Sunshine duration (S) based empirical equations have been employed in this study to estimate the daily global solar radiation on a horizontal surface (G) for six meteorological stations in Burundi. Those equations inc...Sunshine duration (S) based empirical equations have been employed in this study to estimate the daily global solar radiation on a horizontal surface (G) for six meteorological stations in Burundi. Those equations include the Ångström-Prescott linear model and four amongst its derivatives, i.e. logarithmic, exponential, power and quadratic functions. Monthly mean values of daily global solar radiation and sunshine duration data for a period of 20 to 23 years, from the Geographical Institute of Burundi (IGEBU), have been used. For any of the six stations, ten single or double linear regressions have been developed from the above-said five functions, to relate in terms of monthly mean values, the daily clearness index () to each of the next two kinds of relative sunshine duration (RSD): and . In those ratios, G<sub>0</sub>, S<sub>0 </sub>and stand for the extraterrestrial daily solar radiation on a horizontal surface, the day length and the modified day length taking into account the natural site’s horizon, respectively. According to the calculated mean values of the clearness index and the RSD, each station experiences a high number of fairly clear (or partially cloudy) days. Estimated values of the dependent variable (y) in each developed linear regression, have been compared to measured values in terms of the coefficients of correlation (R) and of determination (R<sub>2</sub>), the mean bias error (MBE), the root mean square error (RMSE) and the t-statistics. Mean values of these statistical indicators have been used to rank, according to decreasing performance level, firstly the ten developed equations per station on account of the overall six stations, secondly the six stations on account of the overall ten equations. Nevertheless, the obtained values of those indicators lay in the next ranges for all the developed sixty equations:;;;, with . These results lead to assert that any of the sixty developed linear regressions (and thus equations in terms of and ), fits very adequately measured data, and should be used to estimate monthly average daily global solar radiation with sunshine duration for the relevant station. It is also found that using as RSD, is slightly more advantageous than using for estimating the monthly average daily clearness index, . Moreover, values of statistical indicators of this study match adequately data from other works on the same kinds of empirical equations.展开更多
The search and development of anti-HIV drugs is currently one of the most urgent tasks of pharmacological studies. In this work, a quantitative structure-activity relationship (QSAR) model based on some new norm ind...The search and development of anti-HIV drugs is currently one of the most urgent tasks of pharmacological studies. In this work, a quantitative structure-activity relationship (QSAR) model based on some new norm indexes, was obtained to a series of more than 150 HEPT derivatives (1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine) to find their pEC50 (the required effective concentration to achieve 50% protection of MT-4 cells against the cytopathic effect of virus) and pCC50 (the required cytotoxic concentration to reduce visibility of 50% mock infected cell) activities. The model efficiencies were then validated using the leave-one-out cross validation (LOO-CV) and y- randomization test. Results indicated that this new model was efficient and could provide satisfactory results for prediction of pECso and pCC50 with the higher R2 train and the higher Rt2est. By using the leverage approach, the applicability domain of this model was further investigated and no response outlier was detected for HEFT derivatives involved in this work. Comparison results with reference methods demonstrated that this new method could result in significant improvements for predicting pEC50 and pCC50 of anti-HIV HEPT derivatives. Moreover, results shown in this present study suggested that these two absolutely different activities pECso and pCC50 of anti-HIV HEPT derivatives could be predicted well with a totally similar QSAR model, which indicated that this model mizht have the potential to be further utilized for other biological activities of HEFT derivatives.展开更多
Viscoelastic(VE) dampers, with their stiffness and energy dissipation capabilities, have been widely used in civil engineering for mitigating wind-induced vibration and seismic responses of structures, thus enhancin...Viscoelastic(VE) dampers, with their stiffness and energy dissipation capabilities, have been widely used in civil engineering for mitigating wind-induced vibration and seismic responses of structures, thus enhancing the comfort of residents and serviceability of equipment inside. In past relevant research, most analytical models for characterizing the mechanical behavior of VE dampers were verified by comparing their predictions with performance test results from small-scale specimens, which might not adequately or conservatively represent the actual behavior of full-scale dampers, especially with regard to the ambient temperature, temperature rise, and heat convection effects. Thus, in this study, by using a high-performance testing facility with a temperature control system, full-scale VE dampers were dynamically tested with different displacement amplitudes, excitation frequencies, and ambient temperatures. By comparing the analytical predictions with the experimental results, it is demonstrated that adopting the fractional derivative method together with considering the effects of excitation frequencies, ambient temperatures, temperature rises, softening, and hardening, can reproduce the design performance of full-scale VE dampers very well.展开更多
