期刊文献+
共找到518,545篇文章
< 1 2 250 >
每页显示 20 50 100
Thoughts on Pairing Assistance to Tibet for Promoting Agricultural High-quality Development in Southern Tibet from the Perspective of Agricultural Power
1
作者 Zhiguo SUN Li GAO +3 位作者 Yuanpeng SUN Guangchao CAO Xinying ZHOU Xiaoqiang LI 《Asian Agricultural Research》 2024年第3期18-24,共7页
In the new era,there is an urgent need to further promote pairing assistance to Tibet,promote the simultaneous construction of a strong agriculture in Tibet and the China's Mainland,and compose a Chinese-style mod... In the new era,there is an urgent need to further promote pairing assistance to Tibet,promote the simultaneous construction of a strong agriculture in Tibet and the China's Mainland,and compose a Chinese-style modernization.Southern Tibet,located in the southeastern part of the Tibet Autonomous Region,includes Shannan City and Nyingchi City,is a region assisted by four provincial partners including Hubei Province.This paper introduces the agricultural environment in southern Tibet,studies its agricultural characteristics,and analyzes the main issues of its pairing assistance.Taking forging the strong consciousness of the Chinese national community as the main line,the paper explores strategies for promoting agricultural high-quality development in southern Tibet through pairing assistance to Tibet from the perspective of agricultural power,and proposes some strategies,such as inheriting agricultural cultural heritage,promoting the upgrading of modern seed industry,enhancing the characteristic advantages of highland barley(naked barley)and animal husbandry industries,and developing edible fungi and cold water fish industries. 展开更多
关键词 PAIRING ASSISTANCE to TIBET Southern TIBET Shannan CITY Nyingchi CITY AGRICULTURAL high-quality development AGRICULTURAL power
下载PDF
Building a Business and Strategic Intelligence Policy as a Strategy for Promoting Congolese Business Progress and Healthy Economic Development in Eastern DRC
2
作者 Innocent Bora Uzima 《Intelligent Information Management》 2024年第2期77-103,共27页
The aim of this study was to verify the existence of business and strategic intelligence policies at the level of Congolese companies and at the state level, likely to foster progress and healthy development in the ea... The aim of this study was to verify the existence of business and strategic intelligence policies at the level of Congolese companies and at the state level, likely to foster progress and healthy development in the east of the DRC. The study was based on a mixed perspective consisting of objective analysis of quantitative data and interpretative analysis of qualitative data. The results showed that business and strategic intelligence policies have not been established at either company or state level, as this is an area of activity that is not known to the players in companies and public departments, and there are no units or offices in their organizational structures responsible for managing strategic information for competitiveness on the international market. In addition, there is a real need to establish strategic information management units within companies, upstream, and to set up a national strategic information management department or agency to help local companies compete in the marketplace, downstream. This reflects the importance and timeliness of building business and strategic intelligence policies to ensure economic progress and development in the eastern DRC. Business and strategic intelligence provides companies with an appropriate tool for researching, collecting, processing and disseminating information useful for decision-making among stakeholders, in order to cope with a crisis or competitive situation. The study suggests a number of key recommendations based on its findings. To the government, it is recommended to establish the national policy of business and strategic intelligence by setting up a national agency of strategic intelligence in favor of local companies;and to companies to establish business intelligence units in their organizational structures in favor of stakeholders to foster advantageous decision-making in the competitive market and achieve progress. Finally, the study suggests that studies be carried out to fully understand the opportunities and impact of business and strategic intelligence in African countries, particularly in the DRC. 展开更多
关键词 Business and Strategic Intelligence Strategic Information Congolese Companies Public Departments Decision-Making Information Management Business and Strategic Intelligence Policies PROGRESS Healthy development Mining and Agriculture Sectors International Market Eastern DRC
下载PDF
Computational Strategy Research on the Development of Kiruna,in Sweden
3
作者 Ruocheng Sun 《建筑工程(中英文版)》 2024年第1期9-19,共11页
In Kiruna,nearly all the residents support the migration plan in order to make LKAB able to continue the mining process.Based on current condition,a larger part of this town will be demolished by the sinking land caus... In Kiruna,nearly all the residents support the migration plan in order to make LKAB able to continue the mining process.Based on current condition,a larger part of this town will be demolished by the sinking land caused by iron ore mining processing operated by LKAB.Since then,most of the buildings in the sinking district will be relocated in another district.However,the situation in Kiruna is not quite the same as when this kind of migration happens in another place.In other place,while migration happens,even if not most,a large part of the local residents will resist and fight for their house and properties.Concentrated on the ownership of different buildings and tried find the relationship between the public and private buildings to discover some issue that will help to work on the computational urban design. 展开更多
