It is said that nobody can conquer nature so we have to accept what she renders. With this view always in mind, we（Nepali） are living tolerating the catastrophe of the Krishnabhir（polular landslide） and Trisuli ri...It is said that nobody can conquer nature so we have to accept what she renders. With this view always in mind, we（Nepali） are living tolerating the catastrophe of the Krishnabhir（polular landslide） and Trisuli river. Where hundreds of people have to sacrifice their lives every year during rainy season. These two places have become the greatest source of income for the rulers＇ personal benefit during every incident.展开更多
The developing human and mouse teeth constitute an ideal model system to study the regulatory mechanism underlying organ growth control since their teeth share highly conserved and well-characterized developmental pro...The developing human and mouse teeth constitute an ideal model system to study the regulatory mechanism underlying organ growth control since their teeth share highly conserved and well-characterized developmental processes, and their developmental tempo varies notably. In the current study, we manipulated heterogenous recombination between human and mouse dental tissues and demonstrated that the dental mesenchyme dominates the tooth developmental tempo and FGF8 could be a critical player during this developmental process. Forced activation of FGF8 signaling in the dental mesenchyme of mice promoted cell proliferation, prevented cell apoptosis via p38 and perhaps PI3 K-Akt intracellular signaling,and impelled the transition of the cell cycle from G1-to S-phase in the tooth germ, resulting in the slowdown of the tooth developmental pace. Our results provide compelling evidence that extrinsic signals can profoundly affect tooth developmental tempo, and the dental mesenchymal FGF8 could be a pivotal factor in controlling the developmental pace in a non-cell-autonomous manner during mammalian odontogenesis.展开更多
文摘It is said that nobody can conquer nature so we have to accept what she renders. With this view always in mind, we（Nepali） are living tolerating the catastrophe of the Krishnabhir（polular landslide） and Trisuli river. Where hundreds of people have to sacrifice their lives every year during rainy season. These two places have become the greatest source of income for the rulers＇ personal benefit during every incident.
基金supported by the National Natural Science Foundation of China (81870739, 82001002, 81271102, 81771034)the Natural Science Foundation of Fujian Province (2019J01281, 2020J01180)。
文摘The developing human and mouse teeth constitute an ideal model system to study the regulatory mechanism underlying organ growth control since their teeth share highly conserved and well-characterized developmental processes, and their developmental tempo varies notably. In the current study, we manipulated heterogenous recombination between human and mouse dental tissues and demonstrated that the dental mesenchyme dominates the tooth developmental tempo and FGF8 could be a critical player during this developmental process. Forced activation of FGF8 signaling in the dental mesenchyme of mice promoted cell proliferation, prevented cell apoptosis via p38 and perhaps PI3 K-Akt intracellular signaling,and impelled the transition of the cell cycle from G1-to S-phase in the tooth germ, resulting in the slowdown of the tooth developmental pace. Our results provide compelling evidence that extrinsic signals can profoundly affect tooth developmental tempo, and the dental mesenchymal FGF8 could be a pivotal factor in controlling the developmental pace in a non-cell-autonomous manner during mammalian odontogenesis.
