In order to know the current collaborative development situation and relationship of E-commerce and logistics, the paper evaluates the whole collaborative development level of Chinese E-commerce and logistics from 200...In order to know the current collaborative development situation and relationship of E-commerce and logistics, the paper evaluates the whole collaborative development level of Chinese E-commerce and logistics from 2008 to 2014 using the DEA model. Fund, infrastructure, labor and collaborative development are evaluated and analyzed in this model. The research indicates that E-commerce facilitates the logistics development but logistics can’t support E-commerce development well due to the lag effect which leads to lower collaborative development level. So optimizing the ratio of logistics investment and output, promoting logistics service quality and accelerating logistics development have been the key factors for promoting the collaborative development of E-commerce and logistics.展开更多
The popularity of e-commerce sector in Poland is increasing each year. Thus, it determines the need for market observation and analysis of the changes taking place. This article aims to examine if the dynamics of the ...The popularity of e-commerce sector in Poland is increasing each year. Thus, it determines the need for market observation and analysis of the changes taking place. This article aims to examine if the dynamics of the development of e-commerce in Poland significantly affects the development of the offer of modem warehouse space. Based on available market sector reports the article identifies major factors which stimulate storage management on the one hand, but are certain challenges on the other hand. The article is undoubtedly a good starting point for further tests to examine the model on a sample of entities operating in the industry. E-commerce industry in Poland is growing very rapidly. Retail chains are introducing more and more multi-channel solutions, numerous start-ups are being created, there is increasing interest in internet shopping, which, undoubtedly, enhances the development of the sector. Poland online sales represents only a small percentage in total retail sales and has a lot of catching up to do compared to the mature European markets. However, the situation is clearly more dynamic and the differences are decreasing. More and more companies are operating in the industry, which translates into demand for modem warehouse space. The purpose of this article is to present the dynamic changes taking place in the Polish market, closely linked to the development of e-commerce and an attempt to define their role in shaping the offer of modem warehouse space. E-commerce plays a key role in building global supply chains, in which storage can significantly affect their efficiency and agility. The article highlights the changes in the market warehouse in their many aspects, however, it clearly emphasizes the impact of e-commerce sector. E-commerce is revolutionizing supply chains by rebuilding existing links, such as marketing, payment system, distribution, inventory management, and storage. What important, therefore, is the research problem presented in the article, because it presents current trends and market changes.展开更多
The development of rural e-commerce is becoming an important driver for the transformation of China’s rural economy,and with the rapid development of information technology and the upgrading of the agricultural indus...The development of rural e-commerce is becoming an important driver for the transformation of China’s rural economy,and with the rapid development of information technology and the upgrading of the agricultural industry,rural e-commerce is showing a vigorous momentum of development.Traditionally,agricultural products are mainly sold through traditional farmers’markets,which are subjected to geography and channel limitations,resulting in inefficient circulation of agricultural products.This paper analyzes the definition,the status quo,as well as the influencing factors of rural e-commerce development.On this basis,countermeasures for the advancement of rural e-commerce development are put forward.展开更多
In the 21st century,which is known as the age of information,the integration of electronic technology and e-commerce has become an irreversible trend in the field of business.This trend not only promotes the innovativ...In the 21st century,which is known as the age of information,the integration of electronic technology and e-commerce has become an irreversible trend in the field of business.This trend not only promotes the innovative development of e-commerce,but also brings unprecedented opportunities and challenges for enterprises.With the continuous development and popularization of Internet technology,more and more people choose to carry out shopping,payment and other consumption activities through e-commerce platforms,which also provides merchants with a broader market space and more sales channels.At the same time,e-commerce also brings more convenience and choice to consumers,making it easier for consumers to obtain the goods and services they need.However,the development of e-commerce has also brought some new challenges,such as how to ensure the quality of goods,how to protect consumer privacy and so on.Therefore,enterprises and government departments need to strengthen the supervision and management of e-commerce to ensure its healthy and orderly development.In general,the integration of electronic technology and e-commerce has become an important trend in today’s business field,which brings both opportunities and challenges to enterprises.展开更多
The problems existing in the development of agriculture-related enterprises in earthquake area are evaluated,as well as the prominent issues existing in the process of developing E-commerce,consequently,the correspond...The problems existing in the development of agriculture-related enterprises in earthquake area are evaluated,as well as the prominent issues existing in the process of developing E-commerce,consequently,the corresponding strategies for developing E-commerce in agriculture-related enterprises are proposed.展开更多
In eukaryotic cells,organelles in the secretory,lysosomal,and endocytic pathways actively exchange biological materials with each other through intracellular membrane trafficking,which is the process of transporting t...In eukaryotic cells,organelles in the secretory,lysosomal,and endocytic pathways actively exchange biological materials with each other through intracellular membrane trafficking,which is the process of transporting the cargo of proteins,lipids,and other molecules to appropriate compartments via transport vesicles or intermediates.These processes are strictly regulated by various small GTPases such as the RAS-like in rat brain(RAB)protein family,which is the largest subfamily of the RAS superfamily.Dysfunction of membrane trafficking affects tissue homeostasis and leads to a wide range of diseases,including neurological disorders and neurodegenerative diseases.Therefore,it is important to understand the physiological and pathological roles of RAB proteins in brain function.RAB35,a member of the RAB family,is an evolutionarily conserved protein in metazoans.A wide range of studies using cultured mammalian cells and model organisms have revealed that RAB35 mediates various processes such as cytokinesis,endocytic recycling,actin bundling,and cell migration.RAB35 is also involved in neurite outgrowth and turnover of synaptic vesicles.We generated brain-specific Rab35 knockout mice to study the physiological roles of RAB35 in brain development and function.These mice exhibited defects in anxiety-related behaviors and spatial memory.Strikingly,RAB35 is required for the precise positioning of pyramidal neurons during hippocampal development,and thereby for normal hippocampal lamination.In contrast,layer formation in the cerebral cortex occurred superficially,even in the absence of RAB35,suggesting a predominant role for RAB35 in hippocampal development rather than in cerebral cortex development.Recent studies have suggested an association between RAB35 and neurodegenerative diseases,including Parkinson's disease and Alzheimer's disease.In this review,we provide an overview of the current understanding of subcellular functions of RAB35.We also provide insights into the physiological role of RAB35 in mammalian brain development and function,and discuss the involvement of RAB35 dysfunction in neurodegenerative diseases.展开更多
