Glucocorticoids-based prodrug design:Current strategies and research progress

Attributing to their broad pharmacological effects encompassing anti-inflammation,antitoxin,and immunosuppression,glucocorticoids(GCs)are extensively utilized in the clinic for the treatment of diverse diseases such as lupus erythematosus,nephritis,arthritis,ulcerative colitis,asthma,keratitis,macular edema,and leukemia.However,longterm use often causes undesirable side effects,including metabolic disorders-induced Cushing's syndrome(buffalo back,full moon face,hyperglycemia,etc.),osteoporosis,aggravated infection,psychosis,glaucoma,and cataract.These notorious side effects seriously compromise patients'quality of life,especially in patients with chronic diseases.Therefore,glucocorticoid-based advanced drug delivery systems for reducing adverse effects have received extensive attention.Among them,prodrugs have the advantages of low investment,low risk,and high success rate,making them a promising strategy.In this review,we propose the strategies for the design and summarize current research progress of glucocorticoid-based prodrugs in recent decades,including polymer-based prodrugs,dendrimer-based prodrugs,antibody-drug conjugates,peptide-drug conjugates,carbohydrate-based prodrugs,aliphatic acid-based prodrugs and so on.Besides,we also raise issues that need to be focused on during the development of glucocorticoid-based prodrugs.This review is expected to be helpful for the research and development of novel GCs and prodrugs.

Redesigning the Model of Book Evaluation in the Polish Performance-based Research Funding System

Purpose: This study aims to present the key systemic changes in the Polish book evaluation model to focus on the publisher list, as inspired by the Norwegian Model. Design/methodology/approach: In this study we reconstruct the framework of the 2010 and 2018 models of book evaluation in Poland within the performance-based research funding system. Findings: For almost 20 years the book evaluation system in Poland has been based on the verification of various technical criteria(e.g. length of the book). The new 2018 model is based on the principle of prestige inheritance(a book is worth as much as its publisher is) and is inspired by the publisher list used in the Norwegian Model. In this paper, we argue that this solution may be a more balanced policy instrument than the previous 2010 model in which neither the quality of the publisher nor the quality of the book played any role in the evaluation.Research limitations: We work from the framework of the 2018 model of book evaluation specified in the law on higher education and science from 20 July 2018, as implementation acts are not available yet. Practical implications: This study may provide a valuable point of reference on how structural reforms in the research evaluation model were implemented on a country level. The results of this study may be interesting to policy makers, stakeholders and researchers focused on science policy. Originality/value: This is the very first study that presents the new framework of the Polish research evaluation model and policy instruments for scholarly book evaluation. We describe what motivated policy makers to change the book evaluation model, and what arguments were explicitly raised to argue for the new solution.

Research on the Course of Principles of Concrete Structure Design

Nowadays,education and teaching have become a hot topic,and teaching in colleges and universities is facing a brand-new development direction.Principles of Concrete Structure Design,as one of the main courses,transmits professional knowledge for students,enhances the students’professional ability,and further carries out in-depth research on the course to bring a better teaching effect for students.The article mainly focuses on the research of the principles of concrete structure design course,conducts an analysis of the teaching characteristics of the principles of concrete structure design course,and reasonably sets the teaching content from the optimization of the course teaching objectives;innovative course teaching methods can deepen the effect of knowledge understanding;reform of experimental practice teaching can lay down the effect of the internalization of knowledge,etc.The in-depth description and discussion of the relevant aspects of the research aim to provide guidelines for related research.

Curriculum Reform Practices in “Cosmetic Product Formulation Design and Preparation Technology” Under the Perspective of Integration of Industry, Education, and Research

With the upgrading of industries,the cosmetics industry has posed new requirements for technical talents.As a professional core course in cosmetic technology,“Cosmetic Product Formulation Design and Preparation Technology”serves as the foundation for cultivating students’abilities in cosmetic development and preparation.To foster high-quality skilled talents capable of adapting to the rapid growth of color cosmetics and to better promote the deep integration of scientific and technological industries with curriculum teaching,the teacher team embarked on active explorations and practical teaching research for curriculum teaching reform from four dimensions:strengthening top-level design,enriching teaching content,optimizing teaching design,and reforming assessment methods.These efforts have enhanced students’comprehensive vocational qualities and innovative consciousness,contributing to the teaching reform in higher vocational colleges under the integration of industry,education,and research.

