential equations with logistic growth term, cure rate and discrete type of time delay. Choosing the time delay as a bifurcation parameter, the analysis is mainly focused on the Hopf bifurcation problem to predict the existence of a limit cycle bifurcating from the infected steady state.Further, using center manifold theory and normal form method we derive explicit formulae to determine the stability and direction of the limit cycles. Moreover the mitosis rate r also plays a vital role in the model, so we fix it as second bifurcation parameter in the incidence of viral infection. Our analysis shows that, while both the bifurcation parameters can destabilize the equilibrium E＊ and cause limit cycles. Numerical simulations are performed to investigate the qualitative behaviors of the inherent model.

Hopf Bifurcation of Nonresident Computer Virus Model with Age Structure and Two Delays Effects

This paper constructed and studied a nonresident computer virus model with age structure and two delays effects. The non-negativity and boundedness of the solution of the model have been discussed, and then gave the basic regeneration number, and obtained the conditions for the existence and the stability of the virus-free equilibrium and the computer virus equilibrium. Theoretical analysis shows the conditions under which the model undergoes Hopf bifurcation in three different cases. The numerical examples are provided to demonstrate the theoretical results.

Stability and Hopf bifurcation of a delayed virus infection model with latently infected cells and Beddington-DeAngelis incidence

In this paper,the dynamical behaviors for a five-dimensional virus infection model with Latently Infected Cells and Beddington-DeAngelis incidence are investigated.In the model,four delays which denote the latently infected delay,the intracel-lular delay,virus production period and CTL response delay are considered.We define the basic reproductive number and the CTL immune reproductive number.By using Lyapunov functionals,LaSalle's invariance principle and linearization method,the threshold conditions on the stability of each equilibrium are established.It is proved that when the basic reproductive number is less than or equal to unity,the infection-free equilibrium is globally asy mptot ically stable;when the CTL immune repro-ductive number is less than or equal to unity and the basic reproductive number is greater than unity,the immune free infection equilibrium is globally asymptotically stable;when the CTL immune reproductive number is greater than unity and immune response delay is equal to zero,the immune infection equilibrium is globally asymptotically stable.The results show that immune response delay may destabilize the steady state of infection and lead to Hopf bifurcation.The existence of the Hopf bifurcation is discussed by using immune response delay as a bifurcation parameter.Numerical simulations are carried out to justify the analytical results.

LOCAL STABILITY AND BIFURCATION IN A THREE-UNIT DELAYED NEURAL NETWORK

A system of three-unit networks with coupled cells is investigated.The general formula for bifurcation direction of Hopf bifurcation is calculated and the estimate formula of period of the periodic solution is given.