It is increasingly aware that gut microbiota is closely associated with atherosclerosis.However,which and how specific gut bacteria regulate the progression of atherosclerosis is still poorly understood.In this study,...It is increasingly aware that gut microbiota is closely associated with atherosclerosis.However,which and how specific gut bacteria regulate the progression of atherosclerosis is still poorly understood.In this study,modified linear discriminant analysis was performed in comparing the gut microbiota structures of atherosclerotic and non-atherosclerotic mice,and Desulfovibrio desulfuricans(D.desulfuricans)was found to be associatedwith atherosclerosis.D.desulfuricans-treated Apoe^(-/-) mice showed significantly aggravated atherosclerosis.The proatherogenic effect of D.desulfuricans was attributed to its ability to increase intestinal permeability and subsequent raise in the transit of lipopolysaccharide(LPS)from the intestine to the bloodstream.Excessive LPS in the blood can elicit local and systemic inflammation and activate Toll-like receptor 4(TLR4)/nuclear factor-kB(NF-kB)signaling of endothelial cells.TAK-242,a specific inhibitor of TLR4,can ameliorate the development of D.desulfuricansinduced atherosclerosis by blocking the LPS-induced activation of TLR4/NF-kB signaling.展开更多
基金This work was supported by grants from the National Natural Science Foundation of China(No.12032007 and 31971242)the Chongqing Research Program of Basic Research and Frontier Technology,China(No.cstc2019jcyjzdxmX0028)+1 种基金Chongqing Municipal Education Commission,China(No.KYYJ202001)Fundamental Research Funds for theCentral Universities(No.2019CDYGZD008).
文摘It is increasingly aware that gut microbiota is closely associated with atherosclerosis.However,which and how specific gut bacteria regulate the progression of atherosclerosis is still poorly understood.In this study,modified linear discriminant analysis was performed in comparing the gut microbiota structures of atherosclerotic and non-atherosclerotic mice,and Desulfovibrio desulfuricans(D.desulfuricans)was found to be associatedwith atherosclerosis.D.desulfuricans-treated Apoe^(-/-) mice showed significantly aggravated atherosclerosis.The proatherogenic effect of D.desulfuricans was attributed to its ability to increase intestinal permeability and subsequent raise in the transit of lipopolysaccharide(LPS)from the intestine to the bloodstream.Excessive LPS in the blood can elicit local and systemic inflammation and activate Toll-like receptor 4(TLR4)/nuclear factor-kB(NF-kB)signaling of endothelial cells.TAK-242,a specific inhibitor of TLR4,can ameliorate the development of D.desulfuricansinduced atherosclerosis by blocking the LPS-induced activation of TLR4/NF-kB signaling.
