Inhibitory ability of children with developmental dyscalculia(DD) was investigated to explore the cognitive mechanism underlying DD.According to the definition of developmental dyscalculia,19 children with DD-only and...Inhibitory ability of children with developmental dyscalculia(DD) was investigated to explore the cognitive mechanism underlying DD.According to the definition of developmental dyscalculia,19 children with DD-only and 10 children with DD&RD(DD combined with reading disability) were selected step by step,children in two control groups were matched with children in case groups by gender and age,and the match ratio was 1:1.Psychological testing software named DMDX was used to measure inhibitory ability of the subjects.The differences of reaction time in number Stroop tasks and differences of accuracy in incongruent condition of color-word Stroop tasks and object inhibition tasks between DD-only children and their controls reached significant levels(P<0.05),and the differences of reaction time in number Stroop tasks between dyscalculic and normal children did not disappear after controlling the non-executive components.The difference of accuracy in color-word incongruent tasks between children with DD&RD and normal children reached significant levels(P<0.05).Children with DD-only confronted with general inhibitory deficits,while children with DD&RD confronted with word inhibitory deficits only.展开更多
Multiplex Ligation-Dependent Probe Amplification (MLPA) was used to study the integrity of the chromosomes for two WIL2-derived lymphoblastoid cell lines (TK6 and WTK1) in the presence and absence of ionizing radiatio...Multiplex Ligation-Dependent Probe Amplification (MLPA) was used to study the integrity of the chromosomes for two WIL2-derived lymphoblastoid cell lines (TK6 and WTK1) in the presence and absence of ionizing radiation. WTK1 cells contain a p53 mutation, whereas the TK6 cell line has the native p53 tumor-suppressor gene. Each cell line was isolated pre- and post-irradiation (2 and 3 Gy) and analyzed by MLPA. Using probes that target specific regions on chromosomes associated with a distinct subset of microdeletions and microduplications either established or thought to be responsible for intellectual disability or developmental delay, we have demonstrated that WTK1 and TK6 are not impacted in the same way by irradiation. Instead, each cell line presents its own unique MLPA profile. The most notable differences are the appearance of nine unique probe signals only seen in WTK1 cells. These results are important in the study of how different cell lines can be affected in significantly different ways depending on the presence or absence of wild type p53.展开更多
文摘Inhibitory ability of children with developmental dyscalculia(DD) was investigated to explore the cognitive mechanism underlying DD.According to the definition of developmental dyscalculia,19 children with DD-only and 10 children with DD&RD(DD combined with reading disability) were selected step by step,children in two control groups were matched with children in case groups by gender and age,and the match ratio was 1:1.Psychological testing software named DMDX was used to measure inhibitory ability of the subjects.The differences of reaction time in number Stroop tasks and differences of accuracy in incongruent condition of color-word Stroop tasks and object inhibition tasks between DD-only children and their controls reached significant levels(P<0.05),and the differences of reaction time in number Stroop tasks between dyscalculic and normal children did not disappear after controlling the non-executive components.The difference of accuracy in color-word incongruent tasks between children with DD&RD and normal children reached significant levels(P<0.05).Children with DD-only confronted with general inhibitory deficits,while children with DD&RD confronted with word inhibitory deficits only.
文摘Multiplex Ligation-Dependent Probe Amplification (MLPA) was used to study the integrity of the chromosomes for two WIL2-derived lymphoblastoid cell lines (TK6 and WTK1) in the presence and absence of ionizing radiation. WTK1 cells contain a p53 mutation, whereas the TK6 cell line has the native p53 tumor-suppressor gene. Each cell line was isolated pre- and post-irradiation (2 and 3 Gy) and analyzed by MLPA. Using probes that target specific regions on chromosomes associated with a distinct subset of microdeletions and microduplications either established or thought to be responsible for intellectual disability or developmental delay, we have demonstrated that WTK1 and TK6 are not impacted in the same way by irradiation. Instead, each cell line presents its own unique MLPA profile. The most notable differences are the appearance of nine unique probe signals only seen in WTK1 cells. These results are important in the study of how different cell lines can be affected in significantly different ways depending on the presence or absence of wild type p53.