The interaction between plates and foundations is a typical problem encountered in geotechnical engineering. The long-term plate performance is highly dependent on the theological characteristics of ground soil. Compa...The interaction between plates and foundations is a typical problem encountered in geotechnical engineering. The long-term plate performance is highly dependent on the theological characteristics of ground soil. Compared with conventional linear theology, the fractional calculus-based theory is a more powerful mathematical tool that can address this issue. This paper proposes a fractional Merchant model (FMM) to investigate the time-dependent behavior of a simply supported rectangular plate on viscoelastic foundation. The correspondence principle involving Laplace transforms was employed to derive the closed-form solutions of plate response under uniformly distributed load. The plate deflection, bending moment, and foundation reaction calculated using the FMM were compared with the results obtained from the analogous elastic model (EM) and the standard Merchant model (SMM). It is shown that the upper and lower bound solutions of the FMM can be determined using the EM. In addition, a parametric study was performed to examine the influences of the model parameters on the time- dependent behavior of the plate-foundation interaction problem. The results indicate that a small fractional differential order corresponds to a plate resting on a sandy soil foundation, while the fractional differential order value should be increased for a clayey soil foundation. The long-term performance of a foundation plate can be accurately simulated by varying the values of the fractional differential order and the viscosity coefficient. The observations from this study reveal that the proposed fractional model has the capability to capture the variation of plate deflection over many decades of time.展开更多
On one hand, when the bridge stays in a windy environment, the aerodynamic power would reduce it to act as a non-classic system. Consequently, the transposition of the system’s right eigenmatrix will not equal its le...On one hand, when the bridge stays in a windy environment, the aerodynamic power would reduce it to act as a non-classic system. Consequently, the transposition of the system’s right eigenmatrix will not equal its left eigenmatrix any longer. On the other hand, eigenmatrix plays an important role in model identification, which is the basis of the identification of aerodynamic derivatives. In this study, we follow Scanlan’s simple bridge model and utilize the information provided by the left and right eigenmatrixes to structure a self-contained eigenvector algorithm in the frequency domain. For the purpose of fitting more accurate transfer function, the study adopts the combined sine-wave stimulation method in the numerical simulation. And from the simulation results, we can conclude that the derivatives identified by the self-contained eigenvector algorithm are more dependable.展开更多
We apply the derivative coupling model with ZM and ZM3 parameters to investigate the longitudinal response function in quasielastic electron scattering in the relativistic random phase approximation. The non-spectral ...We apply the derivative coupling model with ZM and ZM3 parameters to investigate the longitudinal response function in quasielastic electron scattering in the relativistic random phase approximation. The non-spectral method is chosen to describe the nucleon Green's function in a finite nucleus. Some remarks have been made in conclusion.展开更多
In this paper we consider Verigin problem with surfaCe tension at freeboundary:where Ω1(t),Ω2(t) are regions of water and oil respectivelyl Γt is a free boundarybetween Ω1(t) and Ω2(t).Let Ω=Ω1(t) ∪Γt∪Ω1(t)...In this paper we consider Verigin problem with surfaCe tension at freeboundary:where Ω1(t),Ω2(t) are regions of water and oil respectivelyl Γt is a free boundarybetween Ω1(t) and Ω2(t).Let Ω=Ω1(t) ∪Γt∪Ω1(t) be a bounded annular domainin R2, Ω2(t) is inside. nt is a normal of Γt, Pointing inwards Ω2(t),P1 and P2 arepressures of water and oil, μ1 and μ2 are viscosities of water and oil respectively, k isthe permeability, φ is the porosity, K and Vn are the curvature and the normal velocityof Γt in the direction of nt.We prove that the classical Verigin problem is the limit case(s-0) of Veriginproblem with surfaCe tension at free boundary.展开更多
Hepatocellular carcinoma(HCC)is one of the most common causes of cancerrelated death around the world due to advanced clinical stage at diagnosis,high incidence of recurrence and metastasis after surgical treatment.It...Hepatocellular carcinoma(HCC)is one of the most common causes of cancerrelated death around the world due to advanced clinical stage at diagnosis,high incidence of recurrence and metastasis after surgical treatment.It is in urgent need to create appropriate animal models to explore the mechanism,patterns,risk factors,and therapeutic strategies of HCC metastasis and recurrence.However,most of the established models lack the phenotype of invasion and metastasis in patient,or have unstable phenotype.To establish HCC models with stable metastasis phenotype requires profound understanding in cancer metastasis biology and scientific methodology.Over the past 3 decades,HCC models with stable metastasis have been extensively studied.This paper reviewed the history and development of HCC animal models and cell models,focusing on the screening and maintaining of metastatic potential and phenotype.In-depth studies using these models vastly promote the understanding of cellular and molecular mechanisms and development of therapeutic strategies on HCC metastasis.展开更多