关键词 Iron Mine Economic PUBLIC PRIVATE Property OWNERSHIP TRANSPORTATION EMPLOYMENT Economical System development History Swarm Intelligence Logic Processing
下载PDF
The Eight Stages of Psychosocial Protective Development: Developmental Psychology 被引量:1
4
作者 Dingyu Chung 《Journal of Behavioral and Brain Science》 2018年第6期369-398,共30页
The proposed universal psychological mechanism for developmental psychology is the mental protective system whose different parts emerge and mature in the eight different stages of psychosocial protective development ... The proposed universal psychological mechanism for developmental psychology is the mental protective system whose different parts emerge and mature in the eight different stages of psychosocial protective development under different social interactions. The proposed eight stages of psychosocial protective development are childhood (infancy, toddlerhood, pre-juvenile age, and juvenile age), adolescence, early young adulthood, late young adulthood, early middle adulthood, late middle adulthood, early late adulthood, and late late adulthood. The mental protection system consists of four socialities (collectivistic, individualistic, interdependent, and generativity), three worldviews (territorial, competitive, and cooperative), and the mental immune system for four regulated and unregulated countermeasures (hyperactivity, phobia, comforter, and rationality) against adversities. During childhood, dependent children have collectivistic sociality under the protection of committed parents and territorial worldview with the boundary of family. Children start with the unregulated mental immune system without delayed gratification due to mental immaturity, and gradually acquire the regulated mental immune system with delayed gratification through mental maturity. Adolescents transit to adulthood. Independent adults have the regulated metal immune system, individualistic sociality with reciprocity, and competitive-cooperative worldviews without boundary. After the age of 50, older people as elder leaders-mentors develop generativity sociality to protect next generation. The paper shows that the mental protective system as the universal psychological mechanism for developmental psychology explains clearly psychosocial protective development, the human evolution, the Piaget’s cognitive development, the Erikson’s psychosocial (ego-social) development, the Confucius’ (educated person’s) six milestones of life, and parent-child relation in the Abrahamic religions (Judaism, Christianity, and Islam) and Confucianism. 展开更多
关键词 developmentAL Psychology Mental Protection System Universal Psychological Mechanism PSYCHOSOCIAL Protective development developmentAL STAGES Brain Human Evolution Jean Piaget. Erik ERIKSON Confucius Abrahamic RELIGIONS Confucianism
下载PDF
Neurodevelopmental outcome in congenital diaphragmatic hernia: Evaluation, predictors and outcome 被引量:1
5
作者 Enrico Danzer Stephen S Kim 《World Journal of Clinical Pediatrics》 2014年第3期30-36,共7页
To review the reported neurodevelopmental outcome of congenital diaphragmatic hernia(CDH) survivors, identify important predictors of developmental disabilities, and describe the pathophysiological mechanisms contribu... To review the reported neurodevelopmental outcome of congenital diaphragmatic hernia(CDH) survivors, identify important predictors of developmental disabilities, and describe the pathophysiological mechanisms contributing to adverse outcome. A Medline search was performed for English-language articles cross-referencing CDH with pertinent search terms. Retrospective, prospective, and longitudinal follow-up studies were examined. The reference lists of identified articles were also searched. Neurodevelopmental dysfunction has been recognized as one of most common and potentially most disabling outcome of CDH. Intelligence appears to be in the low normal to mildly delayed range. Neuromotor dysfunction is common during early childhood. Behavioral problems, hearing impairment, and quality of life related issues are frequently encountered in older children and adolescence. Disease severity correlates with the degree of neurological dysfunction. Neurodevelopmental follow-up in CDH children should become standard of care to identify those who would benefit from early intervention services and improve neurological outcomes. 展开更多
关键词 Congenital DIAPHRAGMATIC HERNIA EXTRACORPOREAL membrane oxygenation NEUROdevelopment Bayley SCALE of infant development Wechsler PRESCHOOL and Primary SCALE of Intelligenc developmental disabilities Quality of life Autism
下载PDF
The Analysis of Human Development Index (HDI) for Categorizing the Member States of the United Nations (UN)
6
作者 Sivarajah Mylevaganam 《Open Journal of Applied Sciences》 2017年第12期661-690,共30页
To categorize the nations to reflect the development status, to date, there are many conceptual frameworks. The Human Development index (HDI) that is published by the United Nations Development Programme is widely acc... To categorize the nations to reflect the development status, to date, there are many conceptual frameworks. The Human Development index (HDI) that is published by the United Nations Development Programme is widely accepted and practiced by many people such as academicians, politicians, and donor organizations. However, though the development of HDI has gone through many revisions since its formulation in 1990, even the current version of the index formulation published in 2016 needs research to better understand and to gap-fill the knowledge base that can enhance the index formulation to facilitate the direction of attention such as release of funds. Therefore, in this paper, based on principal component analysis and K-means clustering algorithm, the