Human brain development is a complex process,and animal models often have significant limitations.To address this,researchers have developed pluripotent stem cell-derived three-dimensional structures,known as brain-li...Human brain development is a complex process,and animal models often have significant limitations.To address this,researchers have developed pluripotent stem cell-derived three-dimensional structures,known as brain-like organoids,to more accurately model early human brain development and disease.To enable more consistent and intuitive reproduction of early brain development,in this study,we incorporated forebrain organoid culture technology into the traditional unguided method of brain organoid culture.This involved embedding organoids in matrigel for only 7 days during the rapid expansion phase of the neural epithelium and then removing them from the matrigel for further cultivation,resulting in a new type of human brain organoid system.This cerebral organoid system replicated the temporospatial characteristics of early human brain development,including neuroepithelium derivation,neural progenitor cell production and maintenance,neuron differentiation and migration,and cortical layer patterning and formation,providing more consistent and reproducible organoids for developmental modeling and toxicology testing.As a proof of concept,we applied the heavy metal cadmium to this newly improved organoid system to test whether it could be used to evaluate the neurotoxicity of environmental toxins.Brain organoids exposed to cadmium for 7 or 14 days manifested severe damage and abnormalities in their neurodevelopmental patterns,including bursts of cortical cell death and premature differentiation.Cadmium exposure caused progressive depletion of neural progenitor cells and loss of organoid integrity,accompanied by compensatory cell proliferation at ectopic locations.The convenience,flexibility,and controllability of this newly developed organoid platform make it a powerful and affordable alternative to animal models for use in neurodevelopmental,neurological,and neurotoxicological studies.展开更多
Global climate change has created substantial difficulties in the areas of sustainability,development,and environmental conservation due to the widespread dependence on fossil fuels for energy production.Nevertheless,...Global climate change has created substantial difficulties in the areas of sustainability,development,and environmental conservation due to the widespread dependence on fossil fuels for energy production.Nevertheless,the promotion of renewable energy programs has the potential to significantly expedite endeavors aimed at tackling climate change.Thus,it is essential to conduct a thorough analysis that considers the financial aspects to fully understand the main hurdles that are preventing the advancement of renewable energy initiatives.Italy is a leading country in the worldwide deployment of renewable energy.The objective of this research is to assess the impact of financial growth,economic progress,and energy expenses on Italy’s adoption of renewable energy sources.By employing the Auto-Regressive Distributed Lag(ARDL)technique,we analyzed annual data spanning from1990 to 2022.Findings revealed that a 1%increase in financial and economic development would boost renewable energy consumption in the long run by 0.29%and 0.48%,respectively.Instead,a 1%increase in energy prices might reduce consumption of renewable energy by 0.05%in the long run.This study’s primary significance lies in furnishing actionable strategies for Italy to augment green finance for renewable energy,fostering sustained social and economic progress.Moreover,the analytical insights gleaned from this research offer valuable insights for energy-importing nations worldwide.展开更多
The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell cultures.However,the lack of systematic and contin...The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell cultures.However,the lack of systematic and continuous comparison between in vivo retinal development and the organotypic retinal explant culture makes this model controversial in postnatal retinal development studies.Thus,we aimed to verify the feasibility of using this model for postnatal retinal development studies by comparing it with the in vivo retina.In this study,we showed that postnatal retinal explants undergo normal development,and exhibit a consistent structure and timeline with retinas in vivo.Initially,we used SOX2 and PAX6 immunostaining to identify retinal progenitor cells.We then examined cell proliferation and migration by immunostaining with Ki-67 and doublecortin,respectively.Ki-67-and doublecortin-positive cells decreased in both in vivo and explants during postnatal retinogenesis,and exhibited a high degree of similarity in abundance and distribution between groups.Additionally,we used Ceh-10 homeodomain-containing homolog,glutamate-ammonia ligase(glutamine synthetase),neuronal nuclei,and ionized calcium-binding adapter molecule 1 immunostaining to examine the emergence of bipolar cells,Müller glia,mature neurons,and microglia,respectively.The timing and spatial patterns of the emergence of these cell types were remarkably consistent between in vivo and explant retinas.Our study showed that the organotypic retinal explant culture model had a high degree of consistency with the progression of in vivo early postnatal retina development.The findings confirm the accuracy and credibility of this model and support its use for long-term,systematic,and continuous observation.展开更多
Creative tourism is a dynamic and innovative approach to tourism,which points out the importance of people's active participation and their immersion in such experiences.In a vernacular context,it should attract p...Creative tourism is a dynamic and innovative approach to tourism,which points out the importance of people's active participation and their immersion in such experiences.In a vernacular context,it should attract people(local and tourists)attention to accomplish its main goals.Despite its rich cultural and natural assets,Kurdistan province faces several challenges that impact its tourism potential.To achieve that,the study uses quantitative approach to thoroughly analyze and evaluate the components of creative tourism in this province.The research focuses on tourists who visited the province's ten towns during the spring and summer of 2023.Data collection utilized a Likert-scale questionnaire ranging from"very good"to"very poor".The study employed a semistructured questionnaire developed through qualitative interviews alongside a researcher-made questionnaire validated by experts from the University of Kurdistan.The qualitative questionnaire achieved a high-reliability score of 93%using Cronbach's alpha coefficient.In-depth interviews and literary research were conducted to identify creative tourism components and indicators,informing the development of a quantitative questionnaire.Data analysis was performed using SPSS 20 and AMOS software to scrutinize the survey findings,providing insights into enhancing creative tourism strategies in Kurdistan province.The results reveal the varying significance of these dimensions,with the cultural dimension identified as the most crucial(factor loading:0.95),followed by the social(0.92),economic(0.88),and managerial/political dimensions(0.83).The study highlights the importance of cultural planning,community engagement,and infrastructural support in fostering creative tourism.Furthermore,it explores the impact of creative industries,such as music and arts rooted in Kurdish culture,on tourism development.Economic diversification and spatialphysical considerations are critical factors in enhancing Kurdistan's appeal as a creative tourism destination,emphasizing sustainable growth and cultural preservation.展开更多
