A comprehensive mission sensitivity analysis index based on Sobol's index called global mission sensitivity( GMS) was proposed in this paper which focused on analyzing the mission sensitivity of components of phas...A comprehensive mission sensitivity analysis index based on Sobol's index called global mission sensitivity( GMS) was proposed in this paper which focused on analyzing the mission sensitivity of components of phased mission systems( PMS). The simulation strategy of GMS based on a Petri net and Monte Carlo method was presented which had broad applicability. Finally,the GMS and Birnbaum's sensitivity of components in a PMS example were compared. The GMS of component is demonstrated to be more adaptable to reflect the component mission sensitivity when the rated reliability parameters of components cannot be obtained, and components have state dependency or the system is subjected to common cause failure.展开更多
Noncompliance to therapeutic regimen is a real public health problem with tremendous socioeconomic consequences. Instead of direct intervention to patients, which can add extra burden to the already overloaded health ...Noncompliance to therapeutic regimen is a real public health problem with tremendous socioeconomic consequences. Instead of direct intervention to patients, which can add extra burden to the already overloaded health system, alternative strategies oriented to drugs’ own properties turns to be more appealing. The aim of this study was establish a rational way to delineate drugs in terms of their “forgiveness”, based on drugs PK/PD properties. A global sensitivity analysis has been performed to identify the most sensitive parameters to dose omissions. A Comparative Drug Forgiveness Index (CDFI), to rank the drugs in terms of their tolerability to non compliance, has been proposed. The index was applied to a number of calcium channel blockers, namely benidipine, nivaldipine, manidipine and felodipine. Using the calculation, benedipine and manidipine showed the best performance among those considered. This result is in accordance with what has been previously reported. The classification method developed here proved to be a powerful quantitative way to delineate drugs in terms of their forgiveness and provides a complementary decision rule for clinical and experimental studies.展开更多
在小麦叶面积指数(leaf area index,LAI)的估算过程中,光谱变量与机器学习算法(MLs)相结合的方法具有较好的性能,但由于输入参数过多会导致数据冗余,使得计算效率降低。为了提高LAI估算的精度和MLs的计算效率,本研究提出了全局敏感性分...在小麦叶面积指数(leaf area index,LAI)的估算过程中,光谱变量与机器学习算法(MLs)相结合的方法具有较好的性能,但由于输入参数过多会导致数据冗余,使得计算效率降低。为了提高LAI估算的精度和MLs的计算效率,本研究提出了全局敏感性分析(global sensitivity analysis,GSA)与MLs相结合的方法(简称GSA-MLs)。首先,基于PROSAIL模拟数据集,利用GSA量化植被生长参数对Sentinel-2光谱变量的影响;此外利用4种变量筛选策略对所有光谱变量进行排序,并选择最优变量作为MLs的输入参数。然后,通过偏最小二乘回归(partial least square regression,PLSR)、支持向量机(support vector machine,SVM)和随机森林(random forest,RF)3种MLs对小麦叶面积指数(LAI)进行估算。结果表明:红边植被指数主要受叶绿素含量的影响,而短波红外相关的植被指数主要受等效水厚度的影响,所有光谱变量均会受到参数之间的交互作用。SLAI-SInteraction筛选得到的30个光谱变量在估算小麦LAI表现最佳(R^(2)=0.94,RMSE=0.38)。并且在模型反演过程中运行时间缩短了54.13%。本研究提出了全局敏感性分析与机器学习相结合的方法,该方法提高了机器学习法估算LAI精度以及应用过程中的计算效率和机理性,该方法有较好的适用性。展开更多
基金National Natural Science Foundation of China(No.71071159)
文摘A comprehensive mission sensitivity analysis index based on Sobol's index called global mission sensitivity( GMS) was proposed in this paper which focused on analyzing the mission sensitivity of components of phased mission systems( PMS). The simulation strategy of GMS based on a Petri net and Monte Carlo method was presented which had broad applicability. Finally,the GMS and Birnbaum's sensitivity of components in a PMS example were compared. The GMS of component is demonstrated to be more adaptable to reflect the component mission sensitivity when the rated reliability parameters of components cannot be obtained, and components have state dependency or the system is subjected to common cause failure.
文摘Noncompliance to therapeutic regimen is a real public health problem with tremendous socioeconomic consequences. Instead of direct intervention to patients, which can add extra burden to the already overloaded health system, alternative strategies oriented to drugs’ own properties turns to be more appealing. The aim of this study was establish a rational way to delineate drugs in terms of their “forgiveness”, based on drugs PK/PD properties. A global sensitivity analysis has been performed to identify the most sensitive parameters to dose omissions. A Comparative Drug Forgiveness Index (CDFI), to rank the drugs in terms of their tolerability to non compliance, has been proposed. The index was applied to a number of calcium channel blockers, namely benidipine, nivaldipine, manidipine and felodipine. Using the calculation, benedipine and manidipine showed the best performance among those considered. This result is in accordance with what has been previously reported. The classification method developed here proved to be a powerful quantitative way to delineate drugs in terms of their forgiveness and provides a complementary decision rule for clinical and experimental studies.
