Kinesin-1 motor protein is a homodimer containing two identical motor domains connected by a common long coiledcoil stalk via two flexible neck linkers. The motor can step on a microtubule with a velocity of about 1 ...Kinesin-1 motor protein is a homodimer containing two identical motor domains connected by a common long coiledcoil stalk via two flexible neck linkers. The motor can step on a microtubule with a velocity of about 1 μm·s-1and an attachment duration of about 1 s under physiological conditions. The available experimental data indicate a tradeoff between velocity and attachment duration under various experimental conditions, such as variation of the solution temperature,variation of the strain between the two motor domains, and so on. However, the underlying mechanism of the tradeoff is unknown. Here, the mechanism is explained by a theoretical study of the dynamics of the motor under various experimental conditions, reproducing quantitatively the available experimental data and providing additional predictions. How the various experimental conditions lead to different decreasing rates of attachment duration versus velocity is also explained.展开更多
The bubble deformation processes were reported when gas was injected into polyme r melt flow field in another paper, the experiments showed that the deformation was severely affected by the volume of the bubble, and ...The bubble deformation processes were reported when gas was injected into polyme r melt flow field in another paper, the experiments showed that the deformation was severely affected by the volume of the bubble, and in turn, for the different bubbles, several different deformation processes were presented d uring their movement along the flow channel. In addition, we could find that the magnitude of the bubble volume was dependent upon the pressure difference of th e gas injection pressure and the melt pressure. In this paper, more experimental conditions were changed to investigate the parameters relevant to the detachmen t of bubbles from the injection nozzle. The experimental results show that the p ressure difference, the melt flow velocity as well as the melt pressure were all critical for the parameters, such as the bubble detachment time, the maximum bu bble diameters and the magnitude of the bubble volume. The morphology changes of bubble were very large when the flow field was abruptly changed, and the situat ions were more complicated.展开更多
文摘Kinesin-1 motor protein is a homodimer containing two identical motor domains connected by a common long coiledcoil stalk via two flexible neck linkers. The motor can step on a microtubule with a velocity of about 1 μm·s-1and an attachment duration of about 1 s under physiological conditions. The available experimental data indicate a tradeoff between velocity and attachment duration under various experimental conditions, such as variation of the solution temperature,variation of the strain between the two motor domains, and so on. However, the underlying mechanism of the tradeoff is unknown. Here, the mechanism is explained by a theoretical study of the dynamics of the motor under various experimental conditions, reproducing quantitatively the available experimental data and providing additional predictions. How the various experimental conditions lead to different decreasing rates of attachment duration versus velocity is also explained.
基金Funded by the National Nature Science Foundation of China(No.19632004,No.10172074) the Research Foundation for the Doctor al Program of Higher Education of China (No.98056113) Guang dong Province Nature Science Foundation ( No. 980573, No.0401154)
文摘The bubble deformation processes were reported when gas was injected into polyme r melt flow field in another paper, the experiments showed that the deformation was severely affected by the volume of the bubble, and in turn, for the different bubbles, several different deformation processes were presented d uring their movement along the flow channel. In addition, we could find that the magnitude of the bubble volume was dependent upon the pressure difference of th e gas injection pressure and the melt pressure. In this paper, more experimental conditions were changed to investigate the parameters relevant to the detachmen t of bubbles from the injection nozzle. The experimental results show that the p ressure difference, the melt flow velocity as well as the melt pressure were all critical for the parameters, such as the bubble detachment time, the maximum bu bble diameters and the magnitude of the bubble volume. The morphology changes of bubble were very large when the flow field was abruptly changed, and the situat ions were more complicated.