The leucine-rich repeat(LRR)protein family is involved in a variety of fundamental metabolic and signaling processes in plants,including growth and defense responses.LRR proteins can be divided into two categories:tho...The leucine-rich repeat(LRR)protein family is involved in a variety of fundamental metabolic and signaling processes in plants,including growth and defense responses.LRR proteins can be divided into two categories:those containing LRR domains along with other structural elements,which are further subdivided into five groups,LRR receptor-like kinases,LRR receptor-like proteins,nucleotide-binding site LRR proteins,LRR-extensin proteins,and polygalacturonase-inhibiting proteins,and those containing only LRR domains.Functionally,various LRR proteins are primarily involved in plant development and responses to environmental stress.Notably,the LRR protein family plays a central role in signal transduction pathways related to stress adaptation.In this review,we classify and analyze the functions of LRR proteins in plants.While extensive research has been conducted on the roles of LRR proteins in disease resistance signaling,these proteins also play important roles in abiotic stress responses.This review highlights recent advances in understanding how LRR proteins mediate responses to biotic and abiotic stresses.Building upon these insights,further exploration of the roles of LRR proteins in abiotic stress resistance may aid efforts to develop rice varieties with enhanced stress and disease tolerance.展开更多
With the development of electronic commerce,there is a special phenomenon in rural areas of China that a lot of farmers in these areas depend on opening shops on Taobao online for a living. The products are made from ...With the development of electronic commerce,there is a special phenomenon in rural areas of China that a lot of farmers in these areas depend on opening shops on Taobao online for a living. The products are made from the village workshop,and farmers become fullyfledged network businessmen. Electronic business platform mode of " Taobao Village" is the result of integrated development of primary,secondary and tertiary industries. In this study,we take two kinds of typical Taobao villages( Dongfeng Village and Yanxia Village) as sample areas,and conduct comparative analysis of this new rural business model based on field survey data,case studies and theoretical research. We also probe into the problems in the development of Taobao villages,and set forth the recommendations for the new rural business model.展开更多
In the era of rapid development of the Intemet, people began to adapt to the huge growth of the Internet to facilitate people' s daily lives, people have been accustomed to staying at home and can easily enjoy the co...In the era of rapid development of the Intemet, people began to adapt to the huge growth of the Internet to facilitate people' s daily lives, people have been accustomed to staying at home and can easily enjoy the convenience and needs of life to achieve quick and easy lifestyle. The advent of the Internet age also become more virtual to business models, and now the development of enterprises has involved the application of e-commerce technology, the company' s business model combines network through electronic technology to some extent, and it made great adjustments and changes in order to deal with the new face of increasingly fierce competition in the market. Thus a new term: "E-commerce" is well known and accepted as more and more people. A regional economic development need of the residents' daily consumption is driven, so local governments need to focus on the various steady development of local small and medium enterprises. Therefore, the development of electronic commerce network technology can indirectly affect a region' s economic development. This paper discusses this issue.展开更多
E-commerce plays an essential role in modern trade today.It is expected that e-commerce volume amounted to 29 trillion USD in the world in 2017,and would grow with the spread of the Internet and information and commun...E-commerce plays an essential role in modern trade today.It is expected that e-commerce volume amounted to 29 trillion USD in the world in 2017,and would grow with the spread of the Internet and information and communication technologies(ICTs).Brazil,Russia,India,China and South Africa(BRICS),together with many others,consider e-commerce a means to facilitate rapid,inclusive and sustainable economic growth,improving the living standards and alleviating poverty.This article examines areas for potential cooperation by BRICS countries in e-commerce development across rural and remote areas to fight poverty.It analyses the current state of e-commerce development in rural and remote areas in each of the BRICS countries,including cases of public and private initiatives to support it.The article also defines the opportunities which e-commerce brings to people living in rural and remote areas.Moreover,it evaluates the existing challenges and risks.The article concludes that despite the rapid e-commerce development in BRICS countries,and significant opportunities created,there are still issues of disproportionate e-commerce in varied regions and the lack of BRICS cooperation in this sphere.Based on a comparative and normative in-depth,systematic analysis,the article develops a set of recommendations for deepening BRICS countries'cooperation in the following areas:infrastructure in rural and remote regions;education;consumer protection;online dispute resolution;coordinated policy in the international scene,including representation of BRICS countries in international indexes,such as the Organization of Economic Co-operation and Development(OECD)Digital Services Trade Restrictiveness Index(STRI).展开更多
With the extensive use of the Internet and mobile technology, E-commerce in China has shown tremendous growth advantages and market potential, especially in promoting the access of eco-agriculture products. The E-comm...With the extensive use of the Internet and mobile technology, E-commerce in China has shown tremendous growth advantages and market potential, especially in promoting the access of eco-agriculture products. The E-commerce of agriculture products has shown diversification on the mainstay. "Three products, one indication"(pollution-free, green product, organic product, geographical indication) has becomes the primary character. Although the market of fresh products occupies a limited and meager profit, the blue sea effect has caused capital to enter into a large-scale development. It is very clearly shown after the analysis that the market of eco-agricultural E-commerce is vast and the expansionist policy for E-commerce environment is favorable. Meanwhile the required hardware and software of network in E-commerce are basically equipped with rapid development of service technology and strong driving force for innovation and development as well as an endless stream of new models and platforms. The whole phrase of development can be divided into five major stages. Through the analysis of five perspectives, such as platform, driver, participant, food supplier and Taobao, 16 types of agro-products E-commerce models and their different types of e-payment support systems are summarized, revealing the two major bottlenecks of development, namely the markets with limited share and low profit-making and the impact of cold chain services on E-commerce development. The thesis finally fortells the ten trends for the future development.展开更多