data that reflect the measures of life expectancy index (LEI), education index (EI), and income index (II) are analyzed to categorize and to rank the member states of the UN using R statistical software package, an open source extensible programming language for statistical computing and graphics. The outcome of the study shows that the proportion of total eigen value (i.e., proportion of total variance) explained by PCA-1 (i.e., first principal component) accounts for more than 85% of the total variation. Moreover, the proportion of total eigen value explained by PCA-1 increases with time (i.e., yearly) though the amount of increase with time is not significant. However, the proportions of total eigen value explained by PCA-2 and PCA-3 decrease with time. Therefore, the loss of information in choosing PCA-1 to represent the chosen explanatory variables (i.e., LEI, EI, and II) may diminish with time if the trend of increasing pattern of proportion of total eigen value explained by PCA-1 with time continues in the future as well. On the other hand, the correlation between EI and PCA-1 increases with time although the magnitude of increase is not that significant. This same trend is observed in II as well. However, in contrast to these observations, the correlation between PCA-1 and LEI decreases with time. These findings imply that the contributions of EI and II to PCA-1 increase with time, but the contribution of LEI to PCA-1 decreases with time. On top of these, as per Hopkins statistic, the clusterability of the information conveyed by PCA-1 alone is far better than the clusterability of the information conveyed by PCA scores (i.e., PCA-1, PCA-2, and PCA-3) and the explanatory variables. Therefore, choosing PCA-1 to represent the chosen explanatory variables is becoming more concrete. 展开更多
关键词 Human development Index Economy Sustainability UNITED Nations development Programme Education Life EXPECTANCY Per Capita INCOME JavaScript R Statistical Software Principal Component ANALYSIS K-Means Clustering HOPKINS Statistic
下载PDF
Establishment of human cerebral organoid systems to model early neural development and assess the central neurotoxicity of environmental toxins
7
作者 Daiyu Hu Yuanqing Cao +6 位作者 Chenglin Cai Guangming Wang Min Zhou Luying Peng Yantao Fan Qiong Lai Zhengliang Gao 《Neural Regeneration Research》 SCIE CAS 2025年第1期242-252,共11页
Human brain development is a complex process,and animal models often have significant limitations.To address this,researchers have developed pluripotent stem cell-derived three-dimensional structures,known as brain-li... Human brain development is a complex process,and animal models often have significant limitations.To address this,researchers have developed pluripotent stem cell-derived three-dimensional structures,known as brain-like organoids,to more accurately model early human brain development and disease.To enable more consistent and intuitive reproduction of early brain development,in this study,we incorporated forebrain organoid culture technology into the traditional unguided method of brain organoid culture.This involved embedding organoids in matrigel for only 7 days during the rapid expansion phase of the neural epithelium and then removing them from the matrigel for further cultivation,resulting in a new type of human brain organoid system.This cerebral organoid system replicated the temporospatial characteristics of early human brain development,including neuroepithelium derivation,neural progenitor cell production and maintenance,neuron differentiation and migration,and cortical layer patterning and formation,providing more consistent and reproducible organoids for developmental modeling and toxicology testing.As a proof of concept,we applied the heavy metal cadmium to this newly improved organoid system to test whether it could be used to evaluate the neurotoxicity of environmental toxins.Brain organoids exposed to cadmium for 7 or 14 days manifested severe damage and abnormalities in their neurodevelopmental patterns,including bursts of cortical cell death and premature differentiation.Cadmium exposure caused progressive depletion of neural progenitor cells and loss of organoid integrity,accompanied by compensatory cell proliferation at ectopic locations.The convenience,flexibility,and controllability of this newly developed organoid platform make it a powerful and affordable alternative to animal models for use in neurodevelopmental,neurological,and neurotoxicological studies. 展开更多
关键词 cadmium cell death cell proliferation cortical development environmental toxins neural progenitor cells NEUROGENESIS NEUROTOXICOLOGY ORGANOIDS stem cells
下载PDF
Pathway and Countermeasure of Farmers Livelihood Transformation in the Ecological Development Area of Northern Guangdong Province from the Perspective of Ecological Protection
8
作者 Jinguo HUANG Xi HUANG +1 位作者 Faming ZENG Xizhi WANG 《Asian Agricultural Research》 2024年第9期7-10,共4页
[Objectives]To explore pathways and countermeasures for transforming farmers livelihoods in the way of reducing their dependence on land while promoting sustainable development and alleviating ecological degradation.[... [Objectives]To explore pathways and countermeasures for transforming farmers livelihoods in the way of reducing their dependence on land while promoting sustainable development and alleviating ecological degradation.[Methods]A combination of field research,literature review,and policy analysis was employed to identify key factors affecting farmers livelihoods and potential strategies for transformation.[Results]The study found that developing ecological agriculture and modern agriculture,promoting agricultural transformation and upgrading,cultivating alternative industries,strengthening ecological engineering construction,and establishing diversified ecological compensation methods and supporting policies are effective strategies for transforming farmers livelihoods.[Conclusions]Implementing these strategies can help alleviate the contradiction between ecological protection and farmers livelihood development,promoting coordinated development of both.This approach not only benefits farmers but also contributes to sustainable environmental management and biodiversity conservation. 展开更多
