Background Specific nutrients combined with exercise may prevent a loss of lean body mass and consequently prevent sarcopenia.We examined the effects of 2 weeks of supplementation with L-carnitine and a single dose of...Background Specific nutrients combined with exercise may prevent a loss of lean body mass and consequently prevent sarcopenia.We examined the effects of 2 weeks of supplementation with L-carnitine and a single dose of branched-chain amino acids(BCAAs)on energy metabolism and body composition before and after exercise and on post-exercise muscle soreness in healthy subjects.Methods A total of 12 young,untrained,healthy women were randomly assigned to two groups who received either 2 weeks of supplementation with L-carnitine(1000 mg/day)and a single dose of BCAAs plus 200 kcal energy(LCAR+BCAA group,n=6)or 200 kcal energy alone(control group,n=6)before 60 min of exercise.Energy substrate metabolism and body composition by bio-impedance were examined before and after exercise.Delayed-onset muscle soreness(DOMS)was evaluated by using a visual analogue scale for 3 days after exercise.Results Serum concentrations of free and acyl-L-carnitine in the LCAR+BCAA group were not significantly different from those in the control group.There were no significant differences in body composition before or after exercise between the two groups.Although serum free fatty acid levels 120 min after the oral ingestion of BCAAs were significantly lower in the LCAR+BCAA group than in the control group,there were no significant differences in serum free fatty acid levels immediately after and 60 min after exercise.DOMS for 3 days after exercise was lower in the LCAR+BCAA group than in the control group,but this difference was not significant.Conclusion Continuous supplementation with L-carnitine combined with a dose of BCAAs in young,untrained,healthy subjects caused a blunted response of stimulated lipolysis after exercise.展开更多
背景:不习惯的运动使骨骼肌损伤,但可以产生一种减轻肌肉再损伤减轻疼痛的特定训练效果-肌肉记忆。目的:基于延迟性肌肉酸痛的病因,综述延迟性肌肉酸痛中骨骼肌记忆的存在及其可能机制,提出防治延迟性肌肉酸痛的新见解。方法:第一作者以...背景:不习惯的运动使骨骼肌损伤,但可以产生一种减轻肌肉再损伤减轻疼痛的特定训练效果-肌肉记忆。目的:基于延迟性肌肉酸痛的病因,综述延迟性肌肉酸痛中骨骼肌记忆的存在及其可能机制,提出防治延迟性肌肉酸痛的新见解。方法:第一作者以“DOMS,Skeletal muscle memory,Exercise Skeletal muscle adaptation,Repeat turn effect,exercise and autophagy,Autophagy and inflammation”为英文检索词,“延迟性肌肉酸痛,骨骼肌记忆,运动性骨骼肌适应,重复回合效应,运动与自噬,自噬与炎症”为中文检索词,检索PubMed、Embase、Web of Science、中国知网及万方数据库1990年1月至2022年12月发表的相关文献,最终纳入102篇文献进行综述。结果与结论:目前认为延迟性肌肉酸痛是由于代谢紊乱、机械损伤和氧化应激所致的急性期炎症反应,而运动性骨骼肌记忆具有减轻延迟性肌肉酸痛、减轻运动再损伤的作用,当离心训练的持续时间、频率和强度逐渐增加时,损伤症状可以被最小化,甚至可以避免。因此基于运动性骨骼肌记忆机制,寻找防治或减轻延迟性肌肉酸痛及运动性肌肉损伤的方法是未来的研究方向。综述的主要目的:①明确运动性骨骼肌记忆的存在;②探讨运动性骨骼肌记忆的可能机制,并提出该记忆与骨骼肌自噬的关系;③通过改善骨骼肌自噬水平为延迟性肌肉酸痛的防治提供新策略。展开更多
OBJECTIVE： To evaluate the effects of Zingiber cassumunar（Plai cream） in either 7% or 14% concentration on delayed onset muscle soreness（DOMS）.METHODS： Seventy-five untrained healthy volunteers（28 males and 47 ...OBJECTIVE： To evaluate the effects of Zingiber cassumunar（Plai cream） in either 7% or 14% concentration on delayed onset muscle soreness（DOMS）.METHODS： Seventy-five untrained healthy volunteers（28 males and 47 females）, performed 4 sets of 25 eccentric repetitions of the dominant quadriceps muscle on an isokinetic dynamometry machine. Participants were then randomized into 3 groups： 14% Plai cream, 7% Plai cream and placebo cream. Two grams of the cream（strips of 5-cm long） were gently rubbed into the quadriceps muscles for 5 min immediately following the exercise and every 8 h thereafter for 7 d in all groups. Muscle soreness, muscle strength, jump height, thigh circumference and creatine kinase were measured before and after eccentric exercise.RESULTS： Compared to the placebo cream the 14% Plai cream substantially reduced muscle soreness over the 7 d by –82%（95% CI = –155% to –6%, P = 0.03）, but had similar muscle soreness effects to 7% Plai cream（–34%, –96% to 27%, P = 0.2）. Compared to the placebo cream the 7% Plai cream resulted in a small non-significant reduction in muscle soreness levels over the following 7 d（–40%, –116% to 36%, P = 0.3）. Compared to placebo cream there was little effect of Plai cream（7% or 14%） on muscle strength, jump height, thigh circumference or creatine kinase concentration. CONCLUSION： Using 14% Plai cream over a 7-day period substantially reduced muscle soreness symptoms compared to 7% Plai cream or a placebo cream. The authors suggest that the administration of 14% Plai cream is a useful alternative in the management of DOMS.TRIAL REGISTRATION： Thai Clinical Trial Registry TCTR20140215001.展开更多
文摘Background Specific nutrients combined with exercise may prevent a loss of lean body mass and consequently prevent sarcopenia.We examined the effects of 2 weeks of supplementation with L-carnitine and a single dose of branched-chain amino acids(BCAAs)on energy metabolism and body composition before and after exercise and on post-exercise muscle soreness in healthy subjects.Methods A total of 12 young,untrained,healthy women were randomly assigned to two groups who received either 2 weeks of supplementation with L-carnitine(1000 mg/day)and a single dose of BCAAs plus 200 kcal energy(LCAR+BCAA group,n=6)or 200 kcal energy alone(control group,n=6)before 60 min of exercise.Energy substrate metabolism and body composition by bio-impedance were examined before and after exercise.Delayed-onset muscle soreness(DOMS)was evaluated by using a visual analogue scale for 3 days after exercise.Results Serum concentrations of free and acyl-L-carnitine in the LCAR+BCAA group were not significantly different from those in the control group.There were no significant differences in body composition before or after exercise between the two groups.Although serum free fatty acid levels 120 min after the oral ingestion of BCAAs were significantly lower in the LCAR+BCAA group than in the control group,there were no significant differences in serum free fatty acid levels immediately after and 60 min after exercise.DOMS for 3 days after exercise was lower in the LCAR+BCAA group than in the control group,but this difference was not significant.Conclusion Continuous supplementation with L-carnitine combined with a dose of BCAAs in young,untrained,healthy subjects caused a blunted response of stimulated lipolysis after exercise.