Based on the fact that e-commerce promotes the development of modern agriculture,the paper summarizes the present situation of agri-cultural e-commerce through related materials.Taking Suzhou city as an example,the pa...Based on the fact that e-commerce promotes the development of modern agriculture,the paper summarizes the present situation of agri-cultural e-commerce through related materials.Taking Suzhou city as an example,the paper analyzes the features of modern agriculture.And themodern agriculture is characterized with apparent industrialization and scaled requirements,the branded and particular agriculture has more advan-tages,leisure agriculture is the very special one.In order to upgrade the degree of agricultural industrialization of Suzhou,promote the communica-tion of agricultural information and sales of products and lower the risks of agricultural production,the e-commerce countermeasures of modern agri-culture have been put forward.Firstly,strengthen the network construction of agricultural information.Secondly,carry out the agricultural e-com-merce business by B2B model.Thirdly,construct the e-commerce platform of leisure agriculture.Fourthly,construct the e-commerce platform ofmodern agriculture.Fifthly,perfect the logistics distribution network of agricultural products of Suzhou.The last point is to accelerate the e-com-merce training of farmers and the introduction of talents.展开更多
Taking the implementation of the"e-commerce entering villages and households"project in Jurong City as an example,a survey plan is formulated,and questionnaires are designed.Through questionnaires,a large nu...Taking the implementation of the"e-commerce entering villages and households"project in Jurong City as an example,a survey plan is formulated,and questionnaires are designed.Through questionnaires,a large number of agricultural households are visited,and the data are collected and collated;and using interviews and field trips,the help of e-commerce for agricultural products sales is understood.Then,the analysis on the entire survey is summarized.Finally,the survey is researched,and it is found that the current rural e-commerce lacks professional talents and the product distribution system is not perfect.For existing problems,corresponding solutions are put forward.展开更多
e-commerce as a new trade, in the form of the current globalization of information and economic globalization, is with its strong competitive advantage and vitality, which can quickly spread to all areas of internatio...e-commerce as a new trade, in the form of the current globalization of information and economic globalization, is with its strong competitive advantage and vitality, which can quickly spread to all areas of international business, and it changes in the international economic landscape had a profound impact. E-commerce is based on the rapid development of computer technology and the wide application is on the use of the Internet and advanced communications technology. It changes the the past, traditional physical trading and cash transactions, in a virtualization market, merchandise presentation via the web. With the online payment, the use of advanced materials and distribution logistics systems are for tangible and intangible commodities trading of a new trade. This new types of transactions overturn the traditional transaction methods, so that the whole business process, whether it is in the application of domestic and foreign trade, and has achieved the goal of online shopping and trading. E-commerce international trade transaction cost savings improve the efficiency of transactions; it changes in the foreign trade transaction process, the development of third-party trading platform is increasing the competitiveness of enterprises and the creation of employment opportunities in all aspects of a country' s foreign trade and the overall economy have had a significant impact. E-commerce is to establish a new economic and trade order, the already mature in the world trading system and the order is being re-shuffling of the emerging e-commerce trade. China is the world' s top-ranked in the world' s total import and export trade power, is under the wave of e-commerce, the difficulties, we should seize opportunities, and meet challenges.展开更多
The development of E-commerce accelerates the development of invisible market; the tangible market's functions of the retail trader will be replaced by the invisible market's function of the Intemet. The retail tra...The development of E-commerce accelerates the development of invisible market; the tangible market's functions of the retail trader will be replaced by the invisible market's function of the Intemet. The retail trader's functions tend to be weakened. With the direct integration by producing and consuming with the progress of E-commerce, the wholesale trader is going to shrink. Simultaneously, the E-commerce has solved the unsuitable contradiction of the producing and consuming structure and challenged the traditional storage industry. By the instance of changing from tangible function to invisible functions and improvement of information environment, the precondition of enterprise's expansion happened to be varied, and the scale of modem business enterprises will have a new developing trend.展开更多
Cut flower production in Yunnan accounts for 80%nationwide.In order to expand the Yunnan Flower sales channels,the promotion of the development of e-commerce is necessary.In 2012 China's online shopping users reac...Cut flower production in Yunnan accounts for 80%nationwide.In order to expand the Yunnan Flower sales channels,the promotion of the development of e-commerce is necessary.In 2012 China's online shopping users reached 247 million people,but e-commerce of fresh flowers lagged behind due to the constraints of preservation facilities and logistics cost.The analysis of the factors restricting the development of floral e-commerce and the proposition of solutions to this problem can promote faster development of Yunnan floral e-commerce.展开更多
文摘In order to know the current collaborative development situation and relationship of E-commerce and logistics, the paper evaluates the whole collaborative development level of Chinese E-commerce and logistics from 2008 to 2014 using the DEA model. Fund, infrastructure, labor and collaborative development are evaluated and analyzed in this model. The research indicates that E-commerce facilitates the logistics development but logistics can’t support E-commerce development well due to the lag effect which leads to lower collaborative development level. So optimizing the ratio of logistics investment and output, promoting logistics service quality and accelerating logistics development have been the key factors for promoting the collaborative development of E-commerce and logistics.