A Design Philosophy From the View of Creation:Design vs.Research

Mankind holds creation as a special human property contributing knowledge and culture.Both design and research belong to creative activities.While research focuses on new findings following the rule of truth,design pays more attention to new designed works following the rule of beauty.Three philosophical principles for design are suggested as ABC principles:A.Design approaches beauty;B.Design balances science and art;C.Design concerns culture.Three types of design are practically discussed,including 2D art or symbol design,3D engineering or product design,and nD program or form design.

Practice and Exploration of Ideological and Political Teaching in Landscape Design Courses for Environmental Design Majors

To implement the fundamental goal of moral education,based on the teaching practice of landscape design courses,we explore how to integrate value shaping,knowledge transfer,and skill cultivation in the teaching links of landscape design courses in environmental design majors,such as selecting design topics,assigning tasks,researching projects,designing works,designing explanations,and defense.

A Custom Manipulator for Dental Implantation Through Model-Based Design

This paper presents a Model-Based Design(MBD)approach for the design and control of a customized manipulator intended for drilling and position-ing of dental implants accurately with minimal human intervention.While performing an intra-oral surgery for a prolonged duration within a limited oral cavity,the tremor of dentist's hand is inevitable.As a result,wielding the drilling tool and inserting the dental implants safely in accurate position and orientation is highly challenging even for experienced dentists.Therefore,we introduce a customized manipulator that is designed ergonomically by taking in to account the dental chair specifications and anthropomorphic data such that it can be readily mounted onto the existing dental chair.The manipulator can be used to drill holes for dental inserts and position them with improved accuracy and safety.Further-more,a thorough multi-body motion analysis of the manipulator was carried out by creating a virtual prototype of the manipulator and simulating its controlled movements in various scenarios.The overall design was prepared and validated in simulation using Solid works,MATLAB and Simulink through Model Based Design(MBD)approach.The motion simulation results indicate that the manipulator could be built as a prototype readily.

Neutronic design investigation of a liquid injection-based second shutdown system for a typical research reactor using MCNPX

Safety systems, built on state-of-the-art technology, are essential for achieving acceptable levels of plant safety to minimize hazards to the reactor and the general public. The second shutdown system(SSS) as an engineered safety feature and a part of the reactor protection system(RPS) is a means for rapidly shutting down a nuclear reactor, keeping it in a subcritical state and serving as a backup to the first shutdown system(FSS). In this research, one SSS with two types of optimum chamber designs is proposed that take into account the main current characteristic features of the Tehran research reactor with improvements over earlier designs. They are based on a liquid neutron absorber injection that is preferably different, diverse, and independent from the FSS based on the rod drop mechanism. The major design characteristics of this SSS with two different chambers were investigated using MCNPX 2.6.0 code. The performed calculations showed that the designed SSS is a reliable shutdown system, assuring an appropriate shutdown margin and injection time, with no significant effects on the effective delayed neutron fraction while causing minimal variations to the core structure. Further, the reasonable financial cost and the prolongation of the operation cycle are additional advantages of this design.

Application of consequence-based design criteria in regions of moderate seismicity

Current design criteria and prineiples of earthquake engineering design are reviewed,including safety factors, probabilistic approach,and two-level and muhi-level functional design ideas.The modern multi-functional idea is discussed in greater details.When designing a structure,its resistance to and the intensity of the earthquake action are considered. The consequence of failure of the structure is considered only through a rough and empirical factor of importance,ranging usually from 1.0 to 1.5.This paper suggests a method of'consequence-based design,'which considers the consequences of malfunctioning instead of simply an importance factor.The main argument for this method is that damage to a structure located in different types of societies may have very different consequences,which are depeudant on its value and usefulness to the society and the seismicity in the region.