One of the key challenges in the total maximum daily load(TMDL)development process is how to define the critical condition for a receiving waterbody.The main concern in using a continuous simulation approach is the ab...One of the key challenges in the total maximum daily load(TMDL)development process is how to define the critical condition for a receiving waterbody.The main concern in using a continuous simulation approach is the absence of any guarantee that the most critical condition will be captured during the selected representative hydrologic period,given the scarcity of long-term continuous data.The objectives of this paper are to clearly address the critical condition in the TMDL development process and to compare continuous and event-based approaches in defining critical condition during TMDL development for a waterbody impacted by both point and nonpoint source pollution.A practical,event-based critical flow-storm(CFS)approach was developed to explicitly addresses the critical condition as a combination of a low stream flow and a storm event of a selected magnitude,both having certain frequencies of occurrence.This paper illustrated the CFS concept and provided its theoretical basis using a derived analytical conceptual model.The CFS approach clearly defined a critical condition,obtained reasonable results and could be considered as an alternative method in TMDL development.展开更多
A popular explicit analytic Borowy 2C PV module model is proposed for power generation prediction.The maximum power point and the open-circuit point which are calculated in this model cannot be equal to the data given...A popular explicit analytic Borowy 2C PV module model is proposed for power generation prediction.The maximum power point and the open-circuit point which are calculated in this model cannot be equal to the data given by manufacturers under standard test condition(STC).The derivation of this model has never been mentioned in any literatures.The parameter forms of 2C model in this paper are more simplified,and the model is decomposed into a STC sub-model and an incremental sub-model.The STC model is derived successfully from an ideal single-diode circuit model.Relative error estimations are developed to do the conformity error measurements.The analysis results showed that though the biases at those critical points are very small,the conformity will depend on both of the two ratio values I_(m)/I_(sc) and V_(m)/V_(oc),which can be used to verify whether 2C model is applicable for the PV module produced by a particular manufacturer.展开更多
文摘Sunshine duration (S) based empirical equations have been employed in this study to estimate the daily global solar radiation on a horizontal surface (G) for six meteorological stations in Burundi. Those equations include the Ångström-Prescott linear model and four amongst its derivatives, i.e. logarithmic, exponential, power and quadratic functions. Monthly mean values of daily global solar radiation and sunshine duration data for a period of 20 to 23 years, from the Geographical Institute of Burundi (IGEBU), have been used. For any of the six stations, ten single or double linear regressions have been developed from the above-said five functions, to relate in terms of monthly mean values, the daily clearness index () to each of the next two kinds of relative sunshine duration (RSD): and . In those ratios, G<sub>0</sub>, S<sub>0 </sub>and stand for the extraterrestrial daily solar radiation on a horizontal surface, the day length and the modified day length taking into account the natural site’s horizon, respectively. According to the calculated mean values of the clearness index and the RSD, each station experiences a high number of fairly clear (or partially cloudy) days. Estimated values of the dependent variable (y) in each developed linear regression, have been compared to measured values in terms of the coefficients of correlation (R) and of determination (R<sub>2</sub>), the mean bias error (MBE), the root mean square error (RMSE) and the t-statistics. Mean values of these statistical indicators have been used to rank, according to decreasing performance level, firstly the ten developed equations per station on account of the overall six stations, secondly the six stations on account of the overall ten equations. Nevertheless, the obtained values of those indicators lay in the next ranges for all the developed sixty equations:;;;, with . These results lead to assert that any of the sixty developed linear regressions (and thus equations in terms of and ), fits very adequately measured data, and should be used to estimate monthly average daily global solar radiation with sunshine duration for the relevant station. It is also found that using as RSD, is slightly more advantageous than using for estimating the monthly average daily clearness index, . Moreover, values of statistical indicators of this study match adequately data from other works on the same kinds of empirical equations.