文摘The popularity of e-commerce sector in Poland is increasing each year. Thus, it determines the need for market observation and analysis of the changes taking place. This article aims to examine if the dynamics of the development of e-commerce in Poland significantly affects the development of the offer of modem warehouse space. Based on available market sector reports the article identifies major factors which stimulate storage management on the one hand, but are certain challenges on the other hand. The article is undoubtedly a good starting point for further tests to examine the model on a sample of entities operating in the industry. E-commerce industry in Poland is growing very rapidly. Retail chains are introducing more and more multi-channel solutions, numerous start-ups are being created, there is increasing interest in internet shopping, which, undoubtedly, enhances the development of the sector. Poland online sales represents only a small percentage in total retail sales and has a lot of catching up to do compared to the mature European markets. However, the situation is clearly more dynamic and the differences are decreasing. More and more companies are operating in the industry, which translates into demand for modem warehouse space. The purpose of this article is to present the dynamic changes taking place in the Polish market, closely linked to the development of e-commerce and an attempt to define their role in shaping the offer of modem warehouse space. E-commerce plays a key role in building global supply chains, in which storage can significantly affect their efficiency and agility. The article highlights the changes in the market warehouse in their many aspects, however, it clearly emphasizes the impact of e-commerce sector. E-commerce is revolutionizing supply chains by rebuilding existing links, such as marketing, payment system, distribution, inventory management, and storage. What important, therefore, is the research problem presented in the article, because it presents current trends and market changes.
基金Research on the Measurement of the Development Level of Rural E-commerce and the Enhancement of Profitability in Guangxi(Project No.2022KY0618).
文摘The development of rural e-commerce is becoming an important driver for the transformation of China’s rural economy,and with the rapid development of information technology and the upgrading of the agricultural industry,rural e-commerce is showing a vigorous momentum of development.Traditionally,agricultural products are mainly sold through traditional farmers’markets,which are subjected to geography and channel limitations,resulting in inefficient circulation of agricultural products.This paper analyzes the definition,the status quo,as well as the influencing factors of rural e-commerce development.On this basis,countermeasures for the advancement of rural e-commerce development are put forward.
文摘In the 21st century,which is known as the age of information,the integration of electronic technology and e-commerce has become an irreversible trend in the field of business.This trend not only promotes the innovative development of e-commerce,but also brings unprecedented opportunities and challenges for enterprises.With the continuous development and popularization of Internet technology,more and more people choose to carry out shopping,payment and other consumption activities through e-commerce platforms,which also provides merchants with a broader market space and more sales channels.At the same time,e-commerce also brings more convenience and choice to consumers,making it easier for consumers to obtain the goods and services they need.However,the development of e-commerce has also brought some new challenges,such as how to ensure the quality of goods,how to protect consumer privacy and so on.Therefore,enterprises and government departments need to strengthen the supervision and management of e-commerce to ensure its healthy and orderly development.In general,the integration of electronic technology and e-commerce has become an important trend in today’s business field,which brings both opportunities and challenges to enterprises.
基金Supported by Rural Development Research Center of Sichuan Province
文摘The problems existing in the development of agriculture-related enterprises in earthquake area are evaluated,as well as the prominent issues existing in the process of developing E-commerce,consequently,the corresponding strategies for developing E-commerce in agriculture-related enterprises are proposed.
基金supported by the Japan Society for the Promotion of Science KAKENHI(grant Nos.23K05678 to IM,19H05711 and 20H00466 to KS)the Joint Research Program of Institute for Molecular and Cellular Regulation,Gunma University(to KS)。
文摘In eukaryotic cells,organelles in the secretory,lysosomal,and endocytic pathways actively exchange biological materials with each other through intracellular membrane trafficking,which is the process of transporting the cargo of proteins,lipids,and other molecules to appropriate compartments via transport vesicles or intermediates.These processes are strictly regulated by various small GTPases such as the RAS-like in rat brain(RAB)protein family,which is the largest subfamily of the RAS superfamily.Dysfunction of membrane trafficking affects tissue homeostasis and leads to a wide range of diseases,including neurological disorders and neurodegenerative diseases.Therefore,it is important to understand the physiological and pathological roles of RAB proteins in brain function.RAB35,a member of the RAB family,is an evolutionarily conserved protein in metazoans.A wide range of studies using cultured mammalian cells and model organisms have revealed that RAB35 mediates various processes such as cytokinesis,endocytic recycling,actin bundling,and cell migration.RAB35 is also involved in neurite outgrowth and turnover of synaptic vesicles.We generated brain-specific Rab35 knockout mice to study the physiological roles of RAB35 in brain development and function.These mice exhibited defects in anxiety-related behaviors and spatial memory.Strikingly,RAB35 is required for the precise positioning of pyramidal neurons during hippocampal development,and thereby for normal hippocampal lamination.In contrast,layer formation in the cerebral cortex occurred superficially,even in the absence of RAB35,suggesting a predominant role for RAB35 in hippocampal development rather than in cerebral cortex development.Recent studies have suggested an association between RAB35 and neurodegenerative diseases,including Parkinson's disease and Alzheimer's disease.In this review,we provide an overview of the current understanding of subcellular functions of RAB35.We also provide insights into the physiological role of RAB35 in mammalian brain development and function,and discuss the involvement of RAB35 dysfunction in neurodegenerative diseases.