A Model for the Design Process Gene Based on the Extensible Basic-element and the Mutation of the Design Process Gene

In this paper a method is developed to model the design process gene based on the extensible basic-element with the purpose of design process optimization and reuse. First, the principle of genetic engineering based design process optimization and reuse is put forward and analyzed. Second, the extensible basic-element model of the design process gene is established based on the models of the design process base and the base pair through analyzing the concept and structure of the design process gene and the extensible basic-element as well as its extensibility. Third, the features of divergence and scalability of the extensible basic-element model of the design process gene are discussed for carrying out the extension translation to the design process gene by way of inserting, deleting and updating design process bases. Finally, an example of building extensible basic-element models for the design process base, base pair and design process gene in mechanical product design and the mutation process of the design process gene in airplane design is presented which demonstrates the application of the method proposed in this paper.

A FORMAL REPRESENTATION FOR FEATURE-BASED DESIGN

Feature based design has been regarded as a promising approach for CAD/CAM integration.This paper aims to establish a domain independent representation formalism for feature based design in three aspects: formal representation,design process model and design algorithm.The implementing scheme and formal description of feature taxonomy,feature operator,feature model validation and feature transformation are given in the paper.The feature based design process model suited for either sequencial or concurrent engineering is proposed and its application to product structural design and process plan design is presented. Some general design algorithms for developing feature based design system are also addressed.The proposed scheme provides a formal methodology elementary for feature based design system development and operation in a structural way.

A Win-Win Undergraduate Graduation Design Model for Students, Teachers, and Training Platforms

Undergraduate graduation design is an important link in the process of undergraduate training,and university platforms have invested a lot of manpower and material resources for this purpose.However,while carrying out student training,it has gradually become the consensus of most university platforms to achieve a win-win situation for teachers and training platforms in order to achieve optimization of resource allocation and motivation of student training.After discussion and practice,this paper proposes a set of undergraduate graduation design training concepts and training modes with a win-win situation for students,teachers,and training platforms.

Under "Integration of Doing, Learning and Teaching", Research on the Project-Based Teaching Innovation of "Landscape Planning and Design"

Based on the research on the project course theory of "integration of theory and practice" in higher vocational education and the analysis of practical teaching in colleges and universities at home and abroad, combined with literature research, case analysis, system theory and other research methods, the project-based teaching goal, model, content and means of "integration of doing, learning and teaching" in higher vocational education is explored, and the project-based teaching model of "Landscape Planning and Design" is discussed combined with the application of information-based teaching methods. So as to provide references for carrying out the project-based teaching in similar courses in higher vocational colleges and really achieve docking the actual post requirements with the course to provide the basis for achieving the purpose of cultivating skilled talents in higher vocational education.

Research on the Design of the Innovative Teaching Platform for College English Linguistics Based on Network Technologies

As a compulsory course for English majors in colleges and universities, English linguistics is of great significance to English majors in colleges and universities. However, as the English linguistics curriculum itself belongs to theoretical teaching, the teaching process requires the two-way interaction between teachers and students, so the teaching effect is not good. College English linguistics takes the cultivation of students' comprehensive abilities to use English as the premise, and emphasizes the cultivation of students' listening and speaking abilities to help students transmit the accurate written and oral information in the process of the social work and communication, thus improving students' English levels and preparing for their future international communication.

Teaching Research and Practice of Logistics Management Major Based on OBE-CDIO-A Case Study of Logistics System Planning and Design Course

The economic and social progress under the new era has put forward new requirements for logistics talents.Based on the teaching concept of OBE-CDIO as well as the training program and objectives of logistics management major in Guangzhou Maritime University,this study analyzes and discusses how the Logistics System Planning and Design course,which is targeted at students majoring in logistics management,enables the students to meet the graduation requirements by virtue of realizing the course objectives.