基金Supported by the National Natural Science Foundation of China(21306137)
文摘The search and development of anti-HIV drugs is currently one of the most urgent tasks of pharmacological studies. In this work, a quantitative structure-activity relationship (QSAR) model based on some new norm indexes, was obtained to a series of more than 150 HEPT derivatives (1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine) to find their pEC50 (the required effective concentration to achieve 50% protection of MT-4 cells against the cytopathic effect of virus) and pCC50 (the required cytotoxic concentration to reduce visibility of 50% mock infected cell) activities. The model efficiencies were then validated using the leave-one-out cross validation (LOO-CV) and y- randomization test. Results indicated that this new model was efficient and could provide satisfactory results for prediction of pECso and pCC50 with the higher R2 train and the higher Rt2est. By using the leverage approach, the applicability domain of this model was further investigated and no response outlier was detected for HEFT derivatives involved in this work. Comparison results with reference methods demonstrated that this new method could result in significant improvements for predicting pEC50 and pCC50 of anti-HIV HEPT derivatives. Moreover, results shown in this present study suggested that these two absolutely different activities pECso and pCC50 of anti-HIV HEPT derivatives could be predicted well with a totally similar QSAR model, which indicated that this model mizht have the potential to be further utilized for other biological activities of HEFT derivatives.
基金Science and Technology Authority of Taiwan under Grant No.107-2221-E-492-004-
文摘Viscoelastic(VE) dampers, with their stiffness and energy dissipation capabilities, have been widely used in civil engineering for mitigating wind-induced vibration and seismic responses of structures, thus enhancing the comfort of residents and serviceability of equipment inside. In past relevant research, most analytical models for characterizing the mechanical behavior of VE dampers were verified by comparing their predictions with performance test results from small-scale specimens, which might not adequately or conservatively represent the actual behavior of full-scale dampers, especially with regard to the ambient temperature, temperature rise, and heat convection effects. Thus, in this study, by using a high-performance testing facility with a temperature control system, full-scale VE dampers were dynamically tested with different displacement amplitudes, excitation frequencies, and ambient temperatures. By comparing the analytical predictions with the experimental results, it is demonstrated that adopting the fractional derivative method together with considering the effects of excitation frequencies, ambient temperatures, temperature rises, softening, and hardening, can reproduce the design performance of full-scale VE dampers very well.
基金supported by the National Natural Science Foundation of China (Grant Nos. 41230636, 41302217)Suzhou Science and Technology Development Program (Grant No. SYG201213)
文摘The interaction between plates and foundations is a typical problem encountered in geotechnical engineering. The long-term plate performance is highly dependent on the theological characteristics of ground soil. Compared with conventional linear theology, the fractional calculus-based theory is a more powerful mathematical tool that can address this issue. This paper proposes a fractional Merchant model (FMM) to investigate the time-dependent behavior of a simply supported rectangular plate on viscoelastic foundation. The correspondence principle involving Laplace transforms was employed to derive the closed-form solutions of plate response under uniformly distributed load. The plate deflection, bending moment, and foundation reaction calculated using the FMM were compared with the results obtained from the analogous elastic model (EM) and the standard Merchant model (SMM). It is shown that the upper and lower bound solutions of the FMM can be determined using the EM. In addition, a parametric study was performed to examine the influences of the model parameters on the time- dependent behavior of the plate-foundation interaction problem. The results indicate that a small fractional differential order corresponds to a plate resting on a sandy soil foundation, while the fractional differential order value should be increased for a clayey soil foundation. The long-term performance of a foundation plate can be accurately simulated by varying the values of the fractional differential order and the viscosity coefficient. The observations from this study reveal that the proposed fractional model has the capability to capture the variation of plate deflection over many decades of time.
基金supported by the State Key Program of National Natural Science Foundation of China (Grant No. 11032009)the National Natural Science Foundation of China (Grant No. 10772048)
文摘On one hand, when the bridge stays in a windy environment, the aerodynamic power would reduce it to act as a non-classic system. Consequently, the transposition of the system’s right eigenmatrix will not equal its left eigenmatrix any longer. On the other hand, eigenmatrix plays an important role in model identification, which is the basis of the identification of aerodynamic derivatives. In this study, we follow Scanlan’s simple bridge model and utilize the information provided by the left and right eigenmatrixes to structure a self-contained eigenvector algorithm in the frequency domain. For the purpose of fitting more accurate transfer function, the study adopts the combined sine-wave stimulation method in the numerical simulation. And from the simulation results, we can conclude that the derivatives identified by the self-contained eigenvector algorithm are more dependable.