关键词 ECOLOGICAL protection FARMERS LIVELIHOOD TRANSFORMATION PATHWAYS and countermeasures ECOLOGICAL development area
下载PDF
BMPRⅡ^(+)neural precursor cells isolated and characterized from organotypic neurospheres:an in vitro model of human fetal spinal cord development 被引量:1
9
作者 Michael W.Weible II Michael D.Lovelace +2 位作者 Hamish D.Mundell Tsz Wai Rosita Pang Tailoi Chan-Ling 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第2期447-457,共11页
Roof plate secretion of bone morphogenetic proteins(BMPs)directs the cellular fate of sensory neurons during spinal cord development,including the formation of the ascending sensory columns,though their biology is not... Roof plate secretion of bone morphogenetic proteins(BMPs)directs the cellular fate of sensory neurons during spinal cord development,including the formation of the ascending sensory columns,though their biology is not well understood.Type-ⅡBMP receptor(BMPRⅡ),the cognate receptor,is expressed by neural precursor cells during embryogenesis;however,an in vitro method of enriching BMPRⅡ^(+)human neural precursor cells(hNPCs)from the fetal spinal cord is absent.Immunofluorescence was undertaken on intact second-trimester human fetal spinal cord using antibodies to BMPRⅡand leukemia inhibitory factor(LIF).Regions of highest BMPRⅡ^(+)immunofluorescence localized to sensory columns.Parenchymal and meningeal-associated BMPRⅡ^(+)vascular cells were identified in both intact fetal spinal cord and cortex by co-positivity with vascular lineage markers,CD34/CD39.LIF immunostaining identified a population of somas concentrated in dorsal and ventral horn interneurons,mirroring the expression of LIF receptor/CD118.A combination of LIF supplementation and high-density culture maintained culture growth beyond 10 passages,while synergistically increasing the proportion of neurospheres with a stratified,cytoarchitecture.These neurospheres were characterized by BMPRⅡ^(+)/MAP2ab^(+/–)/βⅢ-tubulin^(+)/nestin^(–)/vimentin^(–)/GFAP^(–)/NeuN^(–)surface hNPCs surrounding a heterogeneous core ofβⅢ-tubulin^(+)/nestin^(+)/vimentin^(+)/GFAP^(+)/MAP2ab^(–)/NeuN^(–)multipotent precursors.Dissociated cultures from tripotential neurospheres contained neuronal(βⅢ-tubulin^(+)),astrocytic(GFAP+),and oligodendrocytic(O4+)lineage cells.Fluorescence-activated cell sorting-sorted BMPRⅡ^(+)hNPCs were MAP2ab^(+/–)/βⅢ-tubulin^(+)/GFAP^(–)/O4^(–)in culture.This is the first isolation of BMPRⅡ^(+)hNPCs identified and characterized in human fetal spinal cords.Our data show that LIF combines synergistically with high-density reaggregate cultures to support the organotypic reorganization of neurospheres,characterized by surface BMPRⅡ^(+)hNPCs.Our study has provided a new methodology for an in vitro model capable of amplifying human fetal spinal cord cell numbers for>10 passages.Investigations of the role BMPRⅡplays in spinal cord development have primarily relied upon mouse and rat models,with interpolations to human development being derived through inference.Because of significant species differences between murine biology and human,including anatomical dissimilarities in central nervous system(CNS)structure,the findings made in murine models cannot be presumed to apply to human spinal cord development.For these reasons,our human in vitro model offers a novel tool to better understand neurodevelopmental pathways,including BMP signaling,as well as spinal cord injury research and testing drug therapies. 展开更多
关键词 BMPR bone morphogenetic protein histotypic human spinal cord development leukemia inhibitory factor NEUROSPHERE ORGANOTYPIC reaggregate sensory columns
下载PDF
The Effect of the MNRI Method on Neurotransmitter Biomarkers of Individuals with Neurodevelopmental Disorders
10
作者 Clayton Bell Jordan Whitney +4 位作者 Trina Deiss Тatiana Tatarinova Lorri Franckle Susan Beaven Jeffrey Davis 《Neuroscience & Medicine》 2019年第3期292-321,共30页
Introduction: The MNRI (Masgutova Neurosensorimotor Reflex Integration) method was developed in 1989 in Russia and has spread world-wide to treat individuals with certain types reflex development deficits, behavior di... Introduction: The MNRI (Masgutova Neurosensorimotor Reflex Integration) method was developed in 1989 in Russia and has spread world-wide to treat individuals with certain types reflex development deficits, behavior disorders, disorders of speech or language development, and learning disabilities. MNRI is based on techniques called “repatterning” or remodulation, meaning re-education, recoding the reflex nerve pathways specific for dynamic and postural reflex schemes. Objectives: Repatterning activates the extra pyramidal nervous system responsible for automatic mechanisms and processes, the extension of links between neurons, the growth of neural nets, myelination, and the creation of new nerve routing. This potential result was tested utilizing urinary measurements of the following neurotransmitters: epinephrine, norepinephrine, dopamine, DOPAC, serotonin, 5-HIAA, glycine, taurine, GABA, glutamate, PEA, and histamine. Methods: Neurological impact of the Masgutova Neurosensorimotor Reflex Method on the magnitude of changes in neurotransmitters was assessed by an external controlled and double-blind method using patients from one of the four diagnosis groups: 1) global developmental disorders;2) cerebral palsy, Traumatic Brain Injury (TBI), Acute Brain Injury (ABI), and seizures;3) ADD/ADHD;and 4) anxiety disorders. Results: The post-MNRI results in participants show a tendency for regulation of the above neurotransmitters resulting in their calming down, decrease of hypervigilance, stress resilience increase, improvements in behavioral and emotional regulation, positive emotions, and cognitive processes control. Conclusion: The application of the Masgutova Neurosensorimotor Reflex Method as a therapy modality offers a novelty paradigm for the treatment using neuro- and immune-modulation technologies presenting a non-pharmaceutical approach, based on use of neurosensorimotor reflex circuit concept. 展开更多