An evaluation of force-based design vs.direct displacement-based design of jointed precast post-tensioned wall systems

The unique features of jointed post-tensioned wall systems, which include minimum structural damage and re-centering capability when subjected to earthquake lateral loads, are the result of using unbonded post-tensioning to attach the walls to the foundation, along with employing energy dissipating shear connectors between the walls. Using acceptance criteria defined in terms of inter-story drift, residual drift, and floor acceleration, this study presents a multiplelevel performance-based seismic evaluation of two five-story unbonded post-tensioned jointed precast wall systems. The design and analysis of these two wall systems, established as the direct displacement-based and force-based solutions for a prototype building used in the PREcast Seismic Structural Systems （PRESSS） program, were performed at 60% scale so that the analysis model could be validated using the PRESSS test data. Both buildings satisfied the performance criteria at four levels of earthquake motions although the design base shear of the direct displacement-based jointed wall system was 50% of that demanded by the force-based design method. The study also investigated the feasibility of controlling the maximum transient inter-story drift in a jointed wall system by increasing the number of energy dissipating shear connectors between the walls but without significantly affecting its re-centering capability.

从Design Research思潮看我国艺术设计工作室教学模式的改革

艺术设计教学改革一直是困扰我国艺术设计教育的一个重大课题,本文将国内当前各大院校流行的艺术设计工作室教学改革模式与欧美发达国家的艺术设计Design Research思潮进行对比,结合美国著名大学艺术设计研究生的实际设计课题,剖析中西方关于艺术设计教育教学模式中存在的较深层次的差异,目的是为完善我国设计工作室教学模式和整个艺术设计教育找出新的办法。

Reliable Space Pursuing for Reliability-based Design Optimization with Black-box Performance Functions

Reliability-based design optimization （RBDO） is intrinsically a double-loop procedure since it involves an overall optimization and an iterative reliability assessment at each search point. Due to the double-loop procedure, the computational expense of RBDO is normally very high. Current RBDO research focuses on problems with explicitly expressed performance functions and readily available gradients. This paper addresses a more challenging type of RBDO problem in which the performance functions are computation intensive. These computation intensive functions are often considered as a ＂black-box＂ and their gradients are not available or not reliable. On the basis of the reliable design space （RDS） concept proposed earlier by the authors, this paper proposes a Reliable Space Pursuing （RSP） approach, in which RDS is first identified and then gradually refined while optimization is performed. It fundamentally avoids the nested optimization and probabilistic assessment loop. Three well known RBDO problems from the literature are used for testing and demonstrating the effectiveness of the proposed RSP method.

Reliability Based Design Optimization of Aero-Engine Spindle Ball Bearings

Aero-engine spindle ball bearings work in harsh conditions which are affected by relatively complex stresses. One of the key factors which affects bearing performance is its structure. In this paper,we used reliability based design optimization method to solve the structure design problem of aero-engine spindle ball bearings.Compared with the optimization design method, the value of equivalent dynamic load using reliability optimization design method was the least by MATLAB simulation. Also the design solutions show that the optimized structure possesses higher reliability than the original solution.

Computer-based Creativity Enhanced Conceptual Design Model for Non-routine Design of Mechanical Systems

Computer-based conceptual design for routine design has made great strides, yet non-routine design has not been given due attention, and it is still poorly automated. Considering that the function-behavior-structure（FBS） model is widely used for modeling the conceptual design process, a computer-based creativity enhanced conceptual design model（CECD） for non-routine design of mechanical systems is presented. In the model, the leaf functions in the FBS model are decomposed into and represented with fine-grain basic operation actions（BOA）, and the corresponding BOA set in the function domain is then constructed. Choosing building blocks from the database, and expressing their multiple functions with BOAs, the BOA set in the structure domain is formed. Through rule-based dynamic partition of the BOA set in the function domain, many variants of regenerated functional schemes are generated. For enhancing the capability to introduce new design variables into the conceptual design process, and dig out more innovative physical structure schemes, the indirect function-structure matching strategy based on reconstructing the combined structure schemes is adopted. By adjusting the tightness of the partition rules and the granularity of the divided BOA subsets, and making full use of the main function and secondary functions of each basic structure in the process of reconstructing of the physical structures, new design variables and variants are introduced into the physical structure scheme reconstructing process, and a great number of simpler physical structure schemes to accomplish the overall function organically are figured out. The creativity enhanced conceptual design model presented has a dominant capability in introducing new deign variables in function domain and digging out simpler physical structures to accomplish the overall function, therefore it can be utilized to solve non-routine conceptual design problem.