Helicobacter pylori neutrophil-activating protein:From molecular pathogenesis to clinical applications

Helicobacter pylori (H. pylori) neutrophil-activating protein (HP-NAP) was originally identified as a virulence factor of H. pylori for its ability to activate neutrophils to generate respiratory burst by releasing reactive oxygen species. Later on, HP-NAP was also found to be involved in the protection of H. pylori from DNA damage, supporting the survival of H. pylori under oxidative stress. This protein is highly conserved and expressed by virtually all clinical isolates of H. pylori. The majority of patients infected with H. pylori produced antibodies specific for HP-NAP, suggesting its important role in immunity. In addition to acting as a pathogenic factor by activating the innate immunity through a wide range of human leukocytes, including neutrophils, monocytes, and mast cells, HP-NAP also mediates adaptive immunity through the induction of T helper cell type I responses. The pro-inflammatory and immunomodulatory properties of HP-NAP not only make it play an important role in disease pathogenesis but also make it a potential candidate for clinical use. Even though there is no convincing evidence to link HP-NAP to a disease outcome, recent findings supporting the pathogenic role of HP-NAP will be reviewed. In addition, the potential clinical applications of HP-NAP in vaccine development, clinical diagnosis, and drug development will be discussed.

The 5^(th) International Conference on Rare Earth Development and Applications ICRE′ 2007

The Second Circular Baotou/China August 7～11, 2007 Organized by The Chinese Society of Rare Earths (CSRE) Baotou National Rare-Earth Hi-Tech Industrial Development Zone Honorary Chairman: Xu Kuangdi, President, the Chinese Academy of Engineering Chairman: Gan Yong, President, General Institute of Iron & Steel; Chairman of CSRE Vice Chairmen: Zhou Chuandian, Xu Guangxian, Li Dongying, Lin Donglu, Tu Hailing, Yang Jianlin, Li Bingrong International Scientific Advisory Board: Gi-Ya Adachi(Japan), J.C.G. Bünzli(Switzerland), Patrick Burk (USA), Przemyslaw Deren(Poland),Philippe Goldner(France), K. A. Gschneider(USA), Huang Boyun(China), Dariusz Kaczorowski (Poland), Nogami Masayuki(Japan), Ni Jiazuan(China), Wieslaw Strek(Poland),Su Qiang(China), Alessandro Trovarelli(Italy), Wang Zhenxi(China), Yang Yingchang (China), Zhang Guocheng (China)

THE 6TH INTERNATIONAL CONFERENCE ON RARE EARTH DEVELOPMENT AND APPLICATIONS ICRE'2010(The Second Circular)

Beijing / China August 2-6, 2010 Organized by The Chinese Society of Rare Earths (CSRE) Co-Organized by Peking University (PKU), Roskill Information Services Ltd., Metallurgical Council

The 2nd International Conference on Rare Earth Development and Applications Held in Beijing

The 2nd International Conference on Rare Earth Development and Applications(ICRE’91),which wassponsored by the Chinese Society of Rare Earths,was held at Beijing International Convention Centre fromMay 27 through May 31,1991.290 scientists attended this conference,among them there were 63 foreign sci-entists.Prof.Yu Zongsen,vice-chairman of the Chinese Society of Rare Earths,presided over the openingceremony.Mr.Xu Daquan,deputy director of the Rare Earth Leading Group of the State Council,vice-minister

GUO BOSHENG,PIONEER FOR DEVELOPING RARE EARTH APPLICATION IN AGRICULTURE IN CHINA

Guo Bosheng, senior engineer/professor, is now a member of the Expert Group of the State Council Rare Earth Leading Group, PRC., director of Rare Earth Development Center for Agricultural Technique. He graduated from Moscow Fine Chemical Industry University in the Sovi-

Self-innovating Accelerating the development and promotion of standards for E-commerce applications

The Eleventh Five-Year Plan places emphasis on enhancing the nation's innovation capabilities. Innovation forms a key part of the strategy to change China's central mode of growth to one that is based on science and technology.……

Long March Launch Vehicles Promote Quick and Sound Development of Satellite Applications

INTRODUCTION Launch vehicles are a precondition and main carrier for space activities for human beings.Their development have directly promoted the technology of satellite applications,manned spaceflight,deep space exploration,and promoted the development of communication,navigation,environmental monitoring,resource exploitation,scientific research and so on.