关键词 Neurotransmitters Masgutova Neurosensorimotor REFLEX METHOD (MNRI) Sensory-Motor REFLEX Integration Immunology Global developmental DISORDERS Cerebral PALSY Traumatic BRAIN INJURY (TBI) Acute BRAIN INJURY (ABI) Seizures ADD/ADHD and Anxiety DISORDERS
下载PDF
Postnatal development of rat retina:a continuous observation and comparison between the organotypic retinal explant model and in vivo development
11
作者 Baoqi Hu Rui Wang +8 位作者 Hanyue Zhang Xiou Wang Sijia Zhou Bo Ma Yan Luan Xin Wang Xinlin Chen Zhichao Zhang Qianyan Kang 《Neural Regeneration Research》 SCIE CAS 2025年第3期900-912,共13页
The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell cultures.However,the lack of systematic and contin... The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell cultures.However,the lack of systematic and continuous comparison between in vivo retinal development and the organotypic retinal explant culture makes this model controversial in postnatal retinal development studies.Thus,we aimed to verify the feasibility of using this model for postnatal retinal development studies by comparing it with the in vivo retina.In this study,we showed that postnatal retinal explants undergo normal development,and exhibit a consistent structure and timeline with retinas in vivo.Initially,we used SOX2 and PAX6 immunostaining to identify retinal progenitor cells.We then examined cell proliferation and migration by immunostaining with Ki-67 and doublecortin,respectively.Ki-67-and doublecortin-positive cells decreased in both in vivo and explants during postnatal retinogenesis,and exhibited a high degree of similarity in abundance and distribution between groups.Additionally,we used Ceh-10 homeodomain-containing homolog,glutamate-ammonia ligase(glutamine synthetase),neuronal nuclei,and ionized calcium-binding adapter molecule 1 immunostaining to examine the emergence of bipolar cells,Müller glia,mature neurons,and microglia,respectively.The timing and spatial patterns of the emergence of these cell types were remarkably consistent between in vivo and explant retinas.Our study showed that the organotypic retinal explant culture model had a high degree of consistency with the progression of in vivo early postnatal retina development.The findings confirm the accuracy and credibility of this model and support its use for long-term,systematic,and continuous observation. 展开更多
关键词 bipolar cells differentiation in vivo microglia Müller glia organotypic retinal explant culture postnatal retina development proliferation retinal progenitor cells
下载PDF
Knowledge Management of Software Productivity and Development Time
12
作者 James A. Rodger Pankaj Pankaj Ata Nahouraii 《Journal of Software Engineering and Applications》 2011年第11期609-618,共10页
In this paper, we identify a set of factors that may be used to forecast software productivity and software development time. Software productivity was measured in function points per person hours, and software develo... In this paper, we identify a set of factors that may be used to forecast software productivity and software development time. Software productivity was measured in function points per person hours, and software development time was measured in number of elapsed days. Using field data on over 130 field software projects from various industries, we empirically test the impact of team size, integrated computer aided software engineering (ICASE) tools, software development type, software development platform, and programming language type on the software development productivity and development time. Our results indicate that team size, software development type, software development platform, and programming language type significantly impact software development productivity. However, only team size significantly impacts software development time. Our results indicate that effective management of software development teams, and using different management strategies for different software development type environments may improve software development productivity. 展开更多
关键词 SOFTWARE Engineering SOFTWARE Metrics FOURTH Generation LANGUAGES CASE TOOLS Field Study TOOLS And Techniques Models And Principles Team Size VOLATILITY development Platform And Type Productivity Elapsed development Time
下载PDF
Spatiotemporal expression of leukemia inhibitory factor receptor protein during neural tube development in embryos with neural tube defects
13
作者 Dong An Xiao-Wei Wei +3 位作者 He-Nan Zhang Dan Liu Wei Ma Zheng-Wei Yuan 《Neural Regeneration Research》 SCIE CAS CSCD 2020年第4期705-711,共7页