基金Supported by National Basic Research Program of China (2009CB824800)National Natural Science Foundation of China (11103001)+1 种基金Hunan Provincial Natural Science Foundation of China (11JJ3006)Research Grants of Changsha University of Science and Technology,the Construct Program of the Key Discipline in Hunan Province and Aid Program for Science and Technology Innovative Research Team in Higher Educational Institute of Hunan Province
文摘We apply the derivative coupling model with ZM and ZM3 parameters to investigate the longitudinal response function in quasielastic electron scattering in the relativistic random phase approximation. The non-spectral method is chosen to describe the nucleon Green's function in a finite nucleus. Some remarks have been made in conclusion.
文摘In this paper we consider Verigin problem with surfaCe tension at freeboundary:where Ω1(t),Ω2(t) are regions of water and oil respectivelyl Γt is a free boundarybetween Ω1(t) and Ω2(t).Let Ω=Ω1(t) ∪Γt∪Ω1(t) be a bounded annular domainin R2, Ω2(t) is inside. nt is a normal of Γt, Pointing inwards Ω2(t),P1 and P2 arepressures of water and oil, μ1 and μ2 are viscosities of water and oil respectively, k isthe permeability, φ is the porosity, K and Vn are the curvature and the normal velocityof Γt in the direction of nt.We prove that the classical Verigin problem is the limit case(s-0) of Veriginproblem with surfaCe tension at free boundary.
基金This work was supported by Beijing Municipal Administration of Hospitals’Ascent Plan[grant number DFL20180701]Special Fund for the Capital Characteristic Clinical Medicine Development Project[grant number Z161100000516077]+1 种基金Beijing Municipal Grant for Medical Talents Group on Peritoneal Surface Oncology[grant number 2017400003235J007]Beijing Health and Science Technology Achievement and Appropriate Technology Promotion Project[grant number 2018-TG-27]Beijing Natural Science Foundation[grant number 7172108].
文摘Hepatocellular carcinoma(HCC)is one of the most common causes of cancerrelated death around the world due to advanced clinical stage at diagnosis,high incidence of recurrence and metastasis after surgical treatment.It is in urgent need to create appropriate animal models to explore the mechanism,patterns,risk factors,and therapeutic strategies of HCC metastasis and recurrence.However,most of the established models lack the phenotype of invasion and metastasis in patient,or have unstable phenotype.To establish HCC models with stable metastasis phenotype requires profound understanding in cancer metastasis biology and scientific methodology.Over the past 3 decades,HCC models with stable metastasis have been extensively studied.This paper reviewed the history and development of HCC animal models and cell models,focusing on the screening and maintaining of metastatic potential and phenotype.In-depth studies using these models vastly promote the understanding of cellular and molecular mechanisms and development of therapeutic strategies on HCC metastasis.
基金This work was supported in part by the Virginia Department of Environmental Quality and the Virginia Environmental Endowment,Richmond,Virginia,USA.
文摘One of the key challenges in the total maximum daily load(TMDL)development process is how to define the critical condition for a receiving waterbody.The main concern in using a continuous simulation approach is the absence of any guarantee that the most critical condition will be captured during the selected representative hydrologic period,given the scarcity of long-term continuous data.The objectives of this paper are to clearly address the critical condition in the TMDL development process and to compare continuous and event-based approaches in defining critical condition during TMDL development for a waterbody impacted by both point and nonpoint source pollution.A practical,event-based critical flow-storm(CFS)approach was developed to explicitly addresses the critical condition as a combination of a low stream flow and a storm event of a selected magnitude,both having certain frequencies of occurrence.This paper illustrated the CFS concept and provided its theoretical basis using a derived analytical conceptual model.The CFS approach clearly defined a critical condition,obtained reasonable results and could be considered as an alternative method in TMDL development.
基金This work was partially supported by Key Science,Technology Project of Zhejiang Province(LZ12E07001)National Natural Science Foundation of China(51307038).
文摘A popular explicit analytic Borowy 2C PV module model is proposed for power generation prediction.The maximum power point and the open-circuit point which are calculated in this model cannot be equal to the data given by manufacturers under standard test condition(STC).The derivation of this model has never been mentioned in any literatures.The parameter forms of 2C model in this paper are more simplified,and the model is decomposed into a STC sub-model and an incremental sub-model.The STC model is derived successfully from an ideal single-diode circuit model.Relative error estimations are developed to do the conformity error measurements.The analysis results showed that though the biases at those critical points are very small,the conformity will depend on both of the two ratio values I_(m)/I_(sc) and V_(m)/V_(oc),which can be used to verify whether 2C model is applicable for the PV module produced by a particular manufacturer.