Function and Application Progress of Probiotics in Food

Probiotics have a long history of use in human production and life.With the gradual deepening of the research on the functions of probiotics,their various nutritional and health benefits for the human body have also become increasingly clear.Existing research shows that probiotics can regulate intestinal flora,and improve immunity and even the symptoms of some diseases.Therefore,in the food industry,the application of probiotics from traditional fermented foods to functional foods has become more and more extensive.In this paper,the research progress of nutritional function and application of probiotics in food at home and abroad was reviewed,in order to provide some reference for the safe application of probiotics in food.

Visual Analysis of the Application and Development Trend of Cinnamon in the Field of Traditional Chinese Medicine Based on CiteSpace

[Objectives]This study was conducted to explore the application and development trend of Chinese medicinal material cinnamon in the field of traditional Chinese medicine.[Methods]Articles published from 2008 to 2023 were exported using"cinnamon"as the subject word in the Chinese database of CNKI.Knowledge graphs were drawn by CiteSpace software on the number of articles published,the institutions publishing articles,and keyword clustering,and the data were sorted by Excel.Combined with the extracted information,the application of cinnamon in traditional Chinese medicine and integrated traditional Chinese and Western medicine was analyzed,and its development trend was discussed and prospected,providing further reference for researchers.[Results]The number of articles published showed an overall upward trend and maintained a high number of articles.In the analysis of the journals publishing articles,the journal with the largest number of articles was West China Journal of Pharmaceutical Sciences,which had certain representativeness.In the analysis of institutions publishing articles,the institution with the largest number of articles was Beijing University of Chinese Medicine,and most institutions had little cooperation.Four categories was obtained in keyword clustering,respectively,general research,component identification,production process and product development of cinnamon."Glycyrrhizin"was the keyword with the earliest burst time,and the hot words that have received much attention in recent years are"medication law"and"data mining".[Conclusions]The application of cinnamon in the field of traditional Chinese medicine is mainly to treat diseases and as raw materials for traditional Chinese medicine products.The development trend is"quality control"and"product research and development".Further research and development of cinnamon in traditional Chinese medicine need to promote the participation of more institutions to participate,and cooperation and communication between institutions should be strengthened to promote the deep integration of production,research and academia.

Critical Success Factors for Citizen Development

The purpose of the research was to assess the impact of Citizen Development activities on digital transformation. The research identified eight categories that contribute to the success of Low-code No-code (LCNC) projects: 1) Strategy;2) Infrastructure;3) Technology;4) Processes & Procedures;5) Governance;6) Culture;7) People;8) Goals & Metrics and selected six critical success factors from these categories: 1) Operational Efficiency;2) Time Savings;3) Timeframe to Realize Value;4) Employee Engagement;5) Participation;6) Number of Sponsored Ideas. End users of the digital transformation efforts through Citizen Development were asked to assess the six critical success measures in terms of performance and importance criteria. The research results identified that focus should be applied to improving “Timeframe to Realize Value”, on “Operational Efficiency”, and on “Time Savings” to deliver success.

Progress in the development and application of plant-based antiviral agents

Plant virus disease is one of the major causes of biological disasters in agriculture worldwide. Given the complexity of transmission media and plant disease infection mechanisms, the prevention and control of plant viral diseases is a great challenge, and an efficient green pesticide is urgently needed. For this reason, when developing candidate drug leads to regulate plant viruses, pesticide experts have focused on characteristics such as low pesticide resistance, eco-friendliness, and novel mechanism. Researchers have also theoretically investigated the molecular targets of viruses infecting agricultural crops. Antiviral screening models have been constructed based on these molecular targets, and the mechanisms of commercial drugs and high-activity compounds have been extensively investigated. After screening, some compounds have been applied in the field and found to have good commercial prospects; these drugs may be used to create new green antiviral pesticides to control plant viruses. This paper reviews the screening, mode of action, development and application of recently used plant-based antiviral agents.