Leukemia inhibitory factor receptor(LIFR),as a neuroregulatory cytokine receptor,generally shows a neuroprotective effect in central nervous system injuries.In this study,to understand the effect of LIFR on pathogenes... Leukemia inhibitory factor receptor(LIFR),as a neuroregulatory cytokine receptor,generally shows a neuroprotective effect in central nervous system injuries.In this study,to understand the effect of LIFR on pathogenesis of neural tube defects,we explored spatiotemporal expression of LIFR at different stages of fetal development in normal and neural tube defect embryos.Spina bifida aperta was induced with all-trans retinoic acid on embryonic day 10 in rats,and the spatiotemporal expression of LIFR was investigated in spina bifida aperta rats and healthy rats from embryonic day 11 to 17.Real time-polymerase chain reaction and western blot assay were used to examine mRNA and protein expression of LIFR in healthy control and neural tube defect embryos.Results of the animal experiment demonstrated that expression of LIFR protein and mRNA in the spinal cords of normal rat embryos increased with embryonic development.LIFR was significantly downregulated in the spinal cords of spina bifida aperta rats compared with healthy rats from embryonic days 11 to 17.Immunohistochemical staining showed that the expression of LIFR in placenta and spinal cord in spina bifida aperta rat embryos was decreased compared with that in control embryos at embryonic day 15.Results from human embryo specimens showed that LIFR mRNA expression was significantly down-regulated in spinal cords of human fetuses with neural tube defects compared with normal controls at a gestational age of 24 to 33 weeks.The results were consistent with the down-regulation of LIFR in the animal experiments.Our study revealed spatiotemporal changes in expression of LIFR during embryonic neurulation.Thus,LIFR might play a specific role in neural tube development.All animal and human experimental procedures were approved by the Medical Ethics Committee of Shengjing Hospital of China Medical University,China(approval No.2016PS106K)on February 25,2016. 展开更多
关键词 amniotic fluid development EMBRYOGENESIS LEUKEMIA INHIBITORY factor receptor nerve regeneration neural tube defect PLACENTA spatiotemporal expression spina bifida aperta spinal CORD serum
下载PDF
Iteration and evaluation of shale oil development technology for continental rift lake basins
14
作者 SUN Huanquan WANG Haitao +8 位作者 YANG Yong LYU Qi ZHANG Feng LIU Zupeng LYU Jing CHEN Tiancheng JIANG Tingxue ZHAO Peirong WU Shicheng 《Petroleum Exploration and Development》 SCIE 2024年第4期993-1008,共16页
By benchmarking with the iteration of drilling technology,fracturing technology and well placement mode for shale oil and gas development in the United States and considering the geological characteristics and develop... By benchmarking with the iteration of drilling technology,fracturing technology and well placement mode for shale oil and gas development in the United States and considering the geological characteristics and development difficulties of shale oil in the Jiyang continental rift lake basin,East China,the development technology system suitable for the geological characteristics of shale oil in continental rift lake basins has been primarily formed through innovation and iteration of the development,drilling and fracturing technologies.The technology system supports the rapid growth of shale oil production and reduces the development investment cost.By comparing it with the shale oil development technology in the United States,the prospect of the shale oil development technology iteration in continental rift lake basins is proposed.It is suggested to continuously strengthen the overall three-dimensional development,improve the precision level of engineering technology,upgrade the engineering technical indicator system,accelerate the intelligent optimization of engineering equipment,explore the application of complex structure wells,form a whole-process integrated quality management system from design to implementation,and constantly innovate the concept and technology of shale oil development,so as to promote the realization of extensive,beneficial and high-quality development of shale oil in continental rift lake basins. 展开更多
关键词 shale oil continental rift lake basin Jiyang Depression DRILLING FRACTURING development technology iteration PROSPECT
下载PDF
Research progress and potential of new enhanced oil recovery methods in oilfield development
15
作者 YUAN Shiyi HAN Haishui +5 位作者 WANG Hongzhuang LUO Jianhui WANG Qiang LEI Zhengdong XI Changfeng LI Junshi 《Petroleum Exploration and Development》 SCIE 2024年第4期963-980,共18页
This paper reviews the basic research means for oilfield development and also the researches and tests of enhanced oil recovery(EOR)methods for mature oilfields and continental shale oil development,analyzes the probl... This paper reviews the basic research means for oilfield development and also the researches and tests of enhanced oil recovery(EOR)methods for mature oilfields and continental shale oil development,analyzes the problems of EOR methods,and proposes the relevant research prospects.The basic research means for oilfield development include in-situ acquisition of formation rock/fluid samples and non-destructive testing.The EOR methods for conventional and shale oil development are classified as improved water flooding(e.g.nano-water flooding),chemical flooding(e.g.low-concentration middle-phase micro-emulsion flooding),gas flooding(e.g.micro/nano bubble flooding),thermal recovery(e.g.air injection thermal-aided miscible flooding),and multi-cluster uniform fracturing/water-free fracturing,which are discussed in this paper for their mechanisms,approaches,and key technique researches and field tests.These methods have been studied with remarkable progress,and some achieved ideal results in field tests.Nonetheless,some problems still exist,such as inadequate research on mechanisms,imperfect matching technologies,and incomplete industrial chains.It is proposed to further strengthen the basic researches and expand the field tests,thereby driving the formation,promotion and application of new technologies. 展开更多
关键词 oilfield development enhanced oil recovery mature oilfield shale oil improved water flooding chemical flooding gas flooding thermal recovery
