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Nanometeric hydroxyapatite in situ formed in demineralized bone matrix by electrochemical technique
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《Chinese Journal of Biomedical Engineering(English Edition)》 2001年第3期130-132,共3页
关键词 bone Nanometeric hydroxyapatite in situ formed in demineralized bone matrix by electrochemical technique DBM
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Development of photoreactive demineralized bone matrix 3D printing colloidal inks for bone tissue engineering
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作者 Katie J.Hogan Hayriye Oztatlı +10 位作者 Marissa R.Perez Sophia Si Reyhan Umurhan Elysa Jui Ziwen Wang Emily Y.Jiang Sa R.Han Mani Diba K.Jane Grande-Allen Bora Garipcan Antonios G.Mikos 《Regenerative Biomaterials》 SCIE EI CSCD 2023年第1期1604-1617,共14页
Demineralized bone matrix(DBM)has been widely used clinically for dental,craniofacial and skeletal bone repair,as an osteoinductive and osteoconductive material.3D printing(3DP)enables the creation of bone tissue engi... Demineralized bone matrix(DBM)has been widely used clinically for dental,craniofacial and skeletal bone repair,as an osteoinductive and osteoconductive material.3D printing(3DP)enables the creation of bone tissue engineering scaffolds with complex geometries and porosity.Photoreactive methacryloylated gelatin nanoparticles(GNP-MAs)3DP inks have been developed,which display gel-like behavior for high print fidelity and are capable of post-printing photocrosslinking for control of scaffold swelling and degradation.Here,novel DBM nanoparticles(DBM-NPs,∼400 nm)were fabricated and characterized prior to incorporation in 3DP inks.The objectives of this study were to determine how these DBM-NPs would influence the printability of composite colloidal 3DP inks,assess the impact of ultraviolet(UV)crosslinking on 3DP scaffold swelling and degradation and evaluate the osteogenic potential of DBM-NP-containing composite colloidal scaffolds.The addition of methacryloylated DBM-NPs(DBM-NP-MAs)to composite colloidal inks(100:0,95:5 and 75:25 GNP-MA:DBM-NP-MA)did not significantly impact the rheological properties associated with printability,such as viscosity and shear recovery or photocrosslinking.UV crosslinking with a UV dosage of 3 J/cm2 directly impacted the rate of 3DP scaffold swelling for all GNP-MA:DBM-NP-MA ratios with an∼40%greater increase in scaffold area and pore area in uncrosslinked versus photocrosslinked scaffolds over 21 days in phosphate-buffered saline(PBS).Likewise,degradation(hydrolytic and enzymatic)over 21 days for all DBM-NP-MA content groups was significantly decreased,∼45%less in PBS and collagenase-containing PBS,in UV-crosslinked versus uncrosslinked groups.The incorporation of DBM-NP-MAs into scaffolds decreased mass loss compared to GNP-MA-only scaffolds during collagenase degradation.An in vitro osteogenic study with bone marrow-derived mesenchymal stem cells demonstrated osteoconductive properties of 3DP scaffolds for the DBM-NP-MA contents examined.The creation of photoreactive DBM-NP-MAs and their application in 3DP provide a platform for the development of ECM-derived colloidal materials and tailored control of biochemical cue presentation with broad tissue engineering applications. 展开更多
关键词 demineralized bone matrix colloidal hydrogels 3D printing bone tissue engineering
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An overview on bone protein extract as the new generation of demineralized bone matrix
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作者 ZHOU ZhiYu ZOU LiJin +2 位作者 LI HaiSheng BUNGER Cody ZOU XueNong 《Science China(Life Sciences)》 SCIE CAS 2012年第12期1045-1056,共12页
Bone protein extract is regarded as the new generation of demineralized bone matrix. The aim of this paper is to describe and characterize the properties of demineralized bone matrix and its new generation product in ... Bone protein extract is regarded as the new generation of demineralized bone matrix. The aim of this paper is to describe and characterize the properties of demineralized bone matrix and its new generation product in addition to its application in animal and human studies. Bone protein extract has features of osteoconductivity, osteoinductivity and osteogenicity, which originate from its unique and precise processing. It has exhibited powerful bone formation capacity both in animal experiments and in clinical trials by providing an optimal microenvironment for osteogenesis. Furthermore, not only does it have excellent bio- compatibility, it also has good compatibility with other implant materials, helping it bridge the host and implanted materials. Bone protein extract could be a promising alternative for demineralized bone matrix as a bone graft substitute. 展开更多
关键词 bone protein extract demineralized bone matrix autologous bone graft OSTEOGENESIS
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Bone Graft Options for Spine Fusion in Adolescent Patients with Idiopathic Scoliosis 被引量:2
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作者 Xi-Ming Xu Gong Zhang +2 位作者 Fei Wang Xian-Zhao Wei Ming Li 《Chinese Medical Journal》 SCIE CAS CSCD 2016年第1期105-107,共3页
Adolescent idiopathic scoliosis (AIS) is one of the most prevalent diseases among teenagers, with an incidence rate of 1-3% worldwide, and at least 0.02% of patients require surgical treatment. The "gold standard"... Adolescent idiopathic scoliosis (AIS) is one of the most prevalent diseases among teenagers, with an incidence rate of 1-3% worldwide, and at least 0.02% of patients require surgical treatment. The "gold standard" procedure is instrumentation and fusion of 10 or more vertebrae with forceful correction of the deformity.Although autogenous bone grafts are the "gold standard" for spine fusion, significant progress has been made in discovering bone graft alternatives, including freeze-dried allograft, demineralized bone matrix (DBM), triosite ceramics, and bone marrow aspirate (BMA), which have been used as substitutes for iliac crest in AIS surgery. 展开更多
关键词 Adolescent Idiopathic Scoliosis ALLOGRAFT CERAMICS demineralized bone matrix Spine Fusion
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