基金supported by the National Key R&D Program of China,No.2019YFA0110300(to ZG)the National Natural Science Foundation of China,Nos.81773302(to YF),32070862(to ZG).
文摘Human brain development is a complex process,and animal models often have significant limitations.To address this,researchers have developed pluripotent stem cell-derived three-dimensional structures,known as brain-like organoids,to more accurately model early human brain development and disease.To enable more consistent and intuitive reproduction of early brain development,in this study,we incorporated forebrain organoid culture technology into the traditional unguided method of brain organoid culture.This involved embedding organoids in matrigel for only 7 days during the rapid expansion phase of the neural epithelium and then removing them from the matrigel for further cultivation,resulting in a new type of human brain organoid system.This cerebral organoid system replicated the temporospatial characteristics of early human brain development,including neuroepithelium derivation,neural progenitor cell production and maintenance,neuron differentiation and migration,and cortical layer patterning and formation,providing more consistent and reproducible organoids for developmental modeling and toxicology testing.As a proof of concept,we applied the heavy metal cadmium to this newly improved organoid system to test whether it could be used to evaluate the neurotoxicity of environmental toxins.Brain organoids exposed to cadmium for 7 or 14 days manifested severe damage and abnormalities in their neurodevelopmental patterns,including bursts of cortical cell death and premature differentiation.Cadmium exposure caused progressive depletion of neural progenitor cells and loss of organoid integrity,accompanied by compensatory cell proliferation at ectopic locations.The convenience,flexibility,and controllability of this newly developed organoid platform make it a powerful and affordable alternative to animal models for use in neurodevelopmental,neurological,and neurotoxicological studies.
文摘Global climate change has created substantial difficulties in the areas of sustainability,development,and environmental conservation due to the widespread dependence on fossil fuels for energy production.Nevertheless,the promotion of renewable energy programs has the potential to significantly expedite endeavors aimed at tackling climate change.Thus,it is essential to conduct a thorough analysis that considers the financial aspects to fully understand the main hurdles that are preventing the advancement of renewable energy initiatives.Italy is a leading country in the worldwide deployment of renewable energy.The objective of this research is to assess the impact of financial growth,economic progress,and energy expenses on Italy’s adoption of renewable energy sources.By employing the Auto-Regressive Distributed Lag(ARDL)technique,we analyzed annual data spanning from1990 to 2022.Findings revealed that a 1%increase in financial and economic development would boost renewable energy consumption in the long run by 0.29%and 0.48%,respectively.Instead,a 1%increase in energy prices might reduce consumption of renewable energy by 0.05%in the long run.This study’s primary significance lies in furnishing actionable strategies for Italy to augment green finance for renewable energy,fostering sustained social and economic progress.Moreover,the analytical insights gleaned from this research offer valuable insights for energy-importing nations worldwide.
基金supported by the National Natural Science Foundation of China,Nos.81901156(to ZZ),82271200(to ZZ),82171308(to XC)the Fundamental Research Funds for the Central Universities,No.xzy012022035(to ZZ)+1 种基金the Natural Science Foundation of Shaanxi Province,Nos.2021JM-261(to QK),2023-YBSF-303(to ZZ)Traditional Chinese Medicine Project of Shaanxi Province,No.2019-ZZ-JC047(to QK)。
文摘The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell cultures.However,the lack of systematic and continuous comparison between in vivo retinal development and the organotypic retinal explant culture makes this model controversial in postnatal retinal development studies.Thus,we aimed to verify the feasibility of using this model for postnatal retinal development studies by comparing it with the in vivo retina.In this study,we showed that postnatal retinal explants undergo normal development,and exhibit a consistent structure and timeline with retinas in vivo.Initially,we used SOX2 and PAX6 immunostaining to identify retinal progenitor cells.We then examined cell proliferation and migration by immunostaining with Ki-67 and doublecortin,respectively.Ki-67-and doublecortin-positive cells decreased in both in vivo and explants during postnatal retinogenesis,and exhibited a high degree of similarity in abundance and distribution between groups.Additionally,we used Ceh-10 homeodomain-containing homolog,glutamate-ammonia ligase(glutamine synthetase),neuronal nuclei,and ionized calcium-binding adapter molecule 1 immunostaining to examine the emergence of bipolar cells,Müller glia,mature neurons,and microglia,respectively.The timing and spatial patterns of the emergence of these cell types were remarkably consistent between in vivo and explant retinas.Our study showed that the organotypic retinal explant culture model had a high degree of consistency with the progression of in vivo early postnatal retina development.The findings confirm the accuracy and credibility of this model and support its use for long-term,systematic,and continuous observation.