下载PDF
Shale oil development techniques and application based on ternary-element storage and flow concept in Jiyang Depression,Bohai Bay Basin,East China
16
作者 YANG Yong 《Petroleum Exploration and Development》 SCIE 2024年第2期380-393,共14页
The ternary-element storage and flow concept for shale oil reservoirs in Jiyang Depression of Bohai Bay Basin,East China,was proposed based on the data of more than 10000 m cores and the production of more than 60 hor... The ternary-element storage and flow concept for shale oil reservoirs in Jiyang Depression of Bohai Bay Basin,East China,was proposed based on the data of more than 10000 m cores and the production of more than 60 horizontal wells.The synergy of three elements(storage,fracture and pressure)contributes to the enrichment and high production of shale oil in Jiyang Depression.The storage element controls the enrichment of shale oil;specifically,the presence of inorganic pores and fractures,as well as laminae of lime-mud rocks,in the saline lake basin,is conducive to the storage of shale oil,and the high hydrocarbon generating capacity and free hydrocarbon content are the material basis for high production.The fracture element controls the shale oil flow;specifically,natural fractures act as flow channels for shale oil to migrate and accumulate,and induced fractures communicate natural fractures to form complex fracture network,which is fundamental to high production.The pressure element controls the high and stable production of shale oil;specifically,the high formation pressure provides the drive force for the migration and accumulation of hydrocarbons,and fracturing stimulation significantly increases the elastic energy of rock and fluid,improves the imbibition replacement of oil in the pores/fractures,and reduces the stress sensitivity,guaranteeing the stable production of shale oil for a long time.Based on the ternary-element storage and flow concept,a 3D development technology was formed,with the core techniques of 3D well pattern optimization,3D balanced fracturing,and full-cycle optimization of adjustment and control.This technology effectively guides the production and provides a support to the large-scale beneficial development of shale oil in Jiyang Depression. 展开更多
关键词 Jiyang Depression continental shale oil reservoir space fracturing stimulation fracture network storage and flow theory 3D development high and stable production
下载PDF
Role of self-help groups on socioeconomic development and the achievement of Sustainable Development Goals(SDGs)among rural women in Cooch Behar District,India
17
作者 Debanjan BASAK Indrajit Roy CHOWDHURY 《Regional Sustainability》 2024年第2期63-74,共12页
This study examines the transformative role of self-help groups(SHGs)in the socioeconomic development of rural women in Cooch Behar District,India,and their contribution toward achieving Sustainable Development Goals(... This study examines the transformative role of self-help groups(SHGs)in the socioeconomic development of rural women in Cooch Behar District,India,and their contribution toward achieving Sustainable Development Goals(SDGs)of the United Nations.In this study,we explored the effect of SHGs on rural women by specifically addressing SDGs,such as no poverty(SDG 1),zero hunger(SDG 2),good health and well-being(SDG 3),quality education(SDG 4),and gender equality(SDG 5).Given this issue,a cross-sectional survey and comparison analyses are needed to assess the socioeconomic development of rural women and their awareness level before and after the participation of rural women in SHGs.The survey conducted as part of this study was divided into three sections,namely,demographic characteristics,socioeconomic development,and awareness level,with each focusing on different aspects.A group of 400 individuals who were part of SHGs completed the questionnaire survey form.The results showed that the participation of rural women in SHGs significantly improved their socioeconomic development and awareness level,as supported by both mean values and t test results.Memberships in SHGs and microcredit programs were the major elements that boosted the socioeconomic development of rural women,which also achieves SDGs 1,2,3,4,and 5.This study revealed that participation in SHGs and related financial services significantly aided rural women in economically disadvantaged communities in accumulating savings and initiating entrepreneurial ventures.Moreover,participation in SHGs was instrumental in enhancing the self-confidence,self-efficacy,and overall self-esteem of rural women.Finally,doing so enabled them to move more freely for work and other activities and to make family and common decisions. 展开更多
关键词 Self-help groups Rural women SOCIOECONOMIC development Sustainable development Goals(SDGs) MICROCREDIT INDIA
下载PDF
Leveraging Robust Artificial Intelligence for Mechatronic Product Development—A Literature Review
18
作者 Alexander Nüßgen René Degen +3 位作者 Marcus Irmer Fabian Richter Cecilia Boström Margot Ruschitzka 《International Journal of Intelligence Science》 2024年第1期1-21,共21页
