Dentoalveolar bacterial infections cause localized tissue and bone destruction, but usually remain well-localized within teeth in immunocompetent hosts. However, in certain cases these infections may invade head and n...Dentoalveolar bacterial infections cause localized tissue and bone destruction, but usually remain well-localized within teeth in immunocompetent hosts. However, in certain cases these infections may invade head and neck tissues, resulting in orofacial abscesses, cellulitis and sepsis, with resultant high morbidity and even mortality. In the present studies, we developed a novel model of spreading dentoalveolar infections in mice by treatment with neutralizing antibodies against both interleukin-la （IL-1a） and IL-1β. Surprisingly male but not female mice given anti-lL-1 antibodies developed orofacial abscesses, weight loss, splenomegaly and sepsis. Female mice developed abscesses and sepsis comparable to males following ovariectomy （OVX）, which was reversed by estrogen supplementation. Anti-lL-1 blockade inhibited IL-12, interferon y （IFNy） and IL-6 but not IL-IO expression in infrabony lesions, suggestive of a local anti-inflammatory response. There was greater infiltration of neutrophils and other inflammatory ceils into lesions in anti-lL-l-treated animals; however, blood leukocytes had reduced bacterial phagocytic and killing activity ex vivo. Estrogen directly stimulated IL-1 production by macrophages, suggesting that the resistance of females to disseminating dentoalveolar infections may be due to their heightened pro-inflammatory responses following bacterial challenge, leading to enhanced localization of these infections.展开更多
Bimaxillary dentoalveolar protrusion is one of the most prevalent malocclusion in Asian population.Traditionally, orthodontic treatment often involves the extraction of four first premolars and demands the least amoun...Bimaxillary dentoalveolar protrusion is one of the most prevalent malocclusion in Asian population.Traditionally, orthodontic treatment often involves the extraction of four first premolars and demands the least amount of anchorage loss, therefore headgear used to be an unavoid- able fate of these patients. Nowadays, along with the development of implant anchorage, more and more patients have benefited from the implant-aided orthodontic treatment, even escaped from orthognathic surgery. However, for extremely severe cases, orthodontists seem to still have to face the limitation of orthodontic treatment and turn to surgeons for cooperation. In this case, we will see how dramatic changes happened on an adult patient with severe bimaxillary dentoalveolar protrusion malocclusion after the orthodontic treatment with microscrew implants as the temporary skeletal anchorage with the patient＇s written informed consent,展开更多
基金supported by grant DE-11664(PS)from the National Institute of Dental and Craniofacial Research/National Institutes of Health(NIDCR/NIH)a grant from the American Association of Endodontists(HY)
文摘Dentoalveolar bacterial infections cause localized tissue and bone destruction, but usually remain well-localized within teeth in immunocompetent hosts. However, in certain cases these infections may invade head and neck tissues, resulting in orofacial abscesses, cellulitis and sepsis, with resultant high morbidity and even mortality. In the present studies, we developed a novel model of spreading dentoalveolar infections in mice by treatment with neutralizing antibodies against both interleukin-la （IL-1a） and IL-1β. Surprisingly male but not female mice given anti-lL-1 antibodies developed orofacial abscesses, weight loss, splenomegaly and sepsis. Female mice developed abscesses and sepsis comparable to males following ovariectomy （OVX）, which was reversed by estrogen supplementation. Anti-lL-1 blockade inhibited IL-12, interferon y （IFNy） and IL-6 but not IL-IO expression in infrabony lesions, suggestive of a local anti-inflammatory response. There was greater infiltration of neutrophils and other inflammatory ceils into lesions in anti-lL-l-treated animals; however, blood leukocytes had reduced bacterial phagocytic and killing activity ex vivo. Estrogen directly stimulated IL-1 production by macrophages, suggesting that the resistance of females to disseminating dentoalveolar infections may be due to their heightened pro-inflammatory responses following bacterial challenge, leading to enhanced localization of these infections.
文摘Bimaxillary dentoalveolar protrusion is one of the most prevalent malocclusion in Asian population.Traditionally, orthodontic treatment often involves the extraction of four first premolars and demands the least amount of anchorage loss, therefore headgear used to be an unavoid- able fate of these patients. Nowadays, along with the development of implant anchorage, more and more patients have benefited from the implant-aided orthodontic treatment, even escaped from orthognathic surgery. However, for extremely severe cases, orthodontists seem to still have to face the limitation of orthodontic treatment and turn to surgeons for cooperation. In this case, we will see how dramatic changes happened on an adult patient with severe bimaxillary dentoalveolar protrusion malocclusion after the orthodontic treatment with microscrew implants as the temporary skeletal anchorage with the patient＇s written informed consent,