Development and application of Baosteel X80 large diameter UOE longitudinal submerged arc welded pipes

With the increase in energy demand, the demand for oil and gas transmission pipes, particularly high-grade longitudinal submerged arc welded pipes （LSAWs）, have been growing in recent years. The construction of the 2nd West -East natural gas transmission pipeline project shows that the oil and gas pipeline construction has entered a new phase of development with X80 pipes being applied in large scales for the first time in China. This paper briefly introduces the 2nd West-East natural gas transmission pipeline project and its main technical requirements with the focus on the features of API standard 5L X80 grade Ф 1219 mm series of U-ing-O-ing-Expanding （ UOE ） LSAW pipes, which Baosteel developed with the integrated technology for the 2nd West-East natural gas transmission pipeline project. The analysis shows the extra-low carbon content, the high contents of manganese and niobium, the fine microstructure, the high strength,the toughness and the good weldability of X80 pipes meet the requirements of ＂the technical specification of LSAW linepipes for the 2nd West-East natural gas transmission pipeline project in China＂. By the end of June 2010, Baosteel had totally produced 322000 t of Ф 1219 mm X80 UOE steel pipes, which have been successfully used in the 2nd West-East natural gas transmission pipeline project, thus filling the gap of the production of large diameter X80 UOE LSAW pipes in China.

Development and Application of Universal Formability Technology

Using mathematical plasticity theories, universal formability (UF) technology has been developed and applied in the automotive stamping engineering and production. As a formability analysis tool, this technology is the major methodology for the development of stamping expert system (solution provider) for (a) product design and feasibility analysis, (b) material automatic selection using nomograms, (c) draw die design using pre-models, and (d) UF and robustness analysis of die performance in finite element analysis (FEA) environment.

Methods for fatigue-life estimation:A review of the current status and future trends

With the development of modern industry and ever more complex structural loads,the possibility of fatigue failure is increasing.Fatigue analysis can be used to evaluate the service life of components and reduce the probability of accidents.Therefore,the development and application of fatigue-analysis technology have important research significance.This paper collects information from a wide field of literature and summarizes the current status of fatigue-analysis research.It covers related theoretical knowledge,fatigue-life prediction methods,and fatigue design methods and their application scenarios,and it summarizes the challenges and research hotspots in the field.On the basis of this examination,future development directions of fatigue-life prediction methods are proposed.The conclusions will have a certain guiding role in the development of fatigue-analysis methods.

A Comparative Analysis of RAD and Agile Technique for Management of Computing Graduation Projects

Computing students face the problem with time and quality of the work while managing their graduation/senior projects.Rapid Application Development(RAD)model is based on continual user involvement for the process of requirement gathering via prototyping.After each iteration,the developers can validate the requirements that are completed in the iteration.Managing a project with RAD is easier but not flexible.On the other hand,Agile project management techniques focus on flexibility,agility,teamwork and quality based on user stories.Continual user involvement is avoided,which requires extensive maintenance time for fixing iteration and release of the story points.This also makes it necessary to provide onsite training to the users of the application.This research provides the pros and cons of RAD and Agile project management techniques,to help students in deciding the best approach for managing their graduation projects.For the evaluation of these techniques,similar case studies were given to the senior project students(having similar CGPAs)for building similar functionality-based applications.The two projects“Life Organizer”developed and managed using RAD and“Smart Patient Assistant(SPA)”developed and managed through Agile methodology were evaluated against the quality assurance criteria for senior projects.The study found that the project developed with RAD methodology performed 13.33%better in providing extensive and elaborated documentation than the students following the Agile technique.On the other hand,SPA-Agile based project,due to teamwork had 2.5%better implementation than Life Organizer-RAD based project.

A Novel Lifecycle Model for Web-based Application Development in Small and Medium Enterprises

Software engineering＇s lifecycle models havc proven to be very important for traditional software development. However, can these models be applied to the development of Web-based applications as well？ In recent years, Web-based applications have become more and more complicated and a lot of efforts have been placed on introducing new technologies such as J2EE, PhP, and .NET, etc., which have been universally accepted as the development technologies for Web-based applications. However, there is no universally accepted process model for the development of Web-based applications. Moreover, shaping the process model for small medium-sized enterprises （SMEs）, which have limited resources, has been relatively neglected. Based on our previous work, this paper presents an expanded lifecycle process model for the development of Web-based applications in SMEs. It consists of three sets of processes, i.e., requirement processes, development processes, and evolution processes. Particularly, the post-delivery evolution processes are important to SMEs to develop and maintain quality web applications with limited resources and time.