Mechatronic product development is a complex and multidisciplinary field that encompasses various domains, including, among others, mechanical engineering, electrical engineering, control theory and software engineeri... Mechatronic product development is a complex and multidisciplinary field that encompasses various domains, including, among others, mechanical engineering, electrical engineering, control theory and software engineering. The integration of artificial intelligence technologies is revolutionizing this domain, offering opportunities to enhance design processes, optimize performance, and leverage vast amounts of knowledge. However, human expertise remains essential in contextualizing information, considering trade-offs, and ensuring ethical and societal implications are taken into account. This paper therefore explores the existing literature regarding the application of artificial intelligence as a comprehensive database, decision support system, and modeling tool in mechatronic product development. It analyzes the benefits of artificial intelligence in enabling domain linking, replacing human expert knowledge, improving prediction quality, and enhancing intelligent control systems. For this purpose, a consideration of the V-cycle takes place, a standard in mechatronic product development. Along this, an initial assessment of the AI potential is shown and important categories of AI support are formed. This is followed by an examination of the literature with regard to these aspects. As a result, the integration of artificial intelligence in mechatronic product development opens new possibilities and transforms the way innovative mechatronic systems are conceived, designed, and deployed. However, the approaches are only taking place selectively, and a holistic view of the development processes and the potential for robust and context-sensitive artificial intelligence along them is still needed. 展开更多
关键词 Artificial Intelligence Mechatronic Product development Knowledge Management Data Analysis Optimization Human Experts Decision-Making Processes V-CYCLE
下载PDF
Metropolitan Housing Development in Urban Fringe Areas-A Case Study of Three Metropolitan Cities of South Africa: Johannesburg, Ekurhuleni and Tshwane
19
作者 Aurobindo Ogra 《Journal of Civil Engineering and Architecture》 2024年第5期244-253,共10页
Purpose:The metropolitan cities of Johannesburg,Ekurhuleni and Tshwane play an important role in the economy of the Gauteng province in South Africa.The region constitutes to 22.4 percent of the total population of So... Purpose:The metropolitan cities of Johannesburg,Ekurhuleni and Tshwane play an important role in the economy of the Gauteng province in South Africa.The region constitutes to 22.4 percent of the total population of South Africa and has a strong presence and contributes in areas of manufacturing sector,financial and business services,retail and wholesale trade,etc.The rapid urban population,increase in the informal settlements and socio-economic opportunities has resulted in considerable urban sprawl in and around the urban fringe areas of these metropolitan cities.The urban fringe areas of these metros often come under the influence of rapid urbanization process and pressures.Coupled with the economical and potential land dynamics and lack of priority of spatial development guidelines,these areas attract rapid and haphazard development from communities and developers.Research Design/Methodology:This research is based on a qualitative approach through a comprehensive literature review that included content analysis of key documents on housing sector such as IDPs(Integrated Development Plans),Municipal Annual Reports,Growth Development Strategies,and among other sectoral documents on housing sector.Some of the key priority issues considered in the housing sector included:eradication of housing backlogs,spatial restructuring of housing,provision of choice in terms of location,tenure and housing typology.Findings:The current paper discusses the approaches of metropolitan housing development processes in three metropolitan cities of South Africa from Gauteng region,namely:Johannesburg,Ekurhuleni and Tshwane.The paper discusses the existing housing sectoral scenario along with the fringe areas in three cities with focus on:formal and informal settlements,housing segregation and the backlogs,current institutional arrangements,role of public private participation,and scope for alternate mechanisms.The paper concludes in discussion on sustainable development options for housing development in urban fringe areas. 展开更多
关键词 Metropolitan housing development urban fringe areas housing backlog informal settlements urban poor land dynamics housing infrastructure PPP(public private partnership)
下载PDF
Construction Method of Civil Aircraft Airborne⁃system Supplier Development Process System
20
作者 PU Youhua LI Lin LI Li 《International Journal of Plant Engineering and Management》 2024年第2期65-77,共13页
Based on the analysis of the development process system status of domestic and foreign civil aircraft airborne system suppliers,this paper proposes the overall construction idea of"a set of civil aircraft process... Based on the analysis of the development process system status of domestic and foreign civil aircraft airborne system suppliers,this paper proposes the overall construction idea of"a set of civil aircraft process system"based on IPD(Integrated product development)in the organization.The development stage,process,activity and task are the logical framework elements of the system construction."Based on process decomposition,vertical stratification,horizontal segmentation,combination of special and common,process customized to tools,role and process integration,giving full consideration to the interface between supplier management and process modules"etc.are the concrete ideas.Moreover,formulate top⁃level system construction standards,implemented by process system management tool platform,so that the process system and development work can be effectively integrated to effectively guide the development work of airborne system suppliers,and meet the quality and airworthiness requirements of civil aircraft development.Through the development application of a certain type of flight control system,the process system and tool platform were verified and optimized in practice. 展开更多
关键词 development process system development assurance process integrated product development(IPD) development stage ACTIVITY
下载PDF
上一页 1 2 250 下一页 到第
使用帮助 返回顶部