基金supported by Exploring Visitor Satisfaction at Hunan's National Eco-Tourism Demonstration Zone in the Post-Pandemic Era:A Study(20YBA188)a project titled"Ecological and Limnological Study of the Zayibar International Wetland,Aiming to Provide Restoration Solutions"(S/01/9/10225),conducted at the Kurdistan Studies Research Institute,University of Kurdistan,in 2024。
文摘Creative tourism is a dynamic and innovative approach to tourism,which points out the importance of people's active participation and their immersion in such experiences.In a vernacular context,it should attract people(local and tourists)attention to accomplish its main goals.Despite its rich cultural and natural assets,Kurdistan province faces several challenges that impact its tourism potential.To achieve that,the study uses quantitative approach to thoroughly analyze and evaluate the components of creative tourism in this province.The research focuses on tourists who visited the province's ten towns during the spring and summer of 2023.Data collection utilized a Likert-scale questionnaire ranging from"very good"to"very poor".The study employed a semistructured questionnaire developed through qualitative interviews alongside a researcher-made questionnaire validated by experts from the University of Kurdistan.The qualitative questionnaire achieved a high-reliability score of 93%using Cronbach's alpha coefficient.In-depth interviews and literary research were conducted to identify creative tourism components and indicators,informing the development of a quantitative questionnaire.Data analysis was performed using SPSS 20 and AMOS software to scrutinize the survey findings,providing insights into enhancing creative tourism strategies in Kurdistan province.The results reveal the varying significance of these dimensions,with the cultural dimension identified as the most crucial(factor loading:0.95),followed by the social(0.92),economic(0.88),and managerial/political dimensions(0.83).The study highlights the importance of cultural planning,community engagement,and infrastructural support in fostering creative tourism.Furthermore,it explores the impact of creative industries,such as music and arts rooted in Kurdish culture,on tourism development.Economic diversification and spatialphysical considerations are critical factors in enhancing Kurdistan's appeal as a creative tourism destination,emphasizing sustainable growth and cultural preservation.
基金supported by the National Natural Science Foundation of China(Grant Nos.32072048 and U2004204)National Key Research and Development Program of China(Grant No.2023YFF1001200)+2 种基金China Rice Research Institute Basal Research Fund(Grant No.CPSIBRF-CNRRI-202404)Academician Workstation of National Nanfan Research Institute(Sanya),Chinese Agricultural Academic Science(CAAS),(Grant Nos.YBXM2422 and YBXM2423)Agricultural Science and Technology Innovation Program of CAAS,China.
文摘The leucine-rich repeat(LRR)protein family is involved in a variety of fundamental metabolic and signaling processes in plants,including growth and defense responses.LRR proteins can be divided into two categories:those containing LRR domains along with other structural elements,which are further subdivided into five groups,LRR receptor-like kinases,LRR receptor-like proteins,nucleotide-binding site LRR proteins,LRR-extensin proteins,and polygalacturonase-inhibiting proteins,and those containing only LRR domains.Functionally,various LRR proteins are primarily involved in plant development and responses to environmental stress.Notably,the LRR protein family plays a central role in signal transduction pathways related to stress adaptation.In this review,we classify and analyze the functions of LRR proteins in plants.While extensive research has been conducted on the roles of LRR proteins in disease resistance signaling,these proteins also play important roles in abiotic stress responses.This review highlights recent advances in understanding how LRR proteins mediate responses to biotic and abiotic stresses.Building upon these insights,further exploration of the roles of LRR proteins in abiotic stress resistance may aid efforts to develop rice varieties with enhanced stress and disease tolerance.
基金Supported by Student Research Training(SRT)Program of Jiangsu Province,China(201410307007Y)
文摘With the development of electronic commerce,there is a special phenomenon in rural areas of China that a lot of farmers in these areas depend on opening shops on Taobao online for a living. The products are made from the village workshop,and farmers become fullyfledged network businessmen. Electronic business platform mode of " Taobao Village" is the result of integrated development of primary,secondary and tertiary industries. In this study,we take two kinds of typical Taobao villages( Dongfeng Village and Yanxia Village) as sample areas,and conduct comparative analysis of this new rural business model based on field survey data,case studies and theoretical research. We also probe into the problems in the development of Taobao villages,and set forth the recommendations for the new rural business model.
文摘In the era of rapid development of the Intemet, people began to adapt to the huge growth of the Internet to facilitate people' s daily lives, people have been accustomed to staying at home and can easily enjoy the convenience and needs of life to achieve quick and easy lifestyle. The advent of the Internet age also become more virtual to business models, and now the development of enterprises has involved the application of e-commerce technology, the company' s business model combines network through electronic technology to some extent, and it made great adjustments and changes in order to deal with the new face of increasingly fierce competition in the market. Thus a new term: "E-commerce" is well known and accepted as more and more people. A regional economic development need of the residents' daily consumption is driven, so local governments need to focus on the various steady development of local small and medium enterprises. Therefore, the development of electronic commerce network technology can indirectly affect a region' s economic development. This paper discusses this issue.
文摘E-commerce plays an essential role in modern trade today.It is expected that e-commerce volume amounted to 29 trillion USD in the world in 2017,and would grow with the spread of the Internet and information and communication technologies(ICTs).Brazil,Russia,India,China and South Africa(BRICS),together with many others,consider e-commerce a means to facilitate rapid,inclusive and sustainable economic growth,improving the living standards and alleviating poverty.This article examines areas for potential cooperation by BRICS countries in e-commerce development across rural and remote areas to fight poverty.It analyses the current state of e-commerce development in rural and remote areas in each of the BRICS countries,including cases of public and private initiatives to support it.The article also defines the opportunities which e-commerce brings to people living in rural and remote areas.Moreover,it evaluates the existing challenges and risks.The article concludes that despite the rapid e-commerce development in BRICS countries,and significant opportunities created,there are still issues of disproportionate e-commerce in varied regions and the lack of BRICS cooperation in this sphere.Based on a comparative and normative in-depth,systematic analysis,the article develops a set of recommendations for deepening BRICS countries'cooperation in the following areas:infrastructure in rural and remote regions;education;consumer protection;online dispute resolution;coordinated policy in the international scene,including representation of BRICS countries in international indexes,such as the Organization of Economic Co-operation and Development(OECD)Digital Services Trade Restrictiveness Index(STRI).
