Dendrowardol C(1)-a novel sesquiterpenoid,with an unprecedented 4/5/6/6 tetracyclic carbon backbone,together with two known cyclopacamphane-type sesquiterpenoids;dendronobilin I(2)and dendrobane A(3)were isolated from...Dendrowardol C(1)-a novel sesquiterpenoid,with an unprecedented 4/5/6/6 tetracyclic carbon backbone,together with two known cyclopacamphane-type sesquiterpenoids;dendronobilin I(2)and dendrobane A(3)were isolated from the stems of Dendrobium wardianum Warner.The structure of 1 was established on the basis of spectroscopic data and the absolute configuration was determined by single-crystal X-ray diffraction crystallography.The hypothetical biosynthetic pathway of 1 was postulated.Compound 1 showed no cytotoxic activity against human tumor cell lines HL-60,SMMC-7721,A-549,MCF-7,and SW480.展开更多
基金This work was financially supported by the National Natural and Science Foundations of China(No.30800090)"Xi-Bu-Zhi-Guang"project(No.2009312D11017)from Chinese Academy of Sciencesthe Fund of the State Key Laboratory of Phytochemistry and Plant Resources in West China(P2010-ZZ012).
文摘Dendrowardol C(1)-a novel sesquiterpenoid,with an unprecedented 4/5/6/6 tetracyclic carbon backbone,together with two known cyclopacamphane-type sesquiterpenoids;dendronobilin I(2)and dendrobane A(3)were isolated from the stems of Dendrobium wardianum Warner.The structure of 1 was established on the basis of spectroscopic data and the absolute configuration was determined by single-crystal X-ray diffraction crystallography.The hypothetical biosynthetic pathway of 1 was postulated.Compound 1 showed no cytotoxic activity against human tumor cell lines HL-60,SMMC-7721,A-549,MCF-7,and SW480.
