Artificial intelligence is a new technological science that researches and develops theories,methods,technologies and application systems for simulating,extending and expanding human intelligence.It simulates certain ...Artificial intelligence is a new technological science that researches and develops theories,methods,technologies and application systems for simulating,extending and expanding human intelligence.It simulates certain human thought processes and intelligent behaviors(such as learning,reasoning,thinking,planning,etc.),and produces a new type of intelligent machine that can respond in a similar way to human intelligence.In the past 30 years,it has achieved rapid development in various industries and related disciplines such as manufacturing,medical care,finance,and transportation.展开更多
miRNAs are non-coding RNAs that play a regulatory role in expression of genes and are associated with diseases. Quantitatively measuring expression levels of miRNAs can help understanding the mechanisms of human disea...miRNAs are non-coding RNAs that play a regulatory role in expression of genes and are associated with diseases. Quantitatively measuring expression levels of miRNAs can help understanding the mechanisms of human diseases and discovering new drug targets. There are three major methods that have been used to measure the expression levels of miRNAs: real-time reverse transcription PCR (qRT-PCR), microarray, and the newly introduced next-generation sequencing (NGS). NGS is not only suitable for profiling of known miRNAs that qRT-PCR and microarray can do too but also able to detect unknown miRNAs that the other two methods are incapable. Profiling of miRNAs by NGS has been progressed rapidly and is a promising field for applications in drug development. This paper will review the technical advancement of NGS for profiling miRNAs, including comparative analyses between different platforms and software packages for analyzing NGS data. Examples and future perspectives of applications of NGS profiling miRNAs in drug development will be discussed.展开更多
This paper reviews the current achievements of the China Argo project. It considers aspects of both the construction of the Argo observing array, float technology, and the quality control and sharing of its data. The ...This paper reviews the current achievements of the China Argo project. It considers aspects of both the construction of the Argo observing array, float technology, and the quality control and sharing of its data. The developments of associated data products and data applications for use in the fields of ocean, atmosphere, and climate research are discussed, particularly those related to tropical cyclones （typhoons）, ocean circulation, mesoscale eddies, turbulence, oceanic heat/salt storage and transportation, water masses, and operational oceanic/atmospheric/climatic forecasts and predictions. Finaliy, the challenges and opportunities involved in the long-term maintenance and sustained development of the China Argo ocean observation network are outlined. Discussion also focuses on the necessity for increasing the number of floats in the Indian Ocean and for expanding the regional Argo observation network in the South China Sea, together with the importance of promoting the use of Argo data by the maritime countries of Southeast Asia and India.展开更多
Internet education has appeared with the development of the lnternet. Since ＂lnternet＋＂ has come up with in the 2015 government work report, it has become a hot word. ＂Intemet＋＂ has been applied to traditional e...Internet education has appeared with the development of the lnternet. Since ＂lnternet＋＂ has come up with in the 2015 government work report, it has become a hot word. ＂Intemet＋＂ has been applied to traditional education, which has reformed the traditional English teaching in middle school. Nowadays, there are many applications in teaching, such as distance education, smart classroom, and so on. Moreover, with the popularizing of big data, it provides all kinds of information for teachers and students in time, helping teachers in middle school to master the process of study among students. Also, parents can know their children＇s performance in school through the big data. In education, the development of the Internet has gone through a few parts from the lowest applications to the complex applications. The applications in education are gradually accepted by every educator. There is no limit of time and space so that people can study anywhere, any time.展开更多
With the continuous development and advancement of computer technology,big data guarantee the establishment of an urban intelligent transportation system,a solid environmental basis to reform its application,and the c...With the continuous development and advancement of computer technology,big data guarantee the establishment of an urban intelligent transportation system,a solid environmental basis to reform its application,and the construction of a deeply integrated data mechanism for big data-driven traffic management.This review paper briefly elaborates on the basic characteristics and sources of traffic big data as well as expounds on the problems and application mechanisms of big data in intelligent transportation systems.展开更多
文摘Artificial intelligence is a new technological science that researches and develops theories,methods,technologies and application systems for simulating,extending and expanding human intelligence.It simulates certain human thought processes and intelligent behaviors(such as learning,reasoning,thinking,planning,etc.),and produces a new type of intelligent machine that can respond in a similar way to human intelligence.In the past 30 years,it has achieved rapid development in various industries and related disciplines such as manufacturing,medical care,finance,and transportation.
文摘miRNAs are non-coding RNAs that play a regulatory role in expression of genes and are associated with diseases. Quantitatively measuring expression levels of miRNAs can help understanding the mechanisms of human diseases and discovering new drug targets. There are three major methods that have been used to measure the expression levels of miRNAs: real-time reverse transcription PCR (qRT-PCR), microarray, and the newly introduced next-generation sequencing (NGS). NGS is not only suitable for profiling of known miRNAs that qRT-PCR and microarray can do too but also able to detect unknown miRNAs that the other two methods are incapable. Profiling of miRNAs by NGS has been progressed rapidly and is a promising field for applications in drug development. This paper will review the technical advancement of NGS for profiling miRNAs, including comparative analyses between different platforms and software packages for analyzing NGS data. Examples and future perspectives of applications of NGS profiling miRNAs in drug development will be discussed.
基金The National Natural Science Foundation under contract No.41621064the Science and Technology Basic Work of the Ministry of Science and Technology of China under contract No.2012FY112300the Public Science and Technology Research Funds Projects of Ocean under contract No.201005033
文摘This paper reviews the current achievements of the China Argo project. It considers aspects of both the construction of the Argo observing array, float technology, and the quality control and sharing of its data. The developments of associated data products and data applications for use in the fields of ocean, atmosphere, and climate research are discussed, particularly those related to tropical cyclones （typhoons）, ocean circulation, mesoscale eddies, turbulence, oceanic heat/salt storage and transportation, water masses, and operational oceanic/atmospheric/climatic forecasts and predictions. Finaliy, the challenges and opportunities involved in the long-term maintenance and sustained development of the China Argo ocean observation network are outlined. Discussion also focuses on the necessity for increasing the number of floats in the Indian Ocean and for expanding the regional Argo observation network in the South China Sea, together with the importance of promoting the use of Argo data by the maritime countries of Southeast Asia and India.
文摘Internet education has appeared with the development of the lnternet. Since ＂lnternet＋＂ has come up with in the 2015 government work report, it has become a hot word. ＂Intemet＋＂ has been applied to traditional education, which has reformed the traditional English teaching in middle school. Nowadays, there are many applications in teaching, such as distance education, smart classroom, and so on. Moreover, with the popularizing of big data, it provides all kinds of information for teachers and students in time, helping teachers in middle school to master the process of study among students. Also, parents can know their children＇s performance in school through the big data. In education, the development of the Internet has gone through a few parts from the lowest applications to the complex applications. The applications in education are gradually accepted by every educator. There is no limit of time and space so that people can study anywhere, any time.
文摘With the continuous development and advancement of computer technology,big data guarantee the establishment of an urban intelligent transportation system,a solid environmental basis to reform its application,and the construction of a deeply integrated data mechanism for big data-driven traffic management.This review paper briefly elaborates on the basic characteristics and sources of traffic big data as well as expounds on the problems and application mechanisms of big data in intelligent transportation systems.