文摘With the extensive use of the Internet and mobile technology, E-commerce in China has shown tremendous growth advantages and market potential, especially in promoting the access of eco-agriculture products. The E-commerce of agriculture products has shown diversification on the mainstay. "Three products, one indication"(pollution-free, green product, organic product, geographical indication) has becomes the primary character. Although the market of fresh products occupies a limited and meager profit, the blue sea effect has caused capital to enter into a large-scale development. It is very clearly shown after the analysis that the market of eco-agricultural E-commerce is vast and the expansionist policy for E-commerce environment is favorable. Meanwhile the required hardware and software of network in E-commerce are basically equipped with rapid development of service technology and strong driving force for innovation and development as well as an endless stream of new models and platforms. The whole phrase of development can be divided into five major stages. Through the analysis of five perspectives, such as platform, driver, participant, food supplier and Taobao, 16 types of agro-products E-commerce models and their different types of e-payment support systems are summarized, revealing the two major bottlenecks of development, namely the markets with limited share and low profit-making and the impact of cold chain services on E-commerce development. The thesis finally fortells the ten trends for the future development.
文摘Based on the fact that e-commerce promotes the development of modern agriculture,the paper summarizes the present situation of agri-cultural e-commerce through related materials.Taking Suzhou city as an example,the paper analyzes the features of modern agriculture.And themodern agriculture is characterized with apparent industrialization and scaled requirements,the branded and particular agriculture has more advan-tages,leisure agriculture is the very special one.In order to upgrade the degree of agricultural industrialization of Suzhou,promote the communica-tion of agricultural information and sales of products and lower the risks of agricultural production,the e-commerce countermeasures of modern agri-culture have been put forward.Firstly,strengthen the network construction of agricultural information.Secondly,carry out the agricultural e-com-merce business by B2B model.Thirdly,construct the e-commerce platform of leisure agriculture.Fourthly,construct the e-commerce platform ofmodern agriculture.Fifthly,perfect the logistics distribution network of agricultural products of Suzhou.The last point is to accelerate the e-com-merce training of farmers and the introduction of talents.
文摘Taking the implementation of the"e-commerce entering villages and households"project in Jurong City as an example,a survey plan is formulated,and questionnaires are designed.Through questionnaires,a large number of agricultural households are visited,and the data are collected and collated;and using interviews and field trips,the help of e-commerce for agricultural products sales is understood.Then,the analysis on the entire survey is summarized.Finally,the survey is researched,and it is found that the current rural e-commerce lacks professional talents and the product distribution system is not perfect.For existing problems,corresponding solutions are put forward.
文摘e-commerce as a new trade, in the form of the current globalization of information and economic globalization, is with its strong competitive advantage and vitality, which can quickly spread to all areas of international business, and it changes in the international economic landscape had a profound impact. E-commerce is based on the rapid development of computer technology and the wide application is on the use of the Internet and advanced communications technology. It changes the the past, traditional physical trading and cash transactions, in a virtualization market, merchandise presentation via the web. With the online payment, the use of advanced materials and distribution logistics systems are for tangible and intangible commodities trading of a new trade. This new types of transactions overturn the traditional transaction methods, so that the whole business process, whether it is in the application of domestic and foreign trade, and has achieved the goal of online shopping and trading. E-commerce international trade transaction cost savings improve the efficiency of transactions; it changes in the foreign trade transaction process, the development of third-party trading platform is increasing the competitiveness of enterprises and the creation of employment opportunities in all aspects of a country' s foreign trade and the overall economy have had a significant impact. E-commerce is to establish a new economic and trade order, the already mature in the world trading system and the order is being re-shuffling of the emerging e-commerce trade. China is the world' s top-ranked in the world' s total import and export trade power, is under the wave of e-commerce, the difficulties, we should seize opportunities, and meet challenges.
文摘The development of E-commerce accelerates the development of invisible market; the tangible market's functions of the retail trader will be replaced by the invisible market's function of the Intemet. The retail trader's functions tend to be weakened. With the direct integration by producing and consuming with the progress of E-commerce, the wholesale trader is going to shrink. Simultaneously, the E-commerce has solved the unsuitable contradiction of the producing and consuming structure and challenged the traditional storage industry. By the instance of changing from tangible function to invisible functions and improvement of information environment, the precondition of enterprise's expansion happened to be varied, and the scale of modem business enterprises will have a new developing trend.
基金Supported by Philosophy and Social Sciences Planning Project in Yunnan Province(YB2013027)Scientific Research Fund Project of Yunnan Provincial Department of Education(2010C034)
文摘Cut flower production in Yunnan accounts for 80%nationwide.In order to expand the Yunnan Flower sales channels,the promotion of the development of e-commerce is necessary.In 2012 China's online shopping users reached 247 million people,but e-commerce of fresh flowers lagged behind due to the constraints of preservation facilities and logistics cost.The analysis of the factors restricting the development of floral e-commerce and the proposition of solutions to this problem can promote faster development of Yunnan floral e-commerce.