文摘背景:不习惯的运动使骨骼肌损伤,但可以产生一种减轻肌肉再损伤减轻疼痛的特定训练效果-肌肉记忆。目的:基于延迟性肌肉酸痛的病因,综述延迟性肌肉酸痛中骨骼肌记忆的存在及其可能机制,提出防治延迟性肌肉酸痛的新见解。方法:第一作者以“DOMS,Skeletal muscle memory,Exercise Skeletal muscle adaptation,Repeat turn effect,exercise and autophagy,Autophagy and inflammation”为英文检索词,“延迟性肌肉酸痛,骨骼肌记忆,运动性骨骼肌适应,重复回合效应,运动与自噬,自噬与炎症”为中文检索词,检索PubMed、Embase、Web of Science、中国知网及万方数据库1990年1月至2022年12月发表的相关文献,最终纳入102篇文献进行综述。结果与结论:目前认为延迟性肌肉酸痛是由于代谢紊乱、机械损伤和氧化应激所致的急性期炎症反应,而运动性骨骼肌记忆具有减轻延迟性肌肉酸痛、减轻运动再损伤的作用,当离心训练的持续时间、频率和强度逐渐增加时,损伤症状可以被最小化,甚至可以避免。因此基于运动性骨骼肌记忆机制,寻找防治或减轻延迟性肌肉酸痛及运动性肌肉损伤的方法是未来的研究方向。综述的主要目的:①明确运动性骨骼肌记忆的存在;②探讨运动性骨骼肌记忆的可能机制,并提出该记忆与骨骼肌自噬的关系;③通过改善骨骼肌自噬水平为延迟性肌肉酸痛的防治提供新策略。
文摘OBJECTIVE： To evaluate the effects of Zingiber cassumunar（Plai cream） in either 7% or 14% concentration on delayed onset muscle soreness（DOMS）.METHODS： Seventy-five untrained healthy volunteers（28 males and 47 females）, performed 4 sets of 25 eccentric repetitions of the dominant quadriceps muscle on an isokinetic dynamometry machine. Participants were then randomized into 3 groups： 14% Plai cream, 7% Plai cream and placebo cream. Two grams of the cream（strips of 5-cm long） were gently rubbed into the quadriceps muscles for 5 min immediately following the exercise and every 8 h thereafter for 7 d in all groups. Muscle soreness, muscle strength, jump height, thigh circumference and creatine kinase were measured before and after eccentric exercise.RESULTS： Compared to the placebo cream the 14% Plai cream substantially reduced muscle soreness over the 7 d by –82%（95% CI = –155% to –6%, P = 0.03）, but had similar muscle soreness effects to 7% Plai cream（–34%, –96% to 27%, P = 0.2）. Compared to the placebo cream the 7% Plai cream resulted in a small non-significant reduction in muscle soreness levels over the following 7 d（–40%, –116% to 36%, P = 0.3）. Compared to placebo cream there was little effect of Plai cream（7% or 14%） on muscle strength, jump height, thigh circumference or creatine kinase concentration. CONCLUSION： Using 14% Plai cream over a 7-day period substantially reduced muscle soreness symptoms compared to 7% Plai cream or a placebo cream. The authors suggest that the administration of 14% Plai cream is a useful alternative in the management of DOMS.TRIAL REGISTRATION： Thai Clinical Trial Registry TCTR20140215001.
文摘从功能内稳态(function-specific homeostasis,FSH)角度分析EIMD/DOMS过程影响运动成绩的正常发挥,而防治措施又大多无效这一现象,结果发现力竭运动所致的EIMD/DOMS,骨骼肌蛋白质代谢远离了蛋白质代谢内稳态(protein metabolite specific homeostasis,PmSH),EIMD/DOMS康复延迟,外源性有利因素干预可促进EIMD/DOMS康复;非力竭运动所致的EIMD/DOMS,蛋白质代谢处于PmSH,EIMD/DOMS正常康复,外源性因素对EIMD/DOMS无明显